This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
2019 antibacterial agents in clinical development: an analysis of the antibacterial clinical development pipeline, https://www.who.int/publications-detail-redirect/9789240000193 (2021)2019 antibacterial agents in clinical development: an analysis of the antibacterial clinical development pipelinehttps://www.who.int/publications-detail-redirect/97892400001932021Search in Google Scholar
Kabra R., Chauhan N., Kumar A., Ingale P., Singh S.: Efflux pumps and antimicrobial resistance: Paradoxical components in systems genomics. Prog. Biophys. Mol. Biol. 141, 15–24 (2019)KabraR.ChauhanN.KumarA.IngaleP.SinghS.Efflux pumps and antimicrobial resistance: Paradoxical components in systems genomicsProg. Biophys. Mol. Biol1411524201910.1016/j.pbiomolbio.2018.07.008Search in Google Scholar
Reygaert W.C.: An overview of the antimicrobial resistance mechanisms of bacteria. AIMS. Microbiol. 4, 482–501 (2018)ReygaertW.C.An overview of the antimicrobial resistance mechanisms of bacteriaAIMS. Microbiol4482501201810.3934/microbiol.2018.3.482Search in Google Scholar
Nikaido H.: Multiple antibiotic resistance and efflux. Curr. Opin. Microbiol. 1, 516–523 (1998)NikaidoH.Multiple antibiotic resistance and effluxCurr. Opin. Microbiol1516523199810.1016/S1369-5274(98)80083-0Search in Google Scholar
Langevin A.M., Dunlop M.J.: Stress introduction rate alters the benefit of AcrAB-TolCefflux pumps. J. Bacteriol. 200, e00525–17 (2017)LangevinA.M.DunlopM.J.Stress introduction rate alters the benefit of AcrAB-TolCefflux pumpsJ. Bacteriol200e0052517201710.1128/JB.00525-17Search in Google Scholar
He X., Lu F., Yuan F., Jiang D., Zhao P., Zhu J., Cheng H., Cao J., Lu G.: Biofilm formation caused by clinical Acinetobacter baumannii isolates is associated with overexpression of the AdeFGH efflux pump. Antimicrob. Agents. Chemother. 59, 4817–4825 (2015)HeX.LuF.YuanF.JiangD.ZhaoP.ZhuJ.ChengH.CaoJ.LuG.Biofilm formation caused by clinical Acinetobacter baumannii isolates is associated with overexpression of the AdeFGH efflux pumpAntimicrob. Agents. Chemother5948174825201510.1128/AAC.00877-15450522726033730Search in Google Scholar
Favre-Bonté S., Köhler T., Van Delden C.: Biofilm formation by Pseudomonas aeruginosa: role of the C4-HSL cell-to-cell signal and inhibition by azithromycin. J. Antimicrob. Chemother. 52, 598–604 (2003)Favre-BontéS.KöhlerT.Van DeldenC.Biofilm formation by Pseudomonas aeruginosa: role of the C4-HSL cell-to-cell signal and inhibition by azithromycinJ. Antimicrob. Chemother52598604200310.1093/jac/dkg39712951348Search in Google Scholar
Schembri M.A., Kjaergaard K., Klemm P.: Global gene expression in Escherichia coli biofilms. Mol. Microbiol. 48, 253–267 (2003)SchembriM.A.KjaergaardK.KlemmP.Global gene expression in Escherichia coli biofilmsMol. Microbiol48253267200310.1046/j.1365-2958.2003.03432.x12657059Search in Google Scholar
Diggle S.P., Winzer K., Lazdunski A., Williams P., Cámara M.: Advancing the quorum in Pseudomonas aeruginosa: MvaT and the regulation of N-acylhomoserine lactone production and virulence gene expression. J. Bacteriol. 184, 2576–2586 (2002)DiggleS.P.WinzerK.LazdunskiA.WilliamsP.CámaraM.Advancing the quorum in Pseudomonas aeruginosa: MvaT and the regulation of N-acylhomoserine lactone production and virulence gene expressionJ. Bacteriol18425762586200210.1128/JB.184.10.2576-2586.200213501211976285Search in Google Scholar
Thanassi D.G., Cheng L.W., Nikaido H.: Active efflux of bile salts by Escherichia coli. J. Bacteriol. 179, 2512–2518 (1997)ThanassiD.G.ChengL.W.NikaidoH.Active efflux of bile salts by Escherichia coliJ. Bacteriol17925122518199710.1128/jb.179.8.2512-2518.19971789979098046Search in Google Scholar
Taylor D.L., Bina X.R., Bina J.E.: Vibrio cholerae VexH encodes a multiple drug efflux pump that contributes to the production of cholera toxin and the toxin co-regulated pilus. PloS One, 7, e38208 (2012)TaylorD.L.BinaX.R.BinaJ.E.Vibrio cholerae VexH encodes a multiple drug efflux pump that contributes to the production of cholera toxin and the toxin co-regulated pilusPloS One7e38208201210.1371/journal.pone.0038208336422522666485Search in Google Scholar
Schindler B.D., Kaatz G.W.: Multi-drug efflux pumps of Gram-positive bacteria. Drug. Resist. Updat. Rev. Comment. Antimicrob. Anticancer. Chemother. 27, 1–13 (2016)SchindlerB.D.KaatzG.W.Multi-drug efflux pumps of Gram-positive bacteria. Drug. ResistUpdat. Rev. Comment. Antimicrob. Anticancer. Chemother27113201610.1016/j.drup.2016.04.003Search in Google Scholar
Li X-Z., Plésiat P., Nikaido H.: The challenge of efflux-mediated antibiotic resistance in Gram-negative bacteria. Clin. Microbiol. Rev. 28, 337–418 (2015)LiX-Z.PlésiatP.NikaidoH.The challenge of efflux-mediated antibiotic resistance in Gram-negative bacteriaClin. Microbiol. Rev28337418201510.1128/CMR.00117-14440295225788514Search in Google Scholar
Handzlik J., Matys A., Kieć-Kononowicz K.: Recent advances in Multi-Drug Resistance (MDR) efflux pump inhibitors of Gram-positive bacteria S. aureus. Antibiotics, 2, 28–45 (2013)HandzlikJ.MatysA.Kieć-KononowiczK.Recent advances in Multi-Drug Resistance (MDR) efflux pump inhibitors of Gram-positive bacteria S. aureusAntibiotics22845201310.3390/antibiotics2010028Search in Google Scholar
Sharma A., Gupta V.K., Pathania R.: Efflux pump inhibitors for bacterial pathogens: From bench to bedside. Indian. J. Med. Res. 149, 129–145 (2019)SharmaA.GuptaV.K.PathaniaR.Efflux pump inhibitors for bacterial pathogens: From bench to bedsideIndian. J. Med. Res149129145201910.4103/ijmr.IJMR_2079_17Search in Google Scholar
Auda I.G., Ali Salman I.M., Odah J.G.: Efflux pumps of Gram-negative bacteria in brief. Gene Reports, 100666 (2020)AudaI.G.Ali SalmanI.M.OdahJ.G.Efflux pumps of Gram-negative bacteria in briefGene Reports100666202010.1016/j.genrep.2020.100666Search in Google Scholar
Lubelski J., Konings W.N., Driessen A.J.M.: Distribution and physiology of ABC-type transporters contributing to multidrug resistance in bacteria. Microbiol. Mol. Biol. Rev. 71, 463–476 (2007)LubelskiJ.KoningsW.N.DriessenA.J.M.Distribution and physiology of ABC-type transporters contributing to multidrug resistance in bacteriaMicrobiol. Mol. Biol. Rev71463476200710.1128/MMBR.00001-07Search in Google Scholar
Pao SS., Paulsen I.T., Saier M.H. Jr.: Major facilitator super-family. Microbiol Mol. Biol. Rev. 62, 1–34 (1998)PaoSS.PaulsenI.T.SaierM.H.Jr.Major facilitator super-familyMicrobiol Mol. Biol. Rev62134199810.1128/MMBR.62.1.1-34.1998Search in Google Scholar
Kuroda T., Tsuchiya T.: Multidrug efflux transporters in the MATE family. Biochim. Biophys. Acta. BBA – Proteins. Proteomics. 1794, 763–768 (2009)KurodaT.TsuchiyaT.Multidrug efflux transporters in the MATE familyBiochim. Biophys. Acta. BBA – Proteins. Proteomics1794763768200910.1016/j.bbapap.2008.11.012Search in Google Scholar
Jack D.L., Yang N.M., Saier M.H Jr.: The drug/metabolite transporter superfamily: The DMT superfamily. Eur. J. Biochem. 268, 3620–3639 (2001)JackD.L.YangN.M.SaierM.HJr.The drug/metabolite transporter superfamily: The DMT superfamilyEur. J. Biochem26836203639200110.1046/j.1432-1327.2001.02265.xSearch in Google Scholar
