1. bookVolumen 25 (2012): Edición 3 (August 2012)
Detalles de la revista
Primera edición
01 Jan 1992
Calendario de la edición
4 veces al año
Acceso abierto

Influence of Additives on Cigarette Related Health Risks

Publicado en línea: 30 Dec 2014
Volumen & Edición: Volumen 25 (2012) - Edición 3 (August 2012)
Páginas: 412 - 493
Recibido: 27 Jul 2011
Aceptado: 25 Jul 2012
Detalles de la revista
Primera edición
01 Jan 1992
Calendario de la edición
4 veces al año

1. Oxford Dictionaries, Online Edition, available at: http://oxforddictionaries.com. *Search in Google Scholar

2. European Parliament and Council: Directive 2001/37/EC of the European Parliament and of the Council of 5 June 2001 on the Approximation of the Laws, Regulations and Administrative Provisions of the Member States Concerning the Manufacture, Pre-sentation and Sale of Tobacco Products; Off. J. Eur. Commun. L 194 (2001) 26–35.Search in Google Scholar

3. WHO Framework Convention on Tobacco Control: Guidelines for Implementation Article 5.3 | Article 8 | Articles 9 and 10 | Article 11 | Article 12 | Article 13 | Article 14 (2011 edition); available at: http://whq libdoc.who.int/publications/2011/9789241501316_ eng.pdf.Search in Google Scholar

4. Kozlowski, S.: Der Schnupftabak im früheren Polen [Snuff in Former Poland]; Fachl. Mitt. Österr. Tabak-regie 2 (1902) 20–24.Search in Google Scholar

5. Berka, F.: Die bei der Tabakfabrikation in Verwen-dung stehenden ätherischen Öle [The Essential Oils Used in Tobacco Manufacturing]; Fachl. Mitt. Österr. Tabakregie 3 (1903) 6–14.Search in Google Scholar

6. Berka, F.: Ein Beitrag zur Kenntnis der bei der Tabak-regie in Verwendung stehenden aromatischen Ingre-dienzien [A Contribution to the Knowledge of the Aromatic Ingredients Used by the K.K. Tobacco Monopoly]; Fachl. Mitt. Österr. Tabakregie 4 (1904) 41–50.Search in Google Scholar

7. Fisher, P.: Tobacco Blending; in: Tobacco. Pro-duction, Chemistry and Technology, edited by D.L. Davis and M.T. Nielsen, Blackwell, Oxford, 1999, pp. 346–352.Search in Google Scholar

8. N.N.: The Toxic Factor in Tobacco; Lancet, 179 (1912) 944–947, ibid. 180 (1912) 547–548.Search in Google Scholar

9. RJReynolds Website: Transforming Tobacco – History: A Look into Our Past; available at: http:// www.rjrt.com/history.aspx.Search in Google Scholar

10. Philip Morris International: Philip Morris International's Input to the Public Consultation on the Pos-sible Revision of the Tobacco Products Directive 2001/37/EC; available at: http://www.pmi.com/eng/ tobacco_regulation/submissions/documents/pmi_ input_to_public_consultation_on_tobacco_products_ directive_with%20annexes_15_dec_2010.pdf.Search in Google Scholar

11. Philip Morris Ltd. Australia: Letter to Dr Michael Wooldridge, Minister for Health and Family Services, July 31, 1998; Bates-No. 2064813389–3399, available at: http://legacy.library.ucsf.edu/tid/eua87d00.Search in Google Scholar

12. La Voie, E.J., S.S. Hecht, D. Hoffmann and E.L. Wynder: The Less Harmful Cigarette and Tobacco Smoke Flavors; in: Banbury Report 3, A Safe Cigarette?, edited by G.B. Gori and F.G. Bock, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY (1980), pp. 251–260.Search in Google Scholar

13. Wynder, E.L. and D. Hoffmann: Tobacco and Tobacco Smoke: Studies in Experimental Carcino-genesis; Academic Press, New York, 1967.Search in Google Scholar

14. Hoffmann, D. and I. Hoffmann: The Changing Ciga-rette: Chemical Studies and Bioassay; in: Risks Associated with Smoking Cigarettes with Low Machine-Measured Yields of Tar and Nicotine, edited by D.R. Shopland and D.M. Burns, Smoking and Tobacco Control Monograph 13, U.S. Department of Health and Human Services, National Institutes of Health, National Cancer Institute, 2001, pp. 159–191.Search in Google Scholar

15. World Health Organization (WHO): Monograph. Ad-vancing Knowledge on Regulating Tobacco Products; WHO, Geneva, Switzerland, 2001, pp. 40–46.Search in Google Scholar

16. Deutsches Krebsforschungszentrum (DKFZ, German Cancer Research Center): Erhöhte Gesundheitsgefähr-dung durch Zusatzstoffe in Tabakerzeugnissen – Konsequenzen für die Produktregulation [Increased Health Hazards Due to Additives in Tobacco Products – Consequences for Product Regulation]; DKFZ, Heidelberg, 2005.Search in Google Scholar

17. Bates, C., M. Jarvis, and G. Connolly: Tobacco Additives – Cigarette Engineering and Nicotine Ad-diction: 14 July 1999; available at: http://www.ash. org.uk/files/documents/ASH_623.pdf.Search in Google Scholar

18. Tiedemann, M. and T. Wall: Bill C-32: An Act to Amend the Tobacco Act; 4 June 2009, revised 4 February 2010, Library of Parliament, Canada, avail-able at: www.parl.gc.ca/Content%2FLOP/Legislative Summaries/40/2/c32-e.pdf.Search in Google Scholar

19. Frankenburg, W.G.: Resilient Tobacco Product and Method of Making the Same; United States Patent 2,592,554, General Cigar Co. Inc., New York, NY (Application Date: August 24,1946).Search in Google Scholar

20. Schweitzer, W.P. and N. Flaxman: Method of Making a Reconstituted Tobacco Sheet Having Improved Filling Power; United States Patent 3,430,634, Kimberly-Clark Corp. (Filing Date: April 14, 1967).Search in Google Scholar

21. Rodgman, A.: Some Studies of the Effects of Additives on Cigarette Mainstream Smoke Properties. II. Casing Materials and Humectants; Beitr. Tabakforsch. Int. 20 (2002) 279–299.Search in Google Scholar

22. Pelouze, J.: Über eine neue Zuckerart aus den Vogel-beeren (A New Type of Sugar in Rowan Berries); Justus Liebigs Ann. Chemie 83 (1852) 47–57.Search in Google Scholar

23. Mäkinen, K.K. and E. Söderling: A Quantitative Study of Mannitol, Sorbitol, Xylitol, and Xylose in Wild Berries and Commercial Fruits; J. Food Sci. 45 (1980) 367–374.Search in Google Scholar

24. Leffingwell, J.C.: Leaf Chemistry: Basic Chemical Constituents of Tobacco Leaf and Differences among Tobacco Types; in: Tobacco. Production, Chemistry and Technology, edited by D.L. Davis and M.T. Nielsen, Blackwell, Oxford, 1999, pp. 265–284.Search in Google Scholar

25. Bradford, J.A., E.S. Harlow, W.R. Harlan, and H.R. Hanmer: Nature of Cigarette Smoke. Volatile Bases and Acids; Ind. Eng. Chem. 29 (1937) 45–50.Search in Google Scholar

26. Sugawara, S., I. Ishizu, and U. Kobashi: Studies on Casing Effects on Cigarettes. I. Change in Chemical Composition with Casing Additives; Sci. Papers Centr. Res. Inst. Jap. Tob. Salt Monop. Corp. 105 (1963) 203–207.Search in Google Scholar

27. Pyriki, C. and W. Moldenhauer: Die Auswirkung der Tabakbehandlung mit verschiedenen Materialien auf den Zigarettenrauch [Effect on Cigarette Smoke of the Treatment of Tobacco with Various Agents]; Ber. Inst. Tabakforsch. Dresden 7 (1960) 216–240.Search in Google Scholar

28. Yoshitani, H., K. Shimura, S. Wakui, K. Yoshifuji, T. Akaki, T. Shinkai, T. Kamachi, and I. Morishita: Studies on Tobacco Casing. (I). Casing Effect of Saccharides (1); Nippon Senbai Kosha Chuo Kenkyusho Kenkyu Hokoku 106 (1964) 281–284.Search in Google Scholar

29. Kamachi, T., H. Nishi, and H. Yoshitani: Studies on Tobacco Casing. (V). On “Casing Agent” as Neutral Sauce; Nippon Senbai Kosha Chuo Kenkyusho Kenkyu Hokoku 109 (1967) 99–105.Search in Google Scholar

30. Spiegelhalder, B., S.J. Kubacki, and S. Fischer: A Method for the Determination of Tobacco-Specific Nitrosamines (TSNA), Nitrate and Nitrite in Tobacco Leaves and Processed Tobacco; Beitr. Tabakforsch. Int. 14 (1989) 135–144.Search in Google Scholar

31. Hoffmann, D., K.D. Brunnemann, B. Prokopczyk, and M.V. Djordjevic: Tobacco Specific N-Nitrosamines and Areca-Derived N-Nitrosamines: Chemistry, Biochemistry, Carcinogenicity, and Relevance to Humans; J. Toxicol. Environ. Health 41 (1994) 1–52.Search in Google Scholar

32. Wiernik, A., A. Christakopoulos, L. Johansson, and I. Wahlberg: Effect of Air-Curing on the Chemical Composition of Tobacco; Rec. Adv. Tob. Sci. 21 (1995) 39–80.Search in Google Scholar

33. Andersen, R.A., H.R. Burton, P.D. Fleming, T.R. Hamilton-Kemp, and S.L. Gay: Effects of Air-Curing Environment on Alkaloid-Derived Nitrosamines in Burley Tobacco; IARC Sci. Publ. 84 (1987) 451–455.Search in Google Scholar

34. Burton, H.R., L.P. Bush, and J.L. Hamilton: Effect of Curing on the Chemical Composition of Burley Tobacco; Rec, Adv. Tob. Sci. 9 (1983) 91–153.Search in Google Scholar

35. Begutter, H., H. Klus, and I. Ultsch: Kapillargas-chromatographische Bestimmung flüchtiger und tabakspezifischer N-Nitrosamine mittels des Thermo-Energy-Analyzers [Determination of Volatile and Tobacco-Specific N-Nitrosamines by Capillary Gas Chromatography – Thermo Energy Analyzer]; J. Chromatogr. 321 (1985) 475–479.Search in Google Scholar

36. Klus, H.: Volatile N-Nitrosamines in the Burley Toaster Exhaust; 1983, unpublished.Search in Google Scholar

37. Bright, M.N., T.M. Larson, and C.I. Lewis: Analytical Method for Determination of Pyrazines and Alkyl-pyrazines in Shredded Tobacco; Paper presented at the 29th Tobacco Chemists’ Research Conference 1975, Oct. 9–10.Search in Google Scholar

38. Coleman III, W.M. and T.A. Perfetti: The Roles of Amino Acids and Sugars in the Production of Volatile Materials in Microwave Heated Tobacco Dust Suspensions; Beitr. Tabakforsch. Int. 17 (1997) 75–95.Search in Google Scholar

39. Schönberg, A. and R. Moubacher: The Strecker De-gradation of -Amino Acids; Chem. Rev. 50 (1952) 261–277.Search in Google Scholar

40. Mauron, J.: The Maillard Reaction in Food: A Critical Review from the Nutritional Standpoint; Prog. Food Nutr. Sci. 5 (1981) 5–35.Search in Google Scholar

41. Fors, S.: Sensory Properties of Volatile Maillard Reaction Products and Related Compounds. A Literature Review; in: The Maillard Reaction in Foods and Nutrition; American Chemical Society Sym-posium Series, No. 215, edited by G.R. Waller and M.S. Feather, ACS, Washington, DC, 1983, pp. 185–286.10.1021/bk-1983-0215.ch012Search in Google Scholar

42. Li, P., M. Wu, and J. Xie: Changes in Levels of Amino Acids and Basic Components in Burley Tobacco Produced by Roasting; Beitr. Tabakforsch. Int. 20 (2003) 459–466.Search in Google Scholar

43. Amrani-Hemaimi, M., C. Cerny, and L.B. Fay: Mechanisms of Formation of Alkylpyrazines in the Maillard Reaction; J. Agric. Food Chem. 43 (1995) 2818–2822.10.1021/jf00059a009Search in Google Scholar

44. Dewick, P.M.: Medicinal Natural Products. A Biosyn-thetic Approach; 2nd edition, John Wiley and Sons, New York, NY, 2002, pp. 221–222.Search in Google Scholar

45. Chandler, R.F.: Licorice, More than Just a Flavor; Can. Pharm. J. 118 (1985) 421–424.Search in Google Scholar

46. Vora, P.S.: Characteristics and Applications of Lico-rice Products in Tobacco; Tob. Int. (1984) 13–20.Search in Google Scholar

47. Tilley, N.M.: The Bright-Tobacco Industry, 1860–1929; University of North Carolina Press, Chapel Hill, 1948, pp. 511–512.Search in Google Scholar

48. Harllee, G.C. and J.C. Leffingwell: Casing Materials – Cocoa (Part I); Tob. Int. 181 (1979) 40–52.Search in Google Scholar

49. Armstrong, R.G., E.J. Deszyck, J.W. Madures, and R.H. Young: Process for Puffing Tobacco; United States Patent 3,771,533, Philip Morris Inc., New York, NY (Filing Date: August 31, 1970).Search in Google Scholar

50. White, J.L. and L.J. Conrad: Process for Increasing Filling Capacity of Tobacco; United States Patent 4,531,529, R.J. Reynolds Tobacco Co., Winston-Salem, NC (Filing Date: October 4, 1982).Search in Google Scholar

51. de la Burde, R.Z. and P.E. Aument: Expanding Tobacco; United States Patent Re. 32,013, Philip Morris Inc., New York, NY (Filing Date: June 28, 1984).Search in Google Scholar

52. Ziehn, K.-D.: Process for Improving the Fillability of Tobacco; United States Patent 4,577,646, H.F. & Ph.F. Reemtsma GmbH & Co., Hamburg (Filing Date: April 20, 1984).Search in Google Scholar

53. Fredrickson, J.D.: Process for Increasing the Filling Capacity of Tobacco; United States Patent 3,524,451, R.J. Reynolds Tobacco Co., Winston-Salem, NC (Filing Date: April 10, 1968).Search in Google Scholar

54. Rowland, F.S. and M.J. Molina: Chlorofluoro-methanes in the Environment; Rev. Geophys. 13 (1975) 1–35.10.1029/RG013i001p00001Search in Google Scholar

55. Dontenwill, W., H.-J. Chevalier, H.-P. Harke, H.-J. Klimisch, G. Reckzeh, B. Fleischmann, and W. Keller: Experimentelle Untersuchungen über die tumorerzeugende Wirkung von Zigarettenrauch-Kondensaten an der Mäusehaut. VII. Mitteilung: Einzelvergleiche von Kondensaten verschiedener modifizierter Zigaretten [Experimental Investigations on the Tumorigenic Activity of Cigarette Smoke Condensate on Mouse Skin. VII. Comparative Studies of Condensates from Different Modified Cigarettes]; Z. Krebsforsch. Klin. Onkol. 89 (1977) 145–151.Search in Google Scholar

56. Coggins, C.R.E., P.H. Ayres, A.T. Mosberg, J.W. Sagartz, and A.W. Hayes: Comparative Inhalation Study in Rats Using Cigarettes Containing Tobacco Expanded with Chlorofluorocarbon-11 (CFC-11) or Hydrochlorofluorocarbon-123 (HCFC-123); Inhal. Toxicol. 5 (1993) 97–115.Search in Google Scholar

57. Theophilus, E.H., D.B. Poindexter, D.R. Meckley, B.R. Bombick, M.F. Borgerding, M.A. Higuchi, P.H. Ayres, M.J. Morton, A.T. Mosberg, and J.E. Swauger: Toxicological Evaluation of Dry Ice Expanded Tobacco; Toxicol. Lett. 145 (2003) 107–119.Search in Google Scholar

58. Theophilus, E.H., B.R. Bombick, D.R. Meckley, M.A. Higuchi, M.F. Borgerding, M.J. Morton, A.T. Mosberg, and J.E. Swauger: Toxicological Evaluation of Propane Expanded Tobacco; Food Chem. Toxicol. 41 (2003) 1771–1780.Search in Google Scholar

59. Theophilus, E.H., D.H. Pence, D.R. Meckley, M.A Higuchi, B.R. Bombick, M.F. Borgerding, P.H. Ayres, and J.E. Swauger: Toxicological Evaluation of Expanded Shredded Tobacco Stems; Food Chem. Toxicol. 42 (2004) 631–639.Search in Google Scholar

60. Christensson, E. and E. Falke: Method for Adding a Flavoring Substance to a Tobacco Rod and Apparatus for Carrying Out the Method; United States Patent 4,913,166, Svenska Tobaks AB, Stockholm (Filing Date: August 15, 1988).Search in Google Scholar

61. Bynre, S.W., B.J. Tompkins, and E.B. Hayes: Production of Tobacco Smoke Filters; United States Patent 4,281,671, American Filtrona Corp., Richmond, VA (Filing Date: April 19, 1979).Search in Google Scholar

62. Deevi, S.: Laminated Metal Foil Packaging Material and Method of Making; United States Patent Application 2004/0139702 A1, Philip Morris Inc. (Filing Date: January 12, 2004).Search in Google Scholar

63. Wilson, S.A.: Theoretical Aspects of Menthol Migration and Transfer; Rec. Adv. Tob. Sci. 19 (1993) 129–153.Search in Google Scholar

64. Borschke, A.J.: Review of Technologies Relating to Menthol Use in Cigarettes; Rec. Adv. Tob. Sci. 19 (1993) 47–70.Search in Google Scholar

65. Klus, H., A. Pachinger, and A. Nowak: Comparison of the Selective Retention Capacity of Cigarette Filters Made from Cellulose Acetate and Polypropylene; CORESTA Joint Meeting of the Smoke and Technology Study Groups, Xian, China, 2001, No. ST 53.Search in Google Scholar

66. Puls, J., S.A. Wilson, and D. Hölter: Degradation of Cellulose Acetate-Based Materials: A Review; J. Polym. Environ. 19 (2011) 152–165.Search in Google Scholar

67. Hoffmann, D., I. Hoffmann, and K. El-Bayoumy: The Less Harmful Cigarette: A Controversial Issue. A Tribute to Ernst L. Wynder; Chem. Res. Toxicol. 14 (2001) 767–790.Search in Google Scholar

68. National Cancer Institute, Smoking and Health Program: Report No. 3. Toward Less Hazardous Ciga-rettes. The Third Set of Experimental Cigarettes; edited by G.B. Gori, NCI, DHEW, Publ. No. (NIH) 77-1280, Washington, DC, 1977.Search in Google Scholar

69. Xue, L., C.E. Thomas, and K.B. Koller: Mainstream Smoke Gas Phase Filtration Performance of Adsorption Materials Evaluated with a Puff-by-Puff Multiplex GC-MS Method; Beitr. Tabakforsch. Int. 20 (2002) 251–256.Search in Google Scholar

70. Figueiredo, J.L., M.F.R. Pereira, M.M.A Freitas, and J.J.M. Orfao: Modification of the Surface Chemistry of Activated Carbons; Carbon 37 (1999) 1379–1389.Search in Google Scholar

71. Ceschini, P.: Aktivitätsverlust der Kohle in Cigaretten-filtern [Decrease of the Carbon Activity in Cigarette Filters]; Beitr. Tabakforsch. 6 (1972) 220–222.Search in Google Scholar

72. Purkis, S.W., C. Mueller, M. Intorp, and H. Seidel: The Influence of Cigarette Designs and Smoking Regimes on Vapour Phase Yields; Beitr. Tabakforsch. Int. 24 (2010) 33–46.Search in Google Scholar

73. International Organisation for Standardisation (ISO): International Standard ISO 3308:2000. Routine Analytical Cigarette-Smoking Machine. Definitions and Standard Conditions; 4th Edition, Geneva, Switzerland, 2000.Search in Google Scholar

74. Health Canada: Determination of “Tar”, Nicotine and Carbon Monoxide in Mainstream Tobacco Smoke. Official Method T-115; December 1999, available at: http://www.hc-sc.gc.ca/hc-ps/alt_formats/hecs-sesc/ pdf/tobac-tabac/legislation/reg/indust/method/_main-principal/nicotine-eng.pdf.Search in Google Scholar

75. Pauly, J.L., H.A. Allaart, M.I. Rodriguez, and R.J. Streck: Fibers Released from Cigarette Filters: An Additional Health Risk to the Smoker?; Cancer Res. 55 (1995) 253–258.Search in Google Scholar

76. Pauly, J.L., S.J. Stegmeier, A.G. Mayer, J.D. Lesses, and R.J. Streck: Release of Carbon Granules from Cigarettes with Charcoal Filters; Tob. Control 6 (1997) 33–40.Search in Google Scholar

