[
1. Abdul S, Poddar SS. A flexible technology for modified release of drugs: multi layered tablets. J Control Release. 2004;97(3):393-405.10.1016/S0168-3659(04)00186-5
]Search in Google Scholar
[
2. Al-Zoubi N, Malamataris S. Three-layer matrix tablets and simple approach of drug release programming. J Drug Del Sci Tech. 2008; 18(6):431-37.10.1016/S1773-2247(08)50083-9
]Search in Google Scholar
[
3. Morita R, Honda R, Takahashi Y. Development of oral controlled release preparations, a PVA swelling controlled release system (SCRS). II. In vitro and in vivo evaluation. J Control Release. 2000; 68(1):115-20.10.1016/S0168-3659(00)00244-3
]Search in Google Scholar
[
4. Vergote GJ, Vervaet C, Van D, Hoste S, De Smed S, Demeester J, et al. An oral controlled release matrix pellet formulation containing nanocrystalline ketoprofen. Int J Pharm. 2001;219(1-2):81-7.10.1016/S0378-5173(01)00628-7
]Search in Google Scholar
[
5. More S, Ghodekar S, Rane B, Bavaskar K, Patil M, Jain A. Multilayered tablet: a novel approach for oral drug delivery. IJPSR. 2015;9(3):872-82.
]Search in Google Scholar
[
6. Dey S, Mahanti B, Khila S, Mazumder B, Gupta SD. Formulation development and optimization of bilayer tablets of aceclofenac. Expert Opin Drug Deliv. 2012;9(9):1041-50.10.1517/17425247.2012.70718722788786
]Search in Google Scholar
[
7. Patra CN, Kumar AB, Pandit HK, Singh SP, Devi MV. Design and evaluation of sustained release bilayer tablets of propranolol hydrochloride. Acta Pharm. 2007;57(4):479-89.10.2478/v10007-007-0038-018165191
]Search in Google Scholar
[
8. Abebe A, Akseli I, Sprockel O, Kottala N, Cuitino AM. Review of bilayer tablet technology. Int J Pharm. 2014;461(1-2):549-58.10.1016/j.ijpharm.2013.12.02824370841
]Search in Google Scholar
[
9. Klinzing G, Zavaliangos A. Understanding the effect of environmental history on bilayer tablet interfacial shear strength. Pharm Res. 2013;30(5):1300-10.10.1007/s11095-012-0969-023334778
]Search in Google Scholar
[
10. Anuar MS, Briscoe BJ. Interfacial elastic relaxation during the ejection of bi-layered tablets. Int J Pharm. 2010;387(1-2):42-7.10.1016/j.ijpharm.2009.11.03119963050
]Search in Google Scholar
[
11. Wu CY, Seville JP. A comparative study of compaction properties of binary and bilayer tablets. Powder Tech. 2009;189:285-94.10.1016/j.powtec.2008.04.026
]Search in Google Scholar
[
12. McGinity JW. Aqueous polymeric coatings for pharmaceutical dosage forms. New York: Marcel Dekker. 1997;549-70.
]Search in Google Scholar
[
13. Desai D, Wang J, Wen H, Li X, Timmins P. Formulation design, challenges, and development considerations for fixed dose combination (FDC) of oral solid dosage forms. Pharm Dev Technol. 2013;18(6):1265-76.10.3109/10837450.2012.660699
]Search in Google Scholar
[
14. Nirmal J, Saisivam S, Peddanna C, Muralidharan S, Godwinkumar S, Nagarajan M. Bilayer tablets of atorvastatin calcium and nicotinic acid: formulation and evaluation. Chem Pharm Bull (Tokyo). 2008; 56(10):1455-8.10.1248/cpb.56.1455
]Search in Google Scholar
[
15. Scott DC, Hollenbeck RG. Design and manufacture of a zero-order sustained-release pellet dosage form through nonuniform drug distribution in a diffusional matrix. Pharm Res. 1991;8(2):156-61.10.1023/A:1015823532764
]Search in Google Scholar
[
16. Shiyani B, Gattani S, Surana S. Formulation and evaluation of bi-layer tablet of metoclopramide hydrochloride and ibuprofen. AAPS Pharm Sci Tech. 2008;9(3):818-27.10.1208/s12249-008-9116-y
]Search in Google Scholar
[
17. Chidambaram N, Porter W, Flood K, Qiu Y. Formulation and characterization of new layered diffusional matrices for zero-order sustained release. J Control Release. 1998;52(1-2):149-58.10.1016/S0168-3659(97)00207-1
]Search in Google Scholar
[
18. Conte U, Maggi L, Colombo P, La MA. Multi-layered hydrophilic matrices as constant release devices (GeomatrixTM Systems). J Control Release. 1993;26(1):39-47.10.1016/0168-3659(93)90207-L
]Search in Google Scholar
[
19. Nangia A, Molly T, Fahie BJ, Chopra SK. Novel regulated release systembased on geometric configuration. Proc Int Symp Control Release Bioactive Mater. 1995;22:294-5.
