RANKL is a new epigenetic biomarker for the vasomotor symptom during Menopause

1Albagha OME, McGuigan FEA, Reid DM, Ralston SH. Estrogen receptor a gene polymorphisms and bone mineral density: haplotype analysis in women from the United Kingdom. J Bone Miner Res. 2001; 16(1): 128-134.AlbaghaOMEMcGuiganFEAReidDMRalstonSHEstrogen receptor a gene polymorphisms and bone mineral density: haplotype analysis in women from the United KingdomJ Bone Miner Res200116112813410.1359/jbmr.2001.16.1.128Search in Google Scholar

2Ambatipudi S, Horvath S, Perrier F, Cuenin C, Hernandez-Vargas H, Le Calvez-Kelm F, et al. DNA methylome analysis identifies accelerated epigenetic ageing associated with postmenopausal breast cancer susceptibility. Eur J Cancer. 2017; 75: 299-307.AmbatipudiSHorvathSPerrierFCueninCHernandez-VargasHLe Calvez-KelmFet alDNA methylome analysis identifies accelerated epigenetic ageing associated with postmenopausal breast cancer susceptibilityEur J Cancer20177529930710.1016/j.ejca.2017.01.014Search in Google Scholar

3Beau I, Touraine P, Meduri G, Gougeon A, Desroches A, Matuchansky C, et al. A novel phenotype related to partial loss of function mutations of the follicle stimulating hormone receptor. J Clin Invest. 1998; 102(7): 1352-1359.BeauITourainePMeduriGGougeonADesrochesAMatuchanskyCet alA novel phenotype related to partial loss of function mutations of the follicle stimulating hormone receptorJ Clin Invest199810271352135910.1172/JCI3795Search in Google Scholar

4Boyce BF, Xing L. Biology of RANK, RANKL, and osteoprotegerin. Arthritis Res Ther. 2007; 9(Suppl 1): S 1.BoyceBFXingLBiology of RANK, RANKL, and osteoprotegerinArthritis Res Ther20079Suppl 1110.1186/ar2165Search in Google Scholar

5Bucay N, Sarosi I, Dunstan C, Morony S, Tarpley J, Capparelli C, et al. Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification. Genes Dev. 1998; 12(9): 1260-1268.BucayNSarosiIDunstanCMoronySTarpleyJCapparelliCet alOsteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcificationGenes Dev19981291260126810.1101/gad.12.9.1260Search in Google Scholar

6Conway GS, Conway E, Walker C, Hoppner W, Gromoll J, Simoni M. Mutation screening and isoform prevalence of the follicle stimulating hormone receptor gene in women with premature ovarian failure, resistant ovary syndrome and polycystic ovary syndrome. Clin Endocrinol (Oxf). 1999; 51(1): 97-99.ConwayGSConwayEWalkerCHoppnerWGromollJSimoniMMutation screening and isoform prevalence of the follicle stimulating hormone receptor gene in women with premature ovarian failure, resistant ovary syndrome and polycystic ovary syndromeClin Endocrinol (Oxf)1999511979910.1046/j.1365-2265.1999.00745.xSearch in Google Scholar

7Cordero A, Pellegrini P, Sanz-Moreno A, Trinidad EM, Serra-Musach J, Deshpande C, et al. Rankl impairs lactogenic differentiation through inhibition of the pro-lactin/stat5 pathway at midgestation. Stem Cells. 2016; 34(4): 1027-1039.CorderoAPellegriniPSanz-MorenoATrinidadEMSerra-MusachJDeshpandeCet alRankl impairs lactogenic differentiation through inhibition of the pro-lactin/stat5 pathway at midgestationStem Cells20163441027103910.1002/stem.2271Search in Google Scholar