78. Pauly, J.L., S.J. Stegmeier, H.A. Allaart, R.T. Cheney, P.J. Zhang, A.G. Mayer, and RJ. Streck: Inhaled Cellulosic and Plastic Fibers Found in Human Lung Tissue; Cancer Epidemiol. Biomarkers Prev. 7 (1998) 419-428.Search in Google Scholar

79. Pauly, J.L., A.B. Mepani, J.D. Lesses, K.M. Cum-mings, and RJ. Streck: Cigarettes with Defective Filters Marketed for 40 Years: What Philip Morris Never Told Smokers; Tob. Control 11, Suppl. I (2002) i51-i61.10.1136/tc.11.suppl_1.i51Search in Google Scholar

80. Hengstberger, M. and M. Stark: Fibre and Particle Release from Cigarette Filters; Beitr. Tabakforsch. Int. 23 (2009) 338-358.Search in Google Scholar

81. Deutsches Institut für Normung: DIN Fachbericht 160. Freisetzung von Fasern und Partikeln aus Zigaretten-filtern [Release of Fibres and Particles from Cigarette Filters]; Beuth Verlag, Berlin, 2008.Search in Google Scholar

82. Agyei-Aye, K., S. Appleton, R.A. Rogers, and CR Taylor: Assessment of the Elution of Charcoal, Cellulose Acetate, and Other Particles from Cigarettes with Charcoal and Activated Charcoal/Resin Filters; Inhal. Toxicol. 16 (2004) 615-635.Search in Google Scholar

83. Johnson, V.C: Carbon particle fallout; Philip Morris USA Inter-Office correspondence, September 25, 1963, Bates-No. 1001885385-5386, available at: http://legacy.library.ucsf.edu/tid/tal38e00.Search in Google Scholar

84. Hasegawa, I.: Carbon Fallout Determination with Bausch and Lomb Image Analyzer; Philip Morris USA Inter-Office Correspondence, September 16, 1975, Bates-No. 0362451-2452, available at: http://legacy.library.ucsf.edu/tid/mkn81a00.Search in Google Scholar

85. European Commission: Commission Implementing Decision of 9 August 2011 on the Compliance of Standard EN 16156:2010 ‘Cigarettes - Assessment of the Ignition Propensity - Safety Requirement’ and of Standard EN ISO 12863:2010 ‘Standard Test Method for Assessing the Ignition Propensity of Cigarettes’ with the General Safety Requirement of Directive 2001/95/EC of the European Parliament and of the Council and Publication of the References of Standard EN 16156:2010 ‘Cigarettes - Assessment of the Ignition Propensity - Safety Requirement’ and of Standard EN ISO 12863:2010 ‘Standard Test Method for Assessing the Ignition Propensity of Cigarettes’ in the Official Journal of the European Union (notified under document C(2011) 5626); Off J. Europ. Union L 205 (10.08.2011) 31-32.Search in Google Scholar

86. The State of New York: Amended Notice of Adoption. Fire Safety Standards for Cigarettes; The New York State Register 26 (April 21, 2004) 19-21.Search in Google Scholar

87. Theophilus, E.H., D.H. Pence, D.R. Meckley, W.K. Shreve, P.H. Ayres, B.R. Bombick, M.F. Borgerding, CD. Garner, and J.E. Swauger: Toxicological Evalu-ation of Cigarettes with Two Banded Cigarette Paper Technologies; Exp. Toxicol. Pathol. 59 (2007) 17-27.Search in Google Scholar

88. Appleton, S., G.R. Krauter, and J.H. Lauterbach: Toxicological Evaluation of a New Cigarette Paper Designed for Lowered Ignition Propensity; presented at the 57th Tobacco Science Research Conference, Norfolk, VA, No. 16, 2003.Search in Google Scholar

89. Lulham, G., J. Miller, W.S. Rickert, and A. Trevedi: In vitro Toxicity of Lower Ignition Propensity (LIP) and Conventional Cigarettes; Toxicologist 90 (2006) No. 1965.Search in Google Scholar

89. Misra, M., R.D. Leverette, J.T. Hamm, M.B. Bennet, J.D. Heck, R. Morrissey, and N. Rajendran: Toxicological Evaluation of a Cigarette Paper with Reduced Ignition Propensity: In vitro and in vivo Tests; Toxicologist 84 (2005) No. 1186.Search in Google Scholar

90. Patskan G., F. Hsu, T. Meisgen, R. Stabbert, P. Van-scheeuwijck, and D. Veltel: Toxicological Characteri-zation of a Novel Cigarette Paper; presented at the 39th Annual Meeting of the Society of Toxicology, Philadelphia, PA, Toxicologist 54 (2000) No. 398.Search in Google Scholar

91. Commission of the European Communities: Report from the Commission to the European Parliament, the Council and the European Economic and Social Committee: Second Report on the Application of the Tobacco Products Directive; COM (2007) 754 final, Brussels, November 27, 2007.Search in Google Scholar

92. European Commission: Directorate-General for Health & Consumers. Scientific Committee on Emerging and Newly Identified Risks (SCENIHR): Addictiveness and Attractiveness of Tobacco Additives; 2010, available at: ec.europa.eu/health/scientific_commit tees/emerging/docs/scenihr o 031.pdf.Search in Google Scholar

93. World Health Organization (WHO): WHO Expert Committee on Addiction-Producing Drugs - 13th Report; Technical Report Series No. 273, available at: http://whqlibdoc.who.int/trs/WHO TRS 273.pdf.Search in Google Scholar

94. World Health Organization (WHO): Management of Substance Abuse - Dependence Syndrome; available at: http://www.who.int/substance_abuse/terminology/ definition1/en/.Search in Google Scholar

95. World Health Organization (WHO): International Sta-tistical Classification of Diseases and Related Health Problems, 10th Revision (ICD-10), Chapter V: Mental and Behavioural Disorders; WHO, version 2010, available at: http://apps.who.int/classifications/ icd10/browse/2010/en#/V.Search in Google Scholar

96. O'Dell, L.E. and T.V. Khroyan: Rodent Models of Nicotine Reward: What Do They Tell Us about Tobacco Abuse in Humans?; Pharmacol. Biochem. Behav. 91 (2009) 481–488.Search in Google Scholar

97. O'Brien, C.P. and E.L. Gardner: Critical Assessment of How to Study Addiction and its Treatment: Human and Non-Human Animal Models; Pharmacol. Ther. 108 (2005) 18-58.Search in Google Scholar

98. Antony, J.C, L.A. Warner, and R.C Kessler: Com-parative Epidemiology of Dependence on Tobacco, Alcohol, Controlled Substances, and Inhalants: Basic Findings from the National Comorbidity Survey; Exp. Clin. Psychopharmacol. 2 (1994) 244-268.Search in Google Scholar

99. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, 4th Edition; American Psychiatric Association, Washington, DC, 1994.Search in Google Scholar

100. Fagerstrom, K.-O. and N.G. Schneider: Measuring Nicotine Dependence: A Review of the Fagerstrom Tolerance Questionnaire; J. Behav. Med. 12 (1989) 159-182.Search in Google Scholar

101. Transdisciplinary Tobacco Use Research Center (TTURC) Tobacco Dependence Phenotype Work-group - T.B. Baker, M.E. Piper, D.E. McCarthy, D.M. Bolt, S.S. Smith, S.-Y. Kim, S. Colby, D. Conti, G.A. Giovino, D. Hatsukami, A. Hyland, S. Krishnan-Sarin, R. Niaura, K.A. Perkins, and B.A. Toll: Time to First Cigarette in the Morning as an Index of Ability to Quit Smoking: Implications for Nicotine Dependence; Nicotine Tob. Res. 9, Suppl. 4 (2007) S555–S570.10.1080/14622200701673480Search in Google Scholar

102. Carter L.P., M.L. Stitzer, J.E. Henningfield, R.J. O'Connor, K.M. Cummings, and D.K. Hatsukami: Abuse Liability Assessment of Tobacco Products Including Potential Reduced Exposure Products; Cancer Epidemiol. Biomarkers Prev. 18 (2009) 3241–3262.Search in Google Scholar

103. Wenusch, A.: Die Reaktion des Tabakrauches [The Reaction of Tobacco Smoke]; Fachl. Mitt. Österr. Tabakregie 2 (1930) 13–15.Search in Google Scholar

104. Brunnemann, K.D. and D. Hoffmann: [Chemical Studies on Tobacco Smoke. XXV.] The pH of Tobacco Smoke; Food Cosmet. Toxicol. 12 (1974) 115–124.Search in Google Scholar

105. Armitage, A.K. and D.M. Turner: Absorption of Nicotine in Cigarette and Cigar Smoke through the Oral Mucosa; Nature 226 (1970) 1231–1232.Search in Google Scholar

106. Riehl, T., D. McMurtrie, V. Heemann, and R. Crellin: Project SHIP Review of Progress; November 12, 1984, Minn. Trial Exhibit 10752, available at: http://tobaccodocuments.org/youth/CgNcBAT 19841112. Rg.html.Search in Google Scholar

107. Woods, J.D. and G.C. Harllee: Historical Review of Smoke pH Data and Sales Trends for Competitive Brand Filter Cigarettes; Project No. 1210, RJR, May 10, 1973, Bates-No. 514804875–4890, available at: http://legacy.library.ucsf.edu/tid/vrf40d00.Search in Google Scholar

108. Newsome, J.R.: Development of a Cigarette with an Increased Smoke pH; (Progress during 1973 on Project TE 5001), January 29, 1974, Bates-No. CGSKLIG19740129.LR, available at: http://legacy. library.ucsf.edu/tid/fwr76b00.Search in Google Scholar

109. Evelyn, S.R.: The Effects of Additives on Smoke Chemistry. Action of Gaseous Ammonia on Flue-Cured Tobacco; Report No. RD 334-R, 1.6.1965, available at: http://tobaccodocuments.org/bat_cdc/ 24897.html.Search in Google Scholar

110. Teague Jr., C.E.: Research Planning Memorandum on Effects of Ammonia and its Salts on Smoke Quality; R.J. Reynolds. Bates-No. 511242075–2078, available at: http://legacy.library.ucsf.edu/tid/gqd53d00.Search in Google Scholar

111. Henningfield, J.E. and M. Zeller: Could Science-Based Regulation Make Tobacco Products Less Addictive?; Yale J. Health Policy Law Ethics 3 (2002) 127–138.Search in Google Scholar

112. Pankow, J.F., A.D. Tavakoli, W. Luo, and L.M. Isabelle: Percent Free Base Nicotine in the Tobacco Smoke Particulate Matter of Selected Commercial and Reference Cigarettes; Chem. Res. Toxicol. 16 (2003) 1014–1018.Search in Google Scholar

113. Henningfield, J.E., J.F. Pankow, and B.E. Garrett: Ammonia and Other Chemical Base Tobacco Additives and Cigarette Nicotine Delivery: Issues and Research Needs; Nicotine Tob. Res. 6 (2004) 199–205.Search in Google Scholar

114. Deutsches Krebsforschungszentrum (Hrsg.): Fakten zum Rauchen: Tabakrauch – ein Giftgemisch [Facts on Smoking: Tobacco Smoke – a Mixture of Toxic Substances]; DKFZ, Heidelberg, Germany, 2008.Search in Google Scholar

115. Wayne, G.F. and C.M. Carpenter: Tobacco Industry Manipulation of Nicotine Dosing; Handb. Exp. Pharmacol. 192 (2009) 457–485.Search in Google Scholar

116. World Health Organization, WHO Study Group on Tobacco Product Regulation: Report on the Scientific Basis of Tobacco Product Regulation. Fourth Report of a WHO Study Group; WHO Technical Report Series 967, WHO, Geneva, Switzerland, 2012.Search in Google Scholar

117. Rickert, W.S.: Partial Characterization of 10 “Common” Brands of American Cigarettes; Project Report for Massachusetts Department of Public Health, Labstat, Inc., Kitchener, Canada, January 30, 1997.Search in Google Scholar

118. Klus, H., H. Begutter, and I. Ultsch: The Effect of Filter Ventilation on the pH of the Mainstream Smoke; Presentation at the CORESTA Smoke Study Meeting, Albufeira, Portugal, 1981, Bates-No. 100544728– 4745, available at: http://legacy.library.ucsf.edu/tid/yvx37a99.Search in Google Scholar

119. Ellis, C.L., R.H. Cox, C.H. Callicut, S.W. Laffoon, K.F. Podraza, J.I. Seeman, R.D. Kinser, D.E. Farthing, and F.S. Hsu: The Effect of Ingredients, Added to Tobacco in a Commercial Marlboro Lights Cigarette, on FTC Nicotine Yield, “Smoke pH”, and Cambridge Filter Trapping Efficiency; Presentation at the CORESTA Smoke and Technology Meeting, Innsbruck, Austria, September 1999. Bates-No. 83171402–1423; available at: http://legacy.library. ucsf.edu/tid/vds62d00.Search in Google Scholar

120. Callicutt, C.H., R.H. Cox, F. Hsu, R.D. Kinser, S.W. Laffoon, P.N. Lee, K.F. Podraza, E.B. Sanders, and J.I. Seeman: The Role of Ammonia in the Transfer of Nicotine from Tobacco to Mainstream Smoke; Regul. Toxicol. Pharmacol. 46 (2006) 1–17.Search in Google Scholar

121. Rodgman, A.: “Smoke pH”: A review; Beitr. Tabak-forsch. Int. 19 (2000) 117–139.Search in Google Scholar

122. Pankow, J.F.: A Consideration of the Role of Gas/Particle Partitioning in the Deposition of Nicotine and Other Tobacco Smoke Compounds in the Respiratory Tract; Chem. Res. Toxicol. 14 (2001) 1465–1481.Search in Google Scholar

123. Ingebrethsen, B.J., C.S. Lyman, C.H. Risner, P. Martin, and B.M. Gordon: Particle-Gas Equilibria of Ammonia and Nicotine in Mainstream Cigarette Smoke; Aerosol Sci. Technol. 35 (2001) 874–886.Search in Google Scholar

124. Benowitz, N.L.: Nicotine Pharmacology and Addiction; in: Nicotine Safety and Toxicity, edited by N.L. Benowitz, Oxford University Press, New York, NY, 1998, pp. 3–16.10.1080/13556219871930Search in Google Scholar

125. Benowitz, N.L., H. Porchet, and P. Jacob III: Nicotine Dependence and Tolerance in Man: Pharmacokinetic and Pharmacodynamic Investigations; Prog. Brain Res. 79 (1989) 279–287.Search in Google Scholar

126. Schievelbein, H.: Nicotine, Resorption and Fate; Pharmacol. Ther. 18 (1982) 233–248.Search in Google Scholar

127. Slade, J.: Nicotine Delivery Devices; in: Nicotine Addiction: Principles and Management, Vol. 4, edited by C.T. Orleans and J. Slade, Oxford University Press, Oxford, U.K., 1993, pp. 3–23.Search in Google Scholar

128. Gourley, S.G. and J.J. McNeil: Antismoking Products; Med. J. Aust. 153 (1990) 699–707.10.5694/j.1326-5377.1990.tb126327.xSearch in Google Scholar

129. Dixon, M., K. Lambing, and J.I. Seeman: Mini-Review: On the Transfer of Nicotine from Tobacco to the Smoker. A Brief Review of Ammonia and “pH” Factors; Beitr. Tabakforsch. Int. 19 (2000) 103–113.Search in Google Scholar

130. Holma, B. and P.O. Hegg: pH- and Protein-Dependent Buffer Capacity and Viscosity of Respiratory Mucus. Their Interrelationships and Influence on Health; Sci. Total Environ. 84 (1989) 71–82.Search in Google Scholar

131. Armitage, A.K., M. Dixon, B.E. Frost, D.C. Mariner, and N.M. Sinclair: The Effect of Tobacco Blend Additives on the Retention of Nicotine and Solanesol in the Human Respiratory Tract and on Subsequent Plasma Nicotine Concentrations During Cigarette Smoking; Chem. Res. Toxicol. 17 (2004) 537–544.Search in Google Scholar

132. Willems, E.W., B. Rambali, W. Vleeming, A. Opperhuizen, and J.G.C. van Amsterdam: Signifi-cance of Ammonium Compounds on Nicotine Expo-sure to Cigarette Smokers; Food Chem. Toxicol. 44 (2006) 678–688.Search in Google Scholar

133. Hunt, J.F., K. Fang, R. Malik, A. Snyder, N. Malhorta, T.A.E. Platts-Mills, and B. Gaston: Endogenous Airway Acidification. Implications for Asthma Patho-physiology; Am. J. Respir. Crit. Care Med. 161 (2000) 694–699.Search in Google Scholar

134. Kostikas, K., G. Papatheodorou, K. Ganas, K. Psathakis, P. Panagou, and S. Loukides: pH in Expired Breath Condensate of Patients with Inflammatory Airway Diseases; Am. J. Respir. Crit. Care Med. 165 (2002) 1364–1370.Search in Google Scholar

135. Hunt, J.F., E. Erwin, L. Palmer, J. Vaughan, N. Malhotra, T.A.E. Platts-Mills, and B. Gaston: Ex-pression and Activity of the pH-Regulatory Gluta-minase in the Human Airway Epithelium; Am. J. Respir. Crit. Care Med. 165 (2002) 101–107.Search in Google Scholar

136. Reininghaus, W.: Bioavailability of Nicotine; INBIFO correspondence to Philip Morris, November 15, 1994, Bates-No.: 2050878704–8707, available at: http:// legacy.library.ucsf.edu/tid/ehu46b00.Search in Google Scholar

137. Hoffmann, D. and I. Hoffmann: Chemistry and Toxicology; in: Cigars: Health Effects and Trends; edited by D.R. Shopland and D.M. Burns, Smoking and Tobacco Control Monograph 9; National Cancer Institute, 1998, pp. 55–104.Search in Google Scholar

138. Seeman, J.I.: Possible Role of Ammonia on the Deposition, Retention and Absorption of Nicotine in Humans While Smoking; Chem. Res. Toxicol. 20 (2007) 326–343.Search in Google Scholar

139. Seeman, J.I. and R.A. Carchman: The Possible Role of Ammonia Toxicity on the Exposure, Deposition, Retention, and the Bioavailability of Nicotine During Smoking; Food. Chem. Toxicol. 46 (2008) 1863–1881.Search in Google Scholar

140. Chen, C. and J.F. Pankow: Gas/Particle Partitioning of Two Acid-Base Active Compounds in Mainstream Tobacco Smoke: Nicotine and Ammonia; J. Agric. Food Chem. 57 (2009) 2678–2690.Search in Google Scholar

141. Lauterbach, J.H.: Comment on Gas/Particle Partitioning of Two Acid-Base Active Compounds in Mainstream Tobacco Smoke: Nicotine and Ammonia; J. Agric. Food. Chem. 58 (2010) 9287–9288.Search in Google Scholar

142. Federal Trade Commission: Cigarettes: Testing for Tar and Nicotine Content; Federal Register, Washington, DC, August 1, 1967, Vol. 32, No. 147, p. 11178.Search in Google Scholar

143. Commonwealth of Massachusetts, Department of Public Health: Cigarette and Smokeless Tobacco Products: Reports of Added Constituents and Nicotine Ratings (105 CMR 660.000); available at: http:// www.mass.gov/eohhs/docs/dph/regs/105cmr660.pdf.Search in Google Scholar

144. Chen, C. and J.F. Pankow: Rebuttal to the Comment on Gas/Particle Partitioning of Two Acid-Base Active Compounds in Mainstream Tobacco Smoke: Nicotine and Ammonia; Agric. Food Chem. 58 (2010) 9289.Search in Google Scholar

145. Van Amsterdam, J., A. Sleijffers, P. van Spiegel, R. Blom, M. Witte, J. van de Kassteele, M. Blokland, P. Steerenberg, and A. Opperhuizen: Effect of Ammonia in Cigarette Tobacco on Nicotine Absorption in Human Smokers; Food Chem. Toxicol. 49 (2011) 3025–3030.Search in Google Scholar

146. Müller, L. and W. Röper: Commentary: It Ain't Necessarily so; Beitr. Tabakforsch. Int. 19 (2000) 51–54.Search in Google Scholar

147. Hind, J.D. and R.B. Seligman: Method of Preparing a Reconstituted Tobacco Sheet Employing a Pectin Adhesive; United States Patent 3,420,241, Philip Morris Inc., New York, NY (Application Date: June 16, 1966).Search in Google Scholar

148. Papeteries de Mauduit: Developments in Cigarette Paper: Manufacturing of Cigarette Paper. Fundamental characteristics; 1984, Bates-No. 2028560522–0536, available at: http://legacy.library.ucsf.edu/tid/ zaz94g00.Search in Google Scholar

149. N.N.: Improved Process of Manufacturing Cigarette Paper; United Kingdom Patent Specification 646,031, Ecusta Paper Corporation (Application Date: May 15, 1947).Search in Google Scholar