]Search in Google Scholar
[
20. Ozeki Y, Ando M, Watanabe Y, Danjo K. Evaluation of novel one-step dry-coated tablets as a platform for delayed-release tablets. J Control Release. 2004;95(1):51-60.10.1016/j.jconrel.2003.10.028
]Search in Google Scholar
[
21. Shivanand P, Sprockel O. A controlled drug delivery system. Int J Pharm. 1998;167:83-96.10.1016/S0378-5173(98)00047-7
]Search in Google Scholar
[
22. Rathbone MJ, Hadgraft J, Roberts MS. Modified-Release Drug Delivery Technology. London: Informa Healthcare. 2002:101-14.10.1201/9780203910337
]Search in Google Scholar
[
23. Rathbone MJ, Hadgraft J, Roberts MS. Modified-Release Drug Delivery Technology. London: Informa Healthcare. 2002:59-76.10.1201/9780203910337
]Search in Google Scholar
[
24. Bettini R, Acerbi D, Caponetti G, Musa R, Magi N, Colombo P, et al. Influence of layer position on in vitro and in vivo release of levodopa methyl ester and carbidopa from three-layer matrix tablets. Eur J Pharm Biopharm. 2002;53(2):227-32.10.1016/S0939-6411(01)00238-7
]Search in Google Scholar
[
25. Castrati L, Mazel V, Busignies V, Diarra H, Rossi A, Tchoreloff P, et al. Comparison of breaking tests for the characterization of the interfacial strength of bilayer tablets. Int J Pharm. 2016;513(1-2): 709-16.10.1016/j.ijpharm.2016.10.005
]Search in Google Scholar
[
26. Efentakis M, Peponaki C. Formulation study and evaluation of matrix and three-layer tablet sustained drug delivery systems based on Carbopols with isosorbite mononitrate. AAPS Pharm Sci Tech. 2008;9(3):917-23.10.1208/s12249-008-9084-2
]Search in Google Scholar
[
27. Li SP, Karth MG, Feld KM, Dipalo LC, Pendaharkar CM, Williams RO. Evaluation of bilayer tablet machines – a case study. Drug Dev Ind Pharm. 1995;21:571-90.10.3109/03639049509048124
]Search in Google Scholar
[
28. Vaithiyalingam SR, Sayeed VA. Critical factors in manufacturing multilay-ered tablets – assessing material attributes, in-process controls, manufacturingprocess and product performance. Int J Pharm. 2010;398:9-13.10.1016/j.ijpharm.2010.07.025
]Search in Google Scholar
[
29. Danckwerts MP. Development of a zero-order release oral compressed tablet with potential for commercial tabletting production. Int J Pharm. 1994;112:34-45.10.1016/0378-5173(94)90259-3
]Search in Google Scholar
[
30. Hildgen D, McMullen JN. A new gradient matrix: formulation and characterization. J Control Release. 1995;34:263-71.10.1016/0168-3659(95)00014-Y
]Search in Google Scholar
[
31. Bangalore S, Kamalakkannan G, Parkar S, Messerli FH. Fixed-dose combinations improve medication compliance: a meta-analysis. Am J Med. 2007;120(8):713-19.10.1016/j.amjmed.2006.08.03317679131
]Search in Google Scholar
[
32. Rathbone MJ, Hadgraft J, Roberts MS. Modified-Release Drug Delivery Technology. London: Informa Healthcare. 2002;1-19.10.1201/9780203910337
]Search in Google Scholar
[
33. LaForce C, Gentile DA, Skoner DP. A randomized, double-blind, parallel-group, multicenter, placebo-controlled study of the safety and efficacy of extended-release guaifenesin/pseudoephedrine hydrochloride for symptom relief as an adjunctive therapy to antibiotic treatment of acute respiratory infections. Postgrad Med. 2008;120(2):53-9.10.3810/pgm.2008.07.179118654069
]Search in Google Scholar
[
34. Qiu Y, Chidambaram N, Flood K. Design and evaluation of layered diffusional matrices for zero-order sustained-release. J Control Release. 1998;51(2-3):123-30.10.1016/S0168-3659(97)00119-3
]Search in Google Scholar
[
35. Yadav G, Bansak M, ThakurN, Khare SP. Multilayer tablets and their drug release kinetic models for oral controlled drug delivery system. Middle-East J Sci Res. 2013;16(6):782-95.
