[1. Ingebrethsen, B.: The physical properties of main–-stream cigarette smoke and their relationship to depo-sition in the respiratory tract; in: Extrapolation of dosi-metric relationships for inhaled particles and gases, Academic Press, San Diego, 1989, pp 125–141.]Search in Google Scholar
[2. Baker, R.: Smoke chemistry; in: Tobacco. Production, Chemistry and Technology, edited by D.L. Davis and M.T. Nielsen, Blackwell Science, Oxford, 1999.]Search in Google Scholar
[3. Ingebrethsen, B. and C.S. Lyman: Particle formation and growth in gases from totally filtered mainstream cigarette smoke; Aerosol Sci. Tech. 36 (2002) 267–276.]Search in Google Scholar
[4. Seeman, J.I., P.J. Lipowicz, J.-J. Piade, L. Poget, E.B. Sanders, J.P. Snyder, and C.G. Trowbridge: On the deposition of volatiles and semi-volatiles from cigarette smoke aerosols. The relative rates of transfer of nicotine and ammonia from particles to the gas phase; Chem. Res. Toxicol. 17 (2004) 1020–1037.]Search in Google Scholar
[5. Stedman, R.L.: The chemical composition of tobacco and tobacco smoke; Chem. Rev. 68 (1968) 153–207.]Search in Google Scholar
[6. Schmeltz, I. and D. Hoffmann: Nitrogen-containing compounds in tobacco and tobacco smoke; Chem. Rev. 77 (1977) 295–311.]Search in Google Scholar
[7. Green, C.R. and A. Rodgman: The tobacco chemists’ research conference: A half century forum for advances in analytical methodology of tobacco and its products; Recent Adv. Tob. Sci. 22 (1996) 131–304.]Search in Google Scholar
[8. Pillsbury, H.C., C.C. Bright, K.J. O'Connor, and F.W. Irish: Tar and nicotine in cigarette smoke; J. Assoc. Official Anal. Chem. 52 (1969) 458–462.]Search in Google Scholar
[9. Rodgman, A.: FTC “tar” and nicotine in mainstream smoke: A retrospective; Recent Adv. Tob. Sci. 23 (1997) 5–74.]Search in Google Scholar
[10. ISO 3402: Determination of nicotine content in smoke condensates. Gas chromatographic method; International Organization for Standardization, Geneva, Switzerland, 1991 (revised 1999).]Search in Google Scholar
[11. Rustemeier, K. and J.-J. Piade: Determination of nicotine in mainstream and sidestream cigarette smoke; in: Analytical determination of nicotine and related compounds and their metabolites, Elsevier, Amsterdam, 1999, pp 489–530.10.1016/B978-044450095-3/50013-9]Search in Google Scholar
[12. U.S. Department of Health and Human Services: Risks associated with smoking cigarettes with low machine-measured yields of tar and nicotine; NIH Pub. No. 02-5074 ed., U.S. Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Bethesda, MD, October 2001.]Search in Google Scholar
[13. Kozlowski, L.T., J.E. Hennigfield, and J. Brigham: Cigarettes, nicotine & health; Sage Publications, Thousand Oaks, CA, 2001, pp 54–56.]Search in Google Scholar
[14. Crooks, E.L. and D. Lynn: The measurement of intra-puff nicotine yield; Beitr. Tabakforsch. Int. 15 (1992) 75–86.]Search in Google Scholar
[15. Kessler, D.A.: Testimony. The control and manipulation of nicotine in cigarettes; Subcommittee on Health and the Environment Committee on Energy and Com-merce, U.S. House of Representatives, Washington, D.C., 1994.]Search in Google Scholar
[16. Philip Morris USA (2003) Tobacco ingredients; http://www.philipmorrisusa.com/product_facts/ingre-dients/tobacco_ingredients.asp, accessed on 11 October 2005.]Search in Google Scholar
[17. R.J. Reynolds (2003) Tobacco ingredients; http://www.rjrt.com/smoking/ingredientsCover.aspx, accessed on 5 January 2006.]Search in Google Scholar
[18. Kessler, D.A., A.M. Witt, P.S. Barnett, M.R. Zeller, S.L. Natanblut, J.P. Wilkenfeld, C.C. Lorraine, L.J. Thompson, and W.B. Schultz: The Food and Drug Administration's regulation of tobacco products; New Eng. J. Med. 335 (1996) 988–994.]Search in Google Scholar
[19. Kessler, D.A., P.S. Barnett, A.M. Witt, M.R. Zeller, J.R. Mande, and W.B. Schultz: The legal and scientific basis for FDA's assertion of jurisdiction over cigarettes and smokeless tobacco; J. Am. Med. Assoc. 277 (1997) 405–409.]Search in Google Scholar
[20. Hurt, R.D. and C.R. Robertson: Prying open the door to the tobacco industry's secrets about nicotine; J. Am. Med. Assoc. 280 (1998) 1173–1181.]Search in Google Scholar
