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Intraarterial Infusion of Lidocaine is Superior to the Subcutaneous Injection of Low Molecular Weight Heparin for Improving the Course of Cerulein-Induced Acute Pancreatitis in Rats

Ryszard Antkowiak

Ryszard Antkowiak

Department of General and Oncologic Surgery, St. Joseph Hospital in MikolowMikolow, Poland
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Antkowiak, Ryszard
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Lukasz Antkowiak

Lukasz Antkowiak

  • Department of Pediatric Neurosurgery, Medical University of Silesia in KatowiceKatowice, Poland
  • Department of Neurosurgery, St. Barbara Regional Hospital and Trauma Center in Sosnowiec, Medical University of Silesia in KatowiceSosnowiec, Poland
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Antkowiak, Lukasz
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Zbigniew Arent

Zbigniew Arent

Experimental and Innovative Medicine Centre, University of AgricultureKrakow, Poland
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Arent, Zbigniew
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Bogna Drozdzowska

Bogna Drozdzowska

Department of Pathomorphology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in KatowiceZabrze, Poland
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Drozdzowska, Bogna
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Anna Kasperczuk

Anna Kasperczuk

Faculty of Mechanical Engineering, Institute of Biomedical Engineering, Bialystok University of TechnologyBialystok, Poland
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Kasperczuk, Anna
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Jacek Bialecki

Jacek Bialecki

Department of General Minimally Invasive and Trauma Surgery, Francis Raszeja Municipal HospitalPoznan, Poland
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Bialecki, Jacek
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Agnieszka Pietsch-Fulbiszewska

Agnieszka Pietsch-Fulbiszewska

Experimental and Innovative Medicine Centre, University of AgricultureKrakow, Poland
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Pietsch-Fulbiszewska, Agnieszka
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Pawel Domoslawski

Pawel Domoslawski

Department of General Gastroenterologic and Endocrine Surgery, Wroclaw Medical UniversityWroclaw, Poland
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Domoslawski, Pawel
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Agata Cieslik-Bielecka

Agata Cieslik-Bielecka

Department of Oral and Maxillofacial Surgery, St. Barbara Regional Hospital and Trauma Center in SosnowiecSosnowiec, Poland
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Cieslik-Bielecka, Agata
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Marek Kucharzewski

Marek Kucharzewski

Wladyslaw Bieganski Collegium Medicum, Jan Długosz University in CzestochowaCzestochowa, Poland
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Kucharzewski, Marek
  
16 abr 2025
Intraarterial Infusion of Lidocaine is Superior to the Subcutaneous Injection of Low Molecular Weight Heparin for Improving the Course of Cerulein-Induced Acute Pancreatitis in Rats's Cover Image
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Categoría del artículo: Review
Publicado en línea: 16 abr 2025
Recibido: 11 dic 2024
Aceptado: 03 mar 2025
DOI: https://doi.org/10.2478/aite-2025-0012
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© 2025 Ryszard Antkowiak et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Fig 1.

Amylase levels in the NaCl, heparin, and lidocaine–heparin groups over the entire preoperative (M0–M1) and postoperative (M2–M4) course. M0 – initial amylase levels, M1 – amylase levels after the induction of pancreatitis – just before the operation, M2 – amylase levels 1 h after drug administration, M3 – amylase levels 3 h after drug administration, M4 – amylase levels 5 h after drug administration. M0, measurement 0; M1, measurement 1; M2, measurement 2; M3, measurement 3; M4, measurement 4.
Amylase levels in the NaCl, heparin, and lidocaine–heparin groups over the entire preoperative (M0–M1) and postoperative (M2–M4) course. M0 – initial amylase levels, M1 – amylase levels after the induction of pancreatitis – just before the operation, M2 – amylase levels 1 h after drug administration, M3 – amylase levels 3 h after drug administration, M4 – amylase levels 5 h after drug administration. M0, measurement 0; M1, measurement 1; M2, measurement 2; M3, measurement 3; M4, measurement 4.

