<abstract xmlns="http://www.w3.org/1999/xhtml">The ability of Monensic acid A (MonH∙H2O) and its neutral metal complexes [M(Mon)2(H2O)2]with ions of Mg2+, Ca2+, Mn2+, Co2+, Ni2+ and Zn2+ to decrease viability and proliferation of primary cell cultures, originating from a chemically induced transplantable liver tumour of Zajdela in rats, and bone marrow cells from the same tumour-bearers, was evaluated. Experimental data revealed that manganese(II) and nickel(II) complexes of Monensin A are relatively more selective against the tumour as compared to the healthy bone marrow cells.</abstract>

The ability of Monensic acid A (MonH∙H2O) and its neutral metal complexes [M(Mon)2(H2O)2]with ions of Mg2+, Ca2+, Mn2+, Co2+, Ni2+ and Zn2+ to decrease viability and proliferation of primary cell cultures, originating from a chemically induced transplantable liver tumour of Zajdela in rats, and bone marrow cells from the same tumour-bearers, was evaluated. Experimental data revealed that manganese(II) and nickel(II) complexes of Monensin A are relatively more selective against the tumour as compared to the healthy bone marrow cells.

Study on <italic>in vitro</italic> Toxicity of Biometal(II) Monensinates Against Rat Zajdela Liver Tumour

Department of Analytical Chemistry, Faculty of Chemistry and Pharmacy

Sofia University “St. Kliment Ohridski”

Biovet Ltd., Research and Development Department

Chemistry-Didactics-Ecology-Metrology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Study on  Toxicity of Biometal(II) Monensinates Against Rat Zajdela Liver Tumour

The ability of Monensic acid A (MonH∙H2O) and its neutral metal complexes [M(Mon)2(H2O)2]with ions of Mg2+, Ca2+, Mn2+, Co2+, Ni2+ and Zn2+ to decrease...

Study on in vitro Toxicity of Biometal(II) Monensinates Against Rat Zajdela Liver Tumour

Publicado en línea: 29 ene 2021

Páginas: 125 - 132

DOI: https://doi.org/10.2478/cdem-2020-0009

Palabras clave
chemically-induced rat tumour of Zajdelа, bone marrow cells, Monensin A biometal(II) complexes, cytotoxic/roliferative effect

© 2020 Radostina Alexandrova et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Study on in vitro Toxicity of Biometal(II) Monensinates Against Rat Zajdela Liver Tumour

Publicado en línea: 29 ene 2021

Páginas: 125 - 132

DOI: https://doi.org/10.2478/cdem-2020-0009

Palabras clavechemically-induced rat tumour of Zajdelа, bone marrow cells, Monensin A biometal(II) complexes, cytotoxic/roliferative effect

© 2020 Radostina Alexandrova et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Palabras clave
chemically-induced rat tumour of Zajdelа, bone marrow cells, Monensin A biometal(II) complexes, cytotoxic/roliferative effect