[21. Pankow, J.F., B.T. Mader, L.M. Isabelle, W. Luo, A. Pavlick, and C. Liang: Conversion of nicotine in tobacco smoke to its volatile and available free-base form through the action of gaseous ammonia; Environ. Sci. Technol. 31 (1997) 2428–2433 (Additions and corrections 33 (1999) 1320).]Search in Google Scholar
[22. Pankow, J.F.: A consideration of the role of gas/particle partitioning in the deposition of nicotine and other tobacco smoke compounds in the respiratory tract; Chem. Res. Toxicol. 14 (2001) 1465–1481.]Search in Google Scholar
[23. Henningfield, J.E., N.L. Benowitz, G.N. Connolly, R.N. Davis, N. Gray, M.L. Myers, and M. Zeller: Reducing tobacco addiction through tobacco product regulation; Tob. Control 13 (2004) 132–135.]Search in Google Scholar
[24. Henningfield, J.E., J.F. Pankow, and B.E. Garrett: Ammonia and other chemical base tobacco additives and cigarette nicotine delivery: Issues and research needs; Nicotine Tob. Res. 6 (2004) 199–205.]Search in Google Scholar
[25. Bates, C., M. Jarvis, and G. Connolly (1999): Tobacco additives – cigarette engineering and nicotine addiction; Action on Smoking and Health (ASH), http://www.ash.org.uk/html/regulation/html/additives.html, accessed on 5 January 2006.]Search in Google Scholar
[26. Willems, E.W., B. Rambali, W. Vleeming, A. Opper-huizen, and J.G.C. van Amster: Significance of ammonium compounds on nicotine exposure to cigarette smokers; Food Chem. Toxicol. 44 (2006) 678–688.]Search in Google Scholar
[27. Saint-Jalm, Y., G. Duval, T. Conte, and I. Bonnichon: Mechanisms of transfer of ammonia in cigarette smoke from ammonium compounds in tobacco; 2000 CORESTA Congress, Lissabon, Portugal, Paper ST9.]Search in Google Scholar
[28. Ellis, C.L., R.H. Cox, C.H. Callicutt, S.W. Laffoon, K.F. Podraza, J.I. Seeman, R.D. Kinser, D.E. Farthing, and F.H. Hsu: The effect of ingredients added to tobacco in a commercial Marlboro Lights cigarette on FTC nicotine yield, “Smoke pH,” and Cambridge filter trapping efficiency; 1999 CORESTA Meeting, Innsbruck, Paper ST 2.]Search in Google Scholar
[29. Armitage, A.K., M. Dixon, B.E. Frost, D.C. Mariner, and N.M. Sinclair: The effect of tobacco blend additives on the retention of nicotine and solanesol in the human respiratory tract and on subsequent plasma nicotine concentrations during cigarette smoking; Chem. Res. Toxicol. 17 (2004) 537–544.]Search in Google Scholar
[30. Callicutt, C.H., R.H. Cox, F. Hsu, R.D. Kinser, S.W. Laffoon, P. Lee, K.F. Podraza, E.B. Sanders, and J.I. Seeman: The role of ammonia in the transfer of nicotine from tobacco to mainstream smoke; Regul. Toxicol. Pharmacol., in press.]Search in Google Scholar
[31. Dixon, M., K. Lambing, and J.I. Seeman: On the transfer of nicotine from tobacco to the smoker. A brief review of ammonia and “pH” factors; Beitr. Tabakforsch. Int. 19 (2000) 103–113.]Search in Google Scholar
[32. Seeman, J.I.: Using “basic principles” to understand complex science: Nicotine smoke chemistry and literature analogies; J. Chem. Ed. 82 (2005) 1577–1582.]Search in Google Scholar
[33. Lipowicz, P. and J.J. Piade: Theory and subsequent deposition of nicotine from mainstream cigarette smoke in a denuder tube; J. Aerosol Res. 35 (2004) 33–45.]Search in Google Scholar
[34. Seeman, J.I., J.A. Fournier, J.B. Paine III, and B.E. Waymack: Thermal properties of nonprotonated and protonated nicotine. The use of thermolysis as a model for smoke formation chemistry; J. Agric. Food Chem. 47 (1999) 5133–5145.]Search in Google Scholar
[35. Fournier, J.A., J.B. Paine III, J.I. Seeman, D.W. Armstrong, and X. Chen: Thermal mechanisms for the transfer of amines, including nicotine, to the gas phase and aerosols; Heterocycles 55 (2001) 59–74.]Search in Google Scholar
[36. Kinser, R.D., F.H. Hsu, D.E. Farthing, L.D. Johnson, and C.L. Ellis: Nicotine collection efficiency in the FTC nicotine method; 53rd Tobacco Science Research Conference, Montreal, Canada, Program Booklet and Abstracts Vol. 53, Paper No. 46, 1999.]Search in Google Scholar
[37. Davies, H.M. and A. Vaught: Research cigarettes; Tobacco and Health Research Institute, University of Kentucky, Lexington, KY, 1990.]Search in Google Scholar
[38. Parrish, M.E., J.L. Lyons-Hart, and K.H. Shafer: Puff-by-puff and intrapuff analysis of cigarette smoke using infrared spectroscopy; Vibrational Spect. 27 (2001) 29–42.]Search in Google Scholar