Fig 2.

Lipase levels in the NaCl, heparin, and lidocaine–heparin groups over the entire preoperative (M0–M1) and postoperative (M2–M4) course. M0 – initial lipase levels, M1 – lipase levels after the induction of pancreatitis – just before the operation, M2 – lipase levels 1 h after drug administration, M3 – lipase levels 3 h after drug administration, M4 – lipase levels 5 h after drug administration. M0, measurement 0; M1, measurement 1; M2, measurement 2; M3, measurement 3; M4, measurement 4.
Lipase levels in the NaCl, heparin, and lidocaine–heparin groups over the entire preoperative (M0–M1) and postoperative (M2–M4) course. M0 – initial lipase levels, M1 – lipase levels after the induction of pancreatitis – just before the operation, M2 – lipase levels 1 h after drug administration, M3 – lipase levels 3 h after drug administration, M4 – lipase levels 5 h after drug administration. M0, measurement 0; M1, measurement 1; M2, measurement 2; M3, measurement 3; M4, measurement 4.

Comparison of amylase levels between the control groups

Measurement Mean amylase levels in the NaCl group [U/L] Mean amylase levels in the heparin group [U/L] Mean amylase levels in the lidocaine–heparin [U/L] p-value
NaCl vs. heparin NaCl vs. lidocaine–heparin Heparin vs. lidocaine–heparin
M0 644.5 708.20 658.0 0.093 0.894 0.234
M1 57,083.4 66,622.0 47,766.22 0.457 0.492 0.069
M2 33,927.0 37,428.0 14,346.89 0.557 <0.001*** <0.001***
M3 20,444.4 23,452.30 11,171.67 0.406 0.002* <0.001***
M4 12,358.3 14,504.40 7914.56 0.361 0.025* 0.001**

Comparison of lipase levels between the control groups

Measurement Mean lipase levels in the NaCl group [U/L] Mean lipase levels in the heparin group [U/L] Mean lipase levels in the lidocaine–heparin [U/L] p-value
NaCl vs. heparin NaCl vs. lidocaine–heparin Heparin vs. lidocaine–heparin
M0 25.99 23.10 14.67 0.909 0.267 0.473
M1 2502.20 3236.28 3077.04 0.116 0.273 0.901
M2 1139.61 1475.14 678.70 0.127 0.032* <0.001**
M3 567.48 783.49 472.91 0.171 0.712 0.039*
M4 281.98 389.79 252.21 0.280 0.907 0.147

Comparison of histopathological findings between three groups

Feature NaCl group Heparin group Lidocaine–heparin group p-value
Pancreatic tissue
Necrosis 0/10 (0%) 2/10 (20%) 3/9 (33%) 0.163
Edema 8/10 (80%) 6/10 (60%) 5/9 (56%) 0.530
Hemorrhagic foci 0/10 (0%) 1/10 (10%) 1/9 (11%) 0.565
Acute inflammation 0/10 (0%) 0/10 (0%) 2/9 (22%) 0.092
Chronic inflammation 7/10 (70%) 9/10 (90%) 9/9 (100%) 0.152
Mean number of veins and arteries (SD) 19.5 (7.25) 17.1 (2.51) 15.0 (8.34) 0.094
Mean number of capillaries (SD) 36.0 (8.76) 27.9 (5.65) 29.44 (6.35) 0.080
Adipose tissue
Necrosis 0/10 (0%) 0/10 (0%) 2/9 (22%) 0.092
Hemorrhagic foci 0/10 (0%) 1/10 (10%) 1/9 (11%) 0.565
Acute inflammation 0/10 (0%) 0/10 (0%) 1/9 (11%) 0.316
Chronic inflammation 2/10 (20%) 4/10 (40%) 6/9 (67%) 0.119
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Temas de la revista:
Medicina, Ciencias médicas básicas, Bioquímica, Inmunología, Medicina Clínica, Medicina Clínica, otros, Química clínica
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