Regulation, Function, and Expression of Matrix Metalloproteinase-9 in Colon, Lung, and Breast Cancers In Silico and Experimental Methods From Iraqi Metastatic Patients

[1]Buttacavoli, M., Di Cara, G., Roz, E., Pucci-Minafra, I., Feo, S., & Cancemi, P. (2021). Integrated multi-omics investigations of metalloproteinases in colon cancer: Focus on MMP2 and MMP9. International journal of molecular sciences, 22(22), 12389. ButtacavoliM. Di CaraG. RozE. Pucci-MinafraI. FeoS. CancemiP. 2021 Integrated multi-omics investigations of metalloproteinases in colon cancer: Focus on MMP2 and MMP9 International journal of molecular sciences 22 22 12389 Search in Google Scholar

[2]Jafarian, A. H., Reisi, H., & Roshan, N. M. (2020). Matrix metalloproteinase-9 (MMP-9) expression in non-small cell lung carcinoma and its association with clinicopathologic factors. Iranian Journal of Pathology, 15(4), 326. JafarianA. H. ReisiH. RoshanN. M. 2020 Matrix metalloproteinase-9 (MMP-9) expression in non-small cell lung carcinoma and its association with clinicopathologic factors Iranian Journal of Pathology 15 4 326 Search in Google Scholar

[3]Thandra, K. C., Barsouk, A., Saginala, K., Aluru, J. S., & Barsouk, A. (2021). Epidemiology of lung cancer. Contemporary Oncology/Współczesna Onkologia, 25(1), 45–52. ThandraK. C. BarsoukA. SaginalaK. AluruJ. S. BarsoukA. 2021 Epidemiology of lung cancer Contemporary Oncology/Współczesna Onkologia 25 1 45 52 Search in Google Scholar

[4]Januškevičienė, I., & Petrikaitė, V. (2019). Heterogeneity of breast cancer: The importance of interaction between different tumor cell populations. Life sciences, 239, 117009. JanuškevičienėI. PetrikaitėV. 2019 Heterogeneity of breast cancer: The importance of interaction between different tumor cell populations Life sciences 239 117009 Search in Google Scholar

[5]Venkitaraman, A. R. (2019). How do mutations affecting the breast cancer genes BRCA1 and BRCA2 cause cancer susceptibility?. DNA repair, 81, 102668. VenkitaramanA. R. 2019 How do mutations affecting the breast cancer genes BRCA1 and BRCA2 cause cancer susceptibility? DNA repair 81 102668 Search in Google Scholar

[6]Zhang, B., Zhang, L., Yue, D., Li, C., Zhang, H., Ye, J., ... & Wang, C. (2020). Genomic characteristics in Chinese non-small cell lung cancer patients and its value in prediction of postoperative prognosis. Translational Lung Cancer Research, 9(4), 1187. ZhangB. ZhangL. YueD. LiC. ZhangH. YeJ. WangC. 2020 Genomic characteristics in Chinese non-small cell lung cancer patients and its value in prediction of postoperative prognosis Translational Lung Cancer Research 9 4 1187 Search in Google Scholar

[7]Costea, T., Vlad, O. C., Miclea, L. C., Ganea, C., Szöllősi, J., & Mocanu, M. M. (2020). Alleviation of multidrug resistance by flavonoid and nonflavonoid compounds in breast, lung, colorectal and prostate cancer. International journal of molecular sciences, 21(2), 401. CosteaT. VladO. C. MicleaL. C. GaneaC. SzöllősiJ. MocanuM. M. 2020 Alleviation of multidrug resistance by flavonoid and nonflavonoid compounds in breast, lung, colorectal and prostate cancer International journal of molecular sciences 21 2 401 Search in Google Scholar

[8]Mondal, S., Adhikari, N., Banerjee, S., Amin, S. A., & Jha, T. (2020). Matrix metalloproteinase-9 (MMP-9) and its inhibitors in cancer: A minireview. European journal of medicinal chemistry, 194, 112260. MondalS. AdhikariN. BanerjeeS. AminS. A. JhaT. 2020 Matrix metalloproteinase-9 (MMP-9) and its inhibitors in cancer: A minireview European journal of medicinal chemistry 194 112260 Search in Google Scholar