8Cordts EB, Santos MC, Bianco B, Barbosa CP, Christofolini DM. Are FSHR polymorphisms risk factors to premature ovarian insufficiency? Gynecol Endocrinol. 2015; 31(8): 663-666.CordtsEBSantosMCBiancoBBarbosaCPChristofoliniDMAre FSHR polymorphisms risk factors to premature ovarian insufficiency?Gynecol Endocrinol201531866366610.3109/09513590.2015.1032933Search in Google Scholar

9da Fonte Kohek MB, Batista MC, Russell AJ, Vass K, Giacaglia LR, Mendonca BB, et al. No evidence of the inactivating mutation (C566T) in the follicle-stimulating hormone receptor gene in Brazilian women with premature ovarian failure. Fertil Steril. 1998; 70(3); 565-567.MBda Fonte KohekBatistaMCRussellAJVassKGiacagliaLRMendoncaBBet alNo evidence of the inactivating mutation (C566T) in the follicle-stimulating hormone receptor gene in Brazilian women with premature ovarian failureFertil Steril199870356556710.1016/S0015-0282(98)00203-9Search in Google Scholar

10Day FR, Thompson DJ, Helgason H, Chasman DI, Fincune H, Sulem P, et al. Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk. Nat Genet. 2017; 49(6): 1-19.DayFRThompsonDJHelgasonHChasmanDIFincuneHSulemPet alGenomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer riskNat Genet201749611910.1038/ng.3841584195228436984Search in Google Scholar

11Levine ME, Lu AT, Chen BH, Hernandez DG, Singleton AB, Ferrucci L, et al. Menopause accelerates biological aging. Proc Natl Acad Sci USA. 2017; 113(33): 9327-9332.LevineMELuATChenBHHernandezDGSingletonABFerrucciLet alMenopause accelerates biological agingProc Natl Acad Sci USA2017113339327933210.1073/pnas.1604558113499594427457926Search in Google Scholar

12Delgado-Calle J, Sañudo C, Fernandez AF, García-Renedo R, Fraga MF, Riancho JA. Role of DNA methylation in the regulation of the RANKL-OPG system in human bone. Epigenetics. 2012: 7(1): 83-91.Delgado-CalleJSañudoCFernandezAFGarcía-RenedoRFragaMFRianchoJARole of DNA methylation in the regulation of the RANKL-OPG system in human boneEpigenetics201271839110.4161/epi.7.1.18753333783322207352Search in Google Scholar

13Elks CE, Perry JR, Sulem P, Chasman DI, Franceschini N, He C, et al. Thirty new loci for age at menarche identified by a meta-analysis of genomewide association studies. Nat Genet. 2010; 42(12): 1077-1085.ElksCEPerryJRSulemPChasmanDIFranceschiniNHeCet alThirty new loci for age at menarche identified by a meta-analysis of genomewide association studiesNat Genet201042121077108510.1038/ng.714314005521102462Search in Google Scholar

14Falconer H, Andersson E, Aanesen A, Fried G. Follicle-stimulating hormone receptor polymorphisms in a population of infertile women. Acta Obstet Gynecol Scand. 2005; 84(8): 806-811.FalconerHAnderssonEAanesenAFriedGFollicle-stimulating hormone receptor polymorphisms in a population of infertile womenActa Obstet Gynecol Scand200584880681110.1111/j.0001-6349.2005.00736.x16026410Search in Google Scholar

15Guerrini MM, Sobacchi C, Cassani B, Abinun M, Kilic SS, Pangrazio A, et al. Human osteoclast-poor osteopetrosis with hypogammaglobulinemia due to TNFRS F11A (RANK) mutations. Am J Hum Genet. 2008; 83(1): 64-76.GuerriniMMSobacchiCCassaniBAbinunMKilicSSPangrazioAet alHuman osteoclast-poor osteopetrosis with hypogammaglobulinemia due to TNFRS F11A (RANK) mutationsAm J Hum Genet2008831647610.1016/j.ajhg.2008.06.015244385018606301Search in Google Scholar

