<abstract xmlns="http://www.w3.org/1999/xhtml"><p> We conducted a cytogenetic study on 865 individuals with idiopathic mental retardation (MR) who were admitted to the Cytogenetics Department of the Iran Blood Transfusion Organisation (IBTO) Research Centre, Tehran, Iran; these were performed on blood samples using conventional staining methods. Chromosome anomalies were identified in 205 of the patients (23.6%). The majority were Down’s syndrome cases (n = 138). In 33 males, a positive fragile X anomaly was found .The remainder (n = 34) had other chromosomal abnormalities including structural chromosome aberrations (n = 23), marker chromosomes with an unknown origin (n = 3), sex chromosome aneuploidy (n = 6) and trisomy 18 (n = 2). The contribution of chromosome aberrations to the cause of MR in this group of patients is discussed.</p></abstract>

We conducted a cytogenetic study on 865 individuals with idiopathic mental retardation (MR) who were admitted to the Cytogenetics Department of the Iran Blood Transfusion Organisation (IBTO) Research Centre, Tehran, Iran; these were performed on blood samples using conventional staining methods. Chromosome anomalies were identified in 205 of the patients (23.6%). The majority were Down’s syndrome cases (n = 138). In 33 males, a positive fragile X anomaly was found .The remainder (n = 34) had other chromosomal abnormalities including structural chromosome aberrations (n = 23), marker chromosomes with an unknown origin (n = 3), sex chromosome aneuploidy (n = 6) and trisomy 18 (n = 2). The contribution of chromosome aberrations to the cause of MR in this group of patients is discussed.

Cytogenetic Findings in Mentally Retarded Iranian Patients

Genetics Department, Iran Blood Transfusion Organisation (IBTO) Research Centre, High Institute for Research and Education in Transfusion Medicine,Tehran, Iran

Clinical Genetics Department, National Research Institute of Genetic Engineering and Biotechnology, Tehran, Iran

Balkan Journal of Medical Genetics

{"article-title":"Cytogenetic Findings in Mentally Retarded Iranian Patients"}

We conducted a cytogenetic study on 865 individuals with idiopathic mental retardation (MR) who were admitted to the Cytogenetics Department of the Iran Blood...

Cytogenetic Findings in Mentally Retarded Iranian Patients

Publicado en línea: 02 abr 2013

Páginas: 29 - 34

DOI: https://doi.org/10.2478/bjmg-2013-0004

This content is open access.