[9]Niland, S., Riscanevo, A. X., & Eble, J. A. (2021). Matrix metalloproteinases shape the tumor microenvironment in cancer progression. International journal of molecular sciences, 23(1), 146. NilandS. RiscanevoA. X. EbleJ. A. 2021 Matrix metalloproteinases shape the tumor microenvironment in cancer progression International journal of molecular sciences 23 1 146 Search in Google Scholar

[10]Huang, H. (2018). Matrix metalloproteinase-9 (MMP-9) as a cancer biomarker and MMP-9 biosensors: recent advances. Sensors, 18(10), 3249. HuangH. 2018 Matrix metalloproteinase-9 (MMP-9) as a cancer biomarker and MMP-9 biosensors: recent advances Sensors 18 10 3249 Search in Google Scholar

[11]Jiang, H., & Li, H. (2021). Prognostic values of tumoral MMP2 and MMP9 overexpression in breast cancer: A systematic review and meta-analysis. BMC cancer, 21, 1–13. JiangH. LiH. 2021 Prognostic values of tumoral MMP2 and MMP9 overexpression in breast cancer: A systematic review and meta-analysis BMC cancer 21 1 13 Search in Google Scholar

[12]Zhang, H., Zhao, B., Zhai, Z. G., Zheng, J. D., Wang, Y. K., & Zhao, Y. Y. (2021). Expression and clinical significance of MMP-9 and P53 in lung cancer. European Review for Medical & Pharmacological Sciences, 25(3). ZhangH. ZhaoB. ZhaiZ. G. ZhengJ. D. WangY. K. ZhaoY. Y. 2021 Expression and clinical significance of MMP-9 and P53 in lung cancer European Review for Medical & Pharmacological Sciences 25 3 Search in Google Scholar

[13]Cabral-Pacheco, G. A., Garza-Veloz, I., Castruita-De la Rosa, C., Ramirez-Acuña, J. M., Perez-Romero, B. A., Guerrero-Rodriguez, J. F., ... & Martinez-Fierro, M. L. (2020). The roles of matrix metalloproteinases and their inhibitors in human diseases. International journal of molecular sciences, 21(24), 9739. Cabral-PachecoG. A. Garza-VelozI. Castruita-De la RosaC. Ramirez-AcuñaJ. M. Perez-RomeroB. A. Guerrero-RodriguezJ. F. Martinez-FierroM. L. 2020 The roles of matrix metalloproteinases and their inhibitors in human diseases International journal of molecular sciences 21 24 9739 Search in Google Scholar

[14]Joseph, C., Alsaleem, M., Orah, N., Narasimha, P. L., Miligy, I. M., Kurozumi, S., ... & Rakha, E. A. (2020). Elevated MMP9 expression in breast cancer is a predictor of shorter patient survival. Breast cancer research and treatment, 182, 267–282. JosephC. AlsaleemM. OrahN. NarasimhaP. L. MiligyI. M. KurozumiS. RakhaE. A. 2020 Elevated MMP9 expression in breast cancer is a predictor of shorter patient survival Breast cancer research and treatment 182 267 282Search in Google Scholar

[15]Chien, Y. C., Liu, L. C., Ye, H. Y., Wu, J. Y., & Yu, Y. L. (2018). EZH2 promotes migration and invasion of triple-negative breast cancer cells via regulating TIMP2-MMP-2/-9 pathway. American journal of cancer research, 8(3), 422. ChienY. C. LiuL. C. YeH. Y. WuJ. Y. YuY. L. 2018 EZH2 promotes migration and invasion of triple-negative breast cancer cells via regulating TIMP2-MMP-2/-9 pathway American journal of cancer research 8 3 422 Search in Google Scholar