Nikaido H., Takatsuka Y.: Mechanisms of RND multidrug efflux pumps. Biochim. Biophys. Acta. BBA – Proteins. Proteomics. 1794, 769–781 (2009)NikaidoH.TakatsukaY.Mechanisms of RND multidrug efflux pumpsBiochim. Biophys. Acta. BBA – Proteins. Proteomics1794769781200910.1016/j.bbapap.2008.10.004Search in Google Scholar
Mi W., Li Y., Yoon S.H., Ernst R.K., Walz T., Liao M.: Structural basis of MsbA-mediated lipopolysaccharide transport. Nature, 549, 233–237 (2017)MiW.LiY.YoonS.H.ErnstR.K.WalzT.LiaoM.Structural basis of MsbA-mediated lipopolysaccharide transportNature549233237201710.1038/nature23649Search in Google Scholar
Higgins C.F.: ABC transporters: physiology, structure and mechanism – an overview. Res. Microbiol. 152, 205–210 (2001)HigginsC.F.ABC transporters: physiology, structure and mechanism – an overviewRes. Microbiol152205210200110.1016/S0923-2508(01)01193-7Search in Google Scholar
Xiong J., Mao D., Liu L.: Research progress on the role of ABC transporters in the drug resistance mechanism of intractable epilepsy. BioMed. Res. Int. 2015, 1–10 (2015)XiongJ.MaoD.LiuL.Research progress on the role of ABC transporters in the drug resistance mechanism of intractable epilepsyBioMed. Res. Int2015110201510.1155/2015/194541460048326491660Search in Google Scholar
Wilkens S.: Structure and mechanism of ABC transporters. F1000Prime. Rep. 7, 14 (2015)WilkensS.Structure and mechanism of ABC transportersF1000Prime. Rep714201510.12703/P7-14433884225750732Search in Google Scholar
van Veen H.W., Venema K., Bolhuis H., Oussenko I., Kok J., Poolman B., Driessen A.J., Konings W.N.: Multidrug resistance mediated by a bacterial homolog of the human multidrug transporter MDR1. Proc. Natl. Acad. Sci. USA, 93, 10668–10672 (1996)van VeenH.W.VenemaK.BolhuisH.OussenkoI.KokJ.PoolmanB.DriessenA.J.KoningsW.N.Multidrug resistance mediated by a bacterial homolog of the human multidrug transporter MDR1Proc. Natl. Acad. Sci. USA931066810672199610.1073/pnas.93.20.10668382128855237Search in Google Scholar
Dalmas O., Do Cao M-A., Lugo M.R., Sharom F.J., Di Pietro A., Jault M.A.: Time-resolved fluorescence resonance energy transfer shows that the bacterial multidrug ABC half-transporter BmrA functions as a homodimer. Biochemistry, 44, 4312–4321 (2005)DalmasO.Do CaoM-A.LugoM.R.SharomF.J.Di PietroA.JaultM.A.Time-resolved fluorescence resonance energy transfer shows that the bacterial multidrug ABC half-transporter BmrA functions as a homodimerBiochemistry4443124321200510.1021/bi048280915766260Search in Google Scholar
Fitzpatrick A.W.P., Du D. et al.: Structure of the MacAB-TolC ABC-type tripartite multidrug efflux pump. Nat. Microbiol. 2, 17070 (2017)FitzpatrickA.W.P.DuD.Structure of the MacAB-TolC ABC-type tripartite multidrug efflux pumpNat. Microbiol217070201710.1038/nmicrobiol.2017.70544782128504659Search in Google Scholar
Choudhuri B.S., Bhakta S., Barik R., Basu J., Kundu M., Chakrabarti P.: Overexpression and functional characterization of an ABC (ATP-binding cassette) transporter encoded by the genes drrA and drrB of Mycobacterium tuberculosis. Biochem. J. 367, 279–285 (2002)ChoudhuriB.S.BhaktaS.BarikR.BasuJ.KunduM.ChakrabartiP.Overexpression and functional characterization of an ABC (ATP-binding cassette) transporter encoded by the genes drrA and drrB of Mycobacterium tuberculosisBiochem. J367279285200210.1042/bj20020615Search in Google Scholar
Robertson G.T., Doyle T.B., Lynch A.S.: Use of an efflux-deficient Streptococcus pneumoniae strain panel to identify ABC-class multidrug transporters involved in intrinsic resistance to antimicrobial agents. Antimicrob. Agents. Chemother. 49, 4781–4783 (2005)RobertsonG.T.DoyleT.B.LynchA.S.Use of an efflux-deficient Streptococcus pneumoniae strain panel to identify ABC-class multidrug transporters involved in intrinsic resistance to antimicrobial agentsAntimicrob. Agents. Chemother4947814783200510.1128/AAC.49.11.4781-4783.2005128015616251330Search in Google Scholar
Hürlimann L.M., Corradi V., Hohl M., Bloemberg G.V., Tieleman D.P., Seeger M.A.: The heterodimeric ABC transporter EfrCD mediates multidrug efflux in Enterococcus faecalis. Antimicrob. Agents. Chemother. 60, 5400–5411 (2016)HürlimannL.M.CorradiV.HohlM.BloembergG.V.TielemanD.P.SeegerM.A.The heterodimeric ABC transporter EfrCD mediates multidrug efflux in Enterococcus faecalisAntimicrob. Agents. Chemother6054005411201610.1128/AAC.00661-16499786027381387Search in Google Scholar
Al-Hamad A., Upton M., Burnie J.: Molecular cloning and characterization of SmrA, a novel ABC multi-drug efflux pump from Stenotrophomonas maltophilia. J. Antimicrob. Chemother. 64, 731–734 (2009)Al-HamadA.UptonM.BurnieJ.Molecular cloning and characterization of SmrA, a novel ABC multi-drug efflux pump from Stenotrophomonas maltophiliaJ. Antimicrob. Chemother64731734200910.1093/jac/dkp27119643774Search in Google Scholar
Matsuo T., Chen J., Minato Y., Ogawa W., Mizushima T., Kuroda T., Tsuchiya T.: SmdAB, a heterodimeric ABC-type multi-drug efflux pump, in Serratia marcescens. J. Bacteriol. 190, 648–654 (2008)MatsuoT.ChenJ.MinatoY.OgawaW.MizushimaT.KurodaT.TsuchiyaT.SmdAB, a heterodimeric ABC-type multi-drug efflux pump, in Serratia marcescensJ. Bacteriol190648654200810.1128/JB.01513-07222369118024518Search in Google Scholar
Huda N., Lee E-W., Chen J., Morita Y., Kuroda T., Mizushima T., Tsuchiya T.: Molecular cloning and characterization of an ABC multidrug efflux pump, VcaM, in non-O1 Vibrio cholerae. Antimicrob. Agents. Chemother. 47, 413–2417 (2003)HudaN.LeeE-W.ChenJ.MoritaY.KurodaT.MizushimaT.TsuchiyaT.Molecular cloning and characterization of an ABC multidrug efflux pump, VcaM, in non-O1 Vibrio choleraeAntimicrob. Agents. Chemother474132417200310.1128/AAC.47.8.2413-2417.2003Search in Google Scholar
Feng Z., Liu D., Liu Z., Liang Y., Wang Y., Liu Q., Liu Z., Zang Z., Cui Y.: Cloning and functional characterization of putative Escherichia coli ABC multidrug efflux transporter YddA. J. Microbiol. Biotechnol. 30, 982–995 (2020)FengZ.LiuD.LiuZ.LiangY.WangY.LiuQ.LiuZ.ZangZ.CuiY.Cloning and functional characterization of putative Escherichia coli ABC multidrug efflux transporter YddAJ. Microbiol. Biotechnol30982995202010.4014/jmb.2003.03003Search in Google Scholar
Quistgaard E.M., Löw C., Guettou F., Nordlund P.: Understanding transport by the major facilitator superfamily (MFS): structures pave the way. Nat. Rev. Mol. Cell. Biol. 17, 123–132 (2016)QuistgaardE.M.LöwC.GuettouF.NordlundP.Understanding transport by the major facilitator superfamily (MFS): structures pave the wayNat. Rev. Mol. Cell. Biol17123132201610.1038/nrm.2015.25Search in Google Scholar
Ren Q., Chen K., Paulsen I.T.: TransportDB: a comprehensive database resource for cytoplasmic membrane transport systems and outer membrane channels. Nucleic. Acids. Res. 35, D274–D279 (2007)RenQ.ChenK.PaulsenI.T.TransportDB: a comprehensive database resource for cytoplasmic membrane transport systems and outer membrane channelsNucleic. Acids. Res35D274D279200710.1093/nar/gkl925Search in Google Scholar
