<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Exploring the construction of an anti-hepatitis B virus drug screening and evaluation system is to better develop anti-HBV virus drugs. In this paper, we analyzed the types of hepatitis B virus present in different hepatocytes, starting from the hepatitis B cell line model. Based on the quadratic, exponential smoothing model, a QES-LSTM viral gene detection model was constructed by introducing a long and short term memory neural network, and experimental analysis of the sensitivity and specificity of viral gene detection was conducted for this model. From the sensitivity experiments, the sensitivity of HBV DNA, DHBV DNA and DHBV cccDNA were 60 copies/ml, 60 copies/ml and 10 copies/ml, respectively. From the specificity experiments, the mean values of specificity of HBV DNA, DHBV DNA, and DHBV cccDNA were 0.489, 0.481, 0.429, respectively, 0.429, which showed positive amplification compared to other types. This indicates that effective discrimination of HBV viral genes is needed in the construction of an anti-HBV virus drug screening and evaluation system, which in turn allows targeted screening of drugs for the treatment of the HBV virus.</p>
</abstract>

Exploring the construction of an anti-hepatitis B virus drug screening and evaluation system is to better develop anti-HBV virus drugs. In this paper, we analyzed the types of hepatitis B virus present in different hepatocytes, starting from the hepatitis B cell line model. Based on the quadratic, exponential smoothing model, a QES-LSTM viral gene detection model was constructed by introducing a long and short term memory neural network, and experimental analysis of the sensitivity and specificity of viral gene detection was conducted for this model. From the sensitivity experiments, the sensitivity of HBV DNA, DHBV DNA and DHBV cccDNA were 60 copies/ml, 60 copies/ml and 10 copies/ml, respectively. From the specificity experiments, the mean values of specificity of HBV DNA, DHBV DNA, and DHBV cccDNA were 0.489, 0.481, 0.429, respectively, 0.429, which showed positive amplification compared to other types. This indicates that effective discrimination of HBV viral genes is needed in the construction of an anti-HBV virus drug screening and evaluation system, which in turn allows targeted screening of drugs for the treatment of the HBV virus.

Construction of a screening and evaluation system for anti-hepatitis B virus drugs based on quadratic exponential smoothing model

Applied Mathematics and Nonlinear Sciences

This work is licensed under the Creative Commons Attribution 4.0 International License.

Exploring the construction of an anti-hepatitis B virus drug screening and evaluation system is to better develop anti-HBV virus drugs. In this paper, we...

Construction of a screening and evaluation system for anti-hepatitis B virus drugs based on quadratic exponential smoothing model

Publicado en línea: 04 oct 2023

Páginas: -

Recibido: 01 dic 2022

Aceptado: 14 abr 2023

DOI: https://doi.org/10.2478/amns.2023.2.00502

Palabras clave
Quadratic exponential smoothing, QES-LSTM model, Hepatitis B virus, Genetic testing, Drug screening

© 2023 Yangding Xu et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Construction of a screening and evaluation system for anti-hepatitis B virus drugs based on quadratic exponential smoothing model

Publicado en línea: 04 oct 2023

Páginas: -

Recibido: 01 dic 2022

Aceptado: 14 abr 2023

DOI: https://doi.org/10.2478/amns.2023.2.00502

Palabras claveQuadratic exponential smoothing, QES-LSTM model, Hepatitis B virus, Genetic testing, Drug screening

© 2023 Yangding Xu et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Palabras clave
Quadratic exponential smoothing, QES-LSTM model, Hepatitis B virus, Genetic testing, Drug screening