[16]Hamad, H. A., Enezei, H. H., Alrawas, A., Zakuan, N. M., Abdullah, N. A., Cheah, Y. K., & Hashim, N. F. M. (2020). Identification of potential chemical substrates as fuel for hypoxic tumors that may be linked to invadopodium formation in hypoxia-induced MDA-MB-231 breast-cancer cell line. Molecules, 25(17), 3876. HamadH. A. EnezeiH. H. AlrawasA. ZakuanN. M. AbdullahN. A. CheahY. K. HashimN. F. M. 2020 Identification of potential chemical substrates as fuel for hypoxic tumors that may be linked to invadopodium formation in hypoxia-induced MDA-MB-231 breast-cancer cell line Molecules 25 17 3876 Search in Google Scholar

[17]Hamad, H. A., Gopalsamy, B., Kqueen, C. Y., & Hashim, N. F. M. (2019). Potential Ability of Phytochemical in Inhibition of Invadopodia Formation and HIF-1α in Cancer Metastasis. Malaysian Journal of Medicine & Health Sciences, 15. HamadH. A. GopalsamyB. KqueenC. Y. HashimN. F. M. 2019 Potential Ability of Phytochemical in Inhibition of Invadopodia Formation and HIF-1α in Cancer Metastasis Malaysian Journal of Medicine & Health Sciences 15 Search in Google Scholar

[18]Szklarczyk, D., Gable, A. L., Nastou, K. C., Lyon, D., Kirsch, R., Pyysalo, S., ... & von Mering, C. (2021). The STRING database in 2021: customizable protein–protein networks, and functional characterization of user-uploaded gene/measurement sets. Nucleic acids research, 49(D1), D605–D612. SzklarczykD. GableA. L. NastouK. C. LyonD. KirschR. PyysaloS. von MeringC. 2021 The STRING database in 2021: customizable protein–protein networks, and functional characterization of user-uploaded gene/measurement sets Nucleic acids research 49 D1 D605 D612 Search in Google Scholar

[19]Tang, Z., Li, C., Kang, B., Gao, G., Li, C., & Zhang, Z. (2017). GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses. Nucleic acids research, 45(W1), W98–W102. TangZ. LiC. KangB. GaoG. LiC. ZhangZ. 2017 GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses Nucleic acids research 45 W1 W98 W102 Search in Google Scholar

[20]Digre, A., & Lindskog, C. (2021). The Human Protein Atlas—Spatial localization of the human proteome in health and disease. Protein Science, 30(1), 218–233. DigreA. LindskogC. 2021 The Human Protein Atlas—Spatial localization of the human proteome in health and disease Protein Science 30 1 218 233 Search in Google Scholar

[21]Labeda, I., Uwuratuw, J. A., Hendarto, J., Lusikooy, R. E., Sampetoding, S., Kusuma, M. I., ... & Faruk, M. (2023). Relationship between metalloproteinase-9 (MMP-9) expression and clinicopathology in colorectal cancer: a cross-sectional study. Annals of Medicine and Surgery, 85(9), 4277–4282. LabedaI. UwuratuwJ. A. HendartoJ. LusikooyR. E. SampetodingS. KusumaM. I. FarukM. 2023 Relationship between metalloproteinase-9 (MMP-9) expression and clinicopathology in colorectal cancer: a cross-sectional study Annals of Medicine and Surgery 85 9 4277 4282Search in Google Scholar

[22]Chien, Y. C., Liu, L. C., Ye, H. Y., Wu, J. Y., & Yu, Y. L. (2018). EZH2 promotes migration and invasion of triple-negative breast cancer cells via regulating TIMP2-MMP-2/-9 pathway. American journal of cancer research, 8(3), 422. ChienY. C. LiuL. C. YeH. Y. WuJ. Y. YuY. L. 2018 EZH2 promotes migration and invasion of triple-negative breast cancer cells via regulating TIMP2-MMP-2/-9 pathway American journal of cancer research 8 3 422 Search in Google Scholar