Henderson P.J.: The 12-transmembrane helix transporters. Curr. Opin. Cell. Biol. 5, 708–721 (1993)HendersonP.J.The 12-transmembrane helix transportersCurr. Opin. Cell. Biol5708721199310.1016/0955-0674(93)90144-FSearch in Google Scholar
Edgar R., Bibi E.: MdfA, an Escherichia coli multi-drug resistance protein with an extraordinarily broad spectrum of drug recognition. J. Bacteriol. 179, 2274 (1997)EdgarR.BibiE.MdfA, an Escherichia coli multi-drug resistance protein with an extraordinarily broad spectrum of drug recognitionJ. Bacteriol1792274199710.1128/jb.179.7.2274-2280.19971789649079913Search in Google Scholar
Putman M., van Veen H.W., Degener J.E., Konings W.N.: The lactococcal secondary multidrug transporter LmrP confers resistance to lincosamides, macrolides, streptogramins and tetracyclines. Microbiology, 147, 2873–2880 (2001)PutmanM.van VeenH.W.DegenerJ.E.KoningsW.N.The lactococcal secondary multidrug transporter LmrP confers resistance to lincosamides, macrolides, streptogramins and tetracyclinesMicrobiology14728732880200110.1099/00221287-147-10-287311577166Search in Google Scholar
Fontaine F., Hequet A., Voisin-Chiret A.S., Bouillon A., Lesnard A., Cresteil T., Jolivalt C., Rault S.: First identification of boronic species as novel potential inhibitors of the Staphylococcus aureus NorA efflux pump. J. Med. Chem. 57, 2536–2548 (2014)FontaineF.HequetA.Voisin-ChiretA.S.BouillonA.LesnardA.CresteilT.JolivaltC.RaultS.First identification of boronic species as novel potential inhibitors of the Staphylococcus aureus NorA efflux pumpJ. Med. Chem5725362548201410.1021/jm401808n24499135Search in Google Scholar
Bolhuis H., van Veen H.W., Poolman B., Driessen A.J., Konings W.N.: Mechanisms of multidrug transporters. FEMS. Microbiol. Rev. 21, 55–84 (1997)BolhuisH.van VeenH.W.PoolmanB.DriessenA.J.KoningsW.N.Mechanisms of multidrug transportersFEMS. Microbiol. Rev215584199710.1111/j.1574-6976.1997.tb00345.x9299702Search in Google Scholar
Li X.Z., Nikaido H.: Efflux-mediated drug resistance in bacteria: an update. Drugs, 69, 1555–1623 (2009)LiX.Z.NikaidoH.Efflux-mediated drug resistance in bacteria: an updateDrugs6915551623200910.2165/11317030-000000000-00000284739719678712Search in Google Scholar
Alav I., Kobylka J., Kuth M.S., Pos K.M., Picard M., Blair J.M.A., Bavro V.N.: Structure, assembly, and function of tripartite efflux and type 1 secretion systems in Gram-negative bacteria. Chem. Rev. 121, 5479–5596 (2021)AlavI.KobylkaJ.KuthM.S.PosK.M.PicardM.BlairJ.M.A.BavroV.N.Structure, assembly, and function of tripartite efflux and type 1 secretion systems in Gram-negative bacteriaChem. Rev12154795596202110.1021/acs.chemrev.1c00055827710233909410Search in Google Scholar
Leung Y.M., Holdbrook D.A., Piggot T.J., Khalid S.: The NorM MATE transporter from N. gonorrhoeae: insights into drug and ion binding from atomistic molecular dynamics simulations. Biophys. J. 107, 460–468 (2014)LeungY.M.HoldbrookD.A.PiggotT.J.KhalidS.The NorM MATE transporter from N. gonorrhoeae: insights into drug and ion binding from atomistic molecular dynamics simulationsBiophys. J107460468201410.1016/j.bpj.2014.06.005410406025028887Search in Google Scholar
Radchenko M., Symersky J., Nie R., Lu M.: Structural basis for the blockade of MATE multidrug efflux pumps. Nat. Commun. 6, 1–11 (2015)RadchenkoM.SymerskyJ.NieR.LuM.Structural basis for the blockade of MATE multidrug efflux pumpsNat. Commun6111201510.1038/ncomms8995486660026246409Search in Google Scholar
Morita Y., Kodama K., Shiota S., Mine T., Kataoka A., Mizushima T., Tsuchiya T.: NorM, a putative multidrug efflux protein, of Vibrio parahaemolyticus and its homolog in Escherichia coli. Antimicrob. Agents. Chemother. 42, 5 (1998)MoritaY.KodamaK.ShiotaS.MineT.KataokaA.MizushimaT.TsuchiyaT.NorM, a putative multidrug efflux protein, of Vibrio parahaemolyticus and its homolog in Escherichia coliAntimicrob. Agents. Chemother425199810.1128/AAC.42.7.17781056829661020Search in Google Scholar
Kusakizako T., Miyauchi H., Ishitani R., Nureki O.: Structural biology of the multidrug and toxic compound extrusion super-family transporters. Biochim. Biophys. Acta. BBA – Biomembr. 1862, 183154 (2020)KusakizakoT.MiyauchiH.IshitaniR.NurekiO.Structural biology of the multidrug and toxic compound extrusion super-family transportersBiochim. Biophys. Acta. BBA – Biomembr1862183154202010.1016/j.bbamem.2019.18315431866287Search in Google Scholar
Kaatz G.W., McAleese F., Seo S.M.: Multi-drug resistance in Staphylococcus aureus due to overexpression of a novel multi-drug and toxin extrusion (MATE) transport protein. Anti microb. Agents. Chemother. 49, 1857–1864 (2005)KaatzG.W.McAleeseF.SeoS.M.Multi-drug resistance in Staphylococcus aureus due to overexpression of a novel multi-drug and toxin extrusion (MATE) transport proteinAnti microb. Agents. Chemother4918571864200510.1128/AAC.49.5.1857-1864.2005108764315855507Search in Google Scholar
McAleese F., Petersen P., Ruzin A., Dunman PM., Murphy E., Projan SJ., Bradford PA.: A novel MATE family efflux pump contributes to the reduced susceptibility of laboratory-derived Staphylococcus aureus mutants to tigecycline. Antimicrob. Agents. Chemother. 49, 1865–1871 (2005)McAleeseF.PetersenP.RuzinA.DunmanPM.MurphyE.ProjanSJ.BradfordPA.A novel MATE family efflux pump contributes to the reduced susceptibility of laboratory-derived Staphylococcus aureus mutants to tigecyclineAntimicrob. Agents. Chemother4918651871200510.1128/AAC.49.5.1865-1871.2005108764415855508Search in Google Scholar
Tanihara Y., Masuda S., Sato T., Katsura T., Ogawa O., Inui K.: Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. Biochem. Pharmacol. 74, 359–371 (2007)TaniharaY.MasudaS.SatoT.KatsuraT.OgawaO.InuiK.Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiportersBiochem. Pharmacol74359371200710.1016/j.bcp.2007.04.01017509534Search in Google Scholar
He G.X., Kuroda T., Mima T., Morita Y., Mizushima T., Tsuchiya T.: An H(+)–coupled multidrug efflux pump, PmpM, a member of the MATE family of transporters, from Pseudomonas aeruginosa. J. Bacteriol. 186, 262–265 (2004)HeG.X.KurodaT.MimaT.MoritaY.MizushimaT.TsuchiyaT.An H(+)–coupled multidrug efflux pump, PmpM, a member of the MATE family of transporters, from Pseudomonas aeruginosaJ. Bacteriol186262265200410.1128/JB.186.1.262-265.200430344914679249Search in Google Scholar
Heir E., Sundheim G., Holck A.L.: The qacG gene on plasmid pST94 confers resistance to quaternary ammonium compounds in staphylococci isolated from the food industry. J. Appl. Microbiol. 86, 378–388 (1999)HeirE.SundheimG.HolckA.L.The qacG gene on plasmid pST94 confers resistance to quaternary ammonium compounds in staphylococci isolated from the food industryJ. Appl. Microbiol86378388199910.1046/j.1365-2672.1999.00672.x10196743Search in Google Scholar
Bay D.C., Rommens K.L., Turner R.J.: Small multi-drug resistance proteins: A multi-drug transporter family that continues to grow. Biochim. Biophys. Acta. BBA – Biomembr. 1778, 1814–1838 (2008)BayD.C.RommensK.L.TurnerR.J.Small multi-drug resistance proteins: A multi-drug transporter family that continues to growBiochim. Biophys. Acta. BBA – Biomembr177818141838200810.1016/j.bbamem.2007.08.01517942072Search in Google Scholar