]Search in Google Scholar
[
36. Maroni A, Zema L, Carea M, Sangalli ME. Oral pulsatile drug delivery systems. Expert Opin Drug Deliv. 2005;2(5):855-71.10.1517/17425247.2.5.85516296783
]Search in Google Scholar
[
37. Akseli I, Abebe A, Sprockel O, Cuitino AM. Mechanistic characterization of bilayer tablet formulations. Powder Tech. 2013; 236:30-6.10.1016/j.powtec.2012.05.048
]Search in Google Scholar
[
38. Akseli I, Dey D, Cetinkaya C. Mechanical property characterization of bilayered tablets using nondestructive air-coupled acoustics. AAPS PharmSciTech. 2010;11(1):90-102.10.1208/s12249-009-9352-9285047920063078
]Search in Google Scholar
[
39. Inman SJ, Briscoe BJ, Pitt KG. Topographic characterization of cellulose bilayered tablets interfaces. Chem Eng Res Dis. 2007;85(A7): 1005-12.10.1205/cherd06188
]Search in Google Scholar
[
40. Busignies V, Mazel V, Diarra H, Tchoreloff P. Role of the elasticity of pharmaceutical materials on the interfacial mechanical strength of bilayer tablets. Int J Pharm. 2013;457(1):260-67.10.1016/j.ijpharm.2013.09.00924055440
]Search in Google Scholar
[
41. Kottala N, Abebe A, Sprockel O, Bergum J, Nikfar F, Cuitino AM. Evaluation of the performance characteristics of bilayer tablets: Part I. Impact of material properties and process parameters on the strength of bilayer tablets. AAPS Pharm Sci Tech. 2012;13(4):1236-42.10.1208/s12249-012-9845-9351347922976242
]Search in Google Scholar
[
42. Kottala N, Abebe A, Sprockel O, Akseli I, Nikfar F, Cuitino AM. Influence of compaction properties and interfacial topography on the performance of bilayer tablets. Int J Pharm. 2012;436(1-2):171-8.10.1016/j.ijpharm.2012.05.02622728259
]Search in Google Scholar
[
43. Kottala N, Abebe A, Sprockel O, Akseli I, Nikfar F, Cuitino AM. Charac-terization of interfacial strength of layered powder-compacted solids. Powder Tech. 2013;239:300-7.10.1016/j.powtec.2012.12.028
]Search in Google Scholar
[
44. Tye CK, Sun CC, Amidon GE. Evaluation of the effects of tableting speed on the relationships between compaction pressure, tablet tensile strength, and tablet solid fraction. J Pharm Sci. 2005;94(3): 465-72.10.1002/jps.2026215696587
]Search in Google Scholar
[
45. Fell JT, Newton JM. Determination of tablet strength by the diametral-compression test. J Pharm Sci. 1970;59(5):688-91.10.1002/jps.2600590523
]Search in Google Scholar
[
46. Wu CY, Best SM, Bentham AC, Hancock BC, Bonfield W. Predicting the tensile strength of compacted multi-component mixtures of pharmaceutical powders. Pharm Res. 2006;23(8):1898-1905.10.1007/s11095-006-9005-6
]Search in Google Scholar
[
47. Dietrich P, Bauer-Brandl A, Schubert R. Influence of tableting forces and lubricant concentration on the adhesion strength in complex layer tablets. Drug Dev Ind Pharm. 2000;26(7):745-54.10.1081/DDC-100101293
]Search in Google Scholar
[
48. Malaterre V, Metz H, Ogorka J, Gurny R, Loggia N, Mader K. Benchtop-magnetic resonance imaging (BT-MRI) characterization of push-pull osmotic controlled release systems. J Control Release. 2009;133(1):31-6.10.1016/j.jconrel.2008.09.007
]Search in Google Scholar
[
49. Niwa M, Hiraishi Y, Iwasaki N, Terada K. Quantitative analysis of the layer separation risk in bilayer tablets using terahertz pulsed imaging. Int J Pharm. 2013;452(1-2):249-56.10.1016/j.ijpharm.2013.05.010
