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Bilateral renal angiomyolipomas and subependymal giant cell astrocytoma associated with tuberous sclerosis complex: A case report and review of the literature

I Rambabova Bushljetik
I Rambabova Bushljetik
, 
M Lazareska
M Lazareska
, 
I Barbov
I Barbov
, 
O Stankov
O Stankov
, 
V Filipce
V Filipce
 y 
G Spasovski
G Spasovski
   | 23 mar 2021
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Article Category: Case report
Publicado en línea: 23 mar 2021
Páginas: 93 - 98
DOI: https://doi.org/10.2478/bjmg-2020-0017
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© 2020 Rambabova Bushljetik I, Lazareska M, Barbov I, Stankov O, Filipce V, Spasovski G, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Figure 1

At the upper pole of the right kidney a large AML, longest diameter of 12.3 × 7.1 cm (arrow left) with heterogenous density, presence of microaneurisms at the posterior and lateral segments, with a dominant lipid component revealed on the urinary tract MRI (red arrow). At the lower pole of the left kidney, an AML with the dimension of 5.3 × 3.7 cm (arrow right) and other multiple AMLs with dimensions of 5-10 mm were found, as well as multiple cysts.
At the upper pole of the right kidney a large AML, longest diameter of 12.3 × 7.1 cm (arrow left) with heterogenous density, presence of microaneurisms at the posterior and lateral segments, with a dominant lipid component revealed on the urinary tract MRI (red arrow). At the lower pole of the left kidney, an AML with the dimension of 5.3 × 3.7 cm (arrow right) and other multiple AMLs with dimensions of 5-10 mm were found, as well as multiple cysts.

Figure 2

On the brain MRI, multiple lesions as subependimal nodules, subcortical tubers and largest tumor mass presented in foramen Monro as SEGA (diameter 3.0 × 1.5 cm) were described.
On the brain MRI, multiple lesions as subependimal nodules, subcortical tubers and largest tumor mass presented in foramen Monro as SEGA (diameter 3.0 × 1.5 cm) were described.

Figure 3

Magnetic resonance imaging of the urinary tract at 12 months after everolimus initiation.
Magnetic resonance imaging of the urinary tract at 12 months after everolimus initiation.

Figure 4

Magnetic resonance imaging of the brain at 12 months after everolimus initiation.
Magnetic resonance imaging of the brain at 12 months after everolimus initiation.

Figure 5

Magnetic resonance imaging of the urinary tract at 36 months after everolimus treatment initiation.
Magnetic resonance imaging of the urinary tract at 36 months after everolimus treatment initiation.

Figure 6

Magnetic resonance imaging of the brain at 36 months after everolimus treatment initiation.
Magnetic resonance imaging of the brain at 36 months after everolimus treatment initiation.

The proband’s clinical diagnostic criteria.

Major FeaturesMinor Features
AngiomyolipomasMultiple renal cysts
Cortical tubersGingival fibromas
SEGA
Hypopigmented macules
Fagial angiofibromas
Cardiac rhabdomyoma

Biochemical laboratory findings in the follow-up period.

ParametersFirst YearSecond YearThird Year
Hb (g/dL)12.112.412.6
RBC (1012/L)3.94.14.0
Platelets (109/L)245.0254.0256.0
Protein/albumin (g/dL)79.0/41.082.0/42.081.0/42.0
SCR (μmol/L)62.061.063.0
BUN (mmol/L)3.82.93.5
Cholesterol (mmol/L)4.04.14.0
HDL (mmol/L)1.21.31.2
LDL (mmol/L)2.32.22.1
Triglycerides (mmol/L)0.961.101.10
CRP (mg/L)1.91.21.6
Proteinuria (g/24 hours)0.130.110.17
eISSN:
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Idioma:
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Calendario de la edición:
2 veces al año
Temas de la revista:
Medicine, Basic Medical Science, other
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