Exenatide improves antioxidant capacity and reduces the expression of LDL receptors and PCSK9 in human insulin-secreting 1.1E7 cell line subjected to hyperglycemia and oxidative stress
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Diabetes [World Health Organization webpage]. Available at https://www.who.int/health-topics/diabetes#tab=tab_1 (Accessed September 2020).Available at https://www.who.int/health-topics/diabetes#tab=tab_1 (Accessed September 2020).Search in Google Scholar
Drucker DJ. Mechanisms of action and therapeutic application of glucagon-like peptide-1. Cell Metab. 2018; 27: 740–756.DruckerDJMechanisms of action and therapeutic application of glucagon-like peptide-120182774075610.1016/j.cmet.2018.03.00129617641Search in Google Scholar
Dardano A, Miccoli R, Bianchi C, Daniele G, Del Prato S. Invited review. Series: Implicaions of the recent CVOTs in type 2 diabetes: Which patients for GLP-1RA or SGLT-2 inhibitor? Diabetes Res. Clin. Pract. 2020; 162: 108112.DardanoAMiccoliRBianchiCDanieleGDel PratoSInvited review. Series: Implicaions of the recent CVOTs in type 2 diabetes: Which patients for GLP-1RA or SGLT-2 inhibitor?202016210811210.1016/j.diabres.2020.10811232198123Search in Google Scholar
Juang JH, Kuo CH, Wu CH, Juang C. Exendin-4 treatment expands graft β-cell mass in diabetic mice transplanted with a marginal number of fresh islets. Cell Transplant. 2008; 17: 641–647.JuangJHKuoCHWuCHJuangCExendin-4 treatment expands graft β-cell mass in diabetic mice transplanted with a marginal number of fresh islets20081764164710.3727/09636890878609276618819252Search in Google Scholar
Miki A, Ricordi C, Sakuma Y, Yamamoto T, Misawa R, Mita A, Molano RD, Vaziri ND, Pileggi A, Ichii H. Divergent antioxidant capacity of human islet cell subsets: A potential cause of beta-cell vulnerability in diabetes and islet transplantation. PLoS. One. 2018; 13: e0196570.MikiARicordiCSakumaYYamamotoTMisawaRMitaAMolanoRDVaziriNDPileggiAIchiiHDivergent antioxidant capacity of human islet cell subsets: A potential cause of beta-cell vulnerability in diabetes and islet transplantation201813e019657010.1371/journal.pone.0196570593377829723228Search in Google Scholar
Bułdak Ł, Machnik G, Bułdak RJ, Łabuzek K, Bołdys A, Belowski D, Basiak M, Okopień B: Exenatide (a GLP-1 agonist) expresses anti-inflammatory properties in cultured human monocytes/macrophages in a protein kinase A and B/Akt manner. Pharmacol. Rep. 2016; 68: 329–337.BułdakŁMachnikGBułdakRJŁabuzekKBołdysABelowskiDBasiakMOkopieńBExenatide (a GLP-1 agonist) expresses anti-inflammatory properties in cultured human monocytes/macrophages in a protein kinase A and B/Akt manner20166832933710.1016/j.pharep.2015.10.00826922535Search in Google Scholar
Zhang P, Li T, Wu X, Nice EC, Huang C, Zhang Y: Oxidative stress and diabetes: Antioxidative strategies. Front Med. 2020; 14: 583–600.ZhangPLiTWuXNiceECHuangCZhangYOxidative stress and diabetes: Antioxidative strategies20201458360010.1007/s11684-019-0729-132248333Search in Google Scholar
Bułdak RJ, Bułdak Ł, Kukla M, Gabriel A, Zwirska-Korczala K. Significance of selected antioxidant enzymes in cancer cell progression. Pol. J. Pathol. 2014; 65: 167–175.BułdakRJBułdakŁKuklaMGabrielAZwirska-KorczalaKSignificance of selected antioxidant enzymes in cancer cell progression20146516717510.5114/pjp.2014.4577925372413Search in Google Scholar
Kondo M, Tanabe K, Amo-Shiinoki K, Hatanaka M, Morii T, Takahashi H, Seino S, Yamada Y, Tanizawa Y. Activation of GLP-1 receptor signalling alleviates cellular stresses and improves beta cell function in a mouse model of Wolfram syndrome. Diabetologia. 2018; 61: 2189–2201.KondoMTanabeKAmo-ShiinokiKHatanakaMMoriiTTakahashiHSeinoSYamadaYTanizawaYActivation of GLP-1 receptor signalling alleviates cellular stresses and improves beta cell function in a mouse model of Wolfram syndrome2018612189220110.1007/s00125-018-4679-y30054673Search in Google Scholar
