Acceso abierto

New approach in Understanding Colorectal Cancer Immunosuppression and Immunotherapy-Based Strategies in the Treatment of Microsatellite Stable Colorectal Cancer


Cite

Rawla P, Sunkara T, Barsouk A. Epidemiology of colorectal cancer: incidence, mortality, survival, and risk factors. Prz Gastroenterol. 2019; 14(2):89-103. Search in Google Scholar

Goodla L, Xue X. The Role of Inflammatory Mediators in Colorectal Cancer Hepatic Metastasis. Cells. 2022; 11(15):2313. Search in Google Scholar

Bhat AA, Nisar S, Singh M et al. Cytokine- and chemokine-induced inflammatory colorectal tumor microenvironment: Emerging avenue for targeted therapy. Cancer Commun (Lond). 2022; 42(8):689-715. Search in Google Scholar

Lucas C, Barnich N, Nguyen HTT. Microblota, Inflammatlon and Colorectal Cancer. Int J Mol Sci. 2017; 18(6):1310. Search in Google Scholar

Grivennikov SI, Greten FR, Karin M. Immunity, inflammation, and cancer. Cell. 2010; 140(6):883-99. Search in Google Scholar

Kim ER, Chang DK. Colorectal cancer in inflammatory bowel disease: the risk, pathogenesis, prevention and diagnosis. World J Gastroenterol. 2014; 20(29):9872-81. Search in Google Scholar

Borowczak J, Szczerbowski K, Maniewski M, et al. The Role of Inflammatory Cytokines in the Pathogenesis of Colorectal Carcinoma-Recent Findings and Review. Biomedicines. 2022; 10(7): 1670. Search in Google Scholar

Coussens LM, Zitvogel L, Palucka AK. Neutralizing tumorpromoting chronic inflammation: a magic bullet? Science. 2013; 339(6117):286-91. Search in Google Scholar

Tuomisto AE, Mäkinen MJ, Väyrynen JP. Systemic inflammation in colorectal cancer: Underlying factors, effects, and prognostic significance. World J Gastroenterol. 2019; 25(31):4383-4404. Search in Google Scholar

Gulubova MV, Chonov DC, Ivanova KV, et al. Intratumoural expression of IL-6/STAT3, IL-17 and FOXP3 immune cells in the mmunosuppressive tumour microenvironment of colorectal cancer. Immune cells-positive for IL-6,STAT3, IL-17 and FOXP3 and colorectal cancer development. Biotechnol Biotechnological Equipment, 2022; 36:1, 327-338, DOI: 10.1080/13102818.2022.2072765 Search in Google Scholar

De Simone V, Franzè E, Ronchetti G, et al. Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth. Oncogene. 2015; 34(27):3493-503. Search in Google Scholar

Kitamura H, Ohno Y, Toyoshima Y, et al. lnterleukin-6/STAT3 signaling as a promising target to improve the efficacy of cancer immunotherapy. Cancer Sci. 2017; 108(10): 1947-1952. Search in Google Scholar

Lin Y, He Z, Ye J, et al. Progress in Understanding the IL-6/STAT3 Pathway in Colorectal Cancer. Onco Targets Ther. 2020; 13:13023-13032. Search in Google Scholar

Rossi JF, Negrier S, James ND, etal. A phase l/ll study of siltuximab (CNTO 328), an anti-interleukin-6 monoclonal antibody, in metastatic renal cell cancer. Br J Cancer 2010; 103:1154-1162. Search in Google Scholar

Puchalski T, Prabhakar U, Jiao Q, et al. Pharmacokinetic and pharmacodynamics modeling of an anti-inteleukin-6 chimeric monoclonal antibody (siltuximab) in patients with metastatic renal cell carcinoma. Clin Cancer Res 2010; 16:1652-1661. Search in Google Scholar

Li J, Xu J, Yan X, et al. Targeting lnterleukin-6 (IL-6) Sensitizes Anti-PD-L1 Treatment in a Colorectal Cancer Preclinical Model. Med Sci Monit. 2018; 24:5501-5508. Search in Google Scholar

Kimura A, Kishimoto T. IL-6: regulator of Treg/Th17 balance. Eur J Immunol 2010; 40:1830-1835. Search in Google Scholar

