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Whey protein protects liver mitochondrial function against oxidative stress in rats exposed to acrolein

Birsen Aydın
Birsen Aydın
, 
Ali Oğuz
Ali Oğuz
, 
Vedat Şekeroğlu
Vedat Şekeroğlu
 y 
Zülal Atlı Şekeroğlu
Zülal Atlı Şekeroğlu
   | 30 sept 2022
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Article Category: Original article
Publicado en línea: 30 sept 2022
Páginas: 200 - 206
Recibido: 01 mar 2022
Aceptado: 01 ago 2022
DOI: https://doi.org/10.2478/aiht-2022-73-3640
© 2022 Birsen Aydın, Ali Oğuz, Vedat Şekeroğlu, and Zülal Atlı Şekeroğlu, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Figure 1

The effects of acrolein (AC) and/or whey protein (WP) on MnSOD (U/mg protein), GPx (nmol of NADPH oxidised/min/mg protein) and GSH (nmol/mg protein) levels. Values are expressed as means ± SD (n=6). (a) significant vs control and (b) significant vs AC (p<0.05). GPx – glutathione peroxidase; GSH – glutathione; MnSOD – mitochondrial super oxide dismutase
The effects of acrolein (AC) and/or whey protein (WP) on MnSOD (U/mg protein), GPx (nmol of NADPH oxidised/min/mg protein) and GSH (nmol/mg protein) levels. Values are expressed as means ± SD (n=6). (a) significant vs control and (b) significant vs AC (p<0.05). GPx – glutathione peroxidase; GSH – glutathione; MnSOD – mitochondrial super oxide dismutase

Figure 2

The effects of acrolein (AC) and/or whey protein (WP) on LP (nmol equivalents of malonedialdehyde/mg protein) and PC (nmol DNPH incorporated/mg protein) levels. Values are mean±SD (n=6). Data analysed by one-way analysis of variance (ANOVA) followed by Tukey’s test for comparison of means. (a) significant against 0.9 % NaCl control and (b) significant against AC at p<0.05. LP – lipid peroxidation; PC – protein carbonyl
The effects of acrolein (AC) and/or whey protein (WP) on LP (nmol equivalents of malonedialdehyde/mg protein) and PC (nmol DNPH incorporated/mg protein) levels. Values are mean±SD (n=6). Data analysed by one-way analysis of variance (ANOVA) followed by Tukey’s test for comparison of means. (a) significant against 0.9 % NaCl control and (b) significant against AC at p<0.05. LP – lipid peroxidation; PC – protein carbonyl

Figure 3

The effects of acrolein (AC) and/or whey protein (WP) on complex I (mmol DCPIP reduced/min/mg protein), complex II (mmol DCPIP reduced/min/mg protein), complex IV (mmol cytochrome c oxidised/min/mg protein) levels. Values are mean±SD (n=6). Data analysed by one-way analysis of variance (ANOVA) followed by Tukey’s test for comparison of means. (a) significant against 0.9 % NaCl control and (b) significant against AC at p<0.05. Complex I – NADH-coenzyme Q oxidoreductase; Complex II – succinate dehydrogenase-coenzyme Q oxidoreductase; Complex IV – cytochrome c oxidase
The effects of acrolein (AC) and/or whey protein (WP) on complex I (mmol DCPIP reduced/min/mg protein), complex II (mmol DCPIP reduced/min/mg protein), complex IV (mmol cytochrome c oxidised/min/mg protein) levels. Values are mean±SD (n=6). Data analysed by one-way analysis of variance (ANOVA) followed by Tukey’s test for comparison of means. (a) significant against 0.9 % NaCl control and (b) significant against AC at p<0.05. Complex I – NADH-coenzyme Q oxidoreductase; Complex II – succinate dehydrogenase-coenzyme Q oxidoreductase; Complex IV – cytochrome c oxidase

Figure 4

The effects of acrolein (AC) and/or whey protein (WP) on ICDH (mmol NADP+ reduced/min/mg protein), α-KGDH (mmol NAD+ reduced/min/mg protein), MDH (mmol NAD+ reduced/min/mg protein) levels. Values are mean±SD (n=6). Data analysed by one-way analysis of variance (ANOVA) followed by Tukey’s test for comparison of means. (a) significant against 0.9 % NaCl control and (b) significant against AC at p<0.05. α-KGDH – α-ketoglutarate dehydrogenase; ICDH – isocitrate dehydrogenase; MDH – malate dehydrogenase
The effects of acrolein (AC) and/or whey protein (WP) on ICDH (mmol NADP+ reduced/min/mg protein), α-KGDH (mmol NAD+ reduced/min/mg protein), MDH (mmol NAD+ reduced/min/mg protein) levels. Values are mean±SD (n=6). Data analysed by one-way analysis of variance (ANOVA) followed by Tukey’s test for comparison of means. (a) significant against 0.9 % NaCl control and (b) significant against AC at p<0.05. α-KGDH – α-ketoglutarate dehydrogenase; ICDH – isocitrate dehydrogenase; MDH – malate dehydrogenase

Figure 5

The effects of acrolein (AC) and/or whey protein (WP) on ATP (nmol/mg protein) level. Values are mean±SD (n=6). Data analysed by one-way analysis of variance (ANOVA) followed by Tukey’s test for comparison of means. (a) significant against 0.9 % NaCl control and (b) significant against AC at p<0.05. ATP – adenosine triphosphate
The effects of acrolein (AC) and/or whey protein (WP) on ATP (nmol/mg protein) level. Values are mean±SD (n=6). Data analysed by one-way analysis of variance (ANOVA) followed by Tukey’s test for comparison of means. (a) significant against 0.9 % NaCl control and (b) significant against AC at p<0.05. ATP – adenosine triphosphate
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Inglés, Slovenian
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Temas de la revista:
Medicine, Basic Medical Science, other
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