<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Total parenteral nutrition (TPN) is a life-saving nutritional therapy in conditions where enteral nutrition is contraindicated or inadequate. However, it has been associated with side effects, one of which is parenteral nutrition–associated liver damage (PNALD). The main features of PNALD are cholestasis, fatty liver disease, and early fibrosis, followed by disease progression, cirrhosis, and liver failure. Risk factors for parenterally fed patients include short bowel syndrome, bacterial overgrowth and translocation, disturbances in hepatobiliary circulation and lack of enteral nutrition, and the choice of an inappropriate fat mixture. The source of the oil present in lipid emulsions is believed to play an important role in the development of long-term complications.</p>
<p>This review analyzes the current literature and research on the pathogenesis of PNALD. Likewise, possible options for preventing this complication were discussed.</p>
</abstract>

Total parenteral nutrition (TPN) is a life-saving nutritional therapy in conditions where enteral nutrition is contraindicated or inadequate. However, it has been associated with side effects, one of which is parenteral nutrition–associated liver damage (PNALD). The main features of PNALD are cholestasis, fatty liver disease, and early fibrosis, followed by disease progression, cirrhosis, and liver failure. Risk factors for parenterally fed patients include short bowel syndrome, bacterial overgrowth and translocation, disturbances in hepatobiliary circulation and lack of enteral nutrition, and the choice of an inappropriate fat mixture. The source of the oil present in lipid emulsions is believed to play an important role in the development of long-term complications.
This review analyzes the current literature and research on the pathogenesis of PNALD. Likewise, possible options for preventing this complication were discussed.

Liver complications of total parenteral nutrition: the latest therapeutic strategies

Department of General Surgery and Clinical Nutrition

Department of Human Nutrition, Faculty of Health Sciences

Postępy Higieny i Medycyny Doświadczalnej

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Total parenteral nutrition (TPN) is a life-saving nutritional therapy in conditions where enteral nutrition is contraindicated or inadequate. However, it has...

Liver complications of total parenteral nutrition: the latest therapeutic strategies

Article Category: Review

Publicado en línea: 25 abr 2023

Páginas: 21 - 26

Recibido: 25 mar 2022

Aceptado: 18 nov 2022

DOI: https://doi.org/10.2478/ahem-2023-0003

Palabras clave
PNALD, parenteral nutrition, fat emulsions, liver diseases

© 2023 Karolina Dąbrowska, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Liver complications of total parenteral nutrition: the latest therapeutic strategies

Article Category: Review

Publicado en línea: 25 abr 2023

Páginas: 21 - 26

Recibido: 25 mar 2022

Aceptado: 18 nov 2022

DOI: https://doi.org/10.2478/ahem-2023-0003

Palabras clavePNALD, parenteral nutrition, fat emulsions, liver diseases

© 2023 Karolina Dąbrowska, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Palabras clave
PNALD, parenteral nutrition, fat emulsions, liver diseases