Mace TA, Shakya R, Pitarresi JR, et al. IL-6 and PD-L1 antibody blockade combination therapy reduces tumour progression in murine models of pancreatic cancer. Gut 2016. https://di.org/10.1136/gutjnl-2016-311585 Search in Google Scholar

Dijkgraaf EM, Santegoets SJ, Reyners AK, et al. A phase I trial combining carboplatin/doxorubicin with tocilizumab, an anti-IL-6R monoclonal antibody, and interferon-α2b in patients with recurrent epithelial ovarian cancer. Ann Oncol. 2015; 26(10):2141-9. Search in Google Scholar

Zhang Y, Rajput A, Jin N, et al. Mechanisms of Immunosuppression in Colorectal Cancer. Cancers (Basel). 2020; 12(12):3850. Search in Google Scholar

Velikova TV, Miteva L, Stanilov N, et al. lnterleukin-6 compared to the other Th17/Treg related cytokines in inflammatory bowel disease and colorectal cancer. World J Gastroenterol. 2020; 26(16):1912-1925. Search in Google Scholar

Tseng-Rogenski SS, Hamaya Y, Choi DY, et al. Interteukin 6 alters localization of hMSH3, leading to DNA mismatch repair defects in colorectal cancer cells. Gastroenterology. 2015; 148(3):579-89. Search in Google Scholar

Grivennikov SI, Wang Κ, Mucida D, et al. Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth. Nature. 2012; 491(7423):254-8. Search in Google Scholar

Chung L, Thiele Orberg E, Geis AL, et al. Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells. Cell Host Microbe. 2018; 23(2):203-214.e5. Search in Google Scholar

Lin Y, Xu J, Su H, et al. lnterleukin-17 is a favorable prognostic marker for colorectal cancer. Clin Transl Oncol. 2015; 17(1):50-6. Search in Google Scholar

Pan B, Shen J, Cao J, et al. lnterleukin-17 promotes angiogenesis by stimulating VEGF production of cancer cells via the STAT3/GIV signaling pathway in non-small-cell lung cancer. Sci Rep. 2015; 5:16053. doi: Search in Google Scholar

Cui G, Li Z, Florholmen J, et al. Dynamic stromal cellular reaction throughout human colorectal adenoma-carcinoma sequence: A role of TH17/IL-17A. Biomed Pharmacother. 2021; 140:111761. Search in Google Scholar

Tong Z, Yang XO, Yan H, et al. A protective role by interleukin 17F in colon tumorigenesis. PLoS One. 2012; 7(4):e34959. Search in Google Scholar

Hurtado CG, Wan F, Housseau F, et al. Roles for Interleukin 17 and Adaptive Immunity in Pathogenesis of Colorectal Cancer. Gastroenterology. 2018 Dec; 155(6):1706-1715. Search in Google Scholar

Li X, Wang Y, Han C, et al. Colorectal cancer progression is associated with accumulation of Th17 lymphocytes in tumor tissues and increased serum levels of interleukin-6. Tohoku J Exp Med. 2014; 233(3):175-82. Search in Google Scholar

Salama P, Phillips M, Grieu F, et al. Tumor-infiltrating FOXP3+T regulatory cells show strong prognostic significance in colorectal cancer. J Clin Oncol. 2009; 27(2):186-92. Search in Google Scholar

Frey DM, Droeser RA, Viehl CT, et al. High frequency of tumor-infiltrating FOXP3(+) regulatory T cells prediets improved survival in mismatch repair-proficient colorectal cancer patients. Int J Cancer. 2010; 126(11):2635-43. Search in Google Scholar

Ladoire S, Martin F, Ghiringhelli F. Prognostic role of FOXP3+ regulatory T cells infiltrating human carcinomas: the paradox of colorectal cancer. Cancer Immunol Immunother. 2011; 60(7):909-18. Search in Google Scholar

Xu P, Fan W, Zhang Z, et al. The Clinicopathological and Prognostic Implications of FoxP3+ Regulatory T Cells in Patients with Colorectal Cancer: A Meta-Analysis. Front Physiol. 2017; 8:950. Search in Google Scholar

Cavalleri T, Bianchi P, Basso G, et al. Alleanza contro il Cancro (ACC) Colorectal Cancer Working Group. Combined Low Densities of FoxP3+ and CD3+ Tumor-infiltrating Lymphocytes Identify Stage II Colorectal Cancer at High Risk of Progression. Cancer Immunol Res. 2019; 7(5):751-758. Search in Google Scholar