Paulsen I.T., Skurray R.A., Tam R., Saier M.H. Jr., Turner R.J., Weiner J.H., Goldberg E.B., Grinius L.L.: The SMR family: a novel family of multidrug efflux proteins involved with the efflux of lipophilic drugs. Mol. Microbiol. 19, 1167–1175 (1996)PaulsenI.T.SkurrayR.A.TamR.SaierM.H.Jr.TurnerR.J.WeinerJ.H.GoldbergE.B.GriniusL.L.The SMR family: a novel family of multidrug efflux proteins involved with the efflux of lipophilic drugsMol. Microbiol1911671175199610.1111/j.1365-2958.1996.tb02462.x8730859Search in Google Scholar
Yerushalmi H., Lebendiker M., Schuldiner S.: EmrE, an Escherichia coli 12-kDa multidrug transporter, exchanges toxic cations and H+ and is soluble in organic solvents. J. Biol. Chem. 270, 6856–6863 (1995)YerushalmiH.LebendikerM.SchuldinerS.EmrE, an Escherichia coli 12-kDa multidrug transporter, exchanges toxic cations and H+ and is soluble in organic solventsJ. Biol. Chem27068566863199510.1074/jbc.270.12.68567896833Search in Google Scholar
Choudhary S., Sar P.: Real-time PCR based analysis of metal resistance genes in metal resistant Pseudomonas aeruginosa strain J007: Real-time PCR-based analysis of metal resistance genes. J. Basic. Microbiol. 56, 688–697 (2016)ChoudharyS.SarP.Real-time PCR based analysis of metal resistance genes in metal resistant Pseudomonas aeruginosa strain J007: Real-time PCR-based analysis of metal resistance genesJ. Basic. Microbiol56688697201610.1002/jobm.20150036426662317Search in Google Scholar
Magnet S., Courvalin P., Lambert T.: Resistance-nodulation-cell division-type efflux pump involved in aminoglycoside resistance in Acinetobacter baumannii strain BM4454. Antimicrob. Agents. Chemother. 45, 3375–3380 (2001)MagnetS.CourvalinP.LambertT.Resistance-nodulation-cell division-type efflux pump involved in aminoglycoside resistance in Acinetobacter baumannii strain BM4454Antimicrob. Agents. Chemother4533753380200110.1128/AAC.45.12.3375-3380.20019084011709311Search in Google Scholar
Xu C., Bilya S.R., Xu W.: adeABC efflux gene in Acinetobacter baumannii. New. Microbes. New. Infect. 30, 100549 (2019)XuC.BilyaS.R.XuW.adeABC efflux gene in Acinetobacter baumanniiNew. Microbes. New. Infect30100549201910.1016/j.nmni.2019.100549653568931193498Search in Google Scholar
Piddock L.J.V.: Clinically relevant chromosomally encoded multidrug resistance efflux pumps in bacteria. Clin. Microbiol. Rev. 19, 382–402 (2006)PiddockL.J.V.Clinically relevant chromosomally encoded multidrug resistance efflux pumps in bacteriaClin. Microbiol. Rev19382402200610.1128/CMR.19.2.382-402.2006147198916614254Search in Google Scholar
Nakashima R., Sakurai K., Yamasaki S., Nishino K., Yamaguchi A.: Structures of the multi-drug exporter AcrB reveal a proximal multisite drug-binding pocket. Nature, 480, 565–569 (2011)NakashimaR.SakuraiK.YamasakiS.NishinoK.YamaguchiA.Structures of the multi-drug exporter AcrB reveal a proximal multisite drug-binding pocketNature480565569201110.1038/nature1064122121023Search in Google Scholar
Du D., Wang Z., James N.R., Voss J.E., Klimont E., Ohene-Agyei T., Venter H., Chiu W., Luisi B.F.: Structure of the AcrAB-TolC multidrug efflux pump. Nature, 509, 512–515 (2014)DuD.WangZ.JamesN.R.VossJ.E.KlimontE.Ohene-AgyeiT.VenterH.ChiuW.LuisiB.F.Structure of the AcrAB-TolC multidrug efflux pumpNature509512515201410.1038/nature13205436190224747401Search in Google Scholar
Li X.Z., Livermore D.M., Nikaido H.: Role of efflux pump(s) in intrinsic resistance of Pseudomonas aeruginosa: resistance to tetracycline, chloramphenicol, and norfloxacin. Antimicrob. Agents. Chemother. 38, 1732–1741 (1994)LiX.Z.LivermoreD.M.NikaidoH.Role of efflux pump(s) in intrinsic resistance of Pseudomonas aeruginosa: resistance to tetracycline, chloramphenicol, and norfloxacinAntimicrob. Agents. Chemother3817321741199410.1128/AAC.38.8.17322846307986003Search in Google Scholar
Tsukazaki T.: Structure-based working model of SecDF, a proton-driven bacterial protein translocation factor. FEMS. Microbiol. Lett. 365, 112 (2018)TsukazakiT.Structure-based working model of SecDF, a proton-driven bacterial protein translocation factorFEMS. Microbiol. Lett365112201810.1093/femsle/fny112597478929718185Search in Google Scholar
Alcalde-Rico M, Hernando-Amado S, Blanco P, Martínez J.L.: Multidrug efflux pumps at the crossroad between antibiotic resistance and bacterial virulence. Front. Microbiol. 7, 1483 (2016)Alcalde-RicoMHernando-AmadoSBlancoPMartínezJ.L.Multidrug efflux pumps at the crossroad between antibiotic resistance and bacterial virulenceFront. Microbiol71483201610.3389/fmicb.2016.01483503025227708632Search in Google Scholar
Soto S.M.: Role of efflux pumps in the antibiotic resistance of bacteria embedded in a biofilm. Virulence, 4, 223–229 (2013)SotoS.M.Role of efflux pumps in the antibiotic resistance of bacteria embedded in a biofilmVirulence4223229201310.4161/viru.23724371198023380871Search in Google Scholar
Liao J., Schurr M.J., Sauer K.: The MerR-like regulator BrlR confers biofilm tolerance by activating multidrug efflux pumps in Pseudomonas aeruginosa biofilms. J. Bacteriol. 195, 3352–3363 (2013)LiaoJ.SchurrM.J.SauerK.The MerR-like regulator BrlR confers biofilm tolerance by activating multidrug efflux pumps in Pseudomonas aeruginosa biofilmsJ. Bacteriol19533523363201310.1128/JB.00318-13371954023687276Search in Google Scholar
Houry A., Gohar M., Deschamps J., Tischenko E., Aymerich S., Gruss A., Briandet R.: Bacterial swimmers that infiltrate and take over the biofilm matrix. Proc. Natl. Acad. Sci. 109, 13088–1309313 (2012)HouryA.GoharM.DeschampsJ.TischenkoE.AymerichS.GrussA.BriandetR.Bacterial swimmers that infiltrate and take over the biofilm matrixProc. Natl. Acad. Sci109130881309313201210.1073/pnas.1200791109342016222773813Search in Google Scholar
Lin Y.T., Huang Y.W., Chen S.J., Chang C.W., Yang T.C.: The SmeYZ efflux pump of Stenotrophomonas maltophilia contributes to drug resistance, virulence-related characteristics, and virulence in mice. Antimicrob. Agents. Chemother. 59, 4067–4073 (2015)LinY.T.HuangY.W.ChenS.J.ChangC.W.YangT.C.The SmeYZ efflux pump of Stenotrophomonas maltophilia contributes to drug resistance, virulence-related characteristics, and virulence in miceAntimicrob. Agents. Chemother5940674073201510.1128/AAC.00372-15446872125918140Search in Google Scholar
Linares J.F., López J.A., Camafeita E., Albar J.P., Rojo F., Martínez J.L.: Overexpression of the multidrug efflux pumps MexCD-OprJ and MexEF-OprN is associated with a reduction of type III secretion in Pseudomonas aeruginosa. J. Bacteriol. 187, 1384–1391 (2005)LinaresJ.F.LópezJ.A.CamafeitaE.AlbarJ.P.RojoF.MartínezJ.L.Overexpression of the multidrug efflux pumps MexCD-OprJ and MexEF-OprN is associated with a reduction of type III secretion in Pseudomonas aeruginosaJ. Bacteriol18713841391200510.1128/JB.187.4.1384-1391.200554560815687203Search in Google Scholar
