<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>The larvae of the insect <italic>Galleria mellonella</italic> have gained wide acceptance as an <italic>in vivo</italic> model for the study of virulence in Gram-negative and Gram-positive bacteria and fungi. Importantly, <italic>G. mellonella</italic> offers an alternative, low-cost, and ethically acceptable method of assessing pathogens. These insects have a number of advantages, including ease of breeding, a rapid developmental cycle, low maintenance costs, and ease of experimental manipulation. Most importantly, <italic>G. mellonella</italic> larvae have a complete immune system and a nonspecific immune response similar to that of humans, making them a valuable model for studying pathogen-host interactions. Furthermore, using this model, it is possible to test the efficacy of various chemical compounds or natural substances that show antimicrobial activity. In this literature review, we provide a comprehensive overview of recent studies of the use of <italic>G. mellonella</italic> in virulence analyses and as a platform for testing the efficacy of new drugs.</p>
</abstract>

The larvae of the insect Galleria mellonella have gained wide acceptance as an in vivo model for the study of virulence in Gram-negative and Gram-positive bacteria and fungi. Importantly, G. mellonella offers an alternative, low-cost, and ethically acceptable method of assessing pathogens. These insects have a number of advantages, including ease of breeding, a rapid developmental cycle, low maintenance costs, and ease of experimental manipulation. Most importantly, G. mellonella larvae have a complete immune system and a nonspecific immune response similar to that of humans, making them a valuable model for studying pathogen-host interactions. Furthermore, using this model, it is possible to test the efficacy of various chemical compounds or natural substances that show antimicrobial activity. In this literature review, we provide a comprehensive overview of recent studies of the use of G. mellonella in virulence analyses and as a platform for testing the efficacy of new drugs.

Galleria Mellonella Larvae as an <italic>In vitro</italic> Model for Testing Microbial Pathogenicity

Department of Microbiology, Institute of Biology

Advancements of Microbiology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Galleria Mellonella Larvae as an  Model for Testing Microbial Pathogenicity

The larvae of the insect Galleria mellonella have gained wide acceptance as an in vivo model for the study of virulence in Gram-negative and Gram-positive...

Galleria Mellonella Larvae as an In vitro Model for Testing Microbial Pathogenicity

Publicado en línea: 09 nov 2023

Páginas: 173 - 182

Recibido: 01 jul 2023

Aceptado: 01 sept 2023

DOI: https://doi.org/10.2478/am-2023-0015

Palabras clave
microbial pathogenesis, model

© 2023 Dawid Gniazdo et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Galleria Mellonella Larvae as an In vitro Model for Testing Microbial Pathogenicity

Publicado en línea: 09 nov 2023

Páginas: 173 - 182

Recibido: 01 jul 2023

Aceptado: 01 sept 2023

DOI: https://doi.org/10.2478/am-2023-0015

Palabras clavemicrobial pathogenesis, model

© 2023 Dawid Gniazdo et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Palabras clave
microbial pathogenesis, model