Yang SH, Xu RX, Cui CJ, Wang Y, Du Y, Chen ZG, Yao YH, Ma CY, Zhu CG, Guo YL, et al. Liraglutide downregulates hepatic LDL receptor and PCSK9 expression in HepG2 cells and db/db mice through a HNF-1a dependent mechanism. Cardiovasc. Diabetol. 2018; 17: 48.YangSHXuRXCuiCJWangYDuYChenZGYaoYHMaCYZhuCGGuoYLLiraglutide downregulates hepatic LDL receptor and PCSK9 expression in HepG2 cells and db/db mice through a HNF-1a dependent mechanism2018174810.1186/s12933-018-0689-9588540829618348Search in Google Scholar
Perego C, Da Dalt L, Pirillo A, Galli A, Catapano AL, Norata GD. Cholesterol metabolism, pancreatic β-cell function and diabetes. Biochim. Biophys. Acta Mol. Basis Dis. 2019; 1865: 2149–2156.PeregoCDa DaltLPirilloAGalliACatapanoALNorataGDCholesterol metabolism, pancreatic β-cell function and diabetes201918652149215610.1016/j.bbadis.2019.04.01231029825Search in Google Scholar
Ramin-Mangata S, Blanchard V, Lambert G. Key aspects of PCSK9 inhibition beyond LDL lowering. Curr. Opin. Lipidol. 2018; 29: 453–458.Ramin-MangataSBlanchardVLambertGKey aspects of PCSK9 inhibition beyond LDL lowering20182945345810.1097/MOL.000000000000055130199407Search in Google Scholar
Abramoff MD, Magalhaes PJ, Ram SJ. Image processing with ImageJ. Biophotonics Inter. 2004; 11: 36–42.AbramoffMDMagalhaesPJRamSJImage processing with ImageJ2004113642Search in Google Scholar
Zhang H, Forman HJ. Acrolein induces heme oxygenase-1 through PKC-delta and PI3K in human bronchial epithelial cells. Am. J. Respir. Cell. Mol. Biol. 2008; 38: 483–490.ZhangHFormanHJAcrolein induces heme oxygenase-1 through PKC-delta and PI3K in human bronchial epithelial cells20083848349010.1165/rcmb.2007-0260OC18048804Search in Google Scholar
Kajimoto Y, Kaneto H. Role of oxidative stress in pancreatic β-cell dysfunction. Ann. N.Y. Acad. Sci. 2004; 1011: 168–176.KajimotoYKanetoHRole of oxidative stress in pancreatic β-cell dysfunction2004101116817610.1007/978-3-662-41088-2_1715126294Search in Google Scholar
Yap MK, Misuan N.: Exendin-4 from Heloderma suspectum venom: From discovery to its latest application as type II diabetes combatant. Basic Clin. Pharmacol. Toxicol. 2019; 124: 513–527.YapMKMisuanN.Exendin-4 from Heloderma suspectum venom: From discovery to its latest application as type II diabetes combatant201912451352710.1111/bcpt.1316930417596Search in Google Scholar
Bułdak Ł, Machnik G, Skudrzyk E, Bołdys A, Okopień B. The impact of exenatide (a GLP-1 agonist) on markers of inflammation and oxidative stress in normal human astrocytes subjected to various glycemic conditions. Exp. Ther. Med. 2019; 17: 2861–2869.BułdakŁMachnikGSkudrzykEBołdysAOkopieńBThe impact of exenatide (a GLP-1 agonist) on markers of inflammation and oxidative stress in normal human astrocytes subjected to various glycemic conditions2019172861286910.3892/etm.2019.7245642522730906473Search in Google Scholar
Alnahdi A, John A, Raza H. N-acetyl cysteine attenuates oxidative stress and glutathione-dependent redox imbalance caused by high glucose/high palmitic acid treatment in pancreatic Rin-5F cells. PLoS. One. 2019; 14: e0226696.AlnahdiAJohnARazaHN-acetyl cysteine attenuates oxidative stress and glutathione-dependent redox imbalance caused by high glucose/high palmitic acid treatment in pancreatic Rin-5F cells201914e022669610.1371/journal.pone.0226696692467931860682Search in Google Scholar
Newsholme P, Keane KN, Carlessi R, Cruzat V. Oxidative stress pathways in pancreatic β-cells and insulin-sensitive cells and tissues: Importance to cell metabolism, function, and dysfunction. Am. J. Physiol. Cell Physiol. 2019; 317: C420–C433.NewsholmePKeaneKNCarlessiRCruzatVOxidative stress pathways in pancreatic β-cells and insulin-sensitive cells and tissues: Importance to cell metabolism, function, and dysfunction2019317C420C43310.1152/ajpcell.00141.201931216193Search in Google Scholar
Rocha S, Gomes D, Lima M, Bronze-da-Rocha E, Santos-Silva A. Peroxiredoxin 2, glutathione peroxidase, and catalase in the cytosol and membrane of erythrocytes under H2O2-induced oxidative stress. Free Radic. Res. 2015; 49: 990–1003.RochaSGomesDLimaMBronze-da-RochaESantos-SilvaAPeroxiredoxin 2, glutathione peroxidase, and catalase in the cytosol and membrane of erythrocytes under H2O2-induced oxidative stress201549990100310.3109/10715762.2015.102840225786472Search in Google Scholar