150. Goodman, B.L. and W.G. Houck, Jr.: Smoking Article Exhibiting Reduced Sidestream Smoke, and Wrapper Paper Therefor; European Patent Application 0402059 A2, Philip Morris Products Inc., Richmond VA (Priority: June 5, 1989).Search in Google Scholar

151. Ishikawa, S., T. Tsutsumi, M. Sato, and K. Inoue: Winding Paper for Smoking Goods; European Patent Specification EP 1403431 B1, Japan Tobacco Inc., Tokyo (Priority: May 16, 2001).Search in Google Scholar

152. DeNoble, V.J. and P.C. Mele: Behavioral Pharma-cology Annual Report June 01, 1983. Philip Morris U.S.A.; Bates-No. 2056144550–4633, available at: http://legacy.library.ucsf.edu/tid/xgl36e00.Search in Google Scholar

153. Johnson, R.R., E.D. Alford, and G.W. Kinzer: Formation of Sucrose Pyrolysis Products; J. Agr. Food Chem. 17 (1969) 22–24.10.1021/jf60161a013Search in Google Scholar

154. Gager Jr., F.L., J.W. Nedlock, and W.J. Martin: Tobacco Additives and Cigarette Smoke. II. Organic, Gas-Phase Products from D-Glucose and Sucrose; Carbohyd. Res. 17 (1971) 335–339.Search in Google Scholar

155. Fenner, M.L. and J. Braven: The Mechanism of Carcinogenesis by Tobacco Smoke. Further Experimental Evidence and a Prediction from the Thiol-Defence Hypothesis; Brit. J. Cancer 22 (1968) 474–479.Search in Google Scholar

156. Pomerleau, O.F.: Neurobiological Interactions of Alcohol and Nicotine; in: Alcohol and Tobacco: From Basic Science to Clinical Practice, edited by J.B. Fertig and J.P. Allen, National Institutes of Health, Bethesda, MD, 1995, pp. 145–158.Search in Google Scholar

157. Gray, N.: Reflections on the Saga of Tar Content: Why Did We Measure the Wrong Thing?; Tob. Control 9 (2000) 90–94.Search in Google Scholar

158. Stedman, R.L.: The Chemical Composition of Tobacco and Tobacco Smoke; Chem. Rev. 68 (1968) 153–207.Search in Google Scholar

159. Cremer, D.R. and K. Eichner: Formation of Volatile Compounds During Heating of Spice Paprika (Capsicum annuum) powder; J. Agric. Food Chem. 48 (2000) 2454–2460.Search in Google Scholar

160. Greger, V. and P. Schieberle: Characterization of the Key Aroma Compounds in Apricots (Prunus armeniaca) by Application of the Molecular Sensory Science Concept; J. Agric Food Chem. 55 (2007) 5221–5228.Search in Google Scholar

161. Fuhrmann, E. and W. Grosch: Character Impact Odorants of the Apple Cultivars Elstar and Cox Orange; Nahrung 46 (2002) 187–193.Search in Google Scholar

162. Phillpotts, D.F., D. Spincer, and D.T. Westcott: The Effects of the Natural Sugar Content of Tobacco upon the Acetaldehyde Concentration Found in Cigarette Smoke; Beitr. Tabakforsch. 8 (1975) 7–10.Search in Google Scholar

163. Baker, R.R.: Smoke Chemistry; in: Tobacco. Production, Chemistry and Technology, edited by D.L. Davis and M.T. Nielsen, Blackwell, Oxford, 1999, pp. 398–439.Search in Google Scholar

164. Pailer, M., H. Kuhn, and I. Grünberger: Über quantitative Unterschiede im Auftreten von nieder-molekularen Carbonylverbindungen im Rauch von Zigaretten verschiedener Tabakmischungen und verschiedenen Feuchtigkeitsgehaltes [On the Quantitative Differences in the Presence of Low Molecular Weight Carbonyls in the Smoke of Cigarettes with Different Tobacco Blends and Different Moisture Content]; Fachl. Mitt. Österr. Tabakregie 3 (1962) 34–39.Search in Google Scholar

165. Chepiga, T.A., M.J. Morton, P.A. Murphy, J.T. Avalos, B.R. Bombick, D.J. Doolittle, M.F. Borger-ding, and J.E. Swauger: A Comparison of the Mainstream Smoke Chemistry and Mutagenicity of a Representative Sample of the US Cigarette Market with Two Kentucky Reference Cigarettes (K1R4F and K1R5F); Food Chem. Toxicol. 38 (2000) 949–962.Search in Google Scholar

166. Quertemont, E. and P. De Witte: Conditioned Stimulus Preference after Acetaldehyde but Not Ethanol Injections; Pharmacol. Biochem. Behav. 68 (2001) 449–454.Search in Google Scholar

167. Seeman, J.I., M. Dixon, and H.-J. Haussmann: Acetaldehyde in Mainstream Tobacco Smoke: Formation and Occurrence in Smoke and Bioavailability in the Smoker; Chem. Res. Toxicol. 15 (2002) 1331–1350.Search in Google Scholar

168. Egle Jr., J.L.: Retention of Inhaled Acetaldehyde in Man; J. Pharmacol. Exp. Ther. 174 (1970) 14–19.Search in Google Scholar

169. Brien, J.F. and C.W. Loomis: Pharmacology of Acetaldehyde; Can. J. Physiol. Pharmacol. 61 (1983) 1–22.10.1139/y83-001Search in Google Scholar

170. McLaughlin, S.D., B.K. Scott, and C.M. Peterson: The Effect of Cigarette Smoking on Breath and Whole Blood-Associated Acetaldehyde; Alcohol 7 (1990) 285-287.Search in Google Scholar

171. Belluzzi, J.D., R. Wang, and F.M. Leslie: Acetaldehyde Enhances Acquisition of Nicotine Self-Administration in Adolescent Rats; Neuropsycho-pharmacology 30 (2005) 705-712.Search in Google Scholar

172. Talhout, R., A. Opperhuizen, and J.G.C. van Amsterdam: Role of Acetaldehyde in Tobacco Smoke Addiction; Eur. Neuropsychopharmacol. 17 (2007) 627-636.Search in Google Scholar

173. Kaburaki, Y., H. Shigematsu, and H. Kusakabe: The Composition of Tobacco Smoke. X. Relation Between Vapor Phase Components of Smoke and Constituents of Tobacco; Nippon Senbai Kosha Chuo Kenkyusho Kenkyu Hokoku 107 (1969) 135-142.Search in Google Scholar

174. Seeman, J.I., S.W. Laffoon, and AJ. Kassman: Evaluation of Relationships Between Mainstream Smoke Acetaldehyde and “Tar” and Carbon Monoxide Yields in Tobacco Smoke and Reducing Sugars in Tobacco Blends of U.S. Commercial Cigarettes; Inhal. Toxicol. 15 (2003) 373-395.Search in Google Scholar

175. Burton, H.R. and G. Childs Jr.: The Thermal Degradation of Tobacco. VI. Influence of Extraction on the Formation of Some Major Gas Phase Constituents; Beitr. Tabakforsch. 8 (1975) 174-180.Search in Google Scholar

176. Hahn, J. and J. Schaub: Influence of Tobacco Additives on the Chemical Composition of Mainstream Smoke; Beitr. Tabakforsch. Int. 24 (2010) 100-116.Search in Google Scholar

177. Roemer, E., S. Wittke, E. Trelles Sticken, J.-J. Piade, T. Bonk, and M.K. Schorp: The Addition of Cocoa, Glycerol, and Saccharose to the Tobacco of Cigarettes: Implications for Smoke Chemistry, in vitro Cytotoxicity, Mutagenicity and Further Endpoints; Beitr. Tabakforsch. Int. 24 (2010) 117-138.Search in Google Scholar

178. Intorp, M., J. Pani, and M. Blumenstock: Influence of Tobacco Additives on the Chemical Composition of Mainstream Smoke - Additional Analysis of Three Tobacco Industry Based Laboratories; Beitr. Tabakforsch. Int. 24 (2010) 139-144.Search in Google Scholar

179. Cahours, X., T. Verron, and S. Purkis: Effect of Sugar Content on Acetaldehyde Yield in Cigarette Smoke; Paper presented at the CORESTA Joint Study Groups Meeting Science / Product Technology Study Groups, Graz, Austria, 2011, abstract ST27.Search in Google Scholar

180. Cahours, X., T. Verron, and S. Purkis: Effect of Sugar Content on Acetaldehyde Yield in Cigarette Smoke; Beitr. Tabakforsch. Int. 25 (2012) 381-395.Search in Google Scholar

181. Baker, R.R.: Sugars, Carbonyls and Smoke. Letter to the Editor; Food Chem. Toxicol. 45 (2007) 1783-1786.Search in Google Scholar

182. Henningfield, J.E., D.K. Hatsukami, M. Zeller, and E. Peters: Conference on Abuse Liability and Appeal of Tobacco Products: Conclusions and Recommen-dations; Drug Alcohol Depend. 116 (2011) 1-7.Search in Google Scholar

183. WHO Framework Convention on Tobacco Control (FCTC): Conference of the Parties to the WHO Framework Convention on Tobacco Control. Fourth session, Punta del Este, Uruguay, November 15-20, 2010. Provisional agenda item 5.2: Draft Guidelines for the Implementation of Articles 9 and 10 of the WHO Framework Convention on Tobacco Control; available at: http://apps.who.int/gb/fctc/PDF/cop4/ FCTC_COP4_6Rev1-en.pdf.Search in Google Scholar

184. Euromonitor: Tobacco in the United States; May 2005.Search in Google Scholar

185. TNS Opinion & Social: Special Eurobarometer 332, Eurobarometer 73.2: Tobacco; May 2010, TNS Opinion & Social, Brussels, Belgium, p. 15.Search in Google Scholar

186. Sanders E., R. Weitkunat, A. Utan, and R. Dempsey: Does the Use of Ingredients Added to Tobacco In-crease Cigarette Addictiveness? A Detailed Analysis; Inhal. Toxicol. 24 (2012) 227–245.Search in Google Scholar

187. Connolly, G.N.: Sweet and Spicy Flavours: New Brands for Minorities and Youth; Tob. Control 13 (2004) 211–212.Search in Google Scholar

188. Manning, K.C., K.J. Kelly, and M.L. Comello: Flavoured Cigarettes, Sensation Seeking, and Adolescents’ Perceptions of Cigarette Brands; Tob. Control 18 (2009) 459–465.Search in Google Scholar

189. Lewis, M.J. and O. Wackowski: Dealing with an Innovative Industry: A Look at Flavored Cigarettes Promoted by Mainstream Brands; Am. J. Public Health 96 (2006) 244–251.Search in Google Scholar

190. Klein, S.M., G.A. Giovani, D.C. Barker, C. Tworek, K.M. Cummings, and R.J. O'Connor: Use of Flavored Cigarettes among Older Adolescent and Adult Smokers: United States, 2004–2005; Nicotine Tob. Res. 10 (2008) 1209–1214.Search in Google Scholar

191. Wikipedia: Generally Recognized as Safe; available at: http://en.wikipedia.org/wiki/Generally_recognized _as_safe.Search in Google Scholar

192. Wynder, E.L. and D. Hoffmann: Experimental Tobacco Carcinogenesis; Adv. Cancer Res. 8 (1964) 249–453.10.1016/S0065-230X(08)60510-2Search in Google Scholar

193. Schmeltz, I., A. Wenger, D. Hoffmann, and T.C. Tso: Chemical Studies on Tobacco Smoke. 63. On the Fate of Nicotine During Pyrolysis and in a Burning Cigarette; J. Agric. Food Chem. 27 (1979) 602–608.Search in Google Scholar

194. Baker, R.R.: A Review of Pyrolysis Studies to Unravel Reaction Steps in Burning Tobacco; J. Anal. Appl. Pyrolysis 11 (1987) 555–573.Search in Google Scholar

195. White, J.L., B.T. Conner, T.A. Perfetti, B.R. Bombick, J.T. Avalos, K.W. Fowler, C.J. Smith, and D.J. Doolittle: Effect of Pyrolysis Temperature on the Mutagenicity of Tobacco Smoke Condensate; Food Chem. Toxicol. 39 (2001) 499–505.Search in Google Scholar

196. Stotesbury, S., H. Digard, L. Willoughby, and A. Couch: The Pyrolysis of Tobacco Additives as a Means of Predicting Their Behavior in a Burning Cigarette; Beitr. Tabakforsch. Int. 18 (1999) 147–163.Search in Google Scholar

197. Stotesbury, S.J., L.J. Willoughby, and A. Couch: Pyrolysis of Cigarette Ingredients Labelled with Stable Isotopes; Beitr. Tabakforsch. Int. 19 (2000) 55–64.Search in Google Scholar

198. Green, J.D., J. Chalmers, and P.J. Kinnard: The Transfer of Tobacco Additives to Cigarette Smoke. Examination of the Possible Contribution of Pyrolysis Products to Mainstream Smoke Composition; Beitr. Tabakforsch. Int. 14 (1989) 283–288.Search in Google Scholar

199. Baker, R.R. and L.J. Bishop: The Pyrolysis of Tobacco Ingredients; J. Anal. Appl. Pyrolysis 71 (2004) 223–311.10.1016/S0165-2370(03)00090-1Search in Google Scholar

200. Baker, R.R. and L.J. Bishop: The Pyrolysis of Non-Volatile Tobacco Ingredients Using a System That Simulates Cigarette Combustion Conditions; J. Anal. Appl. Pyrolysis 74 (2005) 145-170.Search in Google Scholar

201. Muramatsu, M.: Studies on the Transport Phenomena in Naturally Smouldering Cigarettes; Sci. Papers, Centr. Res. Inst, Japan Tob. Salt Monop. Corp. 123 (1981) 9-77.Search in Google Scholar

202. Baker, R.R.: Combustion and Thermal Decomposition Regions Inside a Burning Cigarette; Combust. Flame 30 (1977) 21-32.Search in Google Scholar

203. Baker, R.R.: Product Formation Mechanisms Inside a Burning Cigarette; Prog. Energy Combust. Sci. 7 (1981) 135-153.Search in Google Scholar

204. Massachusetts Department of Public Health: 105 CMR 665.200: Testing for Mainstream Smoke Constituents, 2001. Bates-No. 2081569220-9224; available at: http://legacy.library.ucsf.edu/tid/ ony82c00.Search in Google Scholar

205. Health Canada: Tobacco Reporting Regulations -Analytical Methods for the Determination of Several Different Constituents in Mainstream Smoke; available at: http://www.hc-sc.gc.ca/hc-ps/tobac-tabac/ legislation/reg/indust/method/index-eng.php.Search in Google Scholar

206. Hoffmann, D. and I. Hoffmann: Tobacco Smoke Com-ponents. Letter to the Editor; Beitr. Tabakforsch. Int. 18 (1998) 49-52.Search in Google Scholar

207. Baker, R.R., J.R. Pereira da Silva, and G. Smith: The Effect of Tobacco Ingredients on Smoke Chemistry. Part I: Flavourings and Additives; Food Chem. Toxicol. 42S (2004) S3-S37.10.1016/S0278-6915(03)00189-3Search in Google Scholar

208. Baker, R.R., J.R. Pereira da Silva, and G. Smith: The Effect of Tobacco Ingredients on Smoke Chemistry. Part II: Casing Ingredients; Food Chem. Toxicol. 42S (2004) S39-S52.10.1016/j.fct.2003.08.009Search in Google Scholar

209. Purkis, S.W., C. Mueller, and M. Intorp: The Fate of Ingredients in and Impact on Cigarette Smoke; Food Chem. Toxicol. 49 (2011) 3238-3248.Search in Google Scholar

210. Eisenbrand, G., B. Pool-Zobel, V. Baker, M. Balls, BJ. Blaauboer, A. Boobis, A. Carere, S. Kevekordes, J.-C. Lhuguenot, R. Pieters, and J. Kleiner: Methods of in vitro Toxicology; Food Chem. Toxicol. 40 (2002) 193-236.10.1016/S0278-6915(01)00118-1Search in Google Scholar

211. CORESTA in vitro Toxicology Task Force: The Rationale and Strategy for Conducting in vitro Toxicology Testing of Tobacco Smoke (May 2004); available at: http://www.coresta.org/Reports/IVT TF Rationale-IVT-Testing-Tob.-Smoke_Report_ Jun04.pdf.Search in Google Scholar

212. Andreoli, C, D. Gigante, and A. Nunziata: A Review of in vitro Methods to Assess the Biological Activity of Tobacco Smoke with the Aim of Reducing the Toxicity of Smoke; Toxicol. in vitro 17 (2003) 587-594.Search in Google Scholar

213. Johnson, M.D., J. Schilz, M.V. Djordjevic, J.R. Rice, and P.G. Shields: Evaluation of in vitro Assays for Assessing the Toxicity of Cigarette Smoke and Smokeless Tobacco; Cancer Epidemiol. Biomarkers Prev. 18 (2009) 3263-3304.Search in Google Scholar

214. R.J. Reynolds Tobacco Company: Chemical and Biological Studies on New Cigarette Prototypes That Heat Instead of Burn Tobacco; R.J. Reynolds Tobacco Company, Winston-Salem, NC, 1988, pp. 274-436, Bates-No. 533436276-6657, available at: http://legacy.library.ucsf.edu/tid/brt81b00.Search in Google Scholar

215. Coggins, C.R.E.: A Review of Chronic Inhalation Studies with Mainstream Cigarette Smoke in Rats and Mice; Toxicol. Pathol. 26 (1998) 307–314.Search in Google Scholar

216. Coggins, C.R.E.: A Review of Chronic Inhalation Studies with Mainstream Cigarette Smoke, in Hamsters, Dogs, and Nonhuman Primates; Toxicol. Pathol. 29 (2001) 550–557.Search in Google Scholar

217. Witschi, H., I. Espiritu, S.T. Dance, and M.S. Miller: A Mouse Lung Tumor Model of Tobacco Smoke Carcinogenesis; Toxicol. Sci. 68 (2002) 322–330.Search in Google Scholar

218. Witschi, H.: The A/J Mouse Lung Tumor Model: Strengths and Weaknesses; Presentation at the LSRO Biological Effects Assessment (BEA) Committee Meeting, Bethesda, MD, June 28–29, 2005.Search in Google Scholar

219. Mauderly, J.L., A.P. Gigliotti, E.B. Barr, W.E. Bechtold, S.A. Belinsky, F.F. Hahn, C.A. Hobbs, T.H. March, S.K. Seilkop, and G.L. Finch: Chronic Inhalation Exposure to Mainstream Cigarette Smoke Increases Lung and Nasal Tumor Incidence in Rats; Toxicol. Sci. 81 (2004) 280–292.Search in Google Scholar

220. Hutt J.A., B.R. Vuillemenot, E.B. Barr, M.J. Grimes, F.F. Hahn, C.H. Hobbs, T.H. March, A.P. Gigliotti, S.K. Seilkop, G.L. Finch, J.L. Mauderly, and S.A. Belinsky: Life-Span Inhalation Exposure to Mainstream Cigarette Smoke Induces Lung Cancer in B6C3F1 Mice Through Genetic and Epigenetic Pathways; Carcinogenesis 26 (2005) 1999–2009.Search in Google Scholar

221. Walaszek, Z., M. Hanausek, and T.J. Slaga: The Role of Skin Painting in Predicting Lung Cancer; Int. J. Toxicol. 26 (2007) 345–351.Search in Google Scholar

222. Roemer, E., T.H. Ottmueller, H.-J. Urban, and C. Baillet-Mignard: SKH-1 Mouse Skin Painting: A Short-Term Assay to Evaluate the Tumorigenic Activity of Cigarette Smoke Condensate; Toxicol. Lett. 192 (2010) 155–161.Search in Google Scholar

223. Doull, J., J.P. Frawley, W.J. George, T.A. Loomis, R.A. Squire, and S.L. Taylor: Cigarette Ingredients. A Complete List and Background; Bates-No. 517941576–1600, available at: http://legacy.library. ucsf.edu/tid/dte13d00.Search in Google Scholar

224. Paschke, T., G. Scherer, and W.D. Heller: Effects of Ingredients on Cigarette Smoke Composition and Biological Activity: A Literature Overview; Beitr. Tabakforsch. Int. 20 (2002) 107–247.Search in Google Scholar

225. Rodgman, A.: Some Studies of the Effects of Additives on Cigarette Mainstream Smoke Properties. I. Flavorants; Beitr. Tabakforsch. Int. 20 (2002) 83–103.Search in Google Scholar

226. Rodgman, A.: Some Studies of the Effects of Additives on Cigarette Mainstream Smoke Properties. III. Ingredients Reportedly Used in Various Commercial Cigarette Products in the USA and Elsewhere; Beitr. Tabakforsch. Int. 21 (2004) 47–104.Search in Google Scholar

