Prevalence of five pharmacologically most important CYP2C9 and CYP2C19 allelic variants in the population from the Republic of Srpska in Bosnia and Herzegovina
, , , , , y | 28 jun 2021
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Article Category: Original article
Publicado en línea: 28 jun 2021
Páginas: 129 - 134
Recibido: 01 oct 2020
Aceptado: 01 may 2021
DOI: https://doi.org/10.2478/aiht-2021-72-3499
© 2021 Stojko Vidović, Ranko Škrbić, Miloš P. Stojiljković, Vanja Vidović, Jelena Bećarević, Svjetlana Stoisavljević-Šatara, Nela Maksimović, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Genotype and predicted phenotype prevalences of the CYP2C19 allelic variants in the population of the Republic of Srpska
| Genotype | Participants (N) | Prevalence (%) | Confidence interval (95 %) | Predicted phenotype |
|---|---|---|---|---|
| 89 | 41.20 | 34.57–48.08 | normal metabolisers | |
| 39 | 18.05 | 13.17–23.85 | intermediate metabolisers | |
| 13 | 6.02 | 3.24–10.07 | intermediate metabolisers | |
| - | - | - | intermediate metabolisers | |
| - | - | - | intermediate metabolisers | |
| 9 | 4.17 | 1.92–7.76 | poor metabolisers | |
| - | - | - | poor metabolisers | |
| - | - | - | poor metabolisers | |
| 57 | 26.39 | 20.64–32.80 | rapid metabolisers | |
| 9 | 4.17 | 1.92–7.76 | ultra-rapid metabolisers |
Genotype and predicted phenotype prevalences of the CYP2C9 allelic variants in the population of the Republic of Srpska
| Genotype | Participants (N) | Prevalence (%) | Confidence interval (95 %) | Predicted phenotype |
|---|---|---|---|---|
| 134 | 62.03 | 55.20–68.53 | normal metabolisers | |
| 47 | 21.76 | 16.45–27.86 | intermediate metabolisers | |
| 26 | 12.04 | 8.02–17.14 | intermediate metabolisers | |
| 5 | 2.31 | 0.76–5.32 | intermediate metabolisers | |
| 2 | 0.93 | 0.11–3.30 | poor metabolisers | |
| 2 | 0.93 | 0.11–3.30 | poor metabolisers |
Genotype and the prevalence of the CYP2C9 and CYP2C19 allelic variants in the population of the Republic of Srpska (RS) compared to other populations
| Alleles frequencies | ||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene | Genotype | Genotype frequency n (%) | Alleles | RS | Bosnia and Herzegovina | Macedonia | Croatia | Serbia | Kosovo | Slovenia | Italy | Greece | Germany | Russia | Spain | Eastern Asians | African | African-American | ||||
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| *1/*1 | 162 (75) | C | 0.866 | 0.868 | 0.910 | 0.861 | 0.855 | 0.835 | 0.883 | 0.825 | 0.878 | 0.830 | 0.846 | 0.875 | 0.896 | 0.860 | 0.895 | 0.840 | 0.999 | 0.980 | 0.990 | |
| * |
46 (21.29) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| *2/*2 | 5 (2.31) | T | 0.134 | 0.132 | 0.090 | 0.139 | 0.145 | 0.165 | 0.117 | 0.175 | 0.122 | 0.170 | 0.154 | 0.125 | 0.104 | 0.140 | 0.105 | 0.160 | 0.0001 | 0.020 | 0.010 | |
| *1/*1 | 186 (86.11) | A | 0.928 | 0.911 | - | 0.927 | 0.924 | 0.905 | 0.919 | 0.891 | 0.937 | 0.856 | 0.916 | 0.903 | 0.933 | 0.950 | 0.933 | 0.900 | 0.997 | 0.990 | 0.995 | |
| * |
28 (12.96) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| *3/*3 | 2 (0.93) | c | 0.072 | 0.089 | - | 0.073 | 0.076 | 0.095 | 0.081 | 0.109 | 0.063 | 0.144 | 0.084 | 0.097 | 0.067 | 0.050 | 0.067 | 0.100 | 0.003 | 0.010 | 0.005 | |
| *1/*1 | 155 (71.76) | G | 0.847 | - | 0.830 | 0.856 | 0.852 | 0.850 | 0.837 | 0.870 | 0.841 | - | 0.907 | 0.889 | 0.869 | - | 0.886 | - | - | - | - | |
| * |
52 (24.07) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| *2/*2 | 9 (4.17) | A | 0.153 | - | 0.170 | 0.144 | 0.148 | 0.150 | 0.163 | 0.130 | 0.159 | - | 0.093 | 0.111 | 0.131 | - | 0.114 | - | - | - | - | |
| *1/*1 | 216 (100) | G | 1.00 | - | - | - | - | - | - | - | 0.996 | - | - | 1.00 | 1.00 | - | 0.997 | - | - | - | - | |
| * |
0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| *3/*3 | 0 | A | 0.00 | - | - | - | - | - | - | - | 0.004 | - | - | 0.00 | 0.00 | - | 0.003 | - | - | - | - | |
| *1/*1 | 137 (63.42) | C | 0.796 | - | - | 0.799 | 0.763 | - | 0.778 | 0.810 | - | - | 0.776 | - | - | - | - | - | - | - | - | |
| * |
70 (32.41) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| 9 (4.17) | T | 0.204 | - | - | 0.201 | 0.237 | - | 0.222 | 0.190 | - | - | 0.224 | - | - | - | - | - | - | - | - | ||