<abstract xmlns="http://www.w3.org/1999/xhtml"><bold>Objectives.</bold> With increasing evidence regarding the metabolic basis of osteoarthritis (OA), we studied the relationship between adipose tissue and OA.<bold>Methods.</bold> This study is part of an OA registry in the eastern part of Fars Province, Iran. Overall, 150 patients with OA and 300 sex matched individuals were selected as a control group. They were compared regarding adipokine concentration (leptin, adiponectin, resistin and visfatin), anthropo-metric indices, the Western Ontario and McMaster universities arthritis index score (WOMAC).<bold>Results.</bold> All adipokine levels were higher among OA patients (p&lt;0.001). After adjusting for age, sex, and body mass index (BMI), adipokines showed a significant and positive association with OA (B: 14.12, B: 9.92, B: 24.71 and B: 12.29 for leptin, adiponectin, visfatin, and resistin, respectively; p&lt;0.001). Except the adiponectin that had a negative relationship with BMI in the OA group (r=–0.570, p&lt;0.001), other adipokines had positive relationships with BMI (r=0.781, p&lt;0.001; r=0.530, p&lt;0.001; r=0.549, p&lt;0.001 for leptin, visfatin, and resistin, respectively). Only leptin and adiponectin levels were correlated with pain (B: 0.045, –0.079 and p&lt;0.05).<bold>Conclusion.</bold> The present study shows that aside to the well-known role of mechanical stress in OA pathogenesis (weight load), leptin, adiponectin, visfatin, and resistin, which represent the adi-pose tissue independent on the weight, may play a chemical role in OA pathogenesis. In addition, leptin and adiponectin may be involved in the pain levels among patients with OA.</abstract>

Objectives. With increasing evidence regarding the metabolic basis of osteoarthritis (OA), we studied the relationship between adipose tissue and OA.Methods. This study is part of an OA registry in the eastern part of Fars Province, Iran. Overall, 150 patients with OA and 300 sex matched individuals were selected as a control group. They were compared regarding adipokine concentration (leptin, adiponectin, resistin and visfatin), anthropo-metric indices, the Western Ontario and McMaster universities arthritis index score (WOMAC).Results. All adipokine levels were higher among OA patients (p<0.001). After adjusting for age, sex, and body mass index (BMI), adipokines showed a significant and positive association with OA (B: 14.12, B: 9.92, B: 24.71 and B: 12.29 for leptin, adiponectin, visfatin, and resistin, respectively; p<0.001). Except the adiponectin that had a negative relationship with BMI in the OA group (r=–0.570, p<0.001), other adipokines had positive relationships with BMI (r=0.781, p<0.001; r=0.530, p<0.001; r=0.549, p<0.001 for leptin, visfatin, and resistin, respectively). Only leptin and adiponectin levels were correlated with pain (B: 0.045, –0.079 and p<0.05).Conclusion. The present study shows that aside to the well-known role of mechanical stress in OA pathogenesis (weight load), leptin, adiponectin, visfatin, and resistin, which represent the adi-pose tissue independent on the weight, may play a chemical role in OA pathogenesis. In addition, leptin and adiponectin may be involved in the pain levels among patients with OA.

The role of adipose tissue secretion in the creation and pain level in osteoarthritis

Health policy Research Center, Institute of Health

Endocrine Regulations

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Objectives. With increasing evidence regarding the metabolic basis of osteoarthritis (OA), we studied the relationship between adipose tissue and OA.Methods....

The role of adipose tissue secretion in the creation and pain level in osteoarthritis

Publicado en línea: 01 feb 2020

Páginas: 6 - 13

DOI: https://doi.org/10.2478/enr-2020-0002

Palabras clave
osteoarthritis, adipose tissue, leptin, adiponectin, visfatin, resistin

© 2020 Alireza Askari et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The role of adipose tissue secretion in the creation and pain level in osteoarthritis

Publicado en línea: 01 feb 2020

Páginas: 6 - 13

DOI: https://doi.org/10.2478/enr-2020-0002

Palabras claveosteoarthritis, adipose tissue, leptin, adiponectin, visfatin, resistin

© 2020 Alireza Askari et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Palabras clave
osteoarthritis, adipose tissue, leptin, adiponectin, visfatin, resistin