[1. Vrhovac I, Breljak D, Sabolić I. Glucose transporters in the mammalian blood cells. Period Biol 2014;116:131-8.]Search in Google Scholar
[2. Mueckler M, Thorens B. The SLC2 (GLUT) family of membrane transporters. Mol Aspects Med 2013;34:121-38. doi: 10.1016/j.mam.2012.07.00123506862]Search in Google Scholar
[3. Wright E. Glucose transport families SLC5 and SLC50. Mol Aspects Med 2013;34:183-96. doi: 10.1016/j.mam.2012.11.00223506865]Search in Google Scholar
[4. Wright E, Loo D, Hirayama B. Biology of human sodium glucose transporters. Physiol Rev 2011;91:733-94. doi: 10.1152/physrev.00055.200921527736]Search in Google Scholar
[5. Hediger M, Rhoads D. Molecular physiology of sodiumglucose cotransporters. Physiol Rev 1994;74:993-1026. doi: 10.1152/physrev.1994.74.4.993]Search in Google Scholar
[6. Wright EM, Ghezzi C, Loo DDF. Novel and unexpected functions of SGLTs. Physiology 2017;32:435-43. doi: 10.1152/physiol.00021.2017]Search in Google Scholar
[7. Thorens B, Mueckler M. Glucose transporters in the 21st Century. Am J Physiol-Endoc M 2010;298:E141-5. doi: 10.1152/ajpendo.00712.2009]Search in Google Scholar
[8. Wright EM, Loo DD, Panayotova-Heiermann M, Lostao MP, Hirayama BH, Mackenzie B, Boorer K, Zampighi G. “Active” sugar transport in eukaryotes. J Exp Biol 1994;196:197-212. PMID: 782302210.1242/jeb.196.1.1977823022]Search in Google Scholar
[9. Otto W. On the origin of cancer cells. Science 1956;123:309-14. doi: 10.1126/science.123.3191.309]Search in Google Scholar
[10. Vander Heiden M, Cantley L, Thompson C. Understanding the Warburg effect: the metabolic requiremetns of cell proliferation. Science 2009;324:1029-33. doi: 10.1126/ science.1160809]Search in Google Scholar
[11. Yu L, Chen X, Wang L, Chen S. The sweet trap in tumors: aerobic glycolysis and potential targets for therapy. Oncotarget 2016;7:38908-26. doi: 10.18632/oncotarget.7676]Search in Google Scholar
[12. Herrmann K, Benz MR, Krause BJ, Pomykala KL, Buck AK, Czernin J. (18)F-FDG-PET/CT in evaluating response to therapy in solid tumors: where we are and where we can go. Q J Nucl Med Mol Im 2011;55:620-32. PMID: 22231582]Search in Google Scholar
[13. Ganapathy V, Thangaraju M, Prasad PD. Nutrient transporters in cancer: relevance to Warburg hypothesis and beyond. Pharmacol Therapeut 2009;121:29-40. doi: 10.1016/j. pharmthera.2008.09.005]Search in Google Scholar
[14. Szablewski L. Expression of glucose transporters in cancers. Biochim Biophys Acta 2013;1835:164-9. doi: 10.1016/j.bbcan.2012.12.004]Search in Google Scholar
[15. Ouiddir A, Planès C, Fernandes I, VanHesse A, Clerici C. Hypoxia upregulates activity and expression of the glucose transporter GLUT1 in alveolar epithelial cells. Am J Resp Cell Mol 1999;21:710-8. doi: 10.1165/ajrcmb.21.6.3751]Search in Google Scholar
[16. Zhang J-Z, Behrooz A, Ismail-Beigi F. Regulation of glucose transport by hypoxia. Am J Kidney Dis 1999;34:189-202. doi: 10.1016/S0272-6386(99)70131-9]Search in Google Scholar
[17. Baumann MU, Zamudio S, Ilsley N. Hypoxic upregulation of glucose transporters in BeWo choriocarcinoma cells is mediated by hypoxia-inducible factor-1. Am J Physiol-Cell Ph 2007;293:C477-85. doi: 10.1152/ajpcell.00075.2007]Search in Google Scholar
[18. Gorboulev V, Schürmann A, Vallon V, Kipp H, Jaschke A, Klessen D, Friedrich A, Scherneck S, Rieg T, Cunard R, Veyhl-Wichmann M, Srinivasan A, Balen D, Breljak D, Rexhepaj R, Parker HE, Gribble FM, Reimann F, Lang F, Wiese S, Sabolić I, Sendtner M, Koepsell H. Na+-D-glucose cotransporter SGLT1 is pivotal for intestinal glucose absorption and glucose-dependent incretin secretion. Diabetes 2012;61:187-96. doi: 10.2337/db11-1029]Search in Google Scholar