16Hanada R, Leibbrandt A, Hanada T, Kitaoka S, Furuyashiki T, Fujihara H, et al. Central control of fever and female body temperature by RANKL/RANK. Nature. 2009; 462(7272): 505-509.HanadaRLeibbrandtAHanadaTKitaokaSFuruyashikiTFujiharaHet alCentral control of fever and female body temperature by RANKL/RANKNature2009462727250550910.1038/nature0859619940926Search in Google Scholar

17Hanada R, Penninger JM. Central regulation of body temperature by RANKL/RANK pathway. Clin Calcium. 2011; 21(8): 1201-1208.HanadaRPenningerJMCentral regulation of body temperature by RANKL/RANK pathwayClin Calcium201121812011208Search in Google Scholar

18Hofbauer LC. Osteoprotegerin ligand and osteo-protegerin: Novel implications for osteoclast biology and bone metabolism. Eur J Endocrinol. 1999; 141(3): 195-210.HofbauerLCOsteoprotegerin ligand and osteo-protegerin: Novel implications for osteoclast biology and bone metabolismEur J Endocrinol1999141319521010.1530/eje.0.141019510474114Search in Google Scholar

19Horikoshi M, Day FR, Akiyama M, Hirata M, Kamatani Y, Matsuda K, et al. Elucidating the genetic architecture of reproductive ageing in the Japanese population. Nat Commun. 2018; 9(1): 1977.HorikoshiMDayFRAkiyamaMHirataMKamataniYMatsudaKet alElucidating the genetic architecture of reproductive ageing in the Japanese populationNat Commun201891197710.1038/s41467-018-04398-z595809629773799Search in Google Scholar

20Hsu YH, Niu T, Terwedow HA, Xu X, Feng Y, Li Z, et al. Variation in genes involved in the RANKL/ RANK/OPG bone remodeling pathway are associated with bone mineral density at different skeletal sites in men. Hum Genet. 2006; 118(5): 568-577.HsuYHNiuTTerwedowHAXuXFengYLiZet alVariation in genes involved in the RANKL/ RANK/OPG bone remodeling pathway are associated with bone mineral density at different skeletal sites in menHum Genet2006118556857710.1007/s00439-005-0062-416249885Search in Google Scholar

21Kearns AE, Khosla S, Kostenuik PJ. Receptor activator of nuclear factor kappaB ligand and osteoprotegerin regulation of bone remodeling in health and disease. Endocr Rev. 2008; 29(2): 155-192.KearnsAEKhoslaSKostenuikPJReceptor activator of nuclear factor kappaB ligand and osteoprotegerin regulation of bone remodeling in health and diseaseEndocr Rev200829215519210.1210/er.2007-0014252884618057140Search in Google Scholar

22Kuijper EAM, Blankenstein MA, Luttikhof LJ, Roek SJ, Overbeek A, Hompes PG, et al. Frequency distribution of polymorphisms in the FSH receptor gene in infertility patients of different ethnicity. Reprod Biomed Online. 2010; 20(5): 588-593.KuijperEAMBlankensteinMALuttikhofLJRoekSJOverbeekAHompesPGet alFrequency distribution of polymorphisms in the FSH receptor gene in infertility patients of different ethnicityReprod Biomed Online201020558859310.1016/j.rbmo.2010.02.00420223709Search in Google Scholar

23Kumar TR. FSHβ knockout mouse model: A decade ago and into the future. Endocrine. 2009; 36(1): 1-5.KumarTRFSHβ knockout mouse model: A decade ago and into the futureEndocrine20093611510.1007/s12020-009-9199-6407430519387872Search in Google Scholar

24Marion S, Oakley RH, Kim KM, Caron MG, Barak LS. A β-arrestin binding determinant common to the second intracellular loops of rhodopsin family G protein-coupled receptors. J Biol Chem. 2006; 281(5): 2932-2938.MarionSOakleyRHKimKMCaronMGBarakLSA β-arrestin binding determinant common to the second intracellular loops of rhodopsin family G protein-coupled receptorsJ Biol Chem200628152932293810.1074/jbc.M50807420016319069Search in Google Scholar