Rezalotfi A, Ahmadian E, Aazami H, et al. Gastric Cancer Stem Cells Effect on Th17/Treg Balance; A Bench to Beside Perspective. Front Oncol. 2019; 9:226. Search in Google Scholar

Aristin Revilla S, Kranenburg Ο, Coffer PJ. Colorectal Cancer-lnfiltrating Regulatory T Cells: Functional Heterogeneity, Metabolic Adaptation, and Therapeutic Targeting. Front Immunol. 2022; 13:903564. Search in Google Scholar

Kuwahara T, Hazama S, Suzuki N, et al. Intratumoural-infiltrating CD4+and FOXP3+T cells as strong positive predictive markers for the prognosis of resectable colorectal cancer. Br J Cancer. 2019; 121(8):659-665. Search in Google Scholar

Llosa NJ, Luber B, Tarn AJ, et al. Intratumoral Adaptive Immunosuppression and Type 17 Immunity in Mismatch Repair Proficient Colorectal Tumors. Clin Cancer Res. 2019; 25(17):5250-5259. Search in Google Scholar

Willis JA, Overman MJ, Vilar E. Mismatch Repair-Proficient Colorectal Cancer: Finding the Right TiME to Respond. Clin Cancer Res. 2019;25(17):5185-5187. Search in Google Scholar

Liu C, Liu R, Wang Β, et al. Blocking IL-17A enhances tumor response to anti-PD-1 immunotherapy in microsatellite stable colorectal cancer. J Immunother Cancer. 2021 ;9(1):e001895. Search in Google Scholar

André T, Cohen R, Salem ME. Immune Checkpoint Blockade Therapy in Patients with Colorectal Cancer Harboring Microsatellite Instability/Mismatch Repair Deficiency in 2022. Am Soc Clin Oncol Educ Book. 2022a;42:1-9. Search in Google Scholar

Svrcek M, Lascols O, Cohen R, et al. MSI/MMR-deficient tumor diagnosis: Which standard for screening and for diagnosis? Diagnostic modalities for the colon and other Sites: Differences between tumors. Bull Cancer. 2019;106(2):119-128. Search in Google Scholar

André T, Lonardi S, Wong KYM, et al. Nivolumab plus lowdose ipilimumab in previously treated patients with microsatellite instability-high/mismatch repair-deficient metastatic colorectal cancer: 4-year follow-up from CheckMate 142. Ann Oncol. 2022b;33(10):1052-1060. Search in Google Scholar

Guyot D'Asnières De Salins A, Tachon G, Cohen R, et al. Discordance between immunochemistry of mismatch repair proteins and molecular testing of microsatellite instability in colorectal cancer. ESMO Open. 2021;6(3):100120. Search in Google Scholar

Ganesh K, Stadler ZK, Cercek A, et al. Immunotherapy in colorectal cancer: rationale, challenges and potential. Nat Rev Gastroenterol Hepatol. 2019;16(6):361-375. Search in Google Scholar

Hurwitz H, Fehrenbacher L, Novotny W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. Ν Engl J Med. 2004;350(23):2335-42. Search in Google Scholar

Tabernero J, Yoshino T, Cohn AL, et al. RAISE Study Investigators. Ramucirumab versus placebo in combination with second-line FOLFIRI in patients with metastatic colorectal carcinoma that progressed during or after first-line therapy with bevacizumab, oxaliplatin, and a fluoropyrimidine (RAISE): a randomised, double-blind, multicentre, phase 3 study. Lancet Oncol. 2015;16(5):499-508. Search in Google Scholar

Baran B, Ozupek NM, Tetik NY, et al. Difference between left-sided and right-sided colorectal cancer: a focused review of literature. Gastroenterol Res 2018;11(4): 264-273. Search in Google Scholar

Fakih M, Wong R. Efficacy of the monoclonal antibody EGFR inhibitors for the treatment of metastatic colorectal cancer. Curr Oncol. 2010; 17 Suppl 1(Suppl 1):S3-17. Search in Google Scholar