227. Matula, T.: A Comparative Study of the Mutagenicity of Tobacco Smoke Condensates; Bio-Research Laboratories Ltd. for R.J. Reynolds Tobacco Co., 1977; Bates-No. 501542614–2636, available at: http://legacy.library.ucsf.edu/tid/kbs39d00. For decoding the test material designations, see (225).Search in Google Scholar

228. R.J. Reynolds: RJRT Document Information; available at: http://www.rjrtdocs.com.Search in Google Scholar

229. Carmines, E.L.: Evaluation of the Potential Effects of Ingredients Added to Cigarettes. Part 1: Cigarette Design, Testing Approach, and Review of Results. Food Chem. Toxicol. 40 (2002) 77-91.Search in Google Scholar

230. Rustemeier, K., R. Stabbert, H.-J. Haussmann, E. Roemer, and E.L. Carmines: Evaluation of the Potential Effects of Ingredients Added to Cigarettes. Part 2: Chemical Composition of Mainstream Smoke; Food Chem. Toxicol. 40 (2002) 93-104.Search in Google Scholar

231. Roemer, E., FJ. Tewes, TJ. Meisgen, D.J. Veltel, and E.L. Carmines: Evaluation of the Potential Effects of Ingredients Added to Cigarettes. Part 3: in vitro Genotoxicity and Cytotoxicity; Food Chem. Toxicol. 40 (2002) 105-111.Search in Google Scholar

232. Vanscheeuwijck, P.M., A. Teredesai, P.M. Terpstra, J. Verbeeck, P. Kuhl, B. Gerstenberg, S. Gebel, and E.L. Carmines: Evaluation of the Potential Effects of Ingredients Added to Cigarettes. Part 4: Subchronic Inhalation Toxicity; Food Chem. Toxicol. 40 (2002) 113-131.Search in Google Scholar

233. Wertz, M.S., T. Kyriss, S. Paranjape, and S.A. Glantz: The Toxic Effects of Cigarette Additives. Philip Morris’ Project Mix Reconsidered: An Analysis of Documents Released through Litigation; PLoS Med. 8 (2011): e1001145.10.1371/journal.pmed.1001145324370722205885Search in Google Scholar

234. Dempsey, R.: Comments re: Wertz et al. “The toxic Effects of Cigarette Additives. Philip Morris’ Project Mix Reconsidered: An Analysis of Documents Released Through Litigation; PLoS Medicine 8 (12), published online Dec. 21, 2011, available at: http:// www.plosmedicine.org/annotation/listThread.action? root=17399.10.1371/journal.pmed.1001145Search in Google Scholar

235. Oldham, MJ. and W.J. McKinney Jr.: Comments re: Wertz et al: “The Toxic Effects of Cigarette Additives. Philip Morris’ Project MIX Reconsidered: An Analysis of Documents Released Through Litigation” PLoS Medicine December 2011, Vol 8(12); available at: http://www.plosmedicine.org/ annotation/listThread.action?root=13441.10.1371/journal.pmed.1001145Search in Google Scholar

236. U.S. Food and Drug Administration (FDA): Toxi-cological Principles for the Safety Assessment of Direct Food Additives and Color Additives Used in Food. Redbook II. Draft Guidance, 1993; available at: http://www.fda.gov/Food/GuidanceCompliance Regulatory Information/GuidanceDocuments/FoodIn gredientsandPackaging/Redbook/ucm078717.htm.Search in Google Scholar

237. U.S. Consumer Product Safety Commission and U.S. Department of Health and Human Services: Toxicity Testing Plan, Vol. 5. Toxicity Testing Plan for Low Ignition-Potential Cigarettes; Washington, DC, 1993, Bates-No. 2023696254-6452, available at: http:// legacy.library.ucsf.edu/tid/rnw71f00.Search in Google Scholar

238. Lee, P.N., B.A. Forey, J.S. Fry, J.S. Hamling, J.F. Hamling, E.B. Sanders, and R.A. Carchman: Does Use of Flue-Cured Rather than Blended Cigarettes Affect International Variation in Mortality from Lung Cancer and COPD?; Inhal. Toxicol. 21 (2009) 404-430.Search in Google Scholar

239. Baker, R.R., E.D. Massey, and G. Smith: An Overview of the Effects of Tobacco Ingredients on Smoke Chemistry and Toxicity; Food Chem. Toxicol. 42S (2004) S53-S83.10.1016/j.fct.2004.01.00115072838Search in Google Scholar

241. Renne, R.A., H. Yoshimura, K. Yoshino, G. Lulham, S. Minamisawa, A. Tribukait, D.D. Dietz, K.M. Lee, and R.B. Westerberg: Effects of Flavoring and Casing Ingredients on the Toxicity of Mainstream Cigarette Smoke in Rats; Inhal. Toxicol. 18 (2006) 685-706.Search in Google Scholar

242. Gaworski, CL., MJ. Oldham, K.A. Wagner, C.R.E. Coggins, and G.J. Patskan: An Evaluation of the Toxicity of 95 Ingredients Added Individually to Experimental Cigarettes: Approach and Methods; Inhal. Toxicol. 23 Suppl. 1 (2011) 1-12.Search in Google Scholar

243. Coggins, C.R.E., K.A. Wagner, M.S. Werley, and MJ. Oldham: A Comprehensive Evaluation of the Toxicology of Cigarette Ingredients: Carbohydrates and Natural Products; Inhal. Toxicol. 23 S1 (2011) 13-40.Search in Google Scholar

244. Coggins, C.R.E., J.S. Edmiston, A.M. Jerome, T.B. Langston, EJ. Sena, D.C. Smith, and MJ. Oldham: A Comprehensive Evaluation of the Toxicology of Cigarette Ingredients: Essential Oils and Resins; Inhal. Toxicol. 23 S1 (2011) 41-69.Search in Google Scholar

245. Coggins, C.R.E., M.T. Fisher, D.C. Smith, and MJ. Oldham: A Comprehensive Evaluation of the Toxicology of Cigarette Ingredients: Cocoa-Derived Ingredients; Inhal. Toxicol. 23 S1 (2011) 70-83.Search in Google Scholar

246. Coggins, C.R.E., J.A. Merski, and MJ. Oldham: A Comprehensive Evaluation of the Toxicology of Cigarette Ingredients: Heterocyclic Nitrogen Com-pounds; Inhal. Toxicol. 23 S1 (2011) 84-89.Search in Google Scholar

247. Coggins, C.R.E., EJ. Sena, T.B. Langston, and MJ. Oldham: A Comprehensive Evaluation of the Toxi-cology of Cigarette Ingredients: Aromatic Carbonyl Compounds; Inhal. Toxicol. 23 S1 (2011) 90-101.Search in Google Scholar

248. Coggins, C.R.E., A.M. Jerome, J.S. Edmiston, and MJ. Oldham: A Comprehensive Evaluation of the Toxicology of Cigarette Ingredients: Aliphatic Carbonyl Compounds; Inhal. Toxicol. 23 S1 (2011) 102-118.Search in Google Scholar

249. Coggins, C.R.E., J. Liu, J.A. Merski, M.S. Werley, and MJ. Oldham: A Comprehensive Evaluation of the Toxicology of Cigarette Ingredients: Aliphatic and Aromatic Carboxylic Acids; Inhal. Toxicol. 23 S1 (2011) 119-140.Search in Google Scholar

250. Coggins, C.R.E., K. Frost-Pineda, D.C. Smith, and MJ. Oldham: A Comprehensive Evaluation of the Toxicology of Cigarette Ingredients: Aromatic and Aliphatic Alcohol Compounds; Inhal. Toxicol. 23 S1 (2011) 141-156.Search in Google Scholar

251. Coggins C.R.E., EJ. Sena, and MJ. Oldham: A Comprehensive Evaluation of the Toxicology of Cigarette Ingredients: Inorganic Compounds; Inhal. Toxicol. 23 S1 (2011) 157-171.Search in Google Scholar

252. Gaworski, CL., K.A. Wagner, MJ. Morton, and MJ. Oldham: Insights from a Multi-Year Program Designed to Test the Impact of Ingredients on Mainstream Cigarette Smoke Toxicity; Inhal. Toxicol. 23 S 1 (2011) 172-183.Search in Google Scholar

253. Substance Abuse and Mental Health Services Ad-ministration, Office of Applied Studies: The NSDUH Report: Use of Menthol Cigarettes; Rockville, MD, November 19, 2009, available at: http://oas.samhsa. gov/2k9/134/134MentholCigarettes.htm.Search in Google Scholar

254. Oldham, M.J., H.-J. Haussmann, W. Gomm, L.T. Rimmer, M.J. Morton, and W.J. McKinney: Discrimi-natory Power of Standard Toxicity Assays Used to Evaluate Ingredients Added to Cigarettes; Regul. Toxicol. Pharmacol. 62 (2012) 49–61.Search in Google Scholar

254. Wynder, E.L. and D. Hoffmann: Ein experimenteller Beitrag zur Tabakrauchkanzerogenese [An Experi-mental Contribution to the Problem of Tobacco Smoke Carcinogenesis]; Dtsch. Med. Wochenschr. 88 (1963) 623–628.Search in Google Scholar

255. Mizusaki, S., T. Takashima, and K. Tomaru: Factors Affecting Mutagenic Activity of Cigarette Smoke Condensate in Salmonella typhimurium TA 1538; Mutat. Res. 48 (1977) 29–36.Search in Google Scholar

256. Mizusaki, S., H. Okamoto, A. Akiyama, and Y. Fukuhara: Relation Between Chemical Constituents of Tobacco and Mutagenic Activity of Cigarette Smoke Condensate; Mutat. Res. 48 (1977) 319–326.Search in Google Scholar

257. Gairola, C.: Genetic Effects of Fresh Cigarette Smoke in Saccharomyces cerevisiae; Mutat. Res. 102 (1982) 123–136.Search in Google Scholar

258. Roemer, E., T.J. Meisgen, F.J. Tewes, and R.P. Solana: Discrimination of Cigarette Mainstream Smoke Condensates with the Salmonella Reverse Mutation Assay; Poster presented at the 37th Society of Toxicology Meeting, Seattle, WA, March 1–5, 1998, Abs. 1449; Toxicologist 42 (1998) 295 (full poster text available at http://www.pmusa-science.com).Search in Google Scholar

259. Schramke, H., T.J. Meisgen, F.J. Tewes, W. Gomm, and E. Roemer: The Mouse Lymphoma Thymidine Kinase Assay for the Assessment and Comparison of the Mutagenic Activity of Cigarette Mainstream Smoke Particulate Phase; Toxicology 227 (2006) 193–210.Search in Google Scholar

260. Cole, J., W.J. Muriel, and B.A. Bridges: The Mutagenicity of Sodium Fluoride to L5178Y [wild-type and TK+/- (3.7.2c)] Mouse Lymphoma Cells; Mutagenesis 1 (1986) 157–167.Search in Google Scholar

261. Gaworski, C.L., R. Lemus-Olalde, and E.L. Carmines: Toxicological Evaluation of Potassium Sorbate Added to Cigarette Tobacco; Food Chem. Toxicol. 46 (2008) 339–351.Search in Google Scholar

262. Lemus, R., E.L. Carmines, E. van Miert, C.R.E. Coggins, E. Anskeit, B. Gerstenberg, T.J. Meisgen, H. Schramke, R. Stabbert, H. Völkel, and P.M. Terpstra: Toxicological Comparisons of Cigarettes Containing Different Amounts of Vanillin; Inhal. Toxicol. 19 (2007) 683–699.Search in Google Scholar

263. Eccles, R.: Menthol and Related Cooling Compounds; J. Pharm. Pharmacol. 46 (1994) 618–630.Search in Google Scholar

264. Hall, R.L. and B.L. Oser: Recent Progress in the Consideration of Flavoring Ingredients under the Food Additives Amendment. III. GRAS Substances; Food Technol. 253 (1965) 151–197.Search in Google Scholar

265. Adams, T.B., J.B. Hallagan, J.M. Putnam, T.L. Gierke, J. Doull, I.C. Munro, P. Newberne, P.S. Portoghese, R.L. Smith, B.M. Wagner, C.S. Weil, L.A. Woods, and R.A. Ford: The FEMA GRAS Assessment of Alicyclic Substances Used as Flavour Ingredients; Food Chem. Toxicol. 34 (1996) 763–828.Search in Google Scholar

266. Bundesrepublik Deutschland: Tabakverordnung vom 20. Dezember 1977 (BGBl. I S. 2831), zuletzt durch die Verordnung vom 28. Juni 2010 (BGBl. I S. 851) geändert [Federal Republic of Germany: Tobacco Ordinance of December 20, 1977 (Bundesgesetzblatt I p. 2831), last amended by the ordinance of June 28, 2010 (Bundesgesetzblatt I p. 851)].Search in Google Scholar

267. Heck, J.D.: A Review and Assessment of Menthol Employed as a Cigarette Flavoring Ingredient; Food Chem. Toxicol, 48 (2010) S1-S38.10.1016/j.fct.2009.11.00220113860Search in Google Scholar

268. Andersen, P.H. and N.J. Jensen: Mutagenic Investigation of Peppermint Oil in the Salmo-nella/Mammalian-Microsome Test; Mutat. Res. 138 (1984) 17-20.Search in Google Scholar

269. Ishidate Jr., M, T. Sofuni, K. Yoshikawa, M. Hayashi, T. Nohmi, M. Sawada, and A. Matsuoka: Primary Mutagenicity Screening of Food Additives Currently Used in Japan; Food Chem. Toxicol. 22 (1984) 623-636.Search in Google Scholar

270. Ivett, J.L., B.M. Brown, C. Rodgers, B.E. Anderson, M.A. Resnick, and E. Zeiger: Chromosomal Aberrations and Sister Chromatid Exchange Tests in Chinese Hamster Ovary Cells in vitro. IV. Results with 15 Chemicals; Environ. Mol. Mutagen. 14 (1989) 165-187.Search in Google Scholar

271. Hopp, R.: Menthol: Its Origins, Chemistry, Physiology and Toxicological Properties; Rec. Adv. Tob. Sci. 19 (1993) 3-46.Search in Google Scholar

272. National Institute for Occupational Safety and Health (NIOSH): Health Hazard Evaluation Determination Report No. HE 77-66-531, Sucrets Department, Merck, Sharp and Dohme, West Point, PA, 1978.Search in Google Scholar

273. Stoner, G.D., M.B. Shimkin, AJ. Kniazeff, J.H. Weisburger, E.K. Weisburger, and G.B. Gori: Test for Carcinogenicity of Food Additives and Chemothera-peutic Agents by the Pulmonary Tumor Response in Strain A Mice; Cancer Res. 33 (1973) 3069-3085.Search in Google Scholar

274. U.S. Department of Health, Education, and Welfare: Bioassay of dl-Menthol for Possible Carcinogenicity, CAS No. 89-78-1; National Cancer Institute, Carcinogenesis, Technical Report Series No. 98, 1979, pp. 79-83.Search in Google Scholar

275. Russin, W.A., J.D. Hoesly, CE. Elson, M.A. Tanner, and M.N. Gould: Inhibition of Rat Mammary Carcino-genesis by Monoterpenoids; Carcinogenesis 10 (1989) 2161-2164.Search in Google Scholar

276. Goldstein, E., A.D. Cooper, and B. Tarkington: Effect of Inhaling Medication Vapors from a Colds Preparation on Murine Pulmonary Bacterial Defense Systems; J. Toxicol. Environ. Health 2 (1976) 371-388.Search in Google Scholar

277. Riechelmann, H., C. Brommer, M. Hinni, and C. Martin: Response of Human Ciliated Respiratory Cells to a Mixture of Menthol, Eucalyptus Oil and Pine Needle Oil; Arzneimittelforschung 47 (1997) 1035-1039.Search in Google Scholar

278. Rakieten, N., M.L. Rakieten, and M. Boykin: Effects of Menthol Vapor on the Intact Animal with Special Reference to the Upper Respiratory Tract; J. Am. Pharm. Assoc. 43 (1954) 390-392.Search in Google Scholar

279. RIFM Expert Panel, D. Belsito, D. Bickers, M. Bruze, P. Calow, H. Greim, J.M. Hanifin, A.E. Rogers, J.H. Saurat, I.G. Sipes, and H. Tagami: A Toxicologic and Dermatologic Assessment of Cyclic and Non-Cyclic Terpene Alcohols When Used as Fragrance Ingredients; Food Chem. Toxicol. 46 (2008) S1–S71.10.1016/j.fct.2008.06.08518655821Search in Google Scholar

280. Altria Client Services: Background Information to the Tobacco Products Scientific Advisory Committee, Menthol Discussion; submission of June 30, 2010, available at: http://www.fda.gov/downloads/Advisory Committees/CommitteesMeetingMaterials/Tobacco ProductsScientificAdvisoryCommittee/UCM 218779.pdf.Search in Google Scholar

281. Mitchell, B.C., E.P. Barbee, and R.M. Irby Jr.: The Chromatographic Determination of Menthol in Ciga-rettes and Cigarette Smoke; Tob. Sci. 7 (1963) 64–66.Search in Google Scholar

282. Newell, M.P., P.H. Latimer, and L.R. Haefele: The Fate of Menthol in Cigarette Smoke; presented at the 22nd Tobacco Chemists’ Research Conference, Richmond, VA, 1968, paper No. 24.Search in Google Scholar

283. Jenkins Jr., R.W., R.H. Newman, and M.K. Chavis: Cigarette Smoke Formation Studies. II. Smoke Distri-bution and Mainstream Pyrolytic Composition of Added 14C Menthol (U); Beitr. Tabakforsch. 5 (1970) 299–301.Search in Google Scholar

284. Brozinski, M., U. Dölberg, and G. Lipp: Untersuchun-gen über die Verteilung des Menthols auf Tabak, Filter und Rauch von Mentholcigaretten [The Distribution of Menthol in Tobacco, in Filters and in the Smoke of Mentholated Cigarettes]; Beitr. Tabak-forsch. 6 (1972) 124–130.Search in Google Scholar

285. Best, F.W.: Effects of Some Cigarette Construction Parameters on Menthol Migration and Transfer; Rec. Adv. Tob. Sci. 19 (1993) 155–201.Search in Google Scholar

286. Cook, C.J., J.H. Lauterbach, W.T. Pannell, B.F. Price, W.M. Bowser, D.O. Pinion, and A.K. Spencer: Transfer of Semi-Volatile Components from Tobacco to Smoke; Report at the Joint Meeting of the CORESTA Smoke and Technology Groups, 1999, Innsbruck, Austria, paper ST21.Search in Google Scholar

287. Schmeltz, I. and W.S. Schlotzhauer: Benzo[a]pyrene, Phenols and Other Products from Pyrolysis of the Cigarette Additive, (d,l)-Menthol; Nature 219 (1968) 370–371.Search in Google Scholar

288. Sidney, S., I.S. Tekawa, G.D. Friedman, M.C. Sadler, and D.P. Tashkin: Mentholated Cigarette Use and Lung Cancer; Arch. Intern. Med. 155 (1995) 727–732.Search in Google Scholar

289. Hébert, R.: What`s New in Nicotine & Tobacco Research?; Nicotine Tob. Res. 6, Suppl. 1 (2004) S1–S4.10.1080/14622200310001659189Search in Google Scholar

290. Brinkman, M.C., S.M. Gordon, J.R. Satola, R.R. Kroeger, and J.T. Bernert: Exposure of Nonsmokers to Sidestream Smoke in an Environmental Chamber; presented at the 14th Annual Conference of the International Society of Exposure Analysis, Philadelphia, PA, October 17–21, 2004.Search in Google Scholar

291. Bernert, J.T., S.M. Gordon, R.B. Jain, M.C. Brinkman, C.S. Sosnoff, T.H. Seyler, Y. Xia, J.E. McGuffey, D.L. Ashley, J.L. Pirkle, and E.J. Samp-son: Increases in Tobacco Exposure Biomarkers Measured in Non-Smokers Exposed to Sidestream Cigarette Smoke under Controlled Conditions; Bio-markers 14 (2009) 82–93.Search in Google Scholar

292. Brinkman, M.C., J.C. Chuang, S.M. Gordon, H. Kim, R.R. Kroeger, and P.A. Richter: Uptake and Chemical Characterization of Fine and Ultrafine Particles by Smokers of Different Cigarette Types; Poster presented at the Joint Conference of the Society for Research on Nicotine and Tobacco and SRNT-Europe, Dublin, Ireland, April 27–30, 2009.Search in Google Scholar

293. Brinkman, M.C., J.C. Chuang, S.M. Gordon, H. Kim, R.R. Kroeger, G.M. Polzin, and P.A. Richter: Exposure to and Deposition of Fine and Ultrafine Particles in Smokers of Menthol and Nonmenthol Cigarettes; Inhal. Toxicol. 24 (2012) 255–269.Search in Google Scholar