Tang M., Wei X., Wan X., Ding Z., Ding Y., Liu J.: The role and relationship with efflux pump of biofilm formation in Klebsiella pneumoniae. Microb. Pathog. 147, 104244 (2020)TangM.WeiX.WanX.DingZ.DingY.LiuJ.The role and relationship with efflux pump of biofilm formation in Klebsiella pneumoniaeMicrob. Pathog147104244202010.1016/j.micpath.2020.10424432437832Search in Google Scholar
Sánchez P., Linares J.F., Ruiz-Díez B., Campanario E., Navas A., Baquero F., Martínez J.L.: Fitness of in vitro selected Pseudomonas aeruginosa nalB and nfxB multidrug resistant mutants. J. Antimicrob. Chemother. 50, 657–664 (2002)SánchezP.LinaresJ.F.Ruiz-DíezB.CampanarioE.NavasA.BaqueroF.MartínezJ.L.Fitness of in vitro selected Pseudomonas aeruginosa nalB and nfxB multidrug resistant mutantsJ. Antimicrob. Chemother50657664200210.1093/jac/dkf18512407121Search in Google Scholar
Alav I., Sutton J.M., Rahman K.M.: Role of bacterial efflux pumps in biofilm formation. J. Antimicrob. Chemother. 73, 2003–2020 (2018)AlavI.SuttonJ.M.RahmanK.M.Role of bacterial efflux pumps in biofilm formationJ. Antimicrob. Chemother7320032020201810.1093/jac/dky04229506149Search in Google Scholar
Akinpelu S., Ajayi A., Smith S.I., Adeleye A.I.: Efflux pump activity, biofilm formation and antibiotic resistance profile of Klebsiella spp. isolated from clinical samples at Lagos University Teaching Hospital. BMC Res. Notes. 13, 1–5 (2020)AkinpeluS.AjayiA.SmithS.I.AdeleyeA.I.Efflux pump activity, biofilm formation and antibiotic resistance profile of Klebsiella spp. isolated from clinical samples at Lagos University Teaching HospitalBMC Res. Notes1315202010.1186/s13104-020-05105-2724940732456668Search in Google Scholar
Pasqua M., Grossi M., Zennaro A., Fanelli G., Micheli G., Barras F., Colonna B., Prosseda G.: The varied role of efflux pumps of the MFS family in the interplay of bacteria with animal and plant cells. Microorganisms, 7, e285 (2019)PasquaM.GrossiM.ZennaroA.FanelliG.MicheliG.BarrasF.ColonnaB.ProssedaG.The varied role of efflux pumps of the MFS family in the interplay of bacteria with animal and plant cellsMicroorganisms7e285201910.3390/microorganisms7090285678098531443538Search in Google Scholar
Scoffone V.C., Trespidi G., Barbieri G., Irudal S., Perrin E., Buroni S.: Role of RND efflux pumps in drug resistance of cystic fibrosis pathogens. Antibiot. Basel. Switz. 10, 863 (2021)ScoffoneV.C.TrespidiG.BarbieriG.IrudalS.PerrinE.BuroniS.Role of RND efflux pumps in drug resistance of cystic fibrosis pathogensAntibiot. Basel. Switz10863202110.3390/antibiotics10070863830070434356783Search in Google Scholar
Ugwuanyi F.C., Ajayi A., Ojo D.A., Adeleye A.I., Smith S.I.: Evaluation of efflux pump activity and biofilm formation in multidrug resistant clinical isolates of Pseudomonas aeruginosa isolated from a Federal Medical Center in Nigeria. Ann. Clin. Microbiol. Antimicrob. 20, 11 (2021)UgwuanyiF.C.AjayiA.OjoD.A.AdeleyeA.I.SmithS.I.Evaluation of efflux pump activity and biofilm formation in multidrug resistant clinical isolates of Pseudomonas aeruginosa isolated from a Federal Medical Center in NigeriaAnn. Clin. Microbiol. Antimicrob2011202110.1186/s12941-021-00417-y785218933531042Search in Google Scholar
Holling N., Jones B.V. et al.: Elucidating the genetic basis of crystalline biofilm formation in Proteus mirabilis. Infect. Immun. 82, 1616–1626 (2014)HollingN.JonesB.V.Elucidating the genetic basis of crystalline biofilm formation in Proteus mirabilisInfect. Immun8216161626201410.1128/IAI.01652-13399340324470471Search in Google Scholar
Baugh S., Ekanayaka A.S., Piddock L.J., Webber M.A.: Loss of or inhibition of all multidrug resistance efflux pumps of Salmonella enterica serovar Typhimurium results in impaired ability to form a biofilm. J. Antimicrob. Chemother. 67, 2409–2417 (2012)BaughS.EkanayakaA.S.PiddockL.J.WebberM.A.Loss of or inhibition of all multidrug resistance efflux pumps of Salmonella enterica serovar Typhimurium results in impaired ability to form a biofilmJ. Antimicrob. Chemother6724092417201210.1093/jac/dks22822733653Search in Google Scholar
Krzyżek P., Grande R., Migdał P., Paluch E., Gościniak G.: Bio-film formation as a complex result of virulence and adaptive responses of Helicobacter pylori. Pathogens, 9, 1062 (2020)KrzyżekP.GrandeR.MigdałP.PaluchE.GościniakG.Bio-film formation as a complex result of virulence and adaptive responses of Helicobacter pyloriPathogens91062202010.3390/pathogens9121062776604433353223Search in Google Scholar
Kvist M., Hancock V., Klemm P.: Inactivation of efflux pumps abolishes bacterial biofilm formation. Appl. Environ. Microbiol. 74, 7376–7382 (2008)KvistM.HancockV.KlemmP.Inactivation of efflux pumps abolishes bacterial biofilm formationAppl. Environ. Microbiol7473767382200810.1128/AEM.01310-08259291218836028Search in Google Scholar
Magesh H., Kumar A., Alam A., Priyam., Sekar U., Sumantran V.N., Vaidyanathan R.: Identification of natural compounds which inhibit biofilm formation in clinical isolates of Klebsiella pneumoniae. Indian. J. Exp. Biol. 51, 764–772 (2013)MageshH.KumarA.AlamA.Priyam SekarU.SumantranV.N.VaidyanathanR.Identification of natural compounds which inhibit biofilm formation in clinical isolates of Klebsiella pneumoniaeIndian. J. Exp. Biol517647722013Search in Google Scholar
Rampioni G., Pillai C.R., Longo F., Bondì R., Baldelli V., Messina M., Imperi F., Visca P., Leoni L.: Effect of efflux pump inhibition on Pseudomonas aeruginosa transcriptome and virulence. Sci. Rep. 7, 11392 (2017)RampioniG.PillaiC.R.LongoF.BondìR.BaldelliV.MessinaM.ImperiF.ViscaP.LeoniL.Effect of efflux pump inhibition on Pseudomonas aeruginosa transcriptome and virulenceSci. Rep711392201710.1038/s41598-017-11892-9559601328900249Search in Google Scholar
Casalone E., Vignolini T., Braconi L., Gardini L., Capitanio M., Pavone F.S., Dei S., Teodori E.: 1-benzyl-1,4-diazepane reduces the efflux of resistance-nodulation-cell division pumps in Escherichia coli. Future. Microbiol. 15, 987–999 (2020)CasaloneE.VignoliniT.BraconiL.GardiniL.CapitanioM.PavoneF.S.DeiS.TeodoriE.1-benzyl-1,4-diazepane reduces the efflux of resistance-nodulation-cell division pumps in Escherichia coliFuture. Microbiol15987999202010.2217/fmb-2019-029632840130Search in Google Scholar
Fleeman R.M., Debevec G., Antonen K., Adams J.L., Santos R.G., Welmaker G.S., Houghten R.A., Giulianotti M.A., Shaw L.N.: Identification of a novel polyamine scaffold with potent efflux pump inhibition activity toward multi-drug resistant bacterial pathogens. Front. Microbiol. 9, 1301 (2018)FleemanR.M.DebevecG.AntonenK.AdamsJ.L.SantosR.G.WelmakerG.S.HoughtenR.A.GiulianottiM.A.ShawL.N.Identification of a novel polyamine scaffold with potent efflux pump inhibition activity toward multi-drug resistant bacterial pathogensFront. Microbiol91301201810.3389/fmicb.2018.01301601054529963035Search in Google Scholar
Zimmermann S., Klinger-Strobel M., Bohnert J.A., Wendler S., Rödel J., Pletz M.W., Löffler B., Tuchscherr L.: Clinically approved drugs inhibit the Staphylococcus aureus multidrug NorA efflux pump and reduce biofilm formation. Front. Microbiol. 10, 2762 (2019)ZimmermannS.Klinger-StrobelM.BohnertJ.A.WendlerS.RödelJ.PletzM.W.LöfflerB.TuchscherrL.Clinically approved drugs inhibit the Staphylococcus aureus multidrug NorA efflux pump and reduce biofilm formationFront. Microbiol102762201910.3389/fmicb.2019.02762690166731849901Search in Google Scholar