25Mencej S, Albagha O, Prezelj J, Kocjan T, Marc J. TNFSF11 gene promoter polymorphisms modulate promoter activity and influence bone mineral density in post-menopausal women with osteoporosis. J Mol Endocrinol. 2008; 40(6): 273-279.MencejSAlbaghaOPrezeljJKocjanTMarcJTNFSF11 gene promoter polymorphisms modulate promoter activity and influence bone mineral density in post-menopausal women with osteoporosisJ Mol Endocrinol200840627327910.1677/JME-08-000318502820Search in Google Scholar

26Mitchell ES, Farin FM, Stapleton PL, Tsai JM, Tao EY, Smith-DiJulio K, et al. Association of estrogen-related polymorphisms with age at menarche, age at final menstrual period, and stages of the menopausal transition. Menopause. 2008; 15(1): 105-111.MitchellESFarinFMStapletonPLTsaiJMTaoEYSmith-DiJulioKet alAssociation of estrogen-related polymorphisms with age at menarche, age at final menstrual period, and stages of the menopausal transitionMenopause200815110511110.1097/gme.0b013e31804d240617589376Search in Google Scholar

27Woad KJ, Prendergast D, Winship IM, Shelling AN. FSH receptor gene variants are rarely associated with premature ovarian failure. Reprod Biomed Online. 2013; 26(4): 396-399.WoadKJPrendergastDWinshipIMShellingANFSH receptor gene variants are rarely associated with premature ovarian failureReprod Biomed Online201326439639910.1016/j.rbmo.2013.01.00423419799Search in Google Scholar

28Sun L, Peng Y, Sharrow AC, Iqbal J, Zhang Z, Papachristou DJ, et al. FSH directly regulates bone mass. Cell. 2006; 125(2): 247-260.SunLPengYSharrowACIqbalJZhangZPapachristouDJet alFSH directly regulates bone massCell2006125224726010.1016/j.cell.2006.01.05116630814Search in Google Scholar

29Kalkan R, Altarda M, Tulay P, Tosun O. The interaction between ESRRA and PTH gene methylation and body mass index in post-menopausal cases. Cyprus J Med Sci. 2019; 4(3) X-X. doi: 10.5152/cjms.2019.990.KalkanRAltardaMTulayPTosunOThe interaction between ESRRA and PTH gene methylation and body mass index in post-menopausal casesCyprus J Med Sci201943XX10.5152/cjms.2019.990Open DOISearch in Google Scholar

30Pérez-Sayáns M, Somoza-Martín AM, Barros-Angueira F, Rey JM, Garcia-Garcia A. RANK/RANKL/OPG role in distraction osteogenesis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010; 109(5): 679-686.Pérez-SayánsMSomoza-MartínAMBarros-AngueiraFReyJMGarcia-GarciaARANK/RANKL/OPG role in distraction osteogenesisOral Surg Oral Med Oral Pathol Oral Radiol Endod2010109567968610.1016/j.tripleo.2009.10.04220163972Search in Google Scholar

31Perry JRB, Murray A, Day FR, Ong KK. Molecular insights into the aetiology of female reproductive ageing. Nat Rev Endocrinol. 2015; 11(12): 725-734.PerryJRBMurrayADayFROngKKMolecular insights into the aetiology of female reproductive ageingNat Rev Endocrinol2015111272573410.1038/nrendo.2015.167630926126460341Search in Google Scholar

32Perry JR, Stolk L, Franceschini N, Lunetta KL, Zhai G, McArdle PF, et al. Meta-analysis of genome-wide association data identifies two loci influencing age at menarche. Nat Genet. 2009; 41(6): 648-650.PerryJRStolkLFranceschiniNLunettaKLZhaiGMcArdlePFet alMeta-analysis of genome-wide association data identifies two loci influencing age at menarcheNat Genet200941664865010.1038/ng.386294298619448620Search in Google Scholar

