Heterologous expression of Bacillus subtilis SL-44 glycosyltransferase catalyzed synthesis of ginsenoside Rh2

[1] Park, J. E., Ji, H. W., Kim, H. W., Baek, M., Jung, S., & Sun, J. K. (2022). Ginsenoside rh2 regulates the cfap20dc-as1/microrna-3614-3p/bbx and tnfaip3 axis to induce apoptosis in breast cancer cells. The American journal of Chinese medicine, 50(6), 1703-1717. Search in Google Scholar

[2] Chu, J., Yue, J., Qin, S., Li, Y., & He, B. (2021). Biocatalysis for rare ginsenoside rh2 production in high level with co-immobilized udp-glycosyltransferase bs-yjic mutant and sucrose synthase atsusy. Catalysts, 11(1), 132. Search in Google Scholar

[3] Jin, X., Yang, Q., Cai, N., & Zhang, Z. (2020). A cocktail of betulinic acid, parthenolide, honokiol and ginsenoside rh2 in liposome systems for lung cancer treatment. Nanomedicine, 15(1), 41-54. Search in Google Scholar

[4] Gao, Qiruo, Zheng, & Junhua. (2018). Ginsenoside rh2 inhibits prostate cancer cell growth through suppression of micro rna rna ‐4295 that activates cdkn cdkn 1a. Cell Proliferation, 51(3), art. no. e12438-art. no. e12438. Search in Google Scholar

[5] Yan, H., Jin, H., Fu, Y., Yin, Z., & Yin, C. (2019). Production of rare ginsenosides Rg3 and Rh2 by endophytic bacteria from Panax ginseng. Journal of agricultural and food chemistry, 67(31), 8493-8499. Search in Google Scholar

[6] Siddiqi, M. Z., Ximenes, H. A., Song, B. K., Park, H. Y., Lee, W. H., Han, H., & Im, W. T. (2021). Enhanced production of ginsenoside Rh2 (S) from PPD-type major ginsenosides using BglSk cloned from Saccharibacillus kuerlensis together with two glycosidase in series. Saudi Journal of Biological Sciences, 28(8), 4668-4676. Search in Google Scholar

[7] Wang, M. Z., Xu, Y., Xie, J. F., Jiang, Z. H., & Peng, L. H. (2021). Ginsenoside as a new stabilizer enhances the transfection efficiency and biocompatibility of cationic liposome. Biomaterials Science, 9(24), 8373-8385. Search in Google Scholar

[8] Kim, S. Y., Lee, H. N., Hong, S. J., Kang, H. J., Cho, J. Y., Kim, D., & Kim, Y. M. (2022). Enhanced biotransformation of the minor ginsenosides in red ginseng extract by Penicillium decumbens β-glucosidase. Enzyme and Microbial Technology, 153, 109941. Search in Google Scholar

[9] Hu, Y., Wang, N., Yan, X., Yuan, Y., Luo, F., Jiang, Z., & Zhou, Y. (2019). Ginsenoside Re impacts on biotransformation products of ginsenoside Rb1 by Cellulosimicrobium cellulans sp. 21 and its mechanisms. Process Biochemistry, 77, 57-62. Search in Google Scholar

[10] Dai, L., Liu, C., Li, J., Dong, C., Yang, J., Dai, Z., & Sun, Y. (2018). One-pot synthesis of ginsenoside Rh2 and bioactive unnatural ginsenoside by coupling promiscuous glycosyltransferase from Bacillus subtilis 168 to sucrose synthase. Journal of agricultural and food chemistry, 66(11), 2830-2837. Search in Google Scholar

[11] Li, X., Chu, S., Lin, M., Gao, Y., Liu, Y., Yang, S., & Chen, N. (2020). Anticancer property of ginsenoside Rh2 from ginseng. European Journal of Medicinal Chemistry, 203, 112627. Search in Google Scholar

[12] Zare-Zardini, H., Alemi, A., Taheri-Kafrani, A., Hosseini, S. A., Soltaninejad, H., Hamidieh, A. A., & Farrokhifar, M. (2020). Assessment of a new ginsenoside Rh2 nanoniosomal formulation for enhanced antitumor efficacy on prostate cancer: an in vitro study. Drug design, development and therapy, 3315-3324. Search in Google Scholar