]Search in Google Scholar
[
50. Podczeck F. Theoretical and experimental investigations into the delamination tendencies of bilayer tablets. Int J Pharm. 2011; 408(1-2):102-12.10.1016/j.ijpharm.2011.02.007
]Search in Google Scholar
[
51. Yang L, Venkatesh G, Fassihi R. Compaction simulator study of a novel triple-layer tablet matrix for industrial tableting. Int J Pharm. 1997;152:45-52.10.1016/S0378-5173(97)04911-9
]Search in Google Scholar
[
52. Karehill PG, Glaser M, Nystrom C. Studies on direct compression of tablets. XXIII. The importance of surface roughness for the compactability of some directly compressible materials with different bonding and volume reduction properties. Int J Pharm. 1990;64:35-43.10.1016/0378-5173(90)90176-5
]Search in Google Scholar
[
53. Busignies V, Mazel V, Diarra H, Tchoreloff P. Development of a new test for the easy characterization of the adhesion at the interface of bilayer tablets: proof-of-concept study by experimental design. Int J Pharm. 2014;477(1-2):476-84.10.1016/j.ijpharm.2014.10.05125445527
]Search in Google Scholar
[
54. Takeuchi H, Yasuji T, Yamamoto H, Kawashima Y. Spray-dried lactose composite particles containing an ion complex of alginate-chitosan for designing a dry-coated tablet having a time-controlled releasing function. Pharm Res. 2000;17(1):94-9.10.1023/A:1007530927887
]Search in Google Scholar
[
55. Podczeck F, Drake KR, Newton JM, Haririan I. The strength of bilayered tablets. Eur J Pharm Sci. 2006;29(5):361-6.10.1016/j.ejps.2006.07.00516950605
]Search in Google Scholar
[
56. Podczeck F, Al-Muti E. The tensile strength of bilayered tablets made from different grades of microcrystalline cellulose. Eur J Pharm Sci. 2010;41(3-4):483-8.10.1016/j.ejps.2010.08.00220696243
]Search in Google Scholar
[
57. Picker KM. Time dependence of elastic recovery for characterization of tableting materials. Pharm Dev Technol. 2001;6(1):61-70.10.1081/PDT-10000001411247276
]Search in Google Scholar
[
58. Goutte F, Guemguem F, Dragan C, Vergnault G, Wehrle P. Power of experimental design studies for the validation of pharmaceutical processes: case study of a multilayer tablet manufacturing process. Drug Dev Ind Pharm. 2002;28(7):841-8.10.1081/DDC-120005630
]Search in Google Scholar
[
59. Sugisawa K, Kaneko T, Sago T, Sato T. Rapid quantitative analysis of magnesium stearate in pharmaceutical powders and solid dosage forms by atomic absorption: method development and application in product manufacturing. J Pharm Biomed Anal. 2009;49(3):858-61.10.1016/j.jpba.2009.01.00419195812
]Search in Google Scholar
[
60. Yamamura T, Ohta T, Taira T, Ogawa Y, Sakai Y, Moribe K et al. Effects of automated external lubrication on tablet properties and the stability of eprazinone hydrochloride. Int J Pharm. 2009;370(1-2):1-7.10.1016/j.ijpharm.2008.11.00719059327
]Search in Google Scholar
[
61. Cremer K, Asmussen B. Novel controlled-release tablet with erodible layers. Proc Int Control Release Bioact Mater. 1995;22:732-3.
]Search in Google Scholar
[
62. Dietrich P, Cremer K, Bauer-Brandl A, Schubert R. Complex layer tablets-aspects of a new tabletting technology. Pharm Sci. 1998;1(1):318.
]Search in Google Scholar
[
63. Dietrich P, Cremer K, Bauer-Brandl A, Schubert R. Adhesion strength in two-layer tablets. Pharm Res. 1997;14(11):429.
]Search in Google Scholar