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Bouty A, Ayers KL, Pask A, Heloury Y, Sinclair AH. The Genetic and Environmental Factors Underlying Hypospadias. Sex Dev. 2015;9(5):239–259.BoutyAAyersKLPaskAHelouryYSinclairAHThe Genetic and Environmental Factors Underlying HypospadiasSex Dev201595239259Search in Google Scholar
Blaschko SD, Cunha GR, Baskin LS. Molecular mechanisms of external genitalia development. Differentiation. 2012;84(3):261–268.BlaschkoSDCunhaGRBaskinLSMolecular mechanisms of external genitalia developmentDifferentiation2012843261268Search in Google Scholar
van der Horst HJ, de Wall LL. Hypospadias, all there is to know. Eur J Pediatr. 2017;176(4):435–441.van der HorstHJde WallLLHypospadias, all there is to knowEur J Pediatr20171764435441Search in Google Scholar
George M, Schneuer FJ, Jamieson SE, Holland AJ. Genetic and environmental factors in the aetiology of hypospadias. Pediatr Surg Int. 2015;31(6):519–527.GeorgeMSchneuerFJJamiesonSEHollandAJGenetic and environmental factors in the aetiology of hypospadiasPediatr Surg Int2015316519527Search in Google Scholar
Kalfa N, Gaspari L, Ollivier M, Philibert P, Bergougnoux A, Paris F, et al. Molecular genetics of hypospadias and cryptorchidism recent developments. Clin Genet. 2019;95(1):122–131.KalfaNGaspariLOllivierMPhilibertPBergougnouxAParisFMolecular genetics of hypospadias and cryptorchidism recent developmentsClin Genet2019951122131Search in Google Scholar
Chen Z, Lei Y, Finnell RH, Ding Y, Su Z, Wang Y, et al. Whole-exome sequencing study of hypospadias. iScience. 2023;26(5):106663.ChenZLeiYFinnellRHDingYSuZWangYWhole-exome sequencing study of hypospadiasiScience2023265106663Search in Google Scholar
Haid B, Pechriggl E, Nägele F, Dudas J, Webersinke G, Rammer M, et al. FGF8, FGF10 and FGF receptor 2 in foreskin of children with hypospadias: an analysis of immunohistochemical expression patterns and gene transcription. J Pediatr Urol. 2020;16(1):41.e1–e10.HaidBPechrigglENägeleFDudasJWebersinkeGRammerMFGF8, FGF10 and FGF receptor 2 in foreskin of children with hypospadias: an analysis of immunohistochemical expression patterns and gene transcriptionJ Pediatr Urol202016141.e1e10Search in Google Scholar
Pichler R, Djedovic G, Klocker H, Heidegger I, Strasak A, Loidl W, et al. Quantitative measurement of the androgen receptor in prepuces of boys with and without hypospadias. BJU Int. 2013;112(2):265–270.PichlerRDjedovicGKlockerHHeideggerIStrasakALoidlWQuantitative measurement of the androgen receptor in prepuces of boys with and without hypospadiasBJU Int20131122265270Search in Google Scholar
Qiao L, Rodriguez E Jr, Weiss DA, Ferretti M, Risbridger G, Cunha GR, et al. Expression of estrogen receptor alpha and beta is decreased in hypospadias. J Urol. 2012;187(4):1427–1433.QiaoLRodriguezEJrWeissDAFerrettiMRisbridgerGCunhaGRExpression of estrogen receptor alpha and beta is decreased in hypospadiasJ Urol2012187414271433Search in Google Scholar
Khanna S, Shankar Raman V, Badwal S, Vinu Balraam KV. Quantification of the Androgen and Estrogen Receptors in the Penile Tissues of Hypospadias in Comparison with Normal Children. Fetal Pediatr Pathol. 2023;42(2):175–186.KhannaSShankar RamanVBadwalSVinu BalraamKVQuantification of the Androgen and Estrogen Receptors in the Penile Tissues of Hypospadias in Comparison with Normal ChildrenFetal Pediatr Pathol2023422175186Search in Google Scholar
Kocaturk H, Özkaya F, Adanur S, Yapanoglu T, Aksoy Y. Expression of androgen receptor and estrogen receptor-beta in foreskin tissue of hypospadiac and healthy boys. Arch Esp Urol. 2020;73(2):119–125.KocaturkHÖzkayaFAdanurSYapanogluTAksoyYExpression of androgen receptor and estrogen receptor-beta in foreskin tissue of hypospadiac and healthy boysArch Esp Urol2020732119125Search in Google Scholar
Nikolaev VV, Solontsov YN. [Epidemiology and theories of the origin of hypospadias]. Urologiia. 2018;(3):141–145.NikolaevVVSolontsovYN[Epidemiology and theories of the origin of hypospadias]Urologiia20183141145Search in Google Scholar
