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Effect of the GHRL gene (rs696217) polymorphism on the metabolic disorders in patients with obesity in the Ukrainian population


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Al-Nbaheen MS. Relationship between single nucleotide polymorphism studies in ghrelin gene with obesity subjects. Journal of King Saud University - Science 35, 102393, 2023. Search in Google Scholar

Bai R, Liu Y, Zhao C, Gao J, Liu R. Distribution and effect of ghrelin genotype on plasma lipid and apolipoprotein profiles in obese and nonobese Chinese subjects. Hormones (Athens) 20, 527–535, 2021. Search in Google Scholar

Becer E, Ergoren MC. Dual effect of the GHRL gene variant in the molecular pathogenesis of obesity. Balkan J Med Genet 24, 27–34, 2021. Search in Google Scholar

Berthold HK, Giannakidou E, Krone W, Mantzoros CS, Gouni-Berthold I. The Leu72Met polymorphism of the ghrelin gene is associated with a decreased risk for type 2 diabetes. Clin Chim Acta 399, 112–116, 2009. Search in Google Scholar

Chen B, Xiao W, Zou Z, Zhu J, Li D, Yu J, Yang H. Ghrelin gene single nucleotide polymorphisms and their effects on Nile tilapia (Oreochromis niloticus) growth. Aquacult Rep 18, 100469, 2020. Search in Google Scholar

Dantas VGL, Furtado-Alle L, Souza RLR, Chautard-Freire-Maia EA. Obesity and variants of the GHRL (ghrelin) and BCHE (butyrylcholinesterase) genes. Genet Mol Biol 34, 205–207, 2011. Search in Google Scholar

Flanagan S, Rowe A, Duggan V, Markle E, O’Brien M, Barry G. Development of a real-time PCR assay to detect the single nucleotide polymorphism causing Warmblood Fragile Foal Syndrome. PLoS ONE 16, e0259316, 2021. Search in Google Scholar

Hamdy M, Kassim SK, Khairy E, Maher M, Mansour KA, Albreedy AM. Ghrelin gene polymorphism as a genetic biomarker for prediction of therapy induced clearance in Egyptian chronic HCV patients. Gene 649, 74–79, 2018. Search in Google Scholar

Huang R, Tian S, Cai R, Sun J, Shen Y, Wang S. Ethnicity-specific association between ghrelin Leu72Met polymorphism and type 2 diabetes mellitus susceptibility: An updated meta-analysis. Front Genet 9, 541, 2018. Search in Google Scholar

Hutor NS, Pidruchna SR, Melnyk NA, Avdeev OV, Boykiv AB, Kovtun NY, Skochylo OV, Tverdokhlib NO, Goncharuk-Khomyn MY. The role of prooxidant-antioxidant system in the development of alveolitis after teeth extraction. J Int Dent Med Res 13, 561–565, 2020. Search in Google Scholar

Joatar FE, Al Qarni AA, Ali ME, Masaud AA, Shire AM, Das N, Gumaa K, Giha HA. Leu72Met and other intronic polymorphisms in the GHRL and GHSR genes are not associated with type 2 diabetes mellitus, insulin resistance, or serum ghrelin levels in a Saudi population. Endocrinol Metab (Seoul) 32, 360–369, 2017. Search in Google Scholar

Kamyshna II, Pavlovych LB, Sydorchuk LP, Malyk IV, Kamyshnyi AM. BDNF blood serum linkage with BDNF gene polymorphism (rs6265) in thyroid pathology patients in the West-Ukrainian population. Endocr Regul 55, 193–203, 2021. Search in Google Scholar

Kamyshna II, Pavlovych LB, Kamyshnyi AM. Association between NMDA gene polymorphism (rs4880213) and GRIN2B blood serum levels in thyroid pathology patients. J Med Life 15, 109–116, 2022. Search in Google Scholar

Kim SY, Jo DS, Hwang PH, Park JH, Park SK, Yi HK, Lee DY. Preproghrelin Leu72Met polymorphism is not associated with type 2 diabetes mellitus. Metaboilsm 55, 366–370, 2006. Search in Google Scholar

Korbonits M, Gueorguiev M, O’Grady E, Lecoeur C, Swan DC, Mein CA, Weill J, Grossman AB, Froguel P. A variation in the ghrelin gene increases weight and decreases insulin secretion in tall, obese children. J Clin Endocrinol Metab 87, 4005–4008, 2002. Search in Google Scholar

Kuzuya M, Masuda Y, Hirakawa Y, Iwata M, Enoki H, Hasegawa J, Izawa S, Iguchi A. Falls of the elderly are associated with burden of caregivers in the community. Int J Geriatr Psychiatry 21, 740–745, 2006. Search in Google Scholar

Mager U, Lindi V, Lindstrom, Eriksson JJG, Valle TT, Hamalainen H, Ilanne-Parikka P, Keinanen-Kiukaanniemi S, Tuomilehto J, Laakso M, Pulkkinen L, Uusitupa M. Association of the Leu72Met polymorphism of the ghrelin gene with the risk of type 2 diabetes in subjects with impaired glucose tolerance in the Finnish Diabetes Prevention Study. Diabet Med 23, 685–689, 2006. Search in Google Scholar

Mager U, Kolehmainen M, de Mello VD, Schwab U, Laaksonen DE, Rauramaa R, Gylling H, Atalay M, Pulkkinen L, Uusitupa M. Expression of ghrelin gene in peripheral blood mononuclear cells and plasma ghrelin concentrations in patients with metabolic syndrome. Eur J Endocrinol 158, 499–510, 2008. Search in Google Scholar

Li YY, Lu XZ, Yang XX, Wang H, Geng HY, Gong G, Zhan YY, Kim HJ, Yang ZJ. GHRL gene Leu72Met polymorphism and type 2 diabetes mellitus: A meta-analysis involving 8,194 participants. Front Endocrinol (Lausanne) 10, 5592019, 2019. Search in Google Scholar

Marushchak M, Mazur L, Krynytska I. Insulin receptor substrate-1 gene polymorphism and lipid panel data in type 2 diabetic patients with comorbid obesity and/or essential hypertension. Endocr Regul 57, 1–11, 2023. Search in Google Scholar

Rivera-Leon EA, Llamas-Covarrubias MA, Sanchez-Enriquez S, Martinez-Lopez E, Gonzalez-Hita M, Llamas-Covarrubias IM. Leu72Met polymorphism of GHRL gene decreases susceptibility to type 2 diabetes mellitus in a Mexican population. BMC Endocr Disord 20, 109, 2020. Search in Google Scholar

Ukkola O, Ravussin E, Jacobson P, Snyder EE, Chagnon M, Sjostrom L, Bouchard C. Mutations in the preproghrelin/ghrelin gene associated with obesity in humans. J Clin Endocrinol Metab 86, 3996–3999, 2001. Search in Google Scholar

Yadegari M, Zare-Feyzabadi R, Zakariaeiseraji M, Sahebi R, Shabani N, Khedmatgozar H, Ferns GA, Ghazizadeh H, Mohammadi-Bajgiran M, Jalalian M, Zoghi M, Darban RA, Mohammadian-Ghosooni M, Esmaily H, Avan A, Ghayour-Mobarhan M. Interaction between the genetic variant of rs696217-ghrelin and food intake and obesity and dyslipidemia. Ann Hum Genet 86, 14–23, 2022. Search in Google Scholar

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