294. Hinds, W.C.: Size Characteristics of Cigarette Smoke; Am. Ind. Hyg. Assoc. J. 39 (1978) 48–54.10.1080/0002889778507712Search in Google Scholar

295. Ingebrethsen, B.J.: Evolution of the Particle Size Distribution of Mainstream Cigarette Smoke During a Puff; Aerosol Sci. Technol. 5 (1986) 423–433.Search in Google Scholar

296. Chen, B.T., J. Namenyi, H.C. Yeh, J.L. Mauderly, and R.G. Cuddihy: Physical Characterization of Cigarette Smoke Arerosol Generated from a Walton Smoke Machine; Aerosol Sci. Technol. 12 (1990) 364–375.Search in Google Scholar

297. Bernstein, D.M.: A Review of the Influence of Particle Size, Puff Volume, and Inhalation Pattern on the Deposition of Cigarette Smoke Particles in the Respiratory Tract; Inhal. Toxicol. 16 (2004) 675–689.Search in Google Scholar

298. Van Dijk, W.D., S. Gopal, and P.T.J. Scheepers: Nanoparticles in Cigarette Smoke. Real-Time Un-diluted Measurements by a Scanning Mobility Particle Sizer; Anal. Bioanal. Chem. 399 (2011) 3573–3578.Search in Google Scholar

299. Reid, J.R.: A History of Mentholated Cigarettes: “This Spud's for You”; Rec. Adv. Tob. Sci. 19 (1993) 71–94.Search in Google Scholar

300. Giovino, G.A., S. Sidney, J.C. Gfroerer, P.M. O'Malley, J.A. Allen, P.A. Richter, K.M. Cummings: Epidemiology of Menthol Cigarette Use; Nicotine Tob. Res. 6, Suppl. 1 (2004) S67–S81.10.1080/14622203710001649696Search in Google Scholar

301. Lawrence, D., B. Cadman, and A.C. Hoffmann: Sensory Properties of Menthol and Smoking Topography; Tob. Induc. Dis. 9, Suppl. 1 (2011) S3.Search in Google Scholar

302. Moolchan, E.T.: Adolescent Menthol Smokers: Will They Be a Harder Target for Smoking Cessation?; Nicotine Tob. Res. 6, Suppl. 1 (2004) S93–S95.10.1080/14622203310001649522Search in Google Scholar

303. Kreslake, J.M., G. Ferris Wayne, H.R. Alpert, H.K. Koh, and G.N. Connolly: Tobacco Industry Control of Menthol in Cigarettes and Targeting of Adolescents and Young Adults; Am. J. Public Health 98 (2008) 1685–1692.Search in Google Scholar

304. Center for Regulatory Effectiveness: Request for Correction, Pursuant to the Information Quality Act and its Guidelines, of Information Being Disseminated by the Food and Drug Administration and its Center for Tobacco Products Regarding Menthol Cigarettes and Public Health; e-mail to the Center for Tobacco Products, Food and Drug Administration, Sept. 20, 2010; available at: http://www.fda.gov/downloads/ AdviseryCommittees/CommitteesMeetingMaterials/ TobaccoProductsScientificAdviseryCommittee/UC M237548.pdf.Search in Google Scholar

305. Hyland, A., S. Garten, G.A. Giovino, and K.M. Cummings: Mentholated Cigarettes and Smoking Cessation: Findings from COMMIT; Tob. Control 11 (2002) 135–139.Search in Google Scholar

306. Muscat, J.E., J.P. Richie Jr., and S.D. Stellman: Mentholated Cigarettes and Smoking Habits in Whites and Blacks; Tob. Control 11 (2002) 368–371.Search in Google Scholar

307. Okuyemi, K.S., M. Ebersole-Robinson, N. Nazir, and J.S. Ahluwalia: African-American Menthol and Non-menthol Smokers: Differences in Smoking Cessation Experiences; J. Natl. Med. Assoc. 96 (2004) 1208–1211.Search in Google Scholar

308. Okuyemi, K.S., B. Faseru, L. Sanderson Cox, C.A. Bronars, and J.S. Ahluwalia: Relationship Between Menthol Cigarettes and Smoking Cessation among African American Light Smokers; Addiction 102 (2007) 1979–1986.Search in Google Scholar

309. Ahluwalia, J.S., K. Okuyemi, N. Nollen, W.S. Choi, H. Kaur, K. Pulvers, and M.S. Mayo: The Effects of Nicotine Gum and Counseling among African American Light Smokers: A 2 × 2 Factorial Design; Addiction 101 (2006) 883–891.Search in Google Scholar

310. Okuyemi, K.S., L.S. Cox, N.L. Nollen, T.M. Snow, H. Kaur, W. Choi, N. Nazir, M.S. Mayo, and J.S. Ahluwalia: Baseline Characteristics and Recruitment Strategies in a Randomized Clinical Trial of African-American Light Smokers; Am. J. Health Promot. 21 (2007) 183–191.Search in Google Scholar

311. Center for Regulatory Effectiveness: Center for Regulatory Effectiveness (CRE) Assessment of the Fol-lowing Research Report: “Relationship Between Men-thol Cigarettes and Smoking Cessation among African American Light Smokers” by: Kolawole S. Okuyemi, Babalola Faseru, Lisa Sanderson Cox, Carrie A. Bronars & Jasjit S. Ahluwalia (2007), August 2010.Search in Google Scholar

312. Monteiro-Riviere, N.A.: Anatomical Factors Affecting Barrier Function; in: Dermatotoxicology, 5th Ed, edited by F.N. Marzulli and H.I. Maibach, Taylor & Francis, Washington, DC, 1996.Search in Google Scholar

313. Abobo, C.V., J. Ma, and D. Liang: Effect of Menthol on Nicotine Pharmacokinetics in Rats after Cigarette Smoke Inhalation; Nicotine Tob. Res. 14 (2012) 801–808.Search in Google Scholar

314. Werley, M.S., C.R.E. Coggins, and P.N. Lee: Possible Effects on Smokers of Cigarette Mentholation: A Review of the Evidence Relating to Key Research Questions; Regul. Toxicol. Pharmacol. 47 (2007) 189–203.Search in Google Scholar

315. Li, Q., A. Hyland, G. Giovino, J. Bauer, and M. Cummings: Nicotine Dependence: Comparing Men-thol and Non-Menthol Cigarette Smokers; presented at the 2005 National Conference on Tobacco or Health, Chicago, IL, May 2005.Search in Google Scholar

316. Fagan, P., E.T. Moolchan, A. Hart Jr., A. Rose, D. Lawrence, V.L. Shavers, and J.T. Gibson: Nicotine Dependence and Quitting Behaviors among Menthol and Non-Menthol Smokers with Similar Consumptive Patterns; Addiction 105, Suppl. 1 (2010) 55–74.Search in Google Scholar

317. National Cancer Institute: Risk Factor Monitoring and Methods. Tobacco Use Supplement to the Current Population Survey (TUS-CPS); available at: http:// riskfactor.cancer.gov/studies/tus-cps/results.html.Search in Google Scholar

318. Delnevo, C.D., D.A. Gundersen, M. Hrywna, S.E. Echeverria, and M.B. Steinberg: Smoking-Cessation Prevalence among U.S. Smokers of Menthol Versus Non-Menthol Cigarettes; Am. J. Prev. Med. 41 (2011) 357–365.Search in Google Scholar

319. Hoffman, A.C. and D. Simmons: Menthol Cigarette Smoking and Nicotine Dependence; Tob. Induc. Dis. 9, Suppl. 1 (2011) S5.10.1186/1617-9625-9-S1-S5Search in Google Scholar

321. American Legacy Foundation: Cigarette Smoking among Youth – Results from the 2000 National Youth Tobacco Survey; Legacy First Look Report 7, Washington, DC, 2001.Search in Google Scholar

322. American Legacy Foundation: Cigarette Smoking among Youth – Results from the 2002 National Youth Tobacco Survey; Legacy First Look Report 13, Washington, DC, 2004.Search in Google Scholar

323. Hersey, J.C., S.W. Ng, J.M. Nonnemaker, P. Mowery, K.Y. Thomas, M.-C. Vilsaint, J.A. Allen, and M.L. Haviland: Are Menthol Cigarettes a Starter Product for Youth?; Nicotine Tob. Res. 8 (2006) 403–413.Search in Google Scholar

324. Hersey, J.C., J.M. Nonnemaker, and G. Homsi: Menthol Cigarettes Contribute to the Appeal and Addiction Potential of Smoking for Youth; Nicotine Tob. Res. 12, Suppl. 2 (2010) S136–S146.10.1093/ntr/ntq173Search in Google Scholar

325. American Legacy Foundation: Cigarette Preferences among Youth – Results from the 2006 Legacy Media Tracking Online (LMTO); First Look Report 17, Washington DC, 2007, available at: http://www.legacyforhealth.org/4206.aspx.Search in Google Scholar

326. Wackowski, O. and C.D. Delnevo: Menthol Cigarettes and Indicators of Tobacco Dependence among Adolescents; Addict. Behav. 32 (2007) 1964–1969.Search in Google Scholar

327. ORC Macro International Inc.: 2004 National Youth Tobacco Survey. Methodology Report; August 31, 2005, available at: http://www.cdc.gov/tobacco/data_ statistics/surveys/nyts/.Search in Google Scholar

328. Collins, C.C. and E.T. Moolchan: Shorter Time to First Cigarette of the Day in Menthol Adolescent Ci-garette Smokers; Addict. Behav. 31 (2006) 1460–1464.Search in Google Scholar

329. Murray, R.P., J.E. Connett, M.A. Skeans, and D.P. Tashkin: Menthol Cigarettes and Health Risks in Lung Health Study Data; Nicotine Tob. Res. 9 (2007) 101–107.Search in Google Scholar

330. Lung Health Research Group, Connett, J.E., J.W. Kusek, W.C. Baily, P. O'Hara, and M. Wu: Design of the Lung Health Study: A Randomized Clinical Trial of Early Intervention for Chronic Obstructive Pulmonary Disease; Control. Clin. Trials 14, 2 Suppl. (1993) 3S–19S.10.1016/0197-2456(93)90021-5Search in Google Scholar

331. Anthonisen, N.R., J.E. Connett, and R.P. Murray for the Lung Health Study Research Group: Smoking and Lung Function of Lung Health Study Participants after 11 Years; Am. J. Respir. Crit. Care Med. 166 (2002) 675–679.Search in Google Scholar

332. Murray, R.P., J.E. Connett, C.S. Rand, W. Pan, and N.R. Anthonisen: Persistence of the Effect of the Lung Health Study (LHS) Smoking Intervention over Eleven Years; Prev. Med. 35 (2002) 314–319.Search in Google Scholar

333. Fu, S.S., K.S. Okuyemi, M.R. Partin, J.S. Ahluwalia, D.B. Nelson, B.A. Clothier, and A.M. Joseph: Menthol Cigarettes and Smoking Cessation During an Aided Quit Attempt; Nicotine Tob. Res. 10 (2008) 457–462.Search in Google Scholar

334. Muscat, J.E., G. Chen, A. Knipe, S.D. Stellman, P. Lazarus, and J.P. Richie Jr.: Effects of Menthol on Tobacco Smoke Exposure, Nicotine Dependence, and NNAL Glucuronidation; Cancer Epidemiol. Bio-markers Prev. 18 (2009) 35–41.Search in Google Scholar

335. Foulds J., M. Webb Hooper, M.J. Pletcher, and K.S. Okuyemi: Do Smokers of Menthol Cigarettes Find it Harder to Quit Smoking?; Nicotine Tob. Res. 12, Suppl. 2 (2010) S102–S109.10.1093/ntr/ntq166314537721177366Search in Google Scholar

335. Hoffman, A.C. and D. Miceli: Menthol Cigarettes and Smoking Cessation Behavior; Tob. Induc. Dis. 9, Suppl. 1 (2011) S6.10.1186/1617-9625-9-S1-S6310290521624152Search in Google Scholar

336. Muscat, J.E., H.-P. Liu, S.D. Stellman, and J.P. Richie Jr.: Menthol Smoking in Relation to Time to First Cigarette and Cotinine: Results from a Community-Based Study; Regul. Toxicol. Pharmacol. 63 (2012) 166–170.Search in Google Scholar

337. Blot, W.J., S.S. Cohen, M. Aldrich, J.K. McLaughlin, M.K. Hargreaves, and L.B. Signorello: Lung Cancer Risk among Smokers of Menthol Cigarettes; J. Natl. Cancer Inst. 103 (2011) 810–816.Search in Google Scholar

338. Heck, J.D., L.A. Hamm, and J.H. Lauterbach (for the Non-Voting Industry Representatives on TPSAC): The Industry Menthol Report. Menthol cigarettes: No Disproportionate Impact on Public Health; submitted to the FDA, March 23, 2011, available at: www.fda.gov/downloads/AdvisoryCommittees/Com mitteesMeetingMaterials/TobaccoProductsScientific AdvisoryCommittee/UCM249320.pdf.Search in Google Scholar

339. Tobacco Products Scientific Advisory Committee (TPSAC): Menthol Cigarettes and Public Health: Review of the Scientific Evidence and Recommendations; submitted to FDA on March 23, 2011, final edits from the July 21, 2011 meeting included, available at: http://www.fda.gov/Advisory Committees/CommitteesMeetingMaterials/Tobacco ProductsScientificAdvisoryCommittee/ucm237359. htm.Search in Google Scholar

340. Kaiserman, M.J. and W.S. Rickert: Carcinogens in Tobacco Smoke: Benzo[a]pyrene from Canadian Cigarettes and Cigarette Tobacco; Am. J. Public Health 82 (1992) 1023–1026.Search in Google Scholar

341. Bodnar, J.A. and M.F. Borgerding: Comparison of Selected Smoke Constituent Yields for Menthol and Non-Menthol Cigarettes That Primarily Heat Tobacco and Menthol and Non-Menthol Cigarettes That Burn Tobacco; ACD Test Memorandum, Research and Development Report R.J. Reynolds Tobacco, 2000, Document No.: ACD-MJAB2000-242; Bates-No. 521216275–6308.Search in Google Scholar

342. Steelman, D.T. and B.W. Dawson: Quantitative Determination of 1,3-Butadiene, Acrylonitrile, Iso-prene, Benzene, and Toluene in the Mainstream Vapor Phase Smoke from Prototypes SP111999AA, SP111999AB, PD8609, PD8610, Merit Ultra Light Box, Kentucky Reference 1R4F and 1R5F Cigarettes; Research and Development Report R.J. Reynolds Tobacco, 2000, Document No.: ACD-MTDS2000-024; Bates-No. 521216061–6070.Search in Google Scholar

343. Clapp, W.L. and P. Martin: Determination of Quino-line in Mainstream Smoke TPM from GN19502 Products; Research and Development Report R.J. Reynolds Tobacco, 2000, Document No.: ACD-MWLC2000-060, Bates-No. 521216194–6197.Search in Google Scholar

344. Steelman, D. and B. Smith: Quantitative Deter-mination of 2-Furancarboxaldehyde in Mainstream Smoke from Eclipse SP111999AA, Eclipse SP111999AB (Menthol), PD 8609 (Menthol), 610, Merit Ultra Lights Box, Kentucky Reference 1R4F, Kentucky 1R5F and Industry Monitor 15 cigarettes; Research and Development Report R.J. Reynolds Tobacco, 2000, Document No.: ACD-MDTS 2000-61, Bates-No. 521216168–6175.Search in Google Scholar

345. Blakley, R.L. and D.D. Henry: Yields of Vapor Phase Radicals in Mainstream Smoke from SP111999AA, SP111999AB, PD8609, PD8610, Merit Ultra Light Box, Kentucky Reference 1R4F and 1R5F Cigarettes and a Smoke Blank; Research and Development Report RJ Reynolds Tobacco, 2000, Document No.: ACD-MRLB2000-33; Bates-No. 522187872–7880.Search in Google Scholar

346. Brooks, C.O., D.D. Henry, and H. Chung: Com-parison of Mainstream Smoke from SP111999AA, SP111999AB, PD8609, PD8610, Merit Ultra Lights Box, and 1R4F and 1R5F Kentucky Reference Cigarettes by Gas Chromatography with Mass Selective Detection; Research and Development Report RJ Reynolds Tobacco, 2000, Document No.: ACD-MCOB 2000-315.Search in Google Scholar

347. Gordon, S.M., M.C. Brinkman, R.Q. Meng, G.M. Anderson, J.C. Chuang, R.R. Kroeger, I.L. Reyes, and P.I. Clark: Effect of Cigarette Menthol Content on Mainstream Smoke Emissions; Chem. Res. Toxicol. 24 (2011) 1744–1753.Search in Google Scholar

348. Adam, T., R.R. Baker, and R. Zimmermann: Characterization of Puff-by-Puff Resolved Cigarette Mainstream Smoke by Single Proton Ionization–Time-of-Flight Mass Spectrometry and Principal Component Analysis; J. Agric. Food Chem. 55 (2007) 2055–2061.Search in Google Scholar

349. U.S. Department of Health and Human Services (USDHHS): The Health Consequences of Smoking. A Report of the Surgeon General; Atlanta, GA, 2004.Search in Google Scholar

350. Lee, Y.O. and S.A. Glantz: Menthol: Putting the Pieces Together; Tob. Control 20, Suppl. 2 (2011) ii1–ii7.10.1136/tc.2011.043604308501221504926Search in Google Scholar

351. Avalos J.T., K.W. Fowler, and J.E. Swauger: A Comparison of Ames Activity on Smoke Condensate Derived from Menthol and Non-Menthol Eclipse Ci-garette Prototypes and Menthol and Non-Menthol Tobacco-Burning Cigarettes; R.J. Reynolds Tobacco Company, Research and Development Report, 2000, Document No. EMT2000 113, Bates-No. 521872124–2203; available at: http://legacy.library. ucsf.edu/tid/zmp03h00.Search in Google Scholar

352. Putnam, K.P., D.W. Bombick, and D.J. Doolittle: Use of the Neutral Red Cytotoxicity Assay to Determine the Cytotoxic Potential of Cigarette Smoke Con-densate from Menthol and Non-Menthol Eclipse and Tobacco-Burning Cigarettes; R.J. Reynolds Tobacco Company, Research and Development Report, 2000, Document No. EMT2000 0223, available at: http://legacy.library.ucsf.edu/tid/ehh07h00.Search in Google Scholar

353. Bombick, B.R., D.L. Bowman, J.B. Mabe, and W.T. Morgan: A Comparative Study of Sister Chromatid Exchange Frequencies in Chinese Hamster Ovary Cells Exposed to Cigarette Smoke Condensate from Eclipse Menthol and Non-Menthol Cigarettes, To-bacco-Burning Menthol and Non-Menthol Cigarettes, and Kentucky Reference 1R4F; R.J. Reynolds Tobacco Company, Research and Development Report, July 17, 2000, Document No. EMT000717, Bates-No.: 524775190–5210; available at: http:// legacy.library.ucsf.edu/tid/otw96a00.Search in Google Scholar

354. Camarasa, G. and A. Alomar: Menthol Dermatitis from Cigarettes; Contact Dermatitis 4 (1978) 169–170.Search in Google Scholar

355. Chrisman, B.B.: Menthol and Dermatitis; Arch. Dermatol. 114 (1978) 286.10.1001/archderm.1978.01640140094027Search in Google Scholar

356. Bock, F.G., G.E. Moore, and P.C. Clark: Carcinogenic Activity of Cigarette Smoke Condensate. III. Biological Activity of Refined Tar from Several Types of Cigarettes; J. Natl. Cancer Inst. 34 (1965) 481–493.Search in Google Scholar

357. Schievelbein, H.: Gesundheitsrisiko beim Rauchen von Menthol-Zigaretten? [Risks to Health in Smoking Menthol Cigarettes?]; Münch. Med. Wochenschr. 111 (1969) 2457.Search in Google Scholar

358. Gaworski, C.L., J.D. Heck, M.B. Bennett, and M.L. Wenk: Toxicologic Evaluation of Flavor Ingredients Added to Cigarette Tobacco: Skin Painting Bioassay of Cigarette Smoke Condensate in SENCAR Mice; Toxicology 139 (1999) 1–17.Search in Google Scholar

359. Coggins, C.R.E., P.H. Ayres, A.T. Mosberg, G.T. Burger, J.W. Sagartz, and A.W. Hayes: Comparative Inhalation Study in Rats, Using a Second Prototype of a Cigarette that Heats Rather than Burns Tobacco; Inhal. Toxicol. 1 (1989) 197–226.Search in Google Scholar

360. Coggins, C.R.E., A.T. Mosberg, P.H. Ayres, J.W. Sagartz, G.T. Burger, and A.W. Hayes: Inhalation Comparison in Rats of Menthol Cigarettes Which Burn or Which Only Heat Tobacco; Abstract, 29th Annual Meeting of the Society of Toxicology, Miami Beach, FL, Toxicologist 10 (1990) 200.Search in Google Scholar

