Antidiabetic agents as potential cytotoxic candidates for cancer therapy
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10 jun 2025
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Categoría del artículo: Research Article
Publicado en línea: 10 jun 2025
Páginas: 68 - 89
Recibido: 16 mar 2024
Aceptado: 16 ago 2024
DOI: https://doi.org/10.2478/fco-2023-0041
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© 2024 Raniah I. Alnaser et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Figure 1:
![Difference in glucose metabolism between normal and cancer cells [22].](https://sciendo-parsed.s3.eu-central-1.amazonaws.com/6471cdf2215d2f6c89db169a/j_fco-2023-0041_fig_001.jpg?X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Content-Sha256=UNSIGNED-PAYLOAD&X-Amz-Credential=AKIA6AP2G7AKOUXAVR44%2F20250908%2Feu-central-1%2Fs3%2Faws4_request&X-Amz-Date=20250908T213138Z&X-Amz-Expires=3600&X-Amz-Signature=2a5679c10309e25888d4a5747a7e370d0634e8ec79f3ef10f149a4e98a126884&X-Amz-SignedHeaders=host&x-amz-checksum-mode=ENABLED&x-id=GetObject)
Figure 2:
Summary of the cytotoxic effects of some antidiabetic drugs_
| Metformin | Breast cancer | [ |
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| Colorectal cancer | [ |
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| Endometrial cancer | [ |
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| Ovarian cancer | [ |
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| Skin cancer | [ |
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| Thyroid cancer | [ |
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| Head and neck cancer | [ |
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| Pancreatic cancer | [ |
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| Lung cancer | [ |
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| Glibenclamide | Gastric cancer | [ |
|
| Breast cancer | [ |
||
| Hepatocellular carcinoma | [ |
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| Colon cancer | [ |
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| Glioblastoma | [ |
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| Rosiglitazone | Neuroblastoma | [ |
|
| Vildagliptin and sitagliptin | Colorectal cancer | [ |
|
| Vildagliptin, sitagliptin, and gemigliptin | Thyroid cancer | [ |
|
| Vildagliptin, sitagliptin, and sitagliptin | Chronic myeloid leukemia | [ |
|
| Vildagliptin | Lung cancer | [ |
|
| Sitagliptin | Gastric cancer | [ |
|
| Breast cancer | [ |
||
| Endometrial cancer | [ |
||
| Cervical carcinoma | [ |
||
| Glioblastoma cancer in the brain | [ |
||
| Exenatide-4 | Hepatocellular carcinoma | [ |
|
| Breast cancer | [ |
||
| Prostate cancer | [ |
||
| Endometrial cancer | [ |
||
| Liraglutide | Endometrial cancer | [ |
|
| Dapagliflozin | Pancreatic carcinoma | [ |
|
| Renal carcinoma (in humans) | [ |
||
| Human colon carcinoma | [ |
||
| Canagliflozin | Pancreatic cancer and early-stage lung cancer | [ |
|
| Hepatocellular carcinoma (in humans) | [ |
||
| Lung cancer | [ |
||
| Breast cancer | [ |
||
| Prostate cancer | [ |
||
| Thyroid cancer | [ |
||
| Ipragliflozin | Breast carcinoma | [ |
|