Mahey N., Tambat R., Verma D.K., Chandal N., Thakur K.G., Nandanwar H.: Antifungal azoles as tetracycline resistance modifiers in Staphylococcus aureus. Appl. Environ. Microbiol. 87, e00155–21 (2021)MaheyN.TambatR.VermaD.K.ChandalN.ThakurK.G.NandanwarH.Antifungal azoles as tetracycline resistance modifiers in Staphylococcus aureusAppl. Environ. Microbiol87e0015521202110.1128/AEM.00155-21827681033990311Search in Google Scholar
Nzakizwanayo J., Jones B.V. et al.: Fluoxetine and thioridazine inhibit efflux and attenuate crystalline biofilm formation by Proteus mirabilis. Sci. Rep. 7, 12222 (2017)NzakizwanayoJ.JonesB.V.Fluoxetine and thioridazine inhibit efflux and attenuate crystalline biofilm formation by Proteus mirabilisSci. Rep712222201710.1038/s41598-017-12445-w561033728939900Search in Google Scholar
Chevalier J., Mahamoud A., Baitiche M., Adam E., Viveiros M., Smarandache A., Militaru A., Pascu M.L., Amaral L., Pagès J.M.: Quinazoline derivatives are efficient chemosensitizers of antibiotic activity in Enterobacter aerogenes, Klebsiella pneumoniae and Pseudomonas aeruginosa resistant strains. Int. J. Antimicrob. Agents. 36, 164–168 (2010)ChevalierJ.MahamoudA.BaiticheM.AdamE.ViveirosM.SmarandacheA.MilitaruA.PascuM.L.AmaralL.PagèsJ.M.Quinazoline derivatives are efficient chemosensitizers of antibiotic activity in Enterobacter aerogenes, Klebsiella pneumoniae and Pseudomonas aeruginosa resistant strainsInt. J. Antimicrob. Agents36164168201010.1016/j.ijantimicag.2010.03.02720494558Search in Google Scholar
Lomovskaya O., Lee V.J. et al.: Identification and characterization of inhibitors of multidrug resistance efflux pumps in Pseudomonas aeruginosa: novel agents for combination therapy. Antimicrob Agents Chemother. 45, 105–116 (2001)LomovskayaO.LeeV.J.Identification and characterization of inhibitors of multidrug resistance efflux pumps in Pseudomonas aeruginosa: novel agents for combination therapyAntimicrob Agents Chemother45105116200110.1128/AAC.45.1.105-116.20019024711120952Search in Google Scholar
Siriyong T., Srimanote P., Chusri S., Yingyongnarongkul B.E., Suaisom C., Tipmanee V., Voravuthikunchai S.P.: Conessine as a novel inhibitor of multidrug efflux pump systems in Pseudomonas aeruginosa. BMC. Complement. Altern. Med. 17, 405 (2017)SiriyongT.SrimanoteP.ChusriS.YingyongnarongkulB.E.SuaisomC.TipmaneeV.VoravuthikunchaiS.P.Conessine as a novel inhibitor of multidrug efflux pump systems in Pseudomonas aeruginosaBMC. Complement. Altern. Med17405201710.1186/s12906-017-1913-y555731028806947Search in Google Scholar
Osei Sekyere J., Amoako D.G.: Carbonyl cyanide m-chlorophenylhydrazine (CCCP) reverses resistance to colistin, but not to carbapenems and tigecycline in multidrug-resistant Enterobacteriaceae. Front. Microbiol. 8, 228 (2017)Osei SekyereJ.AmoakoD.G.Carbonyl cyanide m-chlorophenylhydrazine (CCCP) reverses resistance to colistin, but not to carbapenems and tigecycline in multidrug-resistant EnterobacteriaceaeFront. Microbiol8228201710.3389/fmicb.2017.00228530628228261184Search in Google Scholar
Adabi M., Talebi-Taher M., Arbabi L., Afshar M., Fathizadeh S., Minaeian S., Moghadam-Maragheh N., Majidpour A.: Spread of efflux pump overexpressing-mediated fluoroquinolone resistance and multidrug resistance in Pseudomonas aeruginosa by using an efflux pump inhibitor. Infect Chemother. 47, 98–104 (2015)AdabiM.Talebi-TaherM.ArbabiL.AfsharM.FathizadehS.MinaeianS.Moghadam-MaraghehN.MajidpourA.Spread of efflux pump overexpressing-mediated fluoroquinolone resistance and multidrug resistance in Pseudomonas aeruginosa by using an efflux pump inhibitorInfect Chemother4798104201510.3947/ic.2015.47.2.98449528126157587Search in Google Scholar
Ikonomidis A., Tsakris A., Kanellopoulou M., Maniatis A.N., Pournaras S.: Effect of the proton motive force inhibitor carbonyl cyanide-m-chlorophenylhydrazone (CCCP) on Pseudomonas aeruginosa biofilm development. Lett. Appl. Cccp Microbiol. 47, 298–302 (2008)IkonomidisA.TsakrisA.KanellopoulouM.ManiatisA.N.PournarasS.Effect of the proton motive force inhibitor carbonyl cyanide-m-chlorophenylhydrazone (CCCP) on Pseudomonas aeruginosa biofilm developmentLett. Appl. Cccp Microbiol47298302200810.1111/j.1472-765X.2008.02430.xSearch in Google Scholar
Durães F., Resende D.I.S.P., Palmeira A., Szemerédi N., Pinto M.M.M., Spengler G., Sousa E.: Xanthones active against multidrug resistance and virulence mechanisms of bacteria. Antibiotics, 10, 600 (2021)DurãesF.ResendeD.I.S.P.PalmeiraA.SzemerédiN.PintoM.M.M.SpenglerG.SousaE.Xanthones active against multidrug resistance and virulence mechanisms of bacteriaAntibiotics10600202110.3390/antibiotics10050600815868734069329Search in Google Scholar
Oliveira-Tintino C.D.M., Silva T.G.D. et al.: The 1,8-naphthyridines sulfonamides are NorA efflux pump inhibitors. J. Glob. Antimicrob. Resist. 24, 233–240 (2021)Oliveira-TintinoC.D.M.SilvaT.G.D.The 1,8-naphthyridines sulfonamides are NorA efflux pump inhibitorsJ. Glob. Antimicrob. Resist24233240202110.1016/j.jgar.2020.11.02733385589Search in Google Scholar
Pule C.M., Sampson S.L., Warren R.M., Black P.A., van Helden P.D., Victor T.C., Louw G.E.: Efflux pump inhibitors: targeting mycobacterial efflux systems to enhance TB therapy. J. Antimicrob. Chemother. 71, 17–26 (2016)PuleC.M.SampsonS.L.WarrenR.M.BlackP.A.van HeldenP.D.VictorT.C.LouwG.E.Efflux pump inhibitors: targeting mycobacterial efflux systems to enhance TB therapyJ. Antimicrob. Chemother711726201610.1093/jac/dkv31626472768Search in Google Scholar
Fenosa A., Fusté E., Ruiz L., Veiga-Crespo P., Vinuesa T., Guallar V., Villa T.G., Viñas M.: Role of TolC in Klebsiella oxytoca resistance to antibiotics. J. Antimicrob. Chemother. 63, 668–674 (2009)FenosaA.FustéE.RuizL.Veiga-CrespoP.VinuesaT.GuallarV.VillaT.G.ViñasM.Role of TolC in Klebsiella oxytoca resistance to antibioticsJ. Antimicrob. Chemother63668674200910.1093/jac/dkp02719240073Search in Google Scholar
Anoushiravani M., Falsafi T., Niknam V.: Proton motive force-dependent efflux of tetracycline in clinical isolates of Helicobacter pylori. J. Med. Microbiol. 58, 1309–1313 (2009)AnoushiravaniM.FalsafiT.NiknamV.Proton motive force-dependent efflux of tetracycline in clinical isolates of Helicobacter pyloriJ. Med. Microbiol5813091313200910.1099/jmm.0.010876-019574414Search in Google Scholar
Bhattacharyya T., Sharma A., Akhter J., Pathania R.: The small molecule IITR08027 restores the antibacterial activity of fluoroquinolones against multidrug-resistant Acinetobacter baumannii by efflux inhibition. Int. J. Antimicrob. Agents. 50, 219–226 (2017)BhattacharyyaT.SharmaA.AkhterJ.PathaniaR.The small molecule IITR08027 restores the antibacterial activity of fluoroquinolones against multidrug-resistant Acinetobacter baumannii by efflux inhibitionInt. J. Antimicrob. Agents50219226201710.1016/j.ijantimicag.2017.03.00528533185Search in Google Scholar
