Acceso abierto

Surgery plus TKIs therapy for gastrointestinal stromal tumors

Tiequan Yang
Tiequan Yang
, 
Boyang Gao
Boyang Gao
 y 
Keji Zheng
Keji Zheng
   | 10 abr 2024
Postępy Higieny i Medycyny Doświadczalnej's Cover Image
Acerca de este artículo
Artículo anterior
Artículo siguiente
Cite
Article Category: Review
Publicado en línea: 10 abr 2024
Páginas: 45 - 51
Recibido: 30 jul 2023
Aceptado: 13 feb 2024
DOI: https://doi.org/10.2478/ahem-2024-0004
Palabras clave
© 2024 Keji Zheng et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Figure 1.

Flow chart of literature selection process
Flow chart of literature selection process

Figure 2A.

Meta-analysis of 3-year PFS between surgery plus TKIs group and TKIs alone group. A forest plot displays individual study results (squares) along with their confidence intervals (horizontal lines). The size of the square represents the weight of the study. The pooled odds ratio is represented by a diamond, with the diamond’s width indicating the 95% confidence interval for the pooled odds ratio
Meta-analysis of 3-year PFS between surgery plus TKIs group and TKIs alone group. A forest plot displays individual study results (squares) along with their confidence intervals (horizontal lines). The size of the square represents the weight of the study. The pooled odds ratio is represented by a diamond, with the diamond’s width indicating the 95% confidence interval for the pooled odds ratio

Figure 2B.

Begg’s funnel plot for visual assessment of no publication bias for 3-year PFS
Begg’s funnel plot for visual assessment of no publication bias for 3-year PFS

Figure 2C.

Egger’s publication bias plot showed no publication bias for 3-year PFS
Egger’s publication bias plot showed no publication bias for 3-year PFS

Figure 3.

Meta-analysis of 3-year OS between surgery plus TKIs group and TKIs alone group. A forest plot displays individual study results (squares) along with their confidence intervals (horizontal lines). The size of the square represents the weight of the study. The pooled odds ratio is represented by a diamond, with the diamond’s width indicating the 95% confidence interval for the pooled odds ratio
Meta-analysis of 3-year OS between surgery plus TKIs group and TKIs alone group. A forest plot displays individual study results (squares) along with their confidence intervals (horizontal lines). The size of the square represents the weight of the study. The pooled odds ratio is represented by a diamond, with the diamond’s width indicating the 95% confidence interval for the pooled odds ratio

Figure 4.

Meta-analysis of 5-year OS between surgery plus TKIs group and TKIs alone group. A forest plot displays individual study results (squares) along with their confidence intervals (horizontal lines). The size of the square represents the weight of the study. The pooled odds ratio is represented by a diamond, with the diamond’s width indicating the 95% confidence interval for the pooled odds ratio
Meta-analysis of 5-year OS between surgery plus TKIs group and TKIs alone group. A forest plot displays individual study results (squares) along with their confidence intervals (horizontal lines). The size of the square represents the weight of the study. The pooled odds ratio is represented by a diamond, with the diamond’s width indicating the 95% confidence interval for the pooled odds ratio

Figure 5.

Meta-analysis of 5-year OS between surgery plus TKIs group and TKIs alone group for GLM. A forest plot displays individual study results (squares) along with their confidence intervals (horizontal lines). The size of the square represents the weight of the study. The pooled odds ratio is represented by a diamond, with the diamond’s width indicating the 95% confidence interval for the pooled odds ratio
Meta-analysis of 5-year OS between surgery plus TKIs group and TKIs alone group for GLM. A forest plot displays individual study results (squares) along with their confidence intervals (horizontal lines). The size of the square represents the weight of the study. The pooled odds ratio is represented by a diamond, with the diamond’s width indicating the 95% confidence interval for the pooled odds ratio

Characteristics of studies included in meta-analysis of role of surgery for patients with recurrent or metastatic gastrointestinal stromal tumors

Author, Year Country No. of patients Sex(male/female) Mean age (year) Mean Tumor size (cm) Classification of recurrent or metastatic GISTs Type of TKIs Timing of TKIs Surgical management Follow-up (median, range) Study design
Chang SC 2015[18] China 182 S:44/32 S:55.89 ---- metastatic or recurrent GISTs imatinib Preop + Postop

R0 30

R1 9

R2 37

 ---- Retrospective
NS:66/40 NS:58.42
Zaydfudim V 2015[9] USA 87 S:31/23 S:61

S:9

NS:9

 metastatic or recurrent GISTs Imatinib or sunitinib Preop + Postop

R0 32

R1 3

R2 19

 ---- Retrospective
NS:17/16 NS:60
Sato S 2016 [19] Japan 93 S:28/22 S:60 S:7.5 metastatic or recurrent GISTs Imatinib Postop only

R0 29

R1 5

R2 13

 75.2 Retrospective
NS:28/15 NS:69.7 NS:8
Shi YN 2017 [20] China 130 90/54 56 ---- metastatic GISTs Imatinib then sunitinib Postop only

R0 23

R1/R2 9

 48.2 Retrospective
Xiao B 2018 [21] China 102 S:11/10 52 4.4 metastatic GISTs Imatinib then sunitinib Postop only

R0 15

R1/R2 6

 ---- Retrospective
NS:60/21
Xia L 2010 [22] China 39 S:10/9 53 S: 8.9 metastatic GISTs Imatinib Preop + Postop ---- 36 Retrospective
NS:11/9 55 N:9.3
Bauer S 2005[8] USA 90 S:6/6 S:57 ----- Metastatic GISTs Imatinib Preop + Postop

R0 11

R1/R2 1

 ---- Retrospective
NS:45/33 NS:62
Xue A 2022 [23] China 119 S:34/28 56 4 metastatic GISTs imatinib Preop + Postop

R0 44

R1 16

R2 2

 56 Retrospective
NS:37/20

Newcastle-Ottawa Scale Assessment of enrolled studies

Author, Year Selection (0–4) Comparability (0–2) Outcome (0–3) Quality score
Chang SC 2015[18] 4 1 3 8
Zaydfudim V 2015[9] 4 1 2 7
Sato S 2016 [19] 4 1 2 7
Shi YN 2017 [20] 4 1 2 7
Xiao B 2018 [21] 4 1 3 8
Xia L 2010 [22] 4 1 2 7
Bauer S 2005[8] 4 1 3 8
Xue A 2022 [23] 4 1 3 8
eISSN:
1732-2693
Idioma:
Inglés
Calendario de la edición:
Volume Open
Temas de la revista:
Life Sciences, Molecular Biology, Microbiology and Virology, Medicine, Basic Medical Science, Immunology
RSS Feed de revista