Bułdak Ł, Łabuzek K, Bułdak RJ, Machnik G, Bołdys A, Okopień B. Exenatide (a GLP-1 agonist) improves the antioxidative potential of in vitro cultured human monocytes/macrophages. Naunyn Schmiedebergs Arch. Pharmacol. 2015; 388: 905–919.BułdakŁŁabuzekKBułdakRJMachnikGBołdysAOkopieńBExenatide (a GLP-1 agonist) improves the antioxidative potential of in vitro cultured human monocytes/macrophages201538890591910.1007/s00210-015-1124-3453750725980358Search in Google Scholar
Vasu S, McClenaghan NH, McCluskey JT, Flatt PR. Cellular responses of novel human pancreatic β-cell line, 1.1B4 to hyperglycemia. Islets. 2013; 5: 170–177.VasuSMcClenaghanNHMcCluskeyJTFlattPRCellular responses of novel human pancreatic β-cell line, 1.1B4 to hyperglycemia2013517017710.4161/isl.2618423985558Search in Google Scholar
Kim MH, Kim EH, Jung HS, Yang D, Park EY, Jun HS. EX4 stabilizes and activates Nrf2 via PKC, contributing to the prevention of oxidative stress-induced pancreatic beta cell damage. Toxicol. Appl. Pharmacol. 2017; 315: 60–69.KimMHKimEHJungHSYangDParkEYJunHSEX4 stabilizes and activates Nrf2 via PKC, contributing to the prevention of oxidative stress-induced pancreatic beta cell damage2017315606910.1016/j.taap.2016.12.00527939242Search in Google Scholar
Kim JY, Lim DM, Moon CI, Jo KJ, Lee SK, Baik HW, Lee KH, Lee KW, Park KY, Kim BJ. Exendin-4 protects oxidative stress-induced β-cell apoptosis through reduced JNK and GSK3 activity. J. Korean Med. Sci. 2010; 25: 1626–1632.KimJYLimDMMoonCIJoKJLeeSKBaikHWLeeKHLeeKWParkKYKimBJExendin-4 protects oxidative stress-induced β-cell apoptosis through reduced JNK and GSK3 activity2010251626163210.3346/jkms.2010.25.11.1626296700021060752Search in Google Scholar
Geraldes P, King GL. Activation of protein kinase C isoforms and its impact on diabetic complications. Circ. Res. 2010; 106: 1319–1331.GeraldesPKingGLActivation of protein kinase C isoforms and its impact on diabetic complications20101061319133110.1161/CIRCRESAHA.110.217117287759120431074Search in Google Scholar
Zhang L, Tian J, Diao S, Zhang G, Xiao M, Chang D. GLP-1 receptor agonist liraglutide protects cardiomyocytes from IL-1β-induced metabolic disturbance and mitochondrial dysfunction. Chem. Biol. Interact. 2020; 332: 109252.ZhangLTianJDiaoSZhangGXiaoMChangDGLP-1 receptor agonist liraglutide protects cardiomyocytes from IL-1β-induced metabolic disturbance and mitochondrial dysfunction202033210925210.1016/j.cbi.2020.10925232898504Search in Google Scholar
Ooba N, Setoguchi S, Sato T, Kubota K. Lipid-lowering drugs and risk of new-onset diabetes: A cohort study using Japanese healthcare data linked to clinical data for health screening. BMJ Open. 2017; 7: e015935.OobaNSetoguchiSSatoTKubotaKLipid-lowering drugs and risk of new-onset diabetes: A cohort study using Japanese healthcare data linked to clinical data for health screening20177e01593510.1136/bmjopen-2017-015935572609428667223Search in Google Scholar
Aoki K, Kamiyama H, Takihata M, Taguri M, Shibata E, Shinoda K, Yoshii T, Nakajima S, Terauchi Y. Effect of liraglutide on lipids in patients with type 2 diabetes: A pilot study. Endocr. J. 2020; 67: 957–962.AokiKKamiyamaHTakihataMTaguriMShibataEShinodaKYoshiiTNakajimaSTerauchiYEffect of liraglutide on lipids in patients with type 2 diabetes: A pilot study20206795796210.1507/endocrj.EJ19-046432554954Search in Google Scholar
Roehrich ME, Mooser V, Lenain V, Herz J, Nimpf J, Azhar S, Bideau M, Capponi A, Nicod P, Haefliger JA, Waeber G. Insulin-secreting β-cell dysfunction induced by human lipoproteins. J. Biol. Chem. 2003; 278: 18368–18375.RoehrichMEMooserVLenainVHerzJNimpfJAzharSBideauMCapponiANicodPHaefligerJAWaeberGInsulin-secreting β-cell dysfunction induced by human lipoproteins2003278183681837510.1074/jbc.M30010220012594227Search in Google Scholar
Kockx M, Kritharides L. Pancreatic PCSK9 and its involvement in diabetes. J. Thorac. Dis. 2019; 11: S2018–S2022.KockxMKritharidesLPancreatic PCSK9 and its involvement in diabetes201911S2018S202210.21037/jtd.2019.06.37678377731632814Search in Google Scholar