Renau T.E., Ohta T. et al., Nakayama K.: Inhibitors of efflux pumps in Pseudomonas aeruginosa potentiate the activity of the fluoroquinolone antibacterial levofloxacin. J. Med. Chem. 42, 4928–4931 (1999)RenauT.E.OhtaT.NakayamaK.Inhibitors of efflux pumps in Pseudomonas aeruginosa potentiate the activity of the fluoroquinolone antibacterial levofloxacinJ. Med. Chem4249284931199910.1021/jm990459810585202Search in Google Scholar
Gupta S., Cohen K.A., Winglee K., Maiga M., Diarra B., Bishai W.R.: Efflux inhibition with verapamil potentiates bedaquiline in Mycobacterium tuberculosis. Antimicrob. Agents. Chemother. 58, 574–576 (2014)GuptaS.CohenK.A.WingleeK.MaigaM.DiarraB.BishaiW.R.Efflux inhibition with verapamil potentiates bedaquiline in Mycobacterium tuberculosisAntimicrob. Agents. Chemother58574576201410.1128/AAC.01462-13391072224126586Search in Google Scholar
Bohnert J.A., Kern W.V.: Selected arylpiperazines are capable of reversing multi-drug resistance in Escherichia coli overexpressing RND efflux pumps. Antimicrob. Agents. Chemother. 49, 849–852 (2005)BohnertJ.A.KernW.V.Selected arylpiperazines are capable of reversing multi-drug resistance in Escherichia coli overexpressing RND efflux pumpsAntimicrob. Agents. Chemother49849852200510.1128/AAC.49.2.849-852.200554722315673787Search in Google Scholar
Stavri M., Piddock L.J.V., Gibbons S.: Bacterial efflux pump inhibitors from natural sources. J. Antimicrob. Chemother. 59, 1247–1260 (2007)StavriM.PiddockL.J.V.GibbonsS.Bacterial efflux pump inhibitors from natural sourcesJ. Antimicrob. Chemother5912471260200710.1093/jac/dkl46017145734Search in Google Scholar
Kumar A., Qazi G.N. et al.: Novel structural analogues of piperine as inhibitors of the NorA efflux pump of Staphylococcus aureus. J. Antimicrob. Chemother. 61, 1270–1276 (2008)KumarA.QaziG.N.Novel structural analogues of piperine as inhibitors of the NorA efflux pump of Staphylococcus aureusJ. Antimicrob. Chemother6112701276200810.1093/jac/dkn08818334493Search in Google Scholar
Chan B.C., Leung P.C. et al.: Synergistic effects of baicalein with ciprofloxacin against NorA over-expressed methicillin-resistant Staphylococcus aureus (MRSA) and inhibition of MRSA pyruvate kinase. J. Ethnopharmacol. 137, 767–773 (2011)ChanB.C.LeungP.C.Synergistic effects of baicalein with ciprofloxacin against NorA over-expressed methicillin-resistant Staphylococcus aureus (MRSA) and inhibition of MRSA pyruvate kinaseJ. Ethnopharmacol137767773201110.1016/j.jep.2011.06.03921782012Search in Google Scholar
Fujita M., Shiota S., Kuroda T., Hatano T., Yoshida T., Mizushima T., Tsuchiya T.: Remarkable synergies between baicalein and tetracycline, and baicalein and beta-lactams against methicillin-resistant Staphylococcus aureus. Microbiol. Immunol. 49, 391–396 (2005)FujitaM.ShiotaS.KurodaT.HatanoT.YoshidaT.MizushimaT.TsuchiyaT.Remarkable synergies between baicalein and tetracycline, and baicalein and beta-lactams against methicillin-resistant Staphylococcus aureusMicrobiol. Immunol49391396200510.1111/j.1348-0421.2005.tb03732.x15840965Search in Google Scholar
Stermitz F.R., Lorenz P., Tawara J.N., Zenewicz L.A., Lewis K.: Synergy in a medicinal plant: antimicrobial action of berberine potentiated by 5’-methoxyhydnocarpin, a multidrug pump inhibitor. Proc. Natl. Acad. Sci. U S A. 97, 1433–1437 (2000)StermitzF.R.LorenzP.TawaraJ.N.ZenewiczL.A.LewisK.Synergy in a medicinal plant: antimicrobial action of berberine potentiated by 5’-methoxyhydnocarpin, a multidrug pump inhibitorProc. Natl. Acad. Sci. U S A9714331437200010.1073/pnas.0305405972645110677479Search in Google Scholar
AlMatar M., Albarri O., Makky E.A., Köksal F.: Efflux pump inhibitors: new updates. Pharmacol. Rep. PR. 73, 1–16 (2021)AlMatarM.AlbarriO.MakkyE.A.KöksalF.Efflux pump inhibitors: new updatesPharmacol. Rep. PR73116202110.1007/s43440-020-00160-932946075Search in Google Scholar
SudanoRoccaro A., Blanco A.R., Giuliano F., Rusciano D., Enea V.: Epigallocatechin-gallate enhances the activity of tetracycline in staphylococci by inhibiting its efflux from bacterial cells. Antimicrob. Agents. Chemother. 48, 1968–1973 (2004)SudanoRoccaroA.BlancoA.R.GiulianoF.RuscianoD.EneaV.Epigallocatechin-gallate enhances the activity of tetracycline in staphylococci by inhibiting its efflux from bacterial cellsAntimicrob. Agents. Chemother4819681973200410.1128/AAC.48.6.1968-1973.200441560115155186Search in Google Scholar
Joshi P., Kumar A. et al.: Osthol and curcumin as inhibitors of human Pgp and multidrug efflux pumps of Staphylococcus aureus: reversing the resistance against frontline antibacterial drugs. Med. Chem. Comm. 5, 1540–1547 (2014)JoshiP.KumarA.Osthol and curcumin as inhibitors of human Pgp and multidrug efflux pumps of Staphylococcus aureus: reversing the resistance against frontline antibacterial drugsMed. Chem. Comm515401547201410.1039/C4MD00196FSearch in Google Scholar
Negi N., Prakash P., Gupta M.L., Mohapatra T.M.: Possible role of curcumin as an efflux pump inhibitor in multi drug resistant clinical isolates of Pseudomonas aeruginosa. J. Clin. Diagn. Res. JCDR. 8, DC04–DC07 (2014)NegiN.PrakashP.GuptaM.L.MohapatraT.M.Possible role of curcumin as an efflux pump inhibitor in multi drug resistant clinical isolates of Pseudomonas aeruginosaJ. Clin. Diagn. Res. JCDR8DC04DC07201410.7860/JCDR/2014/8329.4965425315825478340Search in Google Scholar
Roy S., Kumari N., Pahwa S., Agrahari U., Bhutani K., Jachak S., Nandanwar H.: NorA efflux pump inhibitory activity of coumarins from Mesua ferrea. Fitoterapia, 90, 140–150 (2013)RoyS.KumariN.PahwaS.AgrahariU.BhutaniK.JachakS.NandanwarH.NorA efflux pump inhibitory activity of coumarins from Mesua ferreaFitoterapia90140150201310.1016/j.fitote.2013.07.01523892000Search in Google Scholar
Oluwatuyi M., Kaatz G.W., Gibbons S.: Antibacterial and resistance modifying activity of Rosmarinus officinalis. Phytochemistry, 65, 3249–3254 (2004)OluwatuyiM.KaatzG.W.GibbonsS.Antibacterial and resistance modifying activity of Rosmarinus officinalisPhytochemistry6532493254200410.1016/j.phytochem.2004.10.00915561190Search in Google Scholar
Lorenzi V., Muselli A., Bernardini A.F., Berti L., Pagès J.M., Amaral L., Bolla J.M.: Geraniol restores antibiotic activities against multidrug-resistant isolates from Gram-negative species. Antimicrob. Agents. Chemother. 53, 2209–2211 (2009)LorenziV.MuselliA.BernardiniA.F.BertiL.PagèsJ.M.AmaralL.BollaJ.M.Geraniol restores antibiotic activities against multidrug-resistant isolates from Gram-negative speciesAntimicrob. Agents. Chemother5322092211200910.1128/AAC.00919-08Search in Google Scholar
Dwivedi G.R., Tyagi R., Sanchita., Tripathi S., Pati S., Srivastava S.K., Darokar M.P., Sharma A.: Antibiotics potentiating potential of catharanthine against superbug Pseudomonas aeruginosa. J. Biomol. Struct. Dyn. 36, 4270–284 (2018)DwivediG.R.TyagiR.Sanchita TripathiS.PatiS.SrivastavaS.K.DarokarM.P.SharmaA.Antibiotics potentiating potential of catharanthine against superbug Pseudomonas aeruginosaJ. Biomol. Struct. Dyn364270284201810.1080/07391102.2017.1413424Search in Google Scholar