[13] Xu, Y., Zhu, B. W., Li, X., Li, Y. F., Ye, X. M., & Hu, J. N. (2022). Glycogen-based pH and redox sensitive nanoparticles with ginsenoside Rh2 for effective treatment of ulcerative colitis. Biomaterials, 280, 121077. Search in Google Scholar

[14] Popov, A., Klimovich, A., Styshova, O., Tsybulsky, A., Hushpulian, D., Osipyants, A., & Poloznikov, A. (2022). Probable mechanisms of Doxorubicin antitumor activity enhancement by ginsenoside Rh2. Molecules, 27(3), 628. Search in Google Scholar

[15] Ben-Eltriki, M., Deb, S., & Guns, E. S. T. (2021). 1α, 25-Dihydroxyvitamin D3 synergistically enhances anticancer effects of ginsenoside Rh2 in human prostate cancer cells. The Journal of Steroid Biochemistry and Molecular Biology, 209, 105828. Search in Google Scholar

[16] Yang, Q., Wang, N., Zhang, J., Chen, G., Xu, H., Meng, Q., & Fan, H. (2019). In vitro and in silico evaluation of stereoselective effect of ginsenoside isomers on platelet P2Y12 receptor. Phytomedicine, 64, 152899. Search in Google Scholar

[17] Song, B. K., Kim, K. M., Choi, K. D., & Im, W. T. (2017). Production of the rare ginsenoside rh2-mix (20(. Journal of microbiology and biotechnology, 27(7), 1233-1241. Search in Google Scholar

[18] Liu, L., Wang, H., Chai, X., Meng, Q., Jiang, S., & Zhao, F. (2022). Advances in biocatalytic synthesis, pharmacological activities, pharmaceutical preparation and metabolism of ginsenoside Rh2. Mini Reviews in Medicinal Chemistry, 22(3), 437-448. Search in Google Scholar

[19] Ma, W., Zhao, L., Ma, Y., Li, Y., Qin, S., & He, B. (2020). Oriented efficient biosynthesis of rare ginsenoside Rh2 from PPD by compiling UGT-Yjic mutant with sucrose synthase. International journal of biological macromolecules, 146, 853-859. Search in Google Scholar

[20] Markus, J., Mathiyalagan, R., Kim, Y. J., Han, Y., Jiménez-Pérez, Z. E., Veronika, S., & Yang, D. C. (2019). Synthesis of hyaluronic acid or O-carboxymethyl chitosan-stabilized ZnO–ginsenoside Rh2 nanocomposites incorporated with aqueous leaf extract of Dendropanax morbifera Léveille: In vitro studies as potential sunscreen agents. New Journal of Chemistry, 43(23), 9188-9200. Search in Google Scholar

[21] Wilson, W. B., & Sander, L. C. (2018). Method development for the certification of a ginsenoside calibration solution via liquid chromatography with absorbance and mass spectrometric detection. Journal of Chromatography A, 1574, 114-121. Search in Google Scholar

[22] Kazan, A., Hu, X., Stahl, A., Frerichs, H., Smirnova, I., & Yesil‐Celiktas, O. (2021). An enzyme immobilized microreactor for continuous‐flow biocatalysis of ginsenoside Rb1. Journal of Chemical Technology & Biotechnology, 96(12), 3349-3357. Search in Google Scholar

[23] Jeong, E. B., Kim, S. A., Shin, K. C., & Oh, D. K. (2020). Biotransformation of protopanaxadiol-type ginsenosides in Korean ginseng extract into food-available compound K by an extracellular enzyme from Aspergillus niger. Search in Google Scholar

[24] Fu, Y. (2019). Biotransformation of ginsenoside Rb1 to Gyp‐XVII and minor ginsenoside Rg3 by endophytic bacterium Flavobacterium sp. GE 32 isolated from Panax ginseng. Letters in applied microbiology, 68(2), 134-141. Search in Google Scholar