[23]Joseph, C., Alsaleem, M., Orah, N., Narasimha, P. L., Miligy, I. M., Kurozumi, S., ... & Rakha, E. A. (2020). Elevated MMP9 expression in breast cancer is a predictor of shorter patient survival. Breast cancer research and treatment, 182, 267–282. JosephC. AlsaleemM. OrahN. NarasimhaP. L. MiligyI. M. KurozumiS. RakhaE. A. 2020 Elevated MMP9 expression in breast cancer is a predictor of shorter patient survival Breast cancer research and treatment 182 267 282Search in Google Scholar

[24]Tan, H., Zhang, M., Xu, L., Zhang, X., & Zhao, Y. (2022). Gypensapogenin H suppresses tumor growth and cell migration in triple-negative breast cancer by regulating PI3K/AKT/NF-κB/MMP-9 signaling pathway. Bioorganic Chemistry, 126, 105913. TanH. ZhangM. XuL. ZhangX. ZhaoY. 2022 Gypensapogenin H suppresses tumor growth and cell migration in triple-negative breast cancer by regulating PI3K/AKT/NF-κB/MMP-9 signaling pathway Bioorganic Chemistry 126 105913 Search in Google Scholar

[25]Li, C., Ma, Y., Fei, F., Zheng, M., Li, Z., Zhao, Q., ... & Zhang, S. (2020). Critical role and its underlying molecular events of the plasminogen receptor, S100A10 in malignant tumor and non-tumor diseases. Journal of Cancer, 11(4), 826. LiC. MaY. FeiF. ZhengM. LiZ. ZhaoQ. ZhangS. 2020 Critical role and its underlying molecular events of the plasminogen receptor, S100A10 in malignant tumor and non-tumor diseases Journal of Cancer 11 4 826 Search in Google Scholar

[26]Kang, C., Wang, L., Wang, D., Zhang, X., & Chen, J. (2020). Lung cancer A549 cells suppressed with overexpressed HNF1B or PCDHA13 inhibited PI3K/AKT phosphorylation. Translational Cancer Research, 9(6), 3819. KangC. WangL. WangD. ZhangX. ChenJ. 2020 Lung cancer A549 cells suppressed with overexpressed HNF1B or PCDHA13 inhibited PI3K/AKT phosphorylation Translational Cancer Research 9 6 3819 Search in Google Scholar

[27]Peeney, D., Fan, Y., Nguyen, T., Meerzaman, D., & Stetler-Stevenson, W. G. (2019). Matrisome-associated gene expression patterns correlating with TIMP2 in cancer. Scientific reports, 9(1), 20142. PeeneyD. FanY. NguyenT. MeerzamanD. Stetler-StevensonW. G. 2019 Matrisome-associated gene expression patterns correlating with TIMP2 in cancer Scientific reports 9 1 20142 Search in Google Scholar

[28]Lu, L., Liu, Q., Wang, P., Wu, Y., Liu, X., Weng, C., ... & Liu, G. (2019). MicroRNA-148b regulates tumor growth of non-small cell lung cancer through targeting MAPK/JNK pathway. BMC cancer, 19, 1–11. LuL. LiuQ. WangP. WuY. LiuX. WengC. LiuG. 2019 MicroRNA-148b regulates tumor growth of non-small cell lung cancer through targeting MAPK/JNK pathway BMC cancer 19 1 11Search in Google Scholar

[29]Mao, Y., Su, C., Yang, H., Ma, X., Zhao, F., Qu, B., ... & Cui, Y. (2024). PI3K/AKT/mTORC1 signalling pathway regulates MMP9 gene activation via transcription factor NF-κB in mammary epithelial cells of dairy cows. Animal Biotechnology, 2314100. MaoY. SuC. YangH. MaX. ZhaoF. QuB. CuiY. 2024 PI3K/AKT/mTORC1 signalling pathway regulates MMP9 gene activation via transcription factor NF-κB in mammary epithelial cells of dairy cows Animal Biotechnology 2314100 Search in Google Scholar