Marrocco G, Grammatico P, Vallasciani S, Gulia C, Zangari A, Marrocco F, et al. Environmental, parental and gestational factors that influence the occurrence of hypospadias in male patients. J Pediatr Urol. 2015;11(1):12–19.MarroccoGGrammaticoPVallascianiSGuliaCZangariAMarroccoFEnvironmental, parental and gestational factors that influence the occurrence of hypospadias in male patientsJ Pediatr Urol20151111219Search in Google Scholar
Zhou X, Zhang X, Zhou X, Abulimiti G, Wang Y, Zhang Q, et al. Identification of endocrine-disrupting chemicals targeting the genes and pathways of genital anomalies in males. Ecotoxicol Environ Saf. 2022; 247:114241.ZhouXZhangXZhouXAbulimitiGWangYZhangQIdentification of endocrine-disrupting chemicals targeting the genes and pathways of genital anomalies in malesEcotoxicol Environ Saf2022247114241Search in Google Scholar
Cripps SM, Mattiske DM, Black JR, Risbridger GP, Govers LC, Phillips TR, et al. A loss of estrogen signaling in the aromatase deficient mouse penis results in mild hypospadias. Differentiation. 2019;109: 42–52.CrippsSMMattiskeDMBlackJRRisbridgerGPGoversLCPhillipsTRA loss of estrogen signaling in the aromatase deficient mouse penis results in mild hypospadiasDifferentiation20191094252Search in Google Scholar
Do MT, Kim L, Im YJ, Hahn S, Park K. Effect of Preoperative Androgen Stimulation on Penile Size and Postoperative Complication Rate in Patients with Hypospadias: A Systematic Review and Meta-analysis. World J Mens Health. 2023; 41(3):558–574.DoMTKimLImYJHahnSParkKEffect of Preoperative Androgen Stimulation on Penile Size and Postoperative Complication Rate in Patients with Hypospadias: A Systematic Review and Meta-analysisWorld J Mens Health2023413558574Search in Google Scholar
Nagaraja MR, Gubbala SP, Delphine Silvia CRW, Amanchy R. Molecular diagnostics of disorders of sexual development: an Indian survey and systems biology perspective. Syst Biol Reprod Med. 2019;65(2):105–120.NagarajaMRGubbalaSPDelphine SilviaCRWAmanchyRMolecular diagnostics of disorders of sexual development: an Indian survey and systems biology perspectiveSyst Biol Reprod Med2019652105120Search in Google Scholar
Celayir A, Moralioglu S, Cetiner H, Kir G, Celayir S. Expression of androgen, estrogen, and progesterone hormone receptors in the penile tissues of children with different types of hypospadias. North Clin Istanb. 2018;6(2):110–116.CelayirAMoraliogluSCetinerHKirGCelayirSExpression of androgen, estrogen, and progesterone hormone receptors in the penile tissues of children with different types of hypospadiasNorth Clin Istanb201862110116Search in Google Scholar
Cunha GR, Risbridger G, Wang H, Place NJ, Grumbach M, Cunha TJ, et al. Development of the external genitalia: perspectives from the spotted hyena (Crocuta crocuta). Differentiation. 2014;87(1–2):4–22.CunhaGRRisbridgerGWangHPlaceNJGrumbachMCunhaTJDevelopment of the external genitalia: perspectives from the spotted hyena (Crocuta crocuta)Differentiation2014871–2422Search in Google Scholar
Joodi M, Amerizadeh F, Hassanian SM, Erfani M, Ghayour-Mobarhan M, Ferns GA, et al. The genetic factors contributing to hypospadias and their clinical utility in its diagnosis. J Cell Physiol. 2019; 234(5):5519–5523.JoodiMAmerizadehFHassanianSMErfaniMGhayour-MobarhanMFernsGAThe genetic factors contributing to hypospadias and their clinical utility in its diagnosisJ Cell Physiol2019234555195523Search in Google Scholar
Lorenzi MV, Long JE, Miki T, Aaronson SA. Expression cloning, developmental expression and chromosomal localization of fibroblast growth factor-8. Oncogene. 1995;10(10):2051–2055.LorenziMVLongJEMikiTAaronsonSAExpression cloning, developmental expression and chromosomal localization of fibroblast growth factor-8Oncogene1995101020512055Search in Google Scholar
Gnanapragasam VJ, Robson CN, Neal DE, Leung HY. Regulation of FGF8 expression by the androgen receptor in human prostate cancer. Oncogene. 2002;21(33):5069–5080.GnanapragasamVJRobsonCNNealDELeungHYRegulation of FGF8 expression by the androgen receptor in human prostate cancerOncogene2002213350695080Search in Google Scholar
Gredler ML, Seifert AW, Cohn MJ. Tissue-specific roles of FGFR-2 in development of the external genitalia. Development. 2015;142(12):2203–2212.GredlerMLSeifertAWCohnMJTissue-specific roles of FGFR-2 in development of the external genitaliaDevelopment20151421222032212Search in Google Scholar