<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Nitrosative stress is an adverse physiological condition mediated by an excessive level of reactive nitrogen species (RNS). RNS react with the different macromolecules <italic>in vivo</italic> and result in the inactivation of these molecules. But the mechanism to counteract the effect of nitrosative stress is poorly understood. <italic>Escherichia coli</italic> is one of the best understood and well-studied microorganism. Although several studies have been reported on <italic>Escherichia coli</italic> to characterize the effect of various stress response but fewer works are there to see the effect of nitrosative stress. <italic>Escherichia coli</italic> encounter numerous stresses during its growth, survival, and infection. They respond to various stress conditions by activating common regulator proteins and thiols. These stress conditions result in the accumulation of these regulator proteins and thiols that allow cells to adjust to specific stress situations, conferring stress tolerance and survival. In this review, different enzymatic and non-enzymatic mechanisms to counteract the effect of nitrosative stress in <italic>Escherichia coli</italic> have been discussed and a hypothesis for the working mechanism of hybrid cluster protein that helps to combat nitrosative stress has been proposed. Here, we have tried to give a clear scenario about the mode of action of stress-responsive elements present in <italic>Escherichia coli</italic>.</p>
</abstract>

Nitrosative stress is an adverse physiological condition mediated by an excessive level of reactive nitrogen species (RNS). RNS react with the different macromolecules in vivo and result in the inactivation of these molecules. But the mechanism to counteract the effect of nitrosative stress is poorly understood. Escherichia coli is one of the best understood and well-studied microorganism. Although several studies have been reported on Escherichia coli to characterize the effect of various stress response but fewer works are there to see the effect of nitrosative stress. Escherichia coli encounter numerous stresses during its growth, survival, and infection. They respond to various stress conditions by activating common regulator proteins and thiols. These stress conditions result in the accumulation of these regulator proteins and thiols that allow cells to adjust to specific stress situations, conferring stress tolerance and survival. In this review, different enzymatic and non-enzymatic mechanisms to counteract the effect of nitrosative stress in Escherichia coli have been discussed and a hypothesis for the working mechanism of hybrid cluster protein that helps to combat nitrosative stress has been proposed. Here, we have tried to give a clear scenario about the mode of action of stress-responsive elements present in Escherichia coli.

Enzymatic and Non-Enzymatic Response during Nitrosative Stress in <italic>Escherichia coli</italic>

Advancements of Microbiology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Enzymatic and Non-Enzymatic Response during Nitrosative Stress in 

Nitrosative stress is an adverse physiological condition mediated by an excessive level of reactive nitrogen species (RNS). RNS react with the different...

Enzymatic and Non-Enzymatic Response during Nitrosative Stress in Escherichia coli

Publicado en línea: 25 jun 2022

Páginas: 81 - 93

Recibido: 01 nov 2021

Aceptado: 01 abr 2022

DOI: https://doi.org/10.2478/am-2022-0008

Palabras clave
nitrosative stress, protein tyrosine nitration, reactive nitrogen species, stress response

© 2022 Rohan Nath et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Enzymatic and Non-Enzymatic Response during Nitrosative Stress in Escherichia coli

Publicado en línea: 25 jun 2022

Páginas: 81 - 93

Recibido: 01 nov 2021

Aceptado: 01 abr 2022

DOI: https://doi.org/10.2478/am-2022-0008

Palabras clavenitrosative stress, protein tyrosine nitration, reactive nitrogen species, stress response

© 2022 Rohan Nath et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Palabras clave
nitrosative stress, protein tyrosine nitration, reactive nitrogen species, stress response