<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>There is a number of diseases for which, scientists are constantly looking for a promising new treatments. Isolation of novel substances with biological activity from plants gives hope for its use in treatment. In this review, we focused on the biological activity of <italic>p</italic>-synephrine (4-(2-aminoethyl)phenol) which was previously confirmed during both <italic>in vitro</italic> and <italic>in vivo</italic> tests. The main part of the review is dedicated to the anti-obesity activity of <italic>p</italic>-synephrine, as obesity is a disease of contemporary civilization. However, synephrine also possesses anti-diabetic, anti-inflammatory and antidepressant activity and it is confirmed to be a hypotensive agent in portal hypertension. The review also emphasize that, based on current knowledge, the use of <italic>p</italic>-synephrine appears to be exceedingly safe with only limited range of side effects. Therefore, it seems that this substance may be of great importance in the pharmacotherapy of many disease states and further research is necessary.</p>
</abstract>

There is a number of diseases for which, scientists are constantly looking for a promising new treatments. Isolation of novel substances with biological activity from plants gives hope for its use in treatment. In this review, we focused on the biological activity of p-synephrine (4-(2-aminoethyl)phenol) which was previously confirmed during both in vitro and in vivo tests. The main part of the review is dedicated to the anti-obesity activity of p-synephrine, as obesity is a disease of contemporary civilization. However, synephrine also possesses anti-diabetic, anti-inflammatory and antidepressant activity and it is confirmed to be a hypotensive agent in portal hypertension. The review also emphasize that, based on current knowledge, the use of p-synephrine appears to be exceedingly safe with only limited range of side effects. Therefore, it seems that this substance may be of great importance in the pharmacotherapy of many disease states and further research is necessary.

<italic>p</italic>-Synephrine and its various pharmacological effects

Student Research Group at the Department of Pharmacology and Pharmacodynamics

Department of Pharmacology and Pharmacodynamics

Current Issues in Pharmacy and Medical Sciences

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

-Synephrine and its various pharmacological effects

{"article-title":{"italic":"p","content":"-Synephrine and its various pharmacological effects"}}

There is a number of diseases for which, scientists are constantly looking for a promising new treatments. Isolation of novel substances with biological...

p-Synephrine and its various pharmacological effects

Publicado en línea: 30 dic 2021

Páginas: 169 - 173

Recibido: 19 jul 2021

Aceptado: 17 sept 2021

DOI: https://doi.org/10.2478/cipms-2021-0031

Palabras clave
-synephrine, anti-obesity activity, anti-diabetic activity, anti-inflammatory activity, antidepressant activity

© 2021 Wojciech Ziemichod et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

p-Synephrine and its various pharmacological effects

Publicado en línea: 30 dic 2021

Páginas: 169 - 173

Recibido: 19 jul 2021

Aceptado: 17 sept 2021

DOI: https://doi.org/10.2478/cipms-2021-0031

Palabras clave-synephrine, anti-obesity activity, anti-diabetic activity, anti-inflammatory activity, antidepressant activity

© 2021 Wojciech Ziemichod et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Palabras clave
-synephrine, anti-obesity activity, anti-diabetic activity, anti-inflammatory activity, antidepressant activity