[39. Parrish, M.E. and C.N. Harward: Measurement of formaldehyde in a single puff of cigarette smoke using tunable diode laser infrared spectroscopy; Applied Spect. 54 (2000) 1665–1677.]Search in Google Scholar
[40. Tang, H., G. Richards, K. Gunther, J. Crawford, M.L. Lee, E.A. Lewis, and D.J. Eatough: Determination of gas phase nicotine and 3-ethenylpyridine, and parti-culate phase nicotine in environmental tobacco smoke with a collection bed-capillary gas chromatography system; J. High Resol. Chromat. Chromat. Comm. 11 (1988) 775–782.]Search in Google Scholar
[41. Ogden, M.W., K.C. Maiolo, P.R. Nelson, D.L. Heavner, and C.R. Green: Artifacts in determining the vapour-particulate phase distribution of environmental tobacco smoke nicotine; Environ. Technol. 14 (1993) 779–785.]Search in Google Scholar
[42. Ogden, M.W. and P.R. Nelson: Detection of alkaloids in environmental tobacco smoke; in: Modern methods of plant analysis, edited by H.F. Linskens and J.F. Jackson, Springer-Verlag, Berlin, 1994, pp 163–189.10.1007/978-3-642-84226-9_7]Search in Google Scholar
[43. Ogden, M.W. and K.C. Maiolo: Comparative evalu-ation of diffusive and active sampling systems for determining airborne nicotine and 3-ethenylpyridine; Environ. Sci. Technol. 26 (1992) 1226–1234.]Search in Google Scholar
[44. American Society for Testing and Materials: Standard test method for nicotine and 3-ethylenylpyridine in indoor air, Method No. D 5075-96; in: Annual book of ASTM standards, American Society for Testing and Materials, West Conshohoken, PA, 1996.]Search in Google Scholar
[45. Houseman, T.H.: Studies of cigarette smoke transfer using radioisotopically labelled tobacco constituents. Part II: The transference of radioisotopically labelled nicotine to cigarette smoke; Beitr. Tabakforsch. 7 (1973) 142–147.]Search in Google Scholar
[46. Stevens, N.A. and M.F. Borgerding: GC-AED studies of nicotine fate in a burning cigarette; Anal. Chem. 71 (1999) 2179–2185.]Search in Google Scholar
[47. U.K. Department of Health (2001): Determination of the fate of nicotine when a cigarette is smoked, LGC Report FN40/M4/01; Smoking Policy Unit, U.K. Department of Health, http://www.advisorybodies.doh.gov.uk/scoth/technicaladvisorygroup/nicotfate.pdf, accessed on 5 January 2006.]Search in Google Scholar
[48. Curran, J.G. Jr. and E.G. Miller Jr.: Factors influencing the elution of high-boiling components of cigarette smoke from filters; Beitr. Tabakforsch. 5 (1969) 64–70.]Search in Google Scholar
[49. Grob, K.: Gas chromatography of cigarette smoke, part III. Separation of the overlap of gas and particulate phase by capillary columns; J. Gas Chromatog. (1965) 52–56.]Search in Google Scholar
[50. Ceschini, P. and D. Cham: Effect of sampling conditions on the composition of the volatile phase of cigarette smoke; Beitr. Tabakforsch. 7 (1974) 294–301.]Search in Google Scholar
[51. Keith, C.H. and J.R. Misenheimer: Vapor filtration by fibrous cigarette filters; Beitr. Tabakforsch. 3 (1966) 583–589.]Search in Google Scholar
[52. Cochran, E.W., M.J. Joseph, S.L. Stinson, and S.S. Summers: Application of a diffusion-denuder method for the investigation of the effects of “Smoke pH” on vapor-phase nicotine yields from different types of cigarettes; Beitr. Tabakforsch. Int. 20 (2003) 365–372.]Search in Google Scholar
[53. Frost, B.E., D.C. Mariner, and N.M. Sinclair: Factors relating to nicotine physio-chemistry and retention in human smokers, 1998 CORESTA Congress, Brighton, England, pp. 211-218.]Search in Google Scholar
[54. Lewis, D.A., I. Colbeck, and D.C. Mariner: Diffusion denuder method for sampling vapor-phase nicotine in mainstream tobacco smoke; Anal. Chem. 66 (1994) 3525–3527.]Search in Google Scholar
[55. Lewis, D.A., I. Colbeck, and D.C. Mariner: Diffusion of mainstream tobacco smoke and its effects upon the evaporation and diffusion of nicotine; J. Aerosol Sci. 26 (1995) 841–846.]Search in Google Scholar
[56. Schmeltz, I., A. Wenger, D. Hoffmann, and T.C. Tso: Chemical studies on tobacco smoke. 63. On the fate of nicotine during pyrolysis and in a burning cigarette; J. Agric. Food Chem. 27 (1979) 602–608.]Search in Google Scholar
[57. Watson, C.H., J. McCraw, G. Polzin, D.L. Ashley, and D. Barr: Development of a method to assess cigarette smoke intake; Environ. Sci. Technol. 38 (2004) 248–253.]Search in Google Scholar
