<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Genetic, endocrine and immunological disorders, anatomical defects in the reproductive tract, certain chronic diseases, toxic substances, or advanced age of the mother are most cited among the main causes of pregnancy loss at various stages. However, the cause of miscarriage or preterm labor in some cases remains unclear. Determination of the etiology about these clinical conditions may reduce the rate of reproductive failure. Similarly, the etiology of other obstetric disorders, such as preeclampsia or postpartum hemorrhage, has not been fully explained. One of the postulated and still under-researched causes of these disorders may be dysbiosis within the reproductive tract. A disturbed microbial balance is not always associated with the presence of an acute infection with clear clinical symptoms. Dysbiosis in conjunction with other pathophysiological factors may increase the risk of the mentioned clinical conditions. The aim of this paper is to show the information indicating the existence of a correlation between dysbiosis and an increase in the risk of obstetric disorders. Further analysis is also required to clarify the mechanism of the effect of dysbiosis on the disruption of metabolic and biochemical processes within the reproductive system during pregnancy.</p>
</abstract>

Genetic, endocrine and immunological disorders, anatomical defects in the reproductive tract, certain chronic diseases, toxic substances, or advanced age of the mother are most cited among the main causes of pregnancy loss at various stages. However, the cause of miscarriage or preterm labor in some cases remains unclear. Determination of the etiology about these clinical conditions may reduce the rate of reproductive failure. Similarly, the etiology of other obstetric disorders, such as preeclampsia or postpartum hemorrhage, has not been fully explained. One of the postulated and still under-researched causes of these disorders may be dysbiosis within the reproductive tract. A disturbed microbial balance is not always associated with the presence of an acute infection with clear clinical symptoms. Dysbiosis in conjunction with other pathophysiological factors may increase the risk of the mentioned clinical conditions. The aim of this paper is to show the information indicating the existence of a correlation between dysbiosis and an increase in the risk of obstetric disorders. Further analysis is also required to clarify the mechanism of the effect of dysbiosis on the disruption of metabolic and biochemical processes within the reproductive system during pregnancy.

Effect of Reproductive System Dysbiosis on the Course of Pregnancy

Advancements of Microbiology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"Effect of Reproductive System Dysbiosis on the Course of Pregnancy"}

Genetic, endocrine and immunological disorders, anatomical defects in the reproductive tract, certain chronic diseases, toxic substances, or advanced age of...

Course of pregnancy	Organ	Microbiota
Physiological pregnancy	vagina	high abundance and low diversity of microbiota: mainly Lactobacillus
Physiological pregnancy	uterus	low numbers and high biodiversity of microbiota: Lactobacillus, Cutibacterium, Escherichia, Staphylococcus, Acinetobacter, Streptococcus, Corynebacterium
Physiological pregnancy	placenta	small numbers and high biodiversity of microbiota: Lactobacillus, Escherichia coli, Cutibacterium acnes, Bacteroides sp. Neisseria lactamica, Fusobacterium sp., Rhodococcus erythropolis, Prevotella tannerae, Neisseria polysaccharea, Streptomyces avermitilis, Enterobacteriaceae sp., Cutibacterium acnes
Physiological pregnancy	cord blood	small amount and high biodiversity of microbiota: Enterococcus faecium, Propionibacterium acnes, Staphylococcus epidermidis i Streptococcus sanguinis
Miscarriage	vagina	decrease in the number of Lactobacillus
Preterm birth	vagina	decrease in the number of Lactobacillus bacteria, increase in the number of bacteria: Bacteroides (Firmicutes), Prevotella (Bacteroidetes), Klebsiella (Proteobacteria) and Mobiluncus (Actinobacteria)
Preeclampsia	placenta	decrease in the number of Lactobacillus, increase in the number of Bacteroides
Postpartum hemorrhage	uterus and placenta	decrease in the number of Lactobacillus, increase in the number of Bacteroides

Effect of Reproductive System Dysbiosis on the Course of Pregnancy

Publicado en línea: 03 jul 2024

Páginas: 93 - 99

Recibido: 01 abr 2024

Aceptado: 01 jun 2024

DOI: https://doi.org/10.2478/am-2024-0008

Palabras clave
female reproductive tract microbiota, genital infections, pregnancy

© 2024 Karolina Piekarz et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Fig. 1.

Composition of the microbiota of the reproductive organs in physiological pregnancy and pregnancy with complications.

Effect of Reproductive System Dysbiosis on the Course of Pregnancy

Publicado en línea: 03 jul 2024

Páginas: 93 - 99

Recibido: 01 abr 2024

Aceptado: 01 jun 2024

DOI: https://doi.org/10.2478/am-2024-0008

Palabras clavefemale reproductive tract microbiota, genital infections, pregnancy

© 2024 Karolina Piekarz et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Fig. 1.

Composition of the microbiota of the reproductive organs in physiological pregnancy and pregnancy with complications.

Palabras clave
female reproductive tract microbiota, genital infections, pregnancy