Mediating function of heart failure in the causal relationship between diastolic blood pressure and hypertensive renal disease with renal failure: a mediated Mendelian randomization study†
Categoría del artículo: Original article
Publicado en línea: 16 sept 2024
Páginas: 285 - 294
Recibido: 03 feb 2024
Aceptado: 18 abr 2024
DOI: https://doi.org/10.2478/fon-2024-0031
Palabras clave
© 2024 Lei Pang et al., published by Sciendo
This work is licensed under the Creative Commons Attribution 4.0 International License.
Objective
To study the causality relationship between diastolic blood pressure (DBP) and hypertensive renal disease with renal failure (HRDRF) and the mediating role of heart failure (HF) in the causality relationship by network Mendelian randomization (MR).
Methods
Genome-wide analysis of DBP, HRDRF, and HF was downloaded from the public database (Genome-Wide Analysis Study [GWAS]) and was used to analyze the results and to conduct mediated MR analysis.
Results
Analysis showed that DBP was positively correlated with HRDRF (OR = 1.0002, 95% CI: 1.0001–1.0003,
Conclusions
DBP can increase the risk of renal disease with renal failure, and HF may play an important role in mediating this causal relationship.