361. Gaworski, C.L., M.M. Dozier, J.M. Gerhart, N. Ra-jendran, L.H. Brennecke, C. Aranyi, and J.D. Heck: 13-Week Inhalation Toxicity Study of Menthol Ciga-rette Smoke; Food Chem. Toxicol. 35 (1997) 683–692.Search in Google Scholar

362. Gaworski, C.L., M.M. Dozier, J.D. Heck, J.M. Gerhart, N. Rajendran, R.M. David, L.H. Brennecke, and R. Morrissey: Toxicologic Evaluation of Flavor Ingredients Added to Cigarette Tobacco: 13-Week Inhalation Exposures in Rats; Inhal. Toxicol. 10 (1998) 357–381.Search in Google Scholar

363. Cundiff, R.H., G.H. Greene, and A.H. Laurene: Column Elution of Humectants from Tobacco and Determination by Vapor Chromatography; Tob. Sci. 8 (1964) 163–168.Search in Google Scholar

364. Smyth Jr., H.F., J. Seaton, and L. Fischer: The Single Dose Toxicity of Some Glycols and Derivatives; J. Ind. Hyg. Toxicol. 23 (1941) 259–268.Search in Google Scholar

365. Kudo, K. and R. Ito: Comparison of Acute Toxicity of Polyglycerin, Natural Glycerin, and Synthetic Gly-cerin; Toho Igakkai Zasshi 19 (1972) 415–417.Search in Google Scholar

366. Gerarde, H.W.: The Pathogenesis of Pulmonary Injury in Kerosene Intoxication; Delaware State Med. J. 31 (1959) 276–280.Search in Google Scholar

367. Deichmann, W.: Glycerol. Effects upon Rabbits and Rats; Am. Indust. Hygiene Assoc. Quart. 2 (1941) 5–6.Search in Google Scholar

368. Haag, H.B. and A.M. Ambrose: Studies on the Phy-siological Effect of Diethylene Glycol. II. Toxicity and Fate; J. Pharmacol. Exp. Ther. 59 (1937) 93–100.Search in Google Scholar

369. Johnson, V., A.J. Carlson, and A. Johnson: Studies on the Physiological Action of Glycerol on the Animal Organism; Am. J. Physiol. 103 (1933) 517-534.Search in Google Scholar

370. Inayama, Y., H. Kitamura, T. Ito, and M. Kanisawa: Effects of Glycerol on 4-Nitroquinoline-1-oxide Induced Pulmonary Tumorigenesis in ddY Mice; Jpn. J. Cancer Res. (GANN) 77 (1986) 103-105.Search in Google Scholar

371. Kitamura, H., Y. Inayama, T. Ito, M. Yabana, W.W. Piegorsch, and M. Kanisawa: Morphologic Alteration of Mouse Clara Cells Induced by Glycerol: Ultrastruc-tural and Morphometric Studies; Exp. Lung Res. 12 (1987) 281-302.Search in Google Scholar

372. Whitlock, G.P., N.B. Guerrant, and R.A. Dutcher: Response of Rats to Diets Containing Propylene Glycol and Glycerol; Proc. Soc. Exp. Biol. Med. 57 (1944) 124-125.Search in Google Scholar

373. RJ. Reynolds Tobacco Co.: Chemical and Biological Studies on New Cigarette Prototypes That Heat Instead of Burn Tobacco; RJ. Reynolds Tobacco Co., Winston-Salem, NC, 1988, pp. 622-691, Bates-No. 533436276-6657, available at: http://legacy.library. ucsf.edu/tid/brt81b00.Search in Google Scholar

374. Doolittle, D.J., D.A. Lee, and CK. Lee: The Geno-toxic Activity of Glycerol in an in vitro Test Battery; Food Chem. Toxicol. 26 (1988) 631-635.Search in Google Scholar

375. Litton Bionetics Inc.: Mutagenic Evaluation of Compound FDA 71-89, Glycerine; NTIS PB-245 479, Kensington, MD, 1975.Search in Google Scholar

376. Greenspan, B.J., O.R. Moss, A.P. Wehner, R.A. Renne, H.A. Ragan, R.B. Westerberg, C.W. Wright, R. Deskin, A.W. Hayes, G.T. Burger, and A.T. Mosberg: Inhalation Studies of Humectant Aerosols in Rats; Toxicologist 8 (1988) 255.Search in Google Scholar

377. Renne, R.A., A.P. Wehner, B.J. Greenspan, H.S. DeFord, H.A. Ragan, R.B. Westerberg, R.L. Busch-bom, G.T. Burger, A.W. Hayes, R.L. Suber, and A. T. Mosberg: 2-Week and 13-Week Inhalation Studies of Aerosolized Glycerol in Rats; Inhal. Toxicol. 4 (1992) 95-111.Search in Google Scholar

378. Guerrant, N.B., G.P. Whitlock, M.L. Wolff, and R.A. Dutcher: Response of Rats to Diets Containing Varying Amounts of Glycerol and Propylene Glycol; Bull. Nat. Formul. Comm./Am. Pharm. Assoc. 15 (1947) 205-229.Search in Google Scholar

379. Wegener, H.: Über die Fortpflanzungsfähigkeit der Ratte nach Einwirkung von Diäthylenglykol [On the Ability of Rats to Reproduce under the Influence of Diethylene Glycol]; Naunyn-Schmiedeberg's Arch. Pharmacol. [Arch. Exp. Pathol. Pharmacol.] 220 (1953) 414-417.Search in Google Scholar

380. Food and Drug Research Laboratories, Inc.: Teratologic Evaluation of FDA 71-89 (Glycerol: Glycerine) in Mice, Rats and Rabbits; NTIS No. PB-234 876, 1974.Search in Google Scholar

381. Verrett, M.J., W.F. Scott, E.F. Reynaldo, E.K. Alterman, and CA. Thomas: Toxicity and Teratogenicity of Food Additive Chemicals in the Developing Chicken Embryo; Toxicol. Appl. Pharmacol. 56 (1980) 265-273.Search in Google Scholar

382. Larson, P.S. and E.S. Harlow: Some Current Applications of Carbon-14 to Animal and Human Physiological Research: Studies with Tobacco and its Constituents; in: Radioisotopes in Scientific Research, Vol. 3. Research with Radioisotopes in Human and Animal Biology and Medicine, edited by R.C Extermann, Pergamon Press, New York, NY, 1958, pp. 62-78. 383. Laurene, A.H., R.H. Cundiff, and G.H. Greene: Determination of Glycerol and Propylene Glycol in Cigarette Smoke; Tob. Sci. 9 (1965) 1–4.Search in Google Scholar

384. Kobashi, U.T., S. Doihara, S. Sugawara, and Y. Kaburaki: Changes in Chemical Composition of Smoke from Cigarettes Imparted with Several Polyols; Sci. Papers, Centr. Res. Inst, Japan Tob. Salt Monop. Corp. 107 (1965) 319-323.Search in Google Scholar

385. Best, F.W.: Radiotracer Studies with Carbon-14 Labeled Glycerol. Fate in Total Smoke; in: Proceedings of the International Conference on the Physical and Chemical Processes Occurring in a Burning Cigarette, Wake Forest University, Winston Salem, NC, April 26-29, 1987, pp. 244-260.Search in Google Scholar

386. Liu, C: Glycerol Transfer in Cigarette Mainstream Smoke; Beitr. Tabakforsch. Int. 21 (2004) 111-116.Search in Google Scholar

387. Stein, Y.S., M.J. Antal, and M. Jones Jr.: A Study of Gas-Phase Pyrolysis of Glycerol; J. Anal. Appl. Pyrolysis 4 (1983) 283-296.10.1016/0165-2370(83)80003-5Search in Google Scholar

388. Carmines, E.L. and CL. Gaworski: Toxicological Evaluation of Glycerin as a Cigarette Ingredient; Food Chem. Toxicol. 43 (2005) 1521-1539.Search in Google Scholar

389. Gager Jr., F.L., CE. Brunot, R.D. Carpenter, F.E. Resnik, and C.J. Varsel: Cigarette Smoke Precursors. I. The Contribution of the Humectant Glycerol to the Acrolein Content of Cigarette smoke; Philip Morris Internal Report, 1961, Bates-No. 2023015684-5690, available at: http://legacy.library.ucsf.edu/tid/mlj24e00.Search in Google Scholar

390. De Souza, J.E. and M. Scherbak: The Effect of Glycerol Added to Tobacco on the Constituents of Cigarette Smoke; Analyst 89 (1964) 735-739.Search in Google Scholar

391. Yip, S.H., L.T. Taylor, M. Ashraf-Khorassani, J. Yu, M.F. Borgerding, W.M. Coleman III, and J.A. Bodnar: HPLC-MS Determination of Acrolein and Acetone Generated from 13C3-Labeled Glycerol Added to Cigarette Tobacco Using Two Machine-Smoking Regimes; Beitr. Tabakforsch. Int. 24 (2010) 48-57.Search in Google Scholar

392. Cinkotai, F.F.: The Growth of Cigarette Smoke Particles Suspended on Fine Platinum Wire in Moist Air; Beitr. Tabakforsch. 4 (1968) 189-195.Search in Google Scholar

393. Robinson, R.J. and C.P. Yu: Theoretical Analysis of Hygroscopic Growth Rate of Mainstream and Side-stream Cigarette Smoke Particles in the Human Respi-ratory Tract; Aerosol Sci. Technol. 28 (1998) 21-32.Search in Google Scholar

394. Baker, R.R. and M. Dixon: The Retention of Tobacco Smoke Constituents in the Human Respiratory Tract; Inhal. Toxicol. 18 (2006) 255-294.Search in Google Scholar

395. Moldoveanu, S.C. and W.M. Coleman III: The Influence of a Humectant on the Retention by Humans of Solanesol from Cigarette Smoke (Part 2, Glycerin); Beitr. Tabakforsch Int. 23 (2009) 377-383.Search in Google Scholar

396. Wilson, J., M.J.L. Clapp, and D.M. Conning: Effect of Glycerol on Local and Systemic Carcinogenicity of Topically Applied Tobacco Condensate; Br. J. Cancer 38 (1978) 250-257.Search in Google Scholar

397. Heck, J.D., CL Gaworski, N. Rajendran, and R.L. Morrissey: Toxicologic Evaluation of Humectants Added to Cigarette Tobacco: 13-Week Smoke Inhalation Study of Glycerin and Propylene Glycol in Fischer 344 Rats; Inhal. Toxicol. 14 (2002) 1135–1152.Search in Google Scholar

398. Florin, I., L. Rutberg, M. Curvall, and C.R. Enzell: Screening of Tobacco Smoke Constituents for Mutagenicity Using the Ames’ Test; Toxicology 18 (1980) 219–232.Search in Google Scholar

399. Sheftel, V.O.: Indirect Food Additives and Polymers. Migration and Toxicology; CRC Press, Boca Raton, FL, 2000, p. 275.10.1201/9781482293821Search in Google Scholar

400. LaKind, J.S., E.A. McKenna, R.P. Hubner, and R.G. Tardiff: A Review of the Comparative Mammalian Toxicity of Ethylene Glycol and Propylene Glycol; Crit. Rev. Toxicol. 29 (1999) 331–365.Search in Google Scholar

401. Suber, R.L., R. Deskin, I. Nikiforov, X. Fouillet, and C.R.E. Coggins: Subchronic Nose-Only Inhalation Study of Propylene Glycol in Sprague-Dawley Rats; Food Chem. Toxicol. 27 (1989) 578–583.Search in Google Scholar

402. U.S. Department of Health and Human Services – National Toxicology Program. Center for the Evaluation of Risks to Human Reproduction: NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Propylene Glycol; NIH Publication No. 04-4482, NIEHS, Research Triangle Park, NC, 2004.Search in Google Scholar

403. Kagan, M.R., J. A. Cunningham, and D. Hoffmann: Propylene Glycol: A Precursor of Propylene Oxide in Cigarette Smoke; 53rd Tobacco Chemists’ Research Conference, 1999, Program Booklet and Abstracts, Vol. 53, Paper No. 41, pp. 42–43.Search in Google Scholar

404. Gordon, B.M. and W.M. Coleman III: Determination of Vinyl Chloride, Ethylene Oxide and Propylene Oxide in Fresh Mainstream Smoke via Gas Chroma-tography/Mass Spectrometry; Presentation at the 57th Tobacco Science Research Conference, Norfolk, VA, Sept. 2003, Program Booklet and Abstracts, Paper 63, P. 58.Search in Google Scholar

405. Diekmann, J., M. Douda, and K. Rustemeier: Rapid and Sensitive Method for the Determination of Propylene Oxide in Cigarette Mainstream Smoke by Gas Chromatography-Mass Spectrometry; J. Chroma-togr. Sci. 44 (2006) 32–34.Search in Google Scholar

406. Gaworski, C.L., M.J. Oldham, and C.R.E. Coggins: Toxicological Considerations on the Use of Propylene Glycol as a Humectant in Cigarettes; Toxicology 269 (2010) 54–66.Search in Google Scholar

407. Bootman J., D.C. Lodge, and H.E. Whalley: Muta-genic Activity of Propylene Oxide in Bacterial and Mammalian Systems; Mutat. Res. 67 (1979) 101–112.Search in Google Scholar

408. Kuper, C.F., P.G.J. Reuzel, V.J. Feron, and H. Ver-schuuren: Chronic Inhalation Toxicity and Carcinogenicity Study of Propylene Oxide in Wistar Rats; Food Chem. Toxicol. 26 (1988) 159–167.Search in Google Scholar

409. Rios-Blanco, M.N., K. Plna, T. Faller, W. Kessler, K. Hakansson, P.E. Kreutzer, A. Ranasinghe, J.G. Filser, D. Segerbäck, and J.A. Swenberg: Propylene Oxide: Mutagenesis, Carcinogenesis and Molecular Dose; Mutat. Res. 380 (1997) 179–197.Search in Google Scholar

410. Kolman, A., M. Chovanec, and S. Osterman-Golkar: Genotoxic Effects of Ethylene Oxide, Propylene Oxide and Epichlorohydrin in Humans: Update Review (1990–2001); Mutat. Res. 512 (2002) 173–194.Search in Google Scholar

411. International Agency for Research on Cancer (IARC): Agents Classified by the IARC Monographs, Volumes 1–105, last updated August 7, 2012; available at: http://monographs.iarc.fr/ENG/Classification/.Search in Google Scholar

412. Moldoveanu S.C. and W.M. Coleman III: The Influence of a Humectant on the Retention by Humans of Solanesol from Cigarette Smoke (Part 1, Propylene Glycol); Beitr. Tabakforsch. Int. 23 (2008) 153–159.Search in Google Scholar

413. Staples, R., A. Misher, and J. Wardell Jr.: Gastro-intestinal Irritant Effect of Glycerin as Compared with Sorbitol and Propylene Glycol in Rats and Dogs; J. Pharm. Sci. 56 (1967) 398–400.Search in Google Scholar

414. MacKenzie, K.M., W.N. Hauck, A.G. Wheeler, and F.J.C. Roe: Three-Generation Reproduction Study of Rats Ingesting up to 10% Sorbitol in the Diet – and a Brief Review of the Toxicological Status of Sorbitol; Food Chem. Toxicol. 24 (1986) 191–200.Search in Google Scholar

415. World Health Organization (WHO): Summary of Toxicological Data of Certain Food Additives and Contaminants; WHO Food Additive Series No. 13: Sorbitol, 2006; available at: http://www.inchem.org/ documents/jecfa/jecmono/v13je08.htm.Search in Google Scholar

416. United Kingdom, Department of Health: Permitted Additives to Tobacco Products in the United Kingdom; London, October 2003.Search in Google Scholar

417. Kobashi, Y. and S. Sakaguchi: Free Sugars in Cigarette Smoke; Tob. Sci. 3 (1959) 161–163.Search in Google Scholar

418. Jetta, G.: The Dehydration of the Pentosanes of Tobacco During Curing and Fermentation [Sulla disidratazione dei pentosani del tabacco durante la cura e la fermentazione]; Boll. Tecnico. Coltiv. Tabacchi (Scafati) III (1904) 25.Search in Google Scholar

419. Sato, S., T. Ohka, M. Nagao, K. Tsuji, and T. Kosuge: Reduction in Mutagenicity of Cigarette Smoke Condensate by Added Sugars; Mutat. Res. 60 (1979) 155–161.Search in Google Scholar

420. Halter, H.M. and T.I. Ito: Effect of Tobacco Reconstitution and Expansion Processes on Smoke Composition; Rec. Adv. Tob. Sci. 4 (1978) 113–132.Search in Google Scholar

421. Gager Jr., F.L., J.W. Nedlock, and W.J. Martin: Tobacco Additives and Cigarette Smoke. Part I. Transfer of D-Glucose, Sucrose and Their Degradation Products to the Smoke; Carbohydr. Res. 17 (1971) 327–333.Search in Google Scholar

422. Gilbert, J.A.S. and A.J. Lindsey: The Thermal Decomposition of Some Tobacco Constituents; Brit. J. Cancer 11 (1957) 398–402.Search in Google Scholar

423. Johnson, R.R. and E.D. Alford: Products from the Pyrolysis of Sucrose; 20th Tobacco Chemists’ Research Conference, Winston-Salem, NC, 1966, Program Booklet and Abstracts, Abstract No. 29, pp. 37–39.Search in Google Scholar

424. Kato, K., N. Takahashi, and Y. Kaburaki: Thermal Analysis of Tobacco Stem Constituents; Sci. Papers, Centr. Res. Inst., Japan Monopoly Corp. 107 (1965) 165–169.Search in Google Scholar

425. Kato, K.: Pyrolysis of Cellulose. Part III. Comparative Studies of Volatile Compounds from Pyrolysates of Cellulose and its Related Compounds; Agr. Biol. Chem. 31 (1967) 657–663.Search in Google Scholar

426. Fagerson, I.S.: Thermal Degradation of Carbo-hydrates. A Review; J. Agric. Food Chem. 17 (1969) 747–750.Search in Google Scholar

427. Roberts, D.L., J.N. Schumacher, R.A. Lloyd, and R.A. Heckman: Carbohydrate Pyrolysis Products. A Review of the Literature; R.J. Reynolds Tobacco RDM, No.7, February 4, 1976; Bates-No. 500616624–6642; available at: http://legacy.library. ucsf.edu/tid/otu69d00.Search in Google Scholar

428. Sanders, E.B., A.I. Goldsmith, and J.I. Seeman: A Model That Distinguishes the Pyrolysis of D-Glucose, D-Fructose, and Sucrose from That of Cellulose. Application to the Understanding of Cigarette Smoke Formation; J. Anal. Appl. Pyrolysis 66 (2002) 29–50.Search in Google Scholar

429. Talhout, R., A. Opperhuizen, J.G.C. van Amsterdam: Sugars as Tobacco Ingredient: Effects on Mainstream Smoke Composition; Food Chem. Toxicol. 44 (2006) 1789–1798.Search in Google Scholar

430. May, T., H. Rommelspacher, and M. Pawlik: [3H]Har-man Binding Experiments. I: A Reversible and Se-lective Radioligand for Monoamine Oxidase Subtype A in the CNS of the Rat; J. Neurochem. 56 (1991) 490–499.Search in Google Scholar

431. Rommelspacher, H., M. Meier-Henco, M. Smolka, and C. Kloft: The Levels of Norharman Are High Enough after Smoking to Affect Monoamino Oxidase B in Platelets; Eur. J. Pharmacol. 441 (2002) 115–125.Search in Google Scholar

432. De la Burde, R., F. Crayton, and A. Bavley: The Fate of Carbohydrates During the Thermal Degradation of Tobacco; Presentation at the 16th Tobacco Chemists’ Research Conference, Program Booklet and Abstracts, 1962, No.13, Bates-No. 1000700733 available at: http://legacy.library.ucsf.edu/tid/bur81a00.Search in Google Scholar

433. De la Burde, R. and E.H. Poindexter Jr.: Oxidative Products of Hexoses in Thermally Treated Tobacco; Nature 198 (1963) 1089–1090.Search in Google Scholar

434. Bell, J.H., A.O. Saunders, and A.W. Spears: The Contribution of Tobacco Constituents to Phenol Yield of Cigarettes; Tob. Sci. 10 (1966) 138–142.Search in Google Scholar

435. Best, F.W.: Sugar Content of Flue-Cured Tobacco and its Relationship to Tobacco and Smoke Composition; R.J. Reynolds Tobacco, RDR, No. 6, January 30, 1970, Bates-No. 511111200–1220; available at: http:// legacy.library.ucsf.edu/tid/sbi53d00.Search in Google Scholar

436. Thornton, R.E. and S.R. Massey: Some Effects of Adding Sugars to Tobacco; Beitr. Tabakforsch. 8 (1975) 11–15.Search in Google Scholar

437. Passey, R.D. and L.A. Elson: Different Smoking Risks of Flue-Cured and Air-Cured Tobaccos; J. Pathol. 101 (1970) P48.Search in Google Scholar