Lee JJ, Chu E. Recent Advances in the Clinical Development of Immune Checkpoint Blockade Therapy for Mismatch Repair Proficient (pMMR)/non-MSI-H Metastatic Colorectal Cancer. Clin Colorectal Cancer. 2018;17(4):258-273. Search in Google Scholar

Wilkinson K, Ng W, Roberts TL, et al. Tumour immune microenvironment biomarkers predicting cytotoxic chemotherapy efficacy in colorectal cancer. J Clin Pathol. 2021;74(10):625-634. Search in Google Scholar

Talaat IM, Elemam NM, Zaher S, et al. Checkpoint molecules on infiltrating immune cells in colorectal tumor microenvironment. Front Med (Lausanne). 2022;9:955599. Search in Google Scholar

Jacobs J, Smits E, Lardon F, et al. Immune Checkpoint Modulation in Colorectal Cancer: What's New and What to Expect. J Immunol Res. 2015;2015:158038. Search in Google Scholar

André T, Shiu KK, Kim TW, et al. KEYNOTE-177 Investigators. Pembrolizumab in Microsatellite-Instability-High Advanced Colorectal Cancer. Ν Engl J Med. 2020;383(23):2207-2218. Search in Google Scholar

Huyghe N, Benidovskaya E, Stevens Ρ, et al. Biomarkers of Response and Resistance to Immunotherapy in Microsatellite Stable Colorectal Cancer: Toward a New Personalized Medicine. Cancers (Basel). 2022;14(9):2241. Search in Google Scholar

Moroney JW, Powderly J, Lieu CH, et al. Safety and Clinical Activity of Atezolizumab Plus Bevacizumab in Patients with Ovarian Cancer: A Phase Ib Study. Clin Cancer Res. 2020;26(21):5631-5637. Search in Google Scholar

Chauvin JM, Zarour HM. TIGIT in cancer immunotherapy. J Immunother Cancer. 2020;8(2):e000957. Search in Google Scholar

Guinney J, Dienstmann R, Wang X, et al. The consensus molecular subtypes of colorectal cancer. Nat Med. 2015;21(11):1350-6. Search in Google Scholar

Lenz HJ, Van Cutsem E, Luisa Limon M, et al. First-Line Nivolumab Plus Low-Dose Ipilimumab for Microsatellite Instability-High/Mismatch Repair-Deficient Metastatic Colorectal Cancer: The Phase II CheckMate 142 Study. J Clin Oncol. 2022 Jan 10;40(2):161-170. doi: 10.1200/JCO.21.01015. Epub 2021 Oct 12. PMID: 34637336. Search in Google Scholar

Gong J, Wang C, Lee PP, et al. Response to PD-1 Blockade in Microsatellite Stable Metastatic Colorectal Cancer Harboring a POLE Mutation. J Natl Compr Canc Netw. 2017;15(2):142-147. Search in Google Scholar

Domingo E, Freeman-Mills L, Rayner E, et al. Somatic POLE proofreading domain mutation, immune response, and prognosis in colorectal cancer: a retrospective, pooled biomarker study. Lancet Gastroenterol Hepatol. 2016;1(3):207-216. Search in Google Scholar

Baraibar I, Mirallas Ο, Saoudi Ν, et al. Combined Treatment with Immunotherapy-Based Strategies for MSS Metastatic Colorectal Cancer. Cancers (Basel). 2021;13(24):6311. Search in Google Scholar

Vincent J, Mignot G, Chalmin F, et al. 5-Fluorouracil selectively kills tumor-associated myeloid-derived suppressor cells resulting in enhanced T cell-dependent antitumor immunity. Cancer Res. 2010;70(8):3052-61. Search in Google Scholar

Di Biasio S, Wortel IM, van Bladel DA, et al. Human CD1c(+) DCs are critical cellular mediators of immune responses induced by immunogenic cell death. Oncoimmunology. 2016;5(8):e1192739. Search in Google Scholar

Galaine J, Turco C, Vauchy C, et al. CD4 T cells target colorectal cancer antigens upregulated by oxaliplatin. Int J Cancer. 2019;145(11):3112-3125. Search in Google Scholar

Stewart R, Morrow M, Hammond SA, et al. Identification and Characterization of MEDI4736, an Antagonistic Anti-PD-L1 Monoclonal Antibody. Cancer Immunol Res. 2015;3(9):1052-62. Search in Google Scholar