Chevalier J., Atifi S., Eyraud A., Mahamoud A., Barbe J., Pagès J.M.: New pyridoquinoline derivatives as potential inhibitors of the fluoroquinolone efflux pump in resistant Enterobacter aerogenes strains. J. Med. Chem. 44, 4023–4026 (2001)ChevalierJ.AtifiS.EyraudA.MahamoudA.BarbeJ.PagèsJ.M.New pyridoquinoline derivatives as potential inhibitors of the fluoroquinolone efflux pump in resistant Enterobacter aerogenes strainsJ. Med. Chem4440234026200110.1021/jm010911zSearch in Google Scholar
Kaatz G.W., Moudgal V.V., Seo S.M., Hansen J.B., Kristiansen J.E.: Phenylpiperidine selective serotonin reuptake inhibitors interfere with multidrug efflux pump activity in Staphylococcus aureus. Int. J. Antimicrob. Agents. 22, 254–261 (2003)KaatzG.W.MoudgalV.V.SeoS.M.HansenJ.B.KristiansenJ.E.Phenylpiperidine selective serotonin reuptake inhibitors interfere with multidrug efflux pump activity in Staphylococcus aureusInt. J. Antimicrob. Agents22254261200310.1016/S0924-8579(03)00220-6Search in Google Scholar
Opperman T.J., Nguyen S.T.: Recent advances toward a molecular mechanism of efflux pump inhibition. Front. Microbiol. 6, 421 (2015)OppermanT.J.NguyenS.T.Recent advances toward a molecular mechanism of efflux pump inhibitionFront. Microbiol6421201510.3389/fmicb.2015.00421441985925999939Search in Google Scholar
Mahmood H.Y., Jamshidi S., Sutton J.M., Rahman K.M.: Current advances in developing inhibitors of bacterial multi-drug efflux pumps. Curr. Med. Chem. 23, 1062–1081 (2016)MahmoodH.Y.JamshidiS.SuttonJ.M.RahmanK.M.Current advances in developing inhibitors of bacterial multi-drug efflux pumpsCurr. Med. Chem2310621081201610.2174/0929867323666160304150522542565626947776Search in Google Scholar
Vargiu A.V., Ruggerone P., Opperman T.J., Nguyen S.T., Nikaido H.: Molecular mechanism of MBX2319 inhibition of Escherichia coli AcrB multidrug efflux pump and comparison with other inhibitors. Antimicrob. Agents. Chemother. 58, 6224–6234 (2014)VargiuA.V.RuggeroneP.OppermanT.J.NguyenS.T.NikaidoH.Molecular mechanism of MBX2319 inhibition of Escherichia coli AcrB multidrug efflux pump and comparison with other inhibitorsAntimicrob. Agents. Chemother5862246234201410.1128/AAC.03283-14418798725114133Search in Google Scholar
Fontaine F., Héquet A., Voisin-Chiret A.S., Bouillon A., Lesnard A., Cresteil T., Jolivalt C., Rault S.: Boronic species as promising inhibitors of the Staphylococcus aureus NorA efflux pump: study of 6-substituted pyridine-3-boronic acid derivatives. Eur. J. Med. Chem. 95, 185–198 (2015)FontaineF.HéquetA.Voisin-ChiretA.S.BouillonA.LesnardA.CresteilT.JolivaltC.RaultS.Boronic species as promising inhibitors of the Staphylococcus aureus NorA efflux pump: study of 6-substituted pyridine-3-boronic acid derivativesEur. J. Med. Chem95185198201510.1016/j.ejmech.2015.02.05625817769Search in Google Scholar
Zeng B., Wang H., Zou L., Zhang A., Yang X., Guan Z.: Evaluation and target validation of indole derivatives as inhibitors of the AcrAB-TolC efflux pump. Biosci. Biotechnol. Biochem. 74, 2237–2241 (2010)ZengB.WangH.ZouL.ZhangA.YangX.GuanZ.Evaluation and target validation of indole derivatives as inhibitors of the AcrAB-TolC efflux pumpBiosci. Biotechnol. Biochem7422372241201010.1271/bbb.10043321071837Search in Google Scholar
Rana T., Singh S., Kaur N., Pathania K., Gaur U.: A review on efflux pump inhibitors of medically important bacteria from plant sources. Int. J. Pharm. Sci. Rev. Res. 26, 101–111 (2014)RanaT.SinghS.KaurN.PathaniaK.GaurU.A review on efflux pump inhibitors of medically important bacteria from plant sourcesInt. J. Pharm. Sci. Rev. Res261011112014Search in Google Scholar
Abbas H., Shaker G., Khattab R., Askoura M.: A new role of metformin as an efflux pump inhibitor in Klebsiella pneumonia. J. Microbiol. Biotechnol. Food Sci. 11, e4232–e4232 (2021)AbbasH.ShakerG.KhattabR.AskouraM.A new role of metformin as an efflux pump inhibitor in Klebsiella pneumoniaJ. Microbiol. Biotechnol. Food Sci11e4232e4232202110.15414/jmbfs.4232Search in Google Scholar
Lee M.D., Galazzo J.L., Staley A.L., Lee J.C., Warren M.S., Fuernkranz H., Chamberland S., Lomovskaya O., Miller G.H.: Microbial fermentation-derived inhibitors of efflux-pump-mediated drug resistance. Farm. Soc. Chim. Ital. 1989. 56, 81–85 (2001)LeeM.D.GalazzoJ.L.StaleyA.L.LeeJ.C.WarrenM.S.FuernkranzH.ChamberlandS.LomovskayaO.MillerG.H.Microbial fermentation-derived inhibitors of efflux-pump-mediated drug resistanceFarm. Soc. Chim. Ital. 1989568185200110.1016/S0014-827X(01)01002-3Search in Google Scholar
Bhardwaj A.K., Mohanty P.: Bacterial efflux pumps involved in multi-drug resistance and their inhibitors: rejuvinating the antimicrobial chemotherapy. Recent. Patents. Anti-Infect. Drug. Disc. 7, 73–89 (2012)BhardwajA.K.MohantyP.Bacterial efflux pumps involved in multi-drug resistance and their inhibitors: rejuvinating the antimicrobial chemotherapy. Recent. PatentsAnti-Infect. Drug. Disc77389201210.2174/157489112799829710Search in Google Scholar
Ferrer-Espada R., Shahrour H., Pitts B., Stewart P.S., Sánchez-Gómez S., Martínez-de-Tejada G.: A permeability-increasing drug synergizes with bacterial efflux pump inhibitors and restores susceptibility to antibiotics in multi-drug resistant Pseudomonas aeruginosa strains. Sci. Rep. 9, 3452 (2019)Ferrer-EspadaR.ShahrourH.PittsB.StewartP.S.Sánchez-GómezS.Martínez-de-TejadaG.A permeability-increasing drug synergizes with bacterial efflux pump inhibitors and restores susceptibility to antibiotics in multi-drug resistant Pseudomonas aeruginosa strainsSci. Rep93452201910.1038/s41598-019-39659-4640111930837499Search in Google Scholar
Keirstead N.D., Kern G. et al.: Early prediction of polymyxin-induced nephrotoxicity with next-generation urinary kidney injury biomarkers. Toxicol. Sci. 137, 278–291 (2014)KeirsteadN.D.KernG.Early prediction of polymyxin-induced nephrotoxicity with next-generation urinary kidney injury biomarkersToxicol. Sci137278291201410.1093/toxsci/kft24724189134Search in Google Scholar
Rathi E., Kumar A., Kini S.G.: Computational approaches in efflux pump inhibitors: current status and prospects. Drug. Discov. Today. 25, 1883–1890 (2020)RathiE.KumarA.KiniS.G.Computational approaches in efflux pump inhibitors: current status and prospectsDrug. Discov. Today2518831890202010.1016/j.drudis.2020.07.01132712312Search in Google Scholar
Pagès J-M., Amaral L., Fanning S.: An original deal for new molecule: reversal of efflux pump activity, a rational strategy to combat Gram-negative resistant bacteria. Curr. Med. Chem. 18, 2969–2980 (2011)PagèsJ-M.AmaralL.FanningS.An original deal for new molecule: reversal of efflux pump activity, a rational strategy to combat Gram-negative resistant bacteriaCurr. Med. Chem1829692980201110.2174/09298671179615046921651484Search in Google Scholar
Mehla J., Zgurskaya H.I. et al.: Predictive rules of efflux inhibition and avoidance in Pseudomonas aeruginosa. mBio. 12, 02785–20 (2021)MehlaJ.ZgurskayaH.I.Predictive rules of efflux inhibition and avoidance in Pseudomonas aeruginosamBio120278520202110.1128/mBio.02785-20784564333468691Search in Google Scholar