438. O'Connor, R.J. and P.J. Hurley: Existing Technologies to Reduce Specific Toxicant Emissions in Cigarette Smoke; Tob. Control 17, Suppl. I (2008) i39–i48.10.1136/tc.2007.023689Search in Google Scholar

439. Baker, R.R.: The Generation of Formaldehyde in Cigarettes – Overview and Recent Experiments; Food Chem. Toxicol. 44 (2006) 1799–1822.Search in Google Scholar

440. Miyake, T. and T. Shibamoto: Quantitative Analysis by Gas Chromatography of Volatile Carbonyl Compounds in Cigarette Smoke; J. Chromatogr. A 693 (1995) 376–381.Search in Google Scholar

441. Smith, C.J., T.A. Perfetti, M.A. Rumple, A. Rodgman, and D.J. Doolittle: “IARC Group 2A Carcinogens” Reported in Cigarette Mainstream Smoke; Food Chem. Toxicol. 38 (2000) 371–383.Search in Google Scholar

442. Zilkey, B.F., W.A. Court, M. R. Binns, E.K. Walker, V.A. Dirks, and P.K. Basrur: Chemical Studies on Canadian Tobacco and Tobacco Smoke. 1. Tobacco, Tobacco Sheet, and Cigarette Smoke Chemical Analysis on Various Treatments of Bright and Burley Tobacco; Tob. Sci. 26 (1982) 54–60.Search in Google Scholar

443. Shelar, G.R., P.F. Bernasek, and O.P. Furin: Sugar/ Nicotine Study; R.J. Reynolds Tobacco, ATP 92-210, Bates-No. 510697389–7410, available at: http://legacy.library.ucsf.edu/tid/fwv46b00.Search in Google Scholar

444. National Cancer Institute, Smoking and Health Program: Report No. 5. Toward Less Hazardous Cigarettes. Summary: Four Skin Painting Bioassays Using Condensate from Experimental Cigarettes; NCI, Bethesda, MA, 1980, p. 13.Search in Google Scholar

445. Borgerding, M. and H. Klus: Analysis of Complex Mixtures – Cigarette Smoke; Exp. Toxicol. Pathol. 57 (2005) 43–73.Search in Google Scholar

446. Stavanja, M.S., P.H. Ayres, D.R. Meckley, B.R. Bombick, D.H. Pence, M.F. Borgerding, M.J. Morton, A.T. Mosberg, and J.E. Swauger: Toxicological Evaluation of Honey as an Ingredient Added to Cigarette Tobacco; J. Toxicol. Environ. Health Part A, 66 (2003) 1453–1473.Search in Google Scholar

447. Stavanja, M.S., P.H. Ayres, D.R. Meckley, E.R. Bombick, M.F. Borgerding, M.J. Morton, C.D. Gar-ner, D.H. Pence, and J.E. Swauger: Safety Assessment of High Fructose Corn Syrup (HFCS) as an Ingredient Added to Tobacco; Exp. Toxicol. Pathol. 57 (2006) 267–281.Search in Google Scholar

448. Roemer E., M.K. Schorp, J.-J. Piadé, J.I. Seeman, D.E. Leyden, and H.-J. Haussmann: Scientific Assessment of the Use of Sugars as Cigarette Tobacco Ingredients: A Review of Published and Other Publicly Available Studies; Crit. Rev. Toxicol. 42 (2012) 244–278.Search in Google Scholar

449. Harllee, J.C. and J.C. Leffingwell: Composition of Casing Materials: Cocoa, its Constituents and Their Organoleptic Properties; 32nd Tobacco Chemists’ Research Conference, Program Booklet and Abstracts, Paper No. 25, 1978, p. 13, Presentation Bates-No. 504421772–1807, available at: http://legacy.library. ucsf.edu/tid/nty65d00.Search in Google Scholar

450. Tarka Jr., S.M., R.B. Morrissey, J.L. Apgar, K.A. Hostetler, and C.A. Shively: Chronic Toxicity/ Carcinogenicity Studies of Cocoa Powder in Rats; Food Chem. Toxicol. 29 (1991) 7–19.Search in Google Scholar

451. Kreiser W.R. and R.A. Martin: Cocoa Products. High Pressure Liquid Chromatographic Determination of Theobromine and Caffeine in Cocoa and Chocolate Products; J. Assoc. Off. Anal. Chem. 61 (1978) 1424–1427.Search in Google Scholar

452. Tarka Jr., S.M.: The Toxicology of Cocoa and Methylxanthines: A Review of the Literature; Crit. Rev. Toxicol. 9 (1982) 275–312.Search in Google Scholar

453. Brusick, D., B. Myhr, S. Galloway, J. Rundell, D.R. Jagannath, and S. Tarka: Genotoxicity of Theo-bromine in a Series of Short-Term Assays; Mutat. Res. 169 (1986) 105–114.Search in Google Scholar

454. Rosenkranz, H.S. and F.K. Ennever: Evaluation of the Genotoxicity of Theobromine and Caffeine; Food Chem. Toxicol. 25 (1987) 247–251.10.1016/0278-6915(87)90091-3Search in Google Scholar

455. Rosenkranz, H.S., G. Klopman, V. Chankong, J. Pet-Edwards, and Y.Y. Haimes: Prediction of Environmental Carcinogens: A Strategy for the Mid-1980s; Environ. Mutagen. 6 (1984) 231–258.Search in Google Scholar

456. Tarka Jr., S.M., R.S. Applebaum, and J.F. Borzelleca: Evaluation of the Teratogenic Potential of Cocoa Powder and Theobromine in New Zealand White Rabbits; Food Chem. Toxicol. 24 (1986) 363–374.Search in Google Scholar

457. Tarka Jr., S.M., R.S. Applebaum, and J.F. Borzelleca: Evaluation of the Perinatal, Postnatal and Teratogenic Effects of Cocoa Powder and Theobromine in Sprague-Dawley/CD Rats; Food Chem. Toxicol. 24 (1986) 375–382.Search in Google Scholar

458. Hostetler, K.A., R.B. Morrissey, S.M. Tarka Jr., J.L. Apgar, and C.A. Shively: Three-Generation Reproductive Study of Cocoa Powder in Rats; Food Chem. Toxicol. 28 (1990) 483–490.Search in Google Scholar

459. Fix Sr., R.J. and F.D. Jordan: Indirect Analysis of Cocoa in Tobacco Products via the Determination of Theobromine; R.J. Reynolds Tobacco R&DM, No. 34, Feb. 14, 1990, Bates-No. 508381660–1679; available at: http://legacy.library.ucsf.edu/tid/zfs93d00.Search in Google Scholar

460. Zaidi, Z.R.: Determination of Theobromine Added to Cigarette Tobacco and Smoke; Laboratory Report No. L.470-R, British-American Tobacco, November 27, 1974, Bates-No. 570320984–570321009, available at: http://legacy.library.ucsf.edu/tid/zxe51f00.Search in Google Scholar

461. Schlotzhauer, W.S.: Fatty Acids and Phenols from Pyrolysis of Cocoa Powder, a Tobacco Product Flavo-rant; Tob. Sci. 22 (1978) 1–2.Search in Google Scholar

462. Park, J.Y., O.C. Kim, D.Y. Na, and Y.T. Kim: The Study of Volatile Compounds in the Pyrolyzates of Cocoa Powder, a Tobacco Product Flavorant; 44th Tobacco Chemists’ Research Conference, Program Booklet and Abstracts, Paper No. 56, 1990, p. 40.Search in Google Scholar

463. Sugimura, T., T. Kawachi, M. Nagao, T. Yahagi, Y. Seino, T. Okamoto, K. Shudo, T. Kosuge, K. Tsuji, K. Wakabayashi, Y. Iitaka, and A. Itai: Mutagenic Principle(s) in Tryptophan and Phenylalanine Pyrolysis Products; Proc. Japan Acad. 53 (1977) 58–61.Search in Google Scholar

464. Yamamoto, T., K. Tsuji, T. Kosuge, T. Okamoto, K. Shudo, K. Takeda, Y. Iitaka, K. Yamaguchi, Y. Seino, T. Yahagi, M. Nagao, and T. Sugimura: Isolation and Structure Determination of Mutagenic Substances in L-Glutamic Acid Pyrolysate. Proc. Japan. Acad. 54 B (1978) 248–250.Search in Google Scholar

465. Simons, F.E.R., A.B. Becker, K.J. Simons, and C.A. Gillespie: The Bronchodilator Effect and Pharmaco-kinetics of Theobromine in Young Patients with Asthma; J. Allergy Clin. Immunol. 76 (1985) 703–707.Search in Google Scholar

466. Rambali, B., I. van Andel, E. Schenk, G. Wolterink, G. van de Werken, H. Stevenson, and W. Vleeming: The Contribution of Cocoa Additive to Cigarette Smoking Addiction; RIVM Report 650270002/2002; RIVM, Bilthoven, The Netherlands, 2003.Search in Google Scholar

467. Roemer, E. and U. Hackenberg: Mouse Skin Bioassay of Smoke Condensates from Cigarettes Containing Different Levels of Cocoa; Food Addit. Contam. 7 (1990) 563–569.Search in Google Scholar

468. Samuelsson, G.: Drugs of Natural Origin. A Textbook of Pharmacognosy; Swedish Pharmaceutical Press, Stockholm, 4th edition, 1999, pp. 308–310.Search in Google Scholar

469. Tanaka, M., N. Mano, E. Akazai, Y. Narui, F. Kato, and Y. Koyama: Inhibition of Mutagenicity by Glycyrrhiza Extract and Glycyrrhizin; J. Pharmaco-biodyn. 10 (1987) 685–688.Search in Google Scholar

470. Størmer, F.C., R. Reistad, and J. Alexander: Glycyr-rhizic Acid in Liquorice. Evaluation of Health Hazards; Food Chem. Toxicol. 31 (1993) 303–312.Search in Google Scholar

471. Isbrucker, R.A. and G.A. Burdock: Risk and Safety Assessment on the Consumption of Licorice Root (Glycyrrhiza sp.), its Extract and Powder as a Food Ingredient, with Emphasis on the Pharmacology and Toxicology of Glycyrrhizin; Regul. Toxicol. Pharma-col. 46 (2006) 167–192.Search in Google Scholar

472. Maser, E.: Significance of Reductases in the Detoxi-fication of the Tobacco-Specific Carcinogen NNK; Trends Pharmacol. Sci. 25 (2004) 235–237.Search in Google Scholar

473. Carmines, E.L., R. Lemus, and C.L. Gaworski: Toxi-cologic Evaluation of Licorice Extract as a Cigarette Ingredient; Food Chem. Toxicol. 43 (2005) 1303–1322.Search in Google Scholar

474. Sakagami, H.: Studies on Components of Licorice Root Used for Tobacco Flavoring. Part III. The Behavior of Glycyrrhizic Acid and Glycyrrhetinic Acid Added to Tobacco on Smoking; Nippon Nougei Kagaku Kaishi 47 (1973) 623–626.Search in Google Scholar

475. Van Andel I., G. Wolterink, G. van de Werken, H. Stevenson, L.A.G.J.M. van Aerts, and W. Vleeming: The Health and Addiction Risk of the Glycyrrhizic Acid Component of Liquorice Root Used in Tobacco Products; RIVM Report 34063001/2003, RIVM, Bilthoven, The Netherlands, 2003.Search in Google Scholar

476. Vora, P.S. and R.M. Tuorto: The Behavior of Licorice Components During the Burning Process of Tobacco Products; 38th Tobacco Chemists’ Research Confe-rence, Program Booklet and Abstracts, Paper No. 38, 1984, p. 20.Search in Google Scholar

477. Green, C.R. and F.W. Best: Pyrolysis Products of Licorice; R.J. Reynolds Tobacco RDM, No.20, Aug. 28, 1974, Bates-No. 521574480–4485, available at: http://legacy.library.ucsf.edu/tid/mih33a00.Search in Google Scholar

478. Green, C.R. and F.W. Best: Pyrolysis Products of Various Smoking Materials; R.J. Reynolds Tobacco; RDR, No. 1, January 7, 1975, Bates-No. 501003513– 3531, available at: http://legacy.library.ucsf.edu/tid/ mij59d00.Search in Google Scholar

479. Frattini, C., C. Bicchi, C. Barettini, and G.M. Nano: Volatile Flavor Components of Licorice; J. Agric. Food Chem. 25 (1977) 1238–1241.10.1021/jf60214a042Search in Google Scholar

480. Yongkuan, C. and H. Wangyun: Pyroloysis of Glycyrrhizic Acid and its Sodium Salts; Tob. Sci. 39 (1995) 49–54.Search in Google Scholar

481. Chung, H.L. and J.C. Aldridge: Thermal Study of Licorice by Online Thermogravimetry/Gas Chromato-graphy/Mass Spectrometry; Presentation at the 53rd Tobacco Science Research Conference, Montreal, Canada, Program Booklet and Abstracts, Paper No. 07, 1999, p. 23.Search in Google Scholar

482. Department of Public Health: Public Hearing on Proposed Regulations: Reports of Added Constituents and Nicotine Ratings. Testimony of William Farone, Former Researcher; Philip Morris, June 12, 1997, Bates-No. 2072822298–2313, available at: http://legacy.library.ucsf.edu/tid/vrq95c00.Search in Google Scholar

483. Lyerly, L.A.: Direct Vapor Chromatographic Determination of Menthol, Propylene Glycol, Nicotine, and Triacetin in Cigarette Smoke; Tob. Sci. 11 (1967) 49–51.Search in Google Scholar

484. Stavanja, M.S., G.M. Curtin, P.H. Ayres, E.R. Bombick, M.F. Borgerding, W.T. Morgan, C.D. Garner, D.H. Pence, and J.E. Swauger: Safety Assessment of Diammonium Phosphate and Urea Used in the Manufacture of Cigarettes; Exp. Toxicol. Pathol. 59 (2008) 339–353.Search in Google Scholar

485. United Kingdom, House of Commons, Health Committee: Health – Second report. The Tobacco Industry and the Health Risks of Smoking; 5th June, 2000, available at: http://www.publications.parlia ment.uk/pa/cm199900/cmselect/cmhealth/27/ 2702.htm.Search in Google Scholar

486. Benhamou, S., E. Benhamou, M. Tirmarche, and R. Flamant: Lung Cancer and Use of Cigarettes: A French Case-Control Study; J. Natl. Cancer Inst. 74 (1985) 1169–1175.Search in Google Scholar

487. Benhamou, E., S. Benhamou, and R. Flamant: Lung Cancer and Women: Results of a French Case-Control Study; Br. J. Cancer 55 (1987) 91–95.Search in Google Scholar

488. Benhamou, E., S. Benhamou, A. Auquier, and R. Flamant: Changes in Pattern of Cigarette Smoking and Lung Cancer Risk: Results of a Case-Control Study; Br. J. Cancer 60 (1989) 601–604.Search in Google Scholar

489. Benhamou, S., E. Benhamou, A. Auquier, and R. Flamant: Differential Effects of Tar Content, Type of Tobacco and Use of a Filter on Lung Cancer Risk in Male Cigarette Smokers; Int. J. Epidemiol. 23 (1994) 437–443.Search in Google Scholar

490. Richie Jr., J.P., S.G. Carmella, J.E. Muscat, D.G. Scott, S.A. Akerkar, and S.S. Hecht: Differences in the Urinary Metabolites of the Tobacco-Specific Lung Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone in Black and White Smokers; Cancer Epide-miol. Biomarkers Prev. 6 (1997) 783–790.Search in Google Scholar

491. Melikian, A.A., M.V. Djordjevic, S. Chen, J. Richie Jr., and S.D. Stellman: Effect of Delivered Dosage of Cigarette Smoke Toxins on the Levels of Urinary Biomarkers of Exposure; Cancer Epidemiol. Bio-markers Prev. 16 (2007) 1408–1415.Search in Google Scholar

492. Heck, J.D.: Smokers of Menthol and Nonmenthol Cigarettes Exhibit Similar Levels of Biomarkers of Smoke Exposure; Cancer Epidemiol. Biomarkers Prev. 18 (2009) 622–629.Search in Google Scholar

493. Ho, M.K., B. Faseru, W.S. Choi, N.L. Nollen, M.S. Mayo, J.L. Thomas, K.S. Okuyemi, J.S. Ahluwalia, N.L. Benowitz, and R.F. Tyndale: Utility and Re-lationships of Biomarkers of Smoking in African-American Light Smokers; Cancer Epidemiol. Bio-markers Prev. 18 (2009) 3426–3434.Search in Google Scholar

494. Mariner, D.C., M. Ashley, C.J. Shepperd, G. Mullard, and M. Dixon: Mouth Level Smoke Exposure Using Analysis of Filters from Smoked Cigarettes: A Study of Eight Countries; Regul. Toxicol. Pharmacol. 61 Suppl. 3 (2011) S39–S50.10.1016/j.yrtph.2010.05.00620510323Search in Google Scholar

495. Shepperd, C.J., A.C. Eldridge, D.C. Mariner, M. McEwan, G. Errington, and M. Dixon: A Study to Estimate and Correlate Cigarette Smoke Exposure in Smokers in Germany as Determined by Filter Analysis and Biomarkers of Exposure; Regul. Toxicol. Pharma-col. 55 (2009) 97–109.Search in Google Scholar

496. Morin, A., C.J. Shepperd, A.C. Eldridge, N. Poirier, and R. Voisine: Estimation and Correlation of Cigarette Smoke Exposure in Canadian Smokers as Determined by Filter Analysis and Biomarkers of Exposure; Regul. Toxicol. Pharmacol. 61, Suppl. 3 (2011) S3–S12.10.1016/j.yrtph.2010.09.02020937342Search in Google Scholar

497. St. Charles, F.K., G.R. Krautter, M. Dixon, and D.C. Mariner: A Comparison of Nicotine Dose Estimates in Smokers Between Filter Analysis, Salivary Cotinine, and Urinary Excretion of Nicotine Metabolites; Psychopharmacology 189 (2006) 345–354.Search in Google Scholar

498. Shepperd, C.J., F.K. St. Charles, M. Lien, and M. Dixon: Validation of Methods for Determining Con-sumer Smoked Cigarette Yields from Cigarette Filter Analysis; Beitr. Tabakforsch. Int. 22 (2006) 176–184.Search in Google Scholar

499. Forey, B., J. Hamling, P. Lee, and N. Wald (editors): International Smoking Statistics. Web Edition. A Collection of Worldwide Historical Data from Thirty Economically Developed Countries; 2nd edition. Oxford University Press, 2002. Online updates available at: http://www.pnlee.co.uk/ISS.htm.Search in Google Scholar

500. Lee, P.N., B.A. Forey, and K.J. Young: International Evidence on Smoking and Lung Cancer (Project IESLC). A First Report. Part I: The Databases – Me-thods Used to Collect and Analyse the Data and Scope of the Information Obtained; P.N. Lee Statistics and Computing Ltd., Sutton, UK, 2003, available at: http://www.pnlee.co.uk/Reports.htm.Search in Google Scholar

501. Lee, P.N., B.A. Forey, and K.J. Young: International Evidence on Smoking and Lung Cancer (project IESLC). A First Report. Part II: Results of Selected Meta-Analyses; P.N. Lee Statistics and Computing Ltd., Sutton, UK, 2003; available at: http://www.pnlee.co.uk/Reports.htm.Search in Google Scholar

502. Friedman, G.D., I. Tekawa, M. Sadler, and S. Sidney: Smoking and Mortality: The Kaiser Permanente Experience; in: Changes in Cigarette-Related Disease Risks and Their Implications for Prevention and Control, Smoking and Tobacco Control Monograph No. 8; edited by D. Shopland, D.M. Burns, L. Gar-finkel, and J.M. Samet, National Cancer Institute, Bethesda, MD, 1997, pp. 477–499.Search in Google Scholar

503. Lange, P., J. Nyboe, M. Appleyard, G. Jensen, and P. Schnohr: Relationship of the Type of Tobacco and Inhalation Pattern to Pulmonary and Total Mortality; Eur. Respir. J. 5 (1992) 1111–1117.Search in Google Scholar

504. Speizer, F.E., M.E. Fay, D.W. Dockery, and B.G. Ferris Jr.: Chronic Obstructive Pulmonary Disease Mortality in Six U.S. Cities; Am. Rev. Respir. Dis. 140 (1989) S49–S55.10.1164/ajrccm/140.3_Pt_2.S492782760Search in Google Scholar

505. Thun, M.J. and C.W. Heath Jr.: Changes in Mortality from Smoking in Two American Cancer Society Prospective Studies since 1959; Prev. Med. 26 (1997) 422–426.Search in Google Scholar

506. Wald, N.J. and H.C. Watt: Prospective Study of Effect of Switching from Cigarettes to Pipes or Cigars on Mortality from Three Smoking Related Diseases; Brit. Med. J. 314 (1997) 1860–1863.Search in Google Scholar