[19. Wright EM, Turk E. The sodium/glucose cotransport family SLC5. Pflügers Arch 2004;447:510-8. doi: 10.1007/s00424-003-1063-6]Search in Google Scholar
[20. Vallon V. Molecular determinants of renal glucose reabsorption. Focus on “Glucose transport by human renal Na+/D-glucose cotransporters SGLT1 and SGLT2”. Am J Physiol-Cell Ph 2011;300:C6-8. doi: 10.1152/ ajpcell.00444.2010]Search in Google Scholar
[21. Loo DDF, Wright EM, Zeuthen T. Water pumps. J Physiol 2002;542:53-60. doi: 10.1113/jphysiol.2002.018713]Search in Google Scholar
[22. Sabolić I, Vrhovac I, Balen Eror D, Gerasimova M, Rose M, Breljak D, Ljubojević M, Brzica H, Sebastiani A, Thal SC, Sauvant C, Kipp H, Vallon V, Koepsell H. Expression of Na+-D-glucose cotransporter SGLT2 in rodents is kidneyspecific and exhibits sex and species differences. Am J Physiol-Cell Ph 2012;302:C1174-88. doi: 10.1152/ajpcell.00450.2011]Search in Google Scholar
[23. Vrhovac I, Balen Eror D, Klessen D, Burger C, Breljak D, Kraus O, Radović N, Jadrijević S, Aleksić I, Walles T, Sauvant C, Sabolić I, Koepsell H. Localizations of Na+-Dglucose cotransporters SGLT1 and SGLT2 in human kidney and of SGLT1 in human small intestine, liver, lung, and heart. Pflügers Arch 2015;467:1881-98. doi: 10.1007/s00424-014-1619-7]Search in Google Scholar
[24. Vrhovac Madunić I, Breljak D, Karaica D, Koepsell H, Sabolić I. Expression profiling and immunolocalization of Na+-D-glucose-cotransporter 1 in mice employing knockout mice as specificity control indicate novel locations and differences between mice and rats. Pflügers Arch 2017;469:1545-65. doi: 10.1007/s00424-017-2056-1]Search in Google Scholar
[25. Chen J, Williams S, Ho S, Loraine H, Hagan D, Whaley JM, Feder JN. Quantitative PCR tissue expression profiling of the human SGLT2 gene and related family members. Diabetes Ther 2010;1:57-92. doi: 10.1007/s13300-010-0006-4]Search in Google Scholar
[26. Kashiwagi Y, Nagoshi T, Yoshino T, Tanaka TD, Ito K, Harada T, Takahashi H, Ikegami M, Anzawa R, Yoshimura M. Expression of SGLT1 in human hearts and impairment of cardiac glucose uptake by phlorizin during ischemiareperfusion injury in mice. PloS One 2015;10:e0130605. doi: 10.1371/journal.pone.0130605]Search in Google Scholar
[27. Sharma P, Khairnar V, Vrhovac Madunić I, Singh Y, Pandyra A, Salker MS, Koepsell H, Sabolić I, Lang F, Lang PA, Lang KS. SGLT1 Deficiency turns Listeria infection into a lethal disease in mice. Cell Physiol Biochem 2017:1358-65. doi: 10.1159/000479197]Search in Google Scholar
[28. Kepe V, Scafoglio C, Liu J, Yong WH, Bergsneider M, Huang SC, Barrio JR, Wright EM. Positron emission tomography of sodium glucose cotransport activity in high grade astrocytomas. J Neuro-Oncol 2018:138:557-69. doi: 10.1007/s11060-018-2823-7]Search in Google Scholar
[29. Scafoglio C, Hirayama BA, Kepe V, Liu J, Ghezzi C, Satyamurthy N, Moatamed NA, Huang J, Koepsell H, Barrio JR, Wright EM. Functional expression of sodium-glucose transporters in cancer. P Natl Acad Sci USA 2015;112:E4111-9. doi: 10.1073/pnas.1511698112]Search in Google Scholar
[30. Ishikawa N, Oguri T, Isobe T, Fujitaka K, Kohno N. SGLT gene expression in primary lung cancers and their metastatic lesions. Jpn J Cancer Res 2001;92:874-9. doi: 10.1111/j.1349-7006.2001.tb01175.x]Search in Google Scholar