33Perry JRB, Day F, Elks CE, Sulem P, Thompson DJ, Ferreira T, et al. Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. Nature. 2010; 514(7520): 92-97.PerryJRBDayFElksCESulemPThompsonDJFerreiraTet alParent-of-origin-specific allelic associations among 106 genomic loci for age at menarcheNature20105147520929710.1038/nature13545418521025231870Search in Google Scholar

34Rendina D, Gianfrancesco F, De Filippo G, Merlotti D, Esposito T, Mingione A, et al. FSHR gene polymorphisms influence bone mineral density and bone turnover in postmenopausal women. Eur J Endocrinol. 2010; 163(1): 165-172.RendinaDGianfrancescoFDe FilippoGMerlottiDEspositoTMingioneAet alFSHR gene polymorphisms influence bone mineral density and bone turnover in postmenopausal womenEur J Endocrinol2010163116517210.1530/EJE-10-004320335500Search in Google Scholar

35Rod A, Jarzabek K, Wolczynski S, Benhaim A, Reznik Y, Denoual-Ziad C, et al. ESR1 and FSHR gene polymorphisms influence ovarian response to FSH in poor responder women with normal FSH Levels. Endocrinol Metab Synd. 2014; 3: 3.RodAJarzabekKWolczynskiSBenhaimAReznikYDenoual-ZiadCet alESR1 and FSHR gene polymorphisms influence ovarian response to FSH in poor responder women with normal FSH LevelsEndocrinol Metab Synd20143310.4172/2161-1017.1000141Search in Google Scholar

36Sundblad V, Chiauzzi VA, Escobar ME, Dain L, Charreau EH. Screening of FSH receptor gene in Argentine women with premature ovarian failure (POF). Mol Cell Endocrinol. 2004; 222(1-2): 53-59.SundbladVChiauzziVAEscobarMEDainLCharreauEHScreening of FSH receptor gene in Argentine women with premature ovarian failure (POF)Mol Cell Endocrinol20042221-2535910.1016/j.mce.2004.05.00215249125Search in Google Scholar

37Zerbetto I, Gromoll J, Luisi S, Reis FM, Nieschlag E, Simoni M, et al. Follicle stimulating hormone receptor and DAZL gene polymorphisms do not affect the age of menopause. Fertil Steril. 2008; 90(6): 2264-2268.ZerbettoIGromollJLuisiSReisFMNieschlagESimoniMet alFollicle stimulating hormone receptor and DAZL gene polymorphisms do not affect the age of menopauseFertil Steril20089062264226810.1016/j.fertnstert.2007.10.03618178196Search in Google Scholar

38Stolk L, Perry JR, Chasman DI, He C, Mangino M, Sulem P, et al. Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. Nat Genet. 2012; 44(3): 260-268.StolkLPerryJRChasmanDIHeCManginoMSulemPet alMeta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathwaysNat Genet201244326026810.1038/ng.1051328864222267201Search in Google Scholar

39Coşkun S, Yücel Y, Çim A, Cengiz B, Oztuzcu S, Varol S, et al. Contribution of polymorphisms in ESR1, ESR2, FSHR, CYP19A1, SHBG, and NRIP1 genes to migraine susceptibility in Turkish population. J Genet. 2016; 95(1): 131-140.CoşkunSYücelYÇimACengizBOztuzcuSVarolSet alContribution of polymorphisms in ESR1, ESR2, FSHR, CYP19A1, SHBG, and NRIP1 genes to migraine susceptibility in Turkish populationJ Genet201695113114010.1007/s12041-016-0625-227019440Search in Google Scholar

40Shang M, Lin L, Cui H. Association of genetic polymorphisms of RANK, RANKL and OPG with bone mineral density in Chinese peri- and postmenopausal women. Clin Biochem. 2013; 46(15): 1493-1501.ShangMLinLCuiHAssociation of genetic polymorphisms of RANK, RANKL and OPG with bone mineral density in Chinese peri- and postmenopausal womenClin Biochem201346151493150110.1016/j.clinbiochem.2013.03.01123531404Search in Google Scholar