507. Kreyberg, L.: Histological Lung Cancer Types. A Morphological and Biological Correlation; Acta Pathol. Microbiol. Scand. Suppl. 157 (1962) 1–103.Search in Google Scholar

508. Munoz N., P. Correa, and F.G Bock: Comparative Carcinogenic Effect of Two Types of Tobacco; Cancer 21 (1968) 376–389.Search in Google Scholar

509. Joly, O.G., J.H. Lubin, and M. Caraballoso: Dark Tobacco and Lung Cancer in Cuba; J. Natl. Cancer Inst. 70 (1983) 1033–1039.Search in Google Scholar

510. Hatsukami, D.K., N.L. Benowitz, S.I. Rennard, C. Oncken, and S.S. Hecht: Biomarkers to Assess the Utility of Potential Reduced Exposure Tobacco Products; Nicotine Tob. Res. 8 (2006) 169–191, corrected and republished: Nicotine Tob. Res. 8 (2006) 600–622.Search in Google Scholar

511. Wagenknecht, L.E, G.R. Cutter, N.J. Haley, S. Sidney, T.A. Manolio, G.H. Hughes, and D.R. Jacobs: Racial Differences in Serum Cotinine Levels among Smokers in the Coronary Artery Risk Development in (Young) Adults Study; Am. J. Public Health 80 (1990) 1053–1056.Search in Google Scholar

512. Garten, S. and R.V. Falkner: Role of Mentholated Cigarettes in Increased Nicotine Dependence and Greater Risk of Tobacco-Attributable Disease; Prev. Med. 38 (2004) 793–798.Search in Google Scholar

513. Ahijevych, K. and B.E. Garrett: Menthol Pharmacology and its Potential Impact on Cigarette Smoking Behavior; Nicotine Tob. Res. 6, Suppl. 1 (2004) S17–S28.10.1080/1462220031000164946914982706Search in Google Scholar

514. Green, B.G. and B.L. McAuliffe: Menthol Desensitization of Capsaicin Irritation: Evidence of a Short-Term Anti-Nociceptive Effect; Physiol. Behav. 68 (2000) 631–639.Search in Google Scholar

515. Nil, R. and K. Bättig: Separate Effects of Cigarette Smoke Yield and Smoke Taste on Smoking Behavior; Psychopharmacology 99 (1989) 54–59.Search in Google Scholar

516. Ahijevych, K.L. and M.E. Wewers: Patterns of Cigarette Consumption and Cotinine Levels among African American Women Smokers; Am. J. Respir. Crit. Care Med. 150 (1994) 1229–1233.Search in Google Scholar

517. Ahijevych, K., J. Gillespie, M. Demirci, and J. Jagadeesh: Menthol and Nonmenthol Cigarettes and Smoke Exposure in Black and White Women; Pharmacol. Biochem. Behav. 53 (1996) 355–360.Search in Google Scholar

518. Ahijevych, K. and L.A. Parsley: Smoke Constituent Exposure and Stage of Change in Black and White Women Cigarette Smokers; Addict. Behav. 24 (1999) 115–120.Search in Google Scholar

519. Comer, A.K. and D.E. Creighton: The Effect of Experimential Conditions on Smoking Behaviour; in: Smoking Behaviour. Physiological and Psychological Influences; edited by R.E. Thornton, Churchill Livingstone, Edinburgh, U.K., 1978, pp. 76–86.Search in Google Scholar

520. Miller, G.E., M.E. Jarvik, N.H. Caskey, S.C. Seger-strom, M.R. Rosenblatt, and W.J. McCarthy: Cigarette Mentholation Increases Smokers’ Exhaled Carbon Monoxide Levels; Exp. Clin. Psychopharmacol. 2 (1994) 154–160.Search in Google Scholar

521. Jarvik, M.E., D.P. Tashkin, N.H. Caskey, W.J. McCarthy, and M.R. Rosenblatt: Mentholated Cigarettes Decrease Puff Volume of Smoke and Increase Carbon Monoxide Absorption; Physiol. Behav. 56 (1994) 563–570.Search in Google Scholar

522. McCarthy, W.J., N.H. Caskey, M.E. Jarvik, T.M. Gross, M.R. Rosenblatt, and C. Carpenter: Menthol vs Nonmenthol Cigarettes: Effects on Smoking Behavior; Am. J. Public Health 85 (1995) 67–72.Search in Google Scholar

523. Clark, P.I., S. Gautam, and L.W. Gerson: Effect of Menthol Cigarettes on Biochemical Markers of Smoke Exposure among Black and White Smokers; Chest 110 (1996) 1194–1198.Search in Google Scholar

524. Ernst, A. and J.D. Zibrak: Carbon Monoxide Poisoning; New Engl. J. Med. 339 (1998) 1603–1608, Correction: New Engl. J. Med. 340 (1999) 1290.10.1056/NEJM1998112633922069828249Search in Google Scholar

525. Benowitz, N.L.: Cotinine as a Biomarker of En-vironmental Tobacco Smoke Exposure; Epidemiol. Rev. 18 (1996) 188–204.Search in Google Scholar

526. Rosenblatt, M.R., R.E. Olmstead, P.N. Iwamoto-Schaap, and M.E. Jarvik: Olfactory Thresholds for Nicotine and Menthol in Smokers (Abstinent and Nonabstinent) and Nonsmokers; Physiol. Behav. 65 (1998) 575–579.Search in Google Scholar

527. Pritchard, W.S., M.E. Houlihan, T.D. Guy, and J.H. Robinson: Little Evidence That “Denicotinized” Menthol Cigarettes Have Pharmacological Effects: An EEG/Heart-Rate/Subjective-Response Study; Psycho-pharmacology 143 (1999) 273–279.Search in Google Scholar

528. Wang, J., H.J. Roethig, S. Appleton, M. Werley, R. Muhammad-Kah, and P. Mendes: The Effect of Menthol Containing Cigarettes on Adult Smokers’ Exposure to Nicotine and Carbon Monoxide; Regul. Toxicol. Pharmacol. 57 (2010) 24–30.Search in Google Scholar

529. Nelson, P.R., P. Chen, M. Dixon, and T. Steichen: A Survey of Mouth Level Exposure to Cigarette Smoke in the United States; Regul. Toxicol. Pharmacol. 61, Suppl. 3 (2011) S25–S38.10.1016/j.yrtph.2010.10.00120937343Search in Google Scholar

530. Ashley, M., M. Dixon, A. Sisodiya, and K. Prasad: Lack of Effect of Menthol Level and Type on Smokers’ Estimated Mouth Level Exposures to Tar and Nicotine Perceived Sensory Characteristics of Cigarette Smoke; Regul. Toxicol. Pharmacol. 63 (2012) 381–390.Search in Google Scholar

531. Pickworth, W.B., E.T. Moolchan, I. Berlin, and R. Murty: Sensory and Physiologic Effects of Menthol and Nonmenthol Cigarettes with Differing Nicotine Delivery; Pharmacol. Biochem. Behav. 71 (2002) 55–61.Search in Google Scholar

532. Patterson, F., N. Benowitz, P. Shields, V. Kaufmann, C. Jepson, P. Wileyto, S. Kucharski, and C. Lerman: Individual Differences in Nicotine Intake per Cigarette; Cancer Epidemiol. Biomarkers Prev. 12 (2003) 468–471.Search in Google Scholar

533. Benowitz, N.L., B. Herrera, and P. Jacob III: Mentholated Cigarette Smoking Inhibits Nicotine Metabolism; J. Pharmacol. Exp. Therap. 310 (2004) 1208–1215.Search in Google Scholar

534. Benowitz, N.L., K.M. Dains, D. Dempsey, C. Havel, M. Wilson, and P. Jacob III: Urine Menthol as a Biomarker of Mentholated Cigarette Smoking; Cancer Epidemiol. Biomarkers Prev. 19 (2010) 3013–3019.10.1158/1055-9965.EPI-10-0706300553920962297Search in Google Scholar

535. St. Charles, F.K., G.R. Krautter, and D.C. Mariner: Post-Puff Respiration Measures on Smokers of Different Tar Yield Cigarettes; Inhal. Toxicol. 21 (2009) 712–718.Search in Google Scholar

536. St. Charles, K., G. Krautter, and D. Mariner: Inhalation Volumes in Smokers of Different Tar Yield Cigarettes; Poster presented at the Meeting of the Society for Research on Nicotine and Tobacco (SRNT), March 20–23, 2005, Prague, Czech Republic, available at: http://www.bat-science.com/groupms/ sites/BAT_7AWFH3.nsf/vwPagesWebLive/DO7A XLK3?opendocument&SKN=1.Search in Google Scholar

537. Caraballo, R.S., D.B. Holiday, S.D. Stellman, P.D. Mowery, G.A. Giovino, J.E. Muscat, M.P. Eriksen, J.T. Bernert, P.A. Richter, and L.T. Kozlowski: Comparison of Serum Cotinine Concentration Within and Across Smokers of Menthol and Nonmenthol Cigarette Brands among Non-Hispanic Black and Non-Hispanic White U.S. Adult Smokers, 2001–2006; Cancer Epidemiol. Biomarkers Prev. 20 (2011) 1329–1340.Search in Google Scholar

538. National Center for Health Statistics: National Health and Nutrition Examination Survey; available at: http://www.cdc.gov/nchs/nhanes/nhanes_question naires.htm.Search in Google Scholar

539. Hebert, J.R. and G.C. Kabat: Menthol Cigarette Smoking and Oesophageal Cancer; Int. J. Epidemiol. 18 (1989) 37–44.Search in Google Scholar

540. Kabat, G.C. and J.R. Hebert: Use of Mentholated Cigarettes and Lung Cancer Risk; Cancer Res. 51 (1991) 6510–6513.Search in Google Scholar

541. Kabat, G.C. and J.R. Hebert: Use of Mentholated Cigarettes and Oropharyngeal Cancer; Epidemiology 5 (1994) 183–188.Search in Google Scholar

542. Carpenter, C.L., M.E. Jarvik, H. Morgenstern, W.J. McCarthy, and S.J. London: Mentholated Cigarette Smoking and Lung Cancer Risk; Ann. Epidemiol. 9 (1999) 114–120.Search in Google Scholar

543. Brooks, D.R., J.R. Palmer, B.L. Strom, and L. Rosenberg: Menthol Cigarettes and Risk of Lung Cancer; Am. J. Epidemiol. 158 (2003) 609–616.Search in Google Scholar

544. Stellman, S.D., Y. Chen, J.E. Muscat, M.V. Djord-jevic, J.P. Richie Jr., P. Lazarus, S. Thompson, N. Al-torki, M. Berwick, M.L. Citron, S. Harlap, T.B. Kaur, A.I. Neugut, S. Olson, J.M. Travaline, P. Witorsch, and Z.-F. Zhang: Lung Cancer Risk in White and Black Americans; Ann. Epidemiol. 13 (2003) 294–302.Search in Google Scholar

545. Jöckel, K.-H., H. Pohlabeln, and I. Jahn: Use of Menthol Cigarettes and Risk of Lung Cancer; Biom. J. 46 Suppl. (2004) 3310.1002/bimj.200490082Search in Google Scholar

546. Etzel, C.J., S. Kachroo, M. Liu, A. D'Amelio, Q. Dong, M.L. Cote, A.S. Wenzlaff, W.K. Hong, A.J. Greisinger, A.G. Schwartz, and M.R. Spitz: Development and Validation of a Lung Cancer Risk Prediction Model for African-Americans; Cancer Prev. Res. 1 (2008) 255–265.Search in Google Scholar

547. Friedman, G.D., M. Sadler, I.S. Tekawa, and S. Sidney: Mentholated Cigarettes and Non-Lung Smoking Related Cancers in California, USA; J. Epidemiol. Community Health 52 (1998) 202.Search in Google Scholar

548. Scanlon, P.D., J.E. Connett, L.A. Waller, M.D. Altose, W.C. Bailey, A.S. Buist, and D.P. Tashkin: Smoking Cessation and Lung Function in Mild-to-Moderate Chronic Obstructive Pulmonary Disease. The Lung Health Study; Am. J. Respir. Crit. Care Med. 161 (2000) 381–390.Search in Google Scholar

549. Pletcher, M.J., B.J. Hulley, T. Houston, C.I. Kiefe, N. Benowitz, and S. Sidney: Menthol Cigarettes, Smoking Cessation, Atherosclerosis, and Pulmonary Function: The Coronary Artery Risk Development in Young Adults (CARDIA) Study; Arch. Intern. Med. 166 (2006) 1915–1922.Search in Google Scholar

550. Lee, P.N.: Systematic Review of the Epidemiological Evidence Comparing Lung Cancer Risk in Smokers of Mentholated and Unmentholated Cigarettes; BMC Pulm. Med. 11 (2011) 18.Search in Google Scholar

551. Rostron, B.: Lung Cancer Mortality Risk for U.S. Menthol Cigarette Smokers; Nicotine Tob. Res. Online: March 1, 2012.10.1093/ntr/nts01422387991Search in Google Scholar

552. Schoenborn, C.A. and G.M. Boyd: Smoking and Other Tobacco Use: United States, 1987; National Center for Health Statistics, Vital Health Stat. 10, No. 169, 1989.10.1037/e609432007-001Search in Google Scholar

553. National Center for Health Statistics: 2010 NHIS Linked Mortality Files; available at: http://www.cdc. gov/nchs/data_access/data_linkage/mortality/nhis_ linkage.htm#data_files.Search in Google Scholar

554. National Center for Health Statistics: 2011 National Health Interview Survey; available at: http://www.cdc.gov/nchs/nhis.htm.Search in Google Scholar

555. National Center for Health Statistics, Data Linkage Team: Comparative Analysis of the NHIS Public-Use and Restricted-Use Linked Mortality Files: 2010 Public-Use Data Release; National Center for Health Statistics, March 2010, Hyattsville, MD, available at: http://www.cdc.gov/NCHS/data/data http://www.cdc. gov/nchs/data_access/data_linkage/mortality/nhis_ linkage.htm#data_fileslinkage/nhis_mort_compare_ 2010_final.pdf.Search in Google Scholar

556. Durkin, D.A., M.O. Kjelsberg, A.S. Buist, J.E. Connett, G.R. Owens, and Recruitment Directors of the Lung Health Study for the Lung Health Study Research Group: Recruitment of Participants in the Lung Health Study, I. Description of Methods; Control. Clin. Trials 14, Suppl. 2 (1993) 20S–37S.Search in Google Scholar

557. Connett, J.E., W.M. Bjornson-Benson, and K. Daniels for the Lung Health Study Research Group: Recruitment of Participants in the Lung Health Study, II. Assessment of Recruiting Strategies; Control. Clin. Trials 14, Suppl. 2 (1993) 38S–51S.Search in Google Scholar

558. Vozoris, N.T.: Mentholated Cigarettes and Cardio-vascular and Pulmonary Diseases: A Population-Based Study; Arch. Intern. Med. 172 (2012) 590–591.Search in Google Scholar

559. Alberg, A.J., M.-J.D. Horner, V.C. Daguise, M.J. Carpenter, C.M. Mosley, B. Vincent, G. Silvestri, C.E. Reed, and J.R. Hebert: Lung and Bronchus Cancer Disparities in South Carolina: Epidemiology and Strategies for Prevention; J. S. C. Med. Assoc. 102 (2006) 183–191.Search in Google Scholar

560. Hebert, J.R.: Invited Commentary: Menthol Cigarettes and Risk of Lung Cancer; Am. J. Epidemiol. 158 (2003) 617–620.Search in Google Scholar

561. Hoffman, A.C.: The Health Effects of Menthol Cigarettes as Compared to Non-Menthol Cigarettes; Tob. Induc. Dis. 9, Suppl. 1 (2011) S7.10.1186/1617-9625-9-S1-S7310290621624153Search in Google Scholar

562. Kabat, G.C., N. Shivappa, and J.R. Hébert: Mentholated Cigarettes and Smoking-Related Cancers Revisited: An Ecologic Examination; Regul. Toxicol. Pharmacol. 63 (2012) 132–139.Search in Google Scholar

563. Song, F., A.J. Eastwood, S. Gilbody, L. Duley, and A.J. Sutton: Publication and Related Biases; Health Technol. Assess. 4 (2000) No. 10.Search in Google Scholar

564. Fowles, J. and D. Noiton: Chemical Factors Influen-cing the Addictiveness and Attractiveness of Cigarettes in New Zealand; Report for the New Zealand Ministry of Health, March 2001.Search in Google Scholar

565. Connolly G.N., G.D. Wayne, D. Lymperis, and M.C. Doherty: How Cigarette Additives Are Used to Mask Environmental Tobacco Smoke; Tob. Control 9 (2000) 283–291.Search in Google Scholar

566. Keithly, L., G.F. Wayne, D.M. Cullen, and G.N Connolly: Industry Research on the Use and Effects of Levulinic Acid: A Case Study in Cigarette Additives; Nicotine Tob. Res. 7 (2005) 761–771.Search in Google Scholar

567. Quin, L.D., W. George, and B.S. Menefee: Some Semiquantitative Gas Chromatographic Studies on the Organic Acids of Tobacco and its Smoke; J. Assoc. Off. Anal. Chem. 44 (1961) 367–373.Search in Google Scholar

568. Court, W.A. and J.G. Hendel: Determination of Nonvolatile Organic and Fatty Acids in Flue-Cured Tobacco by Gas-Liquid Chromatography; J. Chromat. Sci. 16 (1978) 314–317.Search in Google Scholar

569. Sakuma, H., M. Kusama, N. Shimojima, and S. Sugawara: Gas Chromatographic Analysis of the p-Nitrophenylhydrazones of Low Boiling Carbonyl Compounds in Cigarette Smoke; Tob. Sci. 22 (1976) 156–158.Search in Google Scholar

570. Lawson, J.W., B.R. Bullings, and T.A. Perfetti: Salts Provided from Nicotine and Organic Acid as Cigarette Additives; United States Patent 4,830,028, R.J. Reynolds Tobacco Co., Winston-Salem, NC (Filing Date: February 10, 1987).Search in Google Scholar

571. Rabinoff, M., N. Caskey, A. Rissling, and C. Park: Pharmacological and Chemical Effects of Cigarette Additives; Am. J. Public Health 97 (2007) 1981–1991.Search in Google Scholar

572. Verband der Cigarettenindustrie: Scientific Statement from the VdC Working Group ‘Additives’ Concerning the Allegations from C. Bates, M. Jarvis and G. Connolly in ‘Tobacco Additives – Cigarette Engineering and Nicotine Addiction’ on the Additives: Ammonia Compounds, Sugar – Acetaldehyde, Cocoa – Theobromine, Licorice – Glycyrrhizin, Levulinic Acid, Pyridine; November 12, 1999; Bates-No. 2078377943–7949; available at: http://legacy.library. ucsf.edu/tid/tqs72c00.Search in Google Scholar

573. Van Andel, I., E. Schenk, B. Rambali, G. Wolterink, G. van de Werken, H. Stevenson, L.A.G.J.M. van Aerts, and W. Vleeming: The Health- and Addictive Effects Due to Exposure to Aldehydes of Cigarette Smoke, Part 1: Acetaldehyde, Formaldehyde, Acrolein and Propionaldehyde; RIVM report 650270003/2002, RIVM, Bilthoven, The Netherlands, 2003.Search in Google Scholar

574. Stevenson, T. and R.N. Proctor: The Secret and Soul of Marlboro: Phillip [sic] Morris and the Origins, Spread, and Denial of Nicotine Freebasing; Am. J. Public Health 98 (2008) 1184–1194.Search in Google Scholar

575. Green, C.R. and A. Rodgman: The Tobacco Chemists’ Research Conference: A Half Century Forum for Advances in Analytical Methodology of Tobacco and Its Products; Rec. Adv. Tob. Sci. 22 (1996) 131–304.Search in Google Scholar

576. Green, C.R. and A. Rodgman: The Tobacco Chemists’ Research Conference: A Half Century Forum for Advances in Analytical Methodology of Tobacco and Its Products; R.J. Reynolds, 1996, Bates-No. 525445600–5772, http://legacy.library.ucsf.edu/tid/ qzt82a00.Search in Google Scholar

577. Danish Cancer Society: Tobacco Additives – A Study of the Available Literature; Copenhagen, Denmark, 2008.Search in Google Scholar

578. Kahnert, S., U. Nair, U. Mons, and M. Pötschke-Langer: Wirkungen von Menthol als Zusatzstoff in Tabakprodukten und die Notwendigkeit einer Regulie-rung [Effects of Menthol as an Additive in Tobacco Products and the Need for Regulation]; Bundes-gesundheitsblatt Gesundheitsforschung Gesundheits-schutz 55 (2012) 409–415.Search in Google Scholar

579. Hecht, S.S.: Research Opportunities Related to Establishing Standards for Tobacco Products under the Family Smoking Prevention and Tobacco Control Act; Nicotine Tob. Res. 14 (2012) 18–28.Search in Google Scholar

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