[30]Wu, L., Wang, J., Zhao, J., Yao, R., Xu, Q., Ma, L., & Liu, J. (2022). Bioinformatics analysis identified RGS4 as a potential tumor promoter in glioma. Pathology-Research and Practice, 240, 154225. WuL. WangJ. ZhaoJ. YaoR. XuQ. MaL. LiuJ. 2022 Bioinformatics analysis identified RGS4 as a potential tumor promoter in glioma Pathology-Research and Practice 240 154225 Search in Google Scholar

[31]Gu, Y., Yu, J., Ding, C., Zhou, Y., Yang, J., Yu, W., ... & Huang, H. (2021). Flavonoid GL-V9 suppresses invasion and migration of human colorectal cancer cells by inhibiting PI3K/Akt and MMP-2/9 signaling. Journal of Cancer, 12(15), 4542. GuY. YuJ. DingC. ZhouY. YangJ. YuW. HuangH. 2021 Flavonoid GL-V9 suppresses invasion and migration of human colorectal cancer cells by inhibiting PI3K/Akt and MMP-2/9 signaling Journal of Cancer 15 15 4542 Search in Google Scholar

[32]Jian, F., Yanhong, J., Limeng, W., Guoping, N., Yiqing, T., Hao, L., & Zhaoji, P. (2022). TIMP2 is associated with prognosis and immune infiltrates of gastric and colon cancer. International immunopharmacology, 110, 109008. JianF. YanhongJ. LimengW. GuopingN. YiqingT. HaoL. ZhaojiP. 2022 TIMP2 is associated with prognosis and immune infiltrates of gastric and colon cancer International immunopharmacology 110 109008 Search in Google Scholar

[33]Costanzo, L., Soto, B., Meier, R., & Geraghty, P. (2022). The Biology and Function of Tissue Inhibitor of Metalloproteinase 2 in the Lungs. Pulmonary Medicine, 2022. CostanzoL. SotoB. MeierR. GeraghtyP. 2022 The Biology and Function of Tissue Inhibitor of Metalloproteinase 2 in the Lungs Pulmonary Medicine 2022 Search in Google Scholar

[34]Chen, W. Q., Yang, S. J., Xu, W. X., Deng, F., Wang, D. D., & Tang, J. H. (2021). Bioinformatics analysis revealing prognostic significance of TIMP2 gene in breast cancer. Medicine, 100(42), e27489. ChenW. Q. YangS. J. XuW. X. DengF. WangD. D. TangJ. H. 2021 Bioinformatics analysis revealing prognostic significance of TIMP2 gene in breast cancer Medicine 100 42 e27489 Search in Google Scholar

[35]Yu, J., He, Z., He, X., Luo, Z., Lian, L., Wu, B., ... & Chen, H. (2021). Comprehensive analysis of the expression and prognosis for MMPs in human colorectal cancer. Frontiers in Oncology, 11, 771099. YuJ. HeZ. HeX. LuoZ. LianL. WuB. ChenH. 2021 Comprehensive analysis of the expression and prognosis for MMPs in human colorectal cancer Frontiers in Oncology 11 771099 Search in Google Scholar

[36]Augoff, K., Hryniewicz-Jankowska, A., Tabola, R., & Stach, K. (2022). MMP9: a tough target for targeted therapy for cancer. Cancers, 14(7), 1847. AugoffK. Hryniewicz-JankowskaA. TabolaR. StachK. 2022 MMP9: a tough target for targeted therapy for cancer Cancers 14 7 1847 Search in Google Scholar

[37]Rashid, Z. A., & Bardaweel, S. K. (2023). Novel matrix metalloproteinase-9 (MMP-9) inhibitors in cancer treatment. International journal of molecular sciences, 24(15), 12133. RashidZ. A. BardaweelS. K. 2023 Novel matrix metalloproteinase-9 (MMP-9) inhibitors in cancer treatment International journal of molecular sciences 24 15 12133 Search in Google Scholar