41Tu P, Duan P, Zhang RS, Xu DB, Wang Y, Wu HP, et al. Polymorphisms in genes in the RANKL/RANK/ OPG pathway are associated with bone mineral density at different skeletal sites in post-menopausal women. Osteoporos Int. 2015; 26(1): 179-185.TuPDuanPZhangRSXuDBWangYWuHPet alPolymorphisms in genes in the RANKL/RANK/ OPG pathway are associated with bone mineral density at different skeletal sites in post-menopausal womenOsteoporos Int201526117918510.1007/s00198-014-2854-725138264Search in Google Scholar

42Sowers M, Willing M, Bums T, Deschenes S, Hollis B, Crutchfield M, et al. Genetic markers, bone mineral density, and serum osteocalcin levels. J Bone Miner Res. 2009; 14(8): 1411-1419.SowersMWillingMBumsTDeschenesSHollisBCrutchfieldMet alGenetic markers, bone mineral density, and serum osteocalcin levelsJ Bone Miner Res20091481411141910.1359/jbmr.1999.14.8.141110457274Search in Google Scholar

43Wang J, Wang Y, Zhao Y, Li Y, Sun M, Na R et al. Polymorphisms of genes in the OPG/RANKL/RANK pathway in the Mongols of Inner Mongolia China: Relationship to other populations. Int J Clin Exp Med. 2016; 9(2): 3851-3859.WangJWangYZhaoYLiYSunMNaRet alPolymorphisms of genes in the OPG/RANKL/RANK pathway in the Mongols of Inner Mongolia China: Relationship to other populationsInt J Clin Exp Med20169238513859Search in Google Scholar

44Willing M, Sowers M, Aron D, Clark MK, Bums T, Bunten C, et al. Bone mineral density and its change in White women: Estrogen and vitamin D receptor genotypes and their interaction. J Bone Miner Res. 2009; 13(4): 695-705.WillingMSowersMAronDClarkMKBumsTBuntenCet alBone mineral density and its change in White women: Estrogen and vitamin D receptor genotypes and their interactionJ Bone Miner Res200913469570510.1359/jbmr.1998.13.4.6959556070Search in Google Scholar

45Voorhuis M, Onland-Moret NC, van der Schouw YT, Fauser BC, Broekmans FJ. Human studies on genetics of the age at natural menopause: A systematic review. Hum Reprod Update. 2010; 16(4): 364-377.VoorhuisYTOnland-MoretMvan der SchouwNCFauserBCBroekmansFJHuman studies on genetics of the age at natural menopause: A systematic reviewHum Reprod Update201016436437710.1093/humupd/dmp05520071357Search in Google Scholar

46Zaidi M, Blair HC, Iqbal J, Zhu LL, Kumar TR, Zallone A, et al. Proresorptive actions of FSH and bone loss. Ann NY Acad Sei. 2007; 1116: 376-382.ZaidiMBlairHCIqbalJZhuLLKumarTRZalloneAet alProresorptive actions of FSH and bone lossAnn NY Acad Sei2007111637638210.1196/annals.1402.05618083939Search in Google Scholar

47Zheng H, Wang C, Wei H, Fu WZ, Zhang ZL. OPG, RANKL, and RANK gene polymorphisms and the bone mineral density response to alendronate therapy in postmenopausal Chinese women with osteoporosis or osteopenia. Pharmacogenet Genomics. 2016; 26(1): 12-19.ZhengHWangCWeiHFuWZZhangZLOPG, RANKL, and RANK gene polymorphisms and the bone mineral density response to alendronate therapy in postmenopausal Chinese women with osteoporosis or osteopeniaPharmacogenet Genomics2016261121910.1097/FPC.000000000000018126426211Search in Google Scholar