<abstract xmlns="http://www.w3.org/1999/xhtml"> Introduction. Research in NSCLC biomarker field and application of new methods is essential as it is promising strategy to reduce cancer mortality. <bold>Aim of the study. </bold>The aim of the study was to develop new approach for lung cancer biomarker research and introduce novel method into surgical practice, verifying method’s safety and evaluate intraoperative and postoperative complications. <bold>Materials and methods. </bold>50 patients with early stage NSCLC undergoing lobectomy were randomized into two groups - experimental (n = 25) and control group (n = 25). In experimental group at the time of thoracotomy and resection of the lung, paired blood samples were obtained from the lobar pulmonary vein draining lung segment containing tumor and from the peripheral vein which represents the systemic circulation. Safety of the procedure and its influence on surgery was evaluated. <bold>Results. </bold>New approach for lung cancer biomarker research was developed. Injuries of major anatomical structures as pulmonary blood vessels, bronchi, trachea and pericardium due to blood sample collection were not observed. There was no difference in hospital stay and chest tube drainage duration. There were no perioperative deaths in both groups. Morbidity rate in experimental group was similar to control group. <bold>Conclusions. </bold>Application of new method for developing multimodal lung cancer model is safe and does not increase the risk of intraoperative and postoperative complications.</abstract>

Introduction. Research in NSCLC biomarker field and application of new methods is essential as it is promising strategy to reduce cancer mortality. Aim of the study. The aim of the study was to develop new approach for lung cancer biomarker research and introduce novel method into surgical practice, verifying method’s safety and evaluate intraoperative and postoperative complications. Materials and methods. 50 patients with early stage NSCLC undergoing lobectomy were randomized into two groups - experimental (n = 25) and control group (n = 25). In experimental group at the time of thoracotomy and resection of the lung, paired blood samples were obtained from the lobar pulmonary vein draining lung segment containing tumor and from the peripheral vein which represents the systemic circulation. Safety of the procedure and its influence on surgery was evaluated. Results. New approach for lung cancer biomarker research was developed. Injuries of major anatomical structures as pulmonary blood vessels, bronchi, trachea and pericardium due to blood sample collection were not observed. There was no difference in hospital stay and chest tube drainage duration. There were no perioperative deaths in both groups. Morbidity rate in experimental group was similar to control group. Conclusions. Application of new method for developing multimodal lung cancer model is safe and does not increase the risk of intraoperative and postoperative complications.

Application of Novel Methods for Non-Small Cell Lung Cancer (Nsclc) Biomarker Discovery

Department of Thoracic Surgery, Pauls Stradins Clinical University Hospital, Riga, Latvia

Acta Chirurgica Latviensis

Introduction. Research in NSCLC biomarker field and application of new methods is essential as it is promising strategy to reduce cancer mortality. Aim of the...

Application of Novel Methods for Non-Small Cell Lung Cancer (Nsclc) Biomarker Discovery

Publicado en línea: 05 sept 2013

Páginas: 13 - 16

DOI: https://doi.org/10.2478/chilat-2013-0003

This content is open access.