[31. Guo GF, Cai YC, Zhang B, Xu RH, Qiu HJ, Xia LP, Jiang WQ, Hu PL, Chen XX, Zhou FF, Wang F. Overexpression of SGLT1 and EGFR in colorectal cancer showing a correlation with the prognosis. Med Oncol 2011;28(Suppl 1):S197-203. doi: 10.1007/s12032-010-9696-8]Search in Google Scholar
[32. Blais A. Expression of Na(+)-coupled sugar transport in HT-29 cells: modulation by glucose. Am J Physiol-Cell Ph 1991;260:C1245-52. doi: 10.1152/ajpcell.1991.260.6.C1245]Search in Google Scholar
[33. Delezay O, Verrier B, Mabrouk K, van Rietschoten J, Fantini J, Mauchamp J, Gerard C. Characterization of an electrogenic sodium/glucose cotransporter in a human colon epithelial cell line. J Cell Physiol 1995;163:120-8. doi: 10.1002/jcp.1041630114]Search in Google Scholar
[34. Bissonnette P, Gagne H, Coady MJ, Benabdallah K, Lapointe JY, Berteloot A. Kinetic separation and characterization of three sugar transport modes in Caco-2 cells. Am J Physiol 1996;270:G833-43. doi: 10.1152/ajpgi.1996.270.5.G833]Search in Google Scholar
[35. Weihua Z, Tsan R, Huang WC, Wu Q, Chiu CH, Fidler IJ, Hung MC. Survival of cancer cells is maintained by EGFR independent of its kinase activity. Cancer Cell 2008;13:385-93. doi: 10.1016/j.ccr.2008.03.01518455122]Search in Google Scholar
[36. Casneuf VF, Fonteyne P, Van Damme N, Demetter P, Pauwels P, de Hemptinne B, De Vos M, Van de Wiele C, Peeters M. Expression of SGLT1, Bcl-2 and p53 in primary pancreatic cancer related to survival. Cancer Invest 2008;26:852-9. doi: 10.1080/07357900801956363]Search in Google Scholar
[37. Hanabata Y, Nakajima Y, Morita K, Kayamori K, Omura K. Coexpression of SGLT1 and EGFR is associated with tumor differentiation in oral squamous cell carcinoma. Odontology 2012;100:156-63. doi: 10.1007/s10266-011-0033-2]Search in Google Scholar
[38. Helmke BM, Reisser C, Idzkoe M, Dyckhoff G, Herold- Mende C. Expression of SGLT-1 in preneoplastic and neoplastic lesions of the head and neck. Oral Oncol 2004;40:28-35. doi: 10.1016/S1368-8375(03)00129-5]Search in Google Scholar
[39. Blessing A, Xu L, Gao G, Bollu LR, Ren J, Li H, Wu X, Su F, Huang W-C, Hung M-C, Huo L, Palapattu GS, Weihua Z. Sodium/glucose co-transporter 1 expression increases in human diseased prostate. J Cancer Sci Ther 2012;4:306-12. doi: 10.4172/1948-5956.1000159]Search in Google Scholar
[40. Lin H-W, Tseng C-H. A Review on the relationship between SGLT2 inhibitors and cancer. Int J Endocrinol 2014;2014:719578. doi: 10.1155/2014/719578]Search in Google Scholar
[41. Hummel CS, Lu C, Liu J, Ghezzi C, Hirayama BA, Loo DDF, Kepe V, Barrio JR, Wright EM. Structural selectivity of human SGLT inhibitors. Am J Physiol-Cell Ph 2012;302:C373-82. doi: 10.1152/ajpcell.00328.2011]Search in Google Scholar
[42. Vallon V. The mechanisms and therapeutic potential of SGLT2 inhibitors in diabetes mellitus. Annu Rev Med 2015;66:255-70. doi: 10.1146/annurev-med-051013-110046]Search in Google Scholar
[43. Balen D, Ljubojević M, Breljak D, Brzica H, Žlender V, Koepsell H, Sabolić I. Revised immunolocalization of the Na+-D-glucose cotransporter SGLT1 in rat organs with an improved antibody. Am J Physiol-Cell Ph 2008;295:C475-89. doi: 10.1152/ajpcell.00180.2008]Search in Google Scholar
[44. World Health Organization (WHO). [displayed 22 November 2018]. Available at: http://www.who.int/en/news-room/factsheets/detail/cancer]Search in Google Scholar