Cremolini C, Antoniotti C, Rossini D, et al. GONO Foundation Investigatore. Upfront FOLFOXIRI plus bevacizumab and reintroduction after progression versus mFOLFOX6 plus bevacizumab followed by FOLFIRI plus bevacizumab in the treatment of patients with metastatic colorectal cancer (TRIBE2): a multicentre, open-label, phase 3, randomised, controlled trial. Lancet Oncol. 2020;21(4):497-507. Search in Google Scholar

Tabernero J, Grothey A, Arnold D, et al. MODUL cohort 2: an adaptable, randomized, signal-seeking trial of fluoropyrimidine plus bevacizumab with or without atezolizumab maintenance therapy for BRAFwt metastatic colorectal cancer. ESMO Open. 2022;7(5): 100559. Search in Google Scholar

Wang W, Wu L, Zhang J, et al. Chemoimmunotherapy by combining oxaliplatin with immune checkpoint blockades reduced tumor burden in colorectal cancer animai model. Biochem Biophys Res Commun. 2017;487(1):1-7. Search in Google Scholar

Kato Y, Tabata K, Kimura T, et al. Lenvatinib plus anti-PD-1 antibody combination treatment activates CD8+ T cells through reduction of tumor-associated macrophage and activation of the interferon pathway. PLoS One. 2019;14(2):e0212513. Search in Google Scholar

Segal NH, Cercek A, Ku G, et al. Phase II Single-arm Study of Durvalumab and Tremelimumab with Concurrent Radiotherapy in Patients with Mismatch Repair-proficient Metastatic Colorectal Cancer. Clin Cancer Res. 2021 ;27(8):2200-2208. Search in Google Scholar

Vanpouille-Box C, Formenti SC, Demaria S. Toward Precision Radiotherapy for Use with Immune Checkpoint Blockers. Clin Cancer Res. 2018;24(2):259-265. Search in Google Scholar

D'Souza WN, Chang CF, Fischer AM, et al. The Erk2 MAPK regulates CD8 T cell proliferation and survival. J Immunol. 2008; 181(11)7617-29. Search in Google Scholar

Canon J, Rex K, Saiki AY, et al. The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity. Nature. 2019;575(7781):217-223. Search in Google Scholar

Kopetz S, Grothey A, Yaeger R, et al. Encorafenib, Binimetinib, and Cetuximab in BRAF V600E-Mutated Colorectal Cancer. Ν Engl J Med. 2019;381 (17): 1632-1643. Search in Google Scholar

Liu L, Mayes PA, Eastman S, et al. The BRAF and MEK Inhibitors Dabrafenib and Trametinib: Effects on Immune Function and in Combination with Immunomodulatory Antibodies Targeting PD1, PD-L1, and CTLA4. Clin Cancer Res. 2015;21(7):1639-51. Search in Google Scholar

Labrijn AF, Janmaat ML, Reichert JM, et al. Bispecific antibodies: a mechanistic review of the pipeline. Nat Rev Drug Discov. 2019;18(8):585-608. Search in Google Scholar

Osada T, Patel SP, Hammond SA, et al. CEA/CD3 bispecific T cell-engaging (BiTE) antibody-mediated T lymphocyte cytotoxicity maximized by inhibition of both PD1 and PD-L1. Cancer Immunol Immunother. 2015;64(6):677-88. Search in Google Scholar

Caballero-Baños M, Benitez-Ribas D, Tabera J, et al. Phase II randomised trial of autologous tumour lysate dendritic cell plus best supportive care compared with best supportive care in pre-treated advanced colorectal cancer patients. Eur J Cancer. 2016;64:167-74. Search in Google Scholar

Chon HJ, Kim H, Noh JH, et al. STING signaling is a potential immunotherapeutic target in colorectal cancer. J Cancer. 2019;10(20):4932-4938. Search in Google Scholar

Geevarghese SK, Geller DA, de Haan HA, et al. Phase l/ll study of oncolytic herpes simplex virus NV1020 in patients with extensively pretreated refractory colorectal cancer metastatic to the liver. Hum Gene Ther. 2010;21(9):1119-28. Search in Google Scholar

eISSN:
2719-5384
Idioma:
Inglés
Calendario de la edición:
4 veces al año
Temas de la revista:
Medicine, Basic Medical Science, Immunology, Clinical Medicine, other