[45. RS B, Leung J, Kison P, Zasadny K, Flint A, Wahl R. Glucose transporters and FDG uptake in untreated primary human non-small cell lung cancer. J Nucl Med 1999;40:556-65. PMID: 1021021310210213]Search in Google Scholar
[46. Kurata T, Oguri T, Isobe T. Differential expression of facilitative glucose transporter (GLUT) genes in primary lung cancers and their liver metastases. Jpn J Cancer Res 1999;90:1238-43. doi: 10.1111/j.1349-7006.1999.tb00702.x10622535]Search in Google Scholar
[47. Yu M, Yongzhi H, Chen S, Luo X, Lin Y, Zhou Y, Jin H, Hou B, Deng Y, Tu L, Jian Z. The prognostic value of GLUT1 in cancers: a systematic review and meta-analysis. Oncotarget 2015;8:43356-67. doi: 10.18632/oncotarget.17445]Search in Google Scholar
[48. Kamisawa T, Wood LD, Itoi T, Takaori K. Pancreatic cancer. Lancet 2016;388:73-85. doi: 10.1016/S0140-6736(16)00141-0]Search in Google Scholar
[49. Ozaki T, Nakagawara A. Role of p53 in cell death and human cancers. Cancers 2011;3:994-1013. doi: 10.3390/cancers3010994]Search in Google Scholar
[50. Ghezzi C, Wright EM. Regulation of the human Na+- dependent glucose cotransporter hSGLT2. Am J Physiol-Cell Ph 2012;303:C348-54. doi: 10.1152/ajpcell.00115.2012]Search in Google Scholar
[51. Siegel RL, Miller KD, Jemal A. Cancer Statistics. CA Cancer J Clin 2017;67:7-30. doi: 10.3322/caac.21387]Search in Google Scholar
[52. Vaz CV, Marques R, Alves MG, Oliveira PF, Cavaco JE, Maia CJ, Socorro S. Androgens enhance the glycolytic metabolism and lactate export in prostate cancer cells by modulating the expression of GLUT1, GLUT3, PFK, LDH and MCT4 genes. J Cancer Res Clin Oncol 2016;142:5-16. doi: 10.1007/s00432-015-1992-4]Search in Google Scholar
[53. Lai B, Xiao Y, Pu H, Cao Q, Jing H, Liu X. Overexpression of SGLT1 is correlated with tumor development and poor prognosis of ovarian carcinoma. Arch Gynecol Obstet 2012;285:1455-61. doi: 10.1007/s00404-011-2166-5]Search in Google Scholar
[54. Salker MS, Singh Y, Zeng N, Chen H, Zhang S, Umbach AT, Fakhri H, Kohlhofer U, Quintanilla-Martinez L, Durairaj RRP, Barros FSV, Vrljicak P, Ott S, Brucker SY, Wallwiener D, Vrhovac Madunić I, Breljak D, Sabolić I, Koepsell H, Bronsen JJ, Lang F. Loss of endometrial sodium glucose cotransporter SGLT1 is detrimental to embryo survival and fetal growth in pregnancy. Sci Rep 2017;7:12612. doi: 10.1038/s41598-017-11674-3]Search in Google Scholar
[55. Yu AS, Hirayama BA, Timbol G, Liu J, Basarah E, Kepe V, Satyamurthy N, Huang S, Wright EM, Barrio JR. Functional expression of SGLTs in rat brain. Am J Physiol-Cell Ph 2010;1751:C1277-84. doi: 10.1152/ajpcell.00296.2010]Search in Google Scholar
[56. Yu AS, Hirayama BA, Timbol G, Liu J, Diez-Sampedro A, Kepe V, Satyamurthy N, Huang S-C, Wright EM, Barrio JR. Regional distribution of SGLT activity in rat brain in vivo. Am J Physiol-Cell Ph 2013;304:C240-7. doi: 10.1152/ajpcell.00317.2012]Search in Google Scholar
[57. Madunić J, Vrhovac Madunić I, Gajski G, Popić J, Garaj- Vrhovac V. Apigenin: A dietary flavonoid with diverse anticancer properties. Cancer Lett 2018;413:11-22. doi: 10.1016/j.canlet.2017.10.041]Search in Google Scholar
[58. Koepsell H. The Na+ -D-glucose cotransporters SGLT1 and SGLT2 are targets for the treatment of diabetes and cancer. Pharmacol Ther 2017;170:148-65. doi:10.1016/j.pharmthera.2016.10.017]Search in Google Scholar
[59. Yamazaki Y, Harada S, Tokuyama S. Sodium-glucose transporter as a novel therapeutic target in disease. Eur J of Pharmacol 2018;822:25-31. doi: 10.1016/j.ejphar.2018.01.003.]Search in Google Scholar