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Article Category: Special Issue Article
Publicado en línea: 24 ago 2023
Páginas: 28 - 33
Recibido: 14 jun 2023
Aceptado: 23 jun 2023
DOI: https://doi.org/10.2478/afpuc-2023-0005
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© 2023 T. Wolaschka et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Figure 1.
Figure 2.
Composition of polymeric solutions (in grams).
| C940-0.10 | 0.100 | - | - | - | 99.900 | - |
| C940-0.70 | 0.700 | - | - | - | 99.300 | - |
| C940-1.30 | 1.300 | - | - | - | 98.700 | - |
| PCP-0.200 | - | 0.200 | - | - | 99.800 | - |
| PCP-0.225 | - | 0.225 | - | - | 99.775 | - |
| PCP-0.250 | - | 0.250 | - | - | 99.750 | - |
| PCP-0.300 | - | 0.300 | - | - | 99.700 | - |
| PCP-0.400 | - | 0.400 | - | - | 99.600 | - |
| PCP-0.600 | - | 0.600 | - | - | 99.400 | - |
| PCP-1.000 | - | 1.000 | - | - | 99.000 | - |
| CHL-3000 | - | - | 3.000 | - | - | 97.000 |
| CHL-3.50. | - | - | 3.500 | - | - | 96.500 |
| CHM-200. | - | - | - | 2.000 | - | 98.000 |
| CHM-2.50 | - | - | - | 2.500 | - | 97.500 |
| CHM-30.0 | - | - | - | 3.000 | - | 97.000 |
Injectability of polymeric solutions.
| C940-0.10 | + | + | + | + |
| C940-0.70 | − | − | − | − |
| C940-1.30 | − | − | − | − |
| PCP-0.200 | + | + | + | + |
| PCP-0.225 | + | + | + | + |
| PCP-0.250 | + | + | + | + |
| PCP-0.300 | + | + | + | + |
| PCP-0.400 | + | + | + | + |
| PCP-0.600 | + | + | + | + |
| PCP-1.000 | + | + | + | + |
| CHL-3000 | − | − | − | − |
| CHL-3.50. | − | − | − | − |
| CHM-200. | − | − | − | − |
| CHM-2.50 | − | − | − | − |
| CHM-30.0 | − | − | − | − |
Appearance of polymeric solutions and gels, pH of polymeric solutions, and pH of the gelation.
| C940-0.10 | ++ | +++ | 3.57 ± 0.05 | 6.74 ± 0.47 |
| C940-0.70 | ++ | +++ | 2.93 ± 0.10 | 3.01 ± 0.14 |
| C940-1.30 | ++ | +++ | 2.66 ± 0.03 | 2.81 ± 0.02 |
| PCP-0.200 | + | − | 3.68 ± 0.02 | − |
| PCP-0.225 | + | +++ | 3.59 ± 0.05 | 6.61 ± 0.21 |
| PCP-0.250 | + | +++ | 3.56 ± 0.03 | 6.02 ± 0.06 |
| PCP-0.300 | + | +++ | 3.39 ± 0.03 | 5.36 ± 0.30 |
| PCP-0.400 | + | +++ | 3.35 ± 0.04 | 4.19 ± 0.33 |
| PCP-0.600 | + | ++ | 3.26 ± 0.04 | 4.03 ± 0.08 |
| PCP-1.000 | + | + | 3.32 ± 0.24 | 3.36 ± 0.37 |
| CHL-3000 | + | np | 4.62 ± 0.09 | 7.00 ± 0.00 |
| CHL-3.50. | + | np | 5.05 ± 0.02 | 6.50 ± 0.00 |
| CHM-200. | ++ | np | 4.33 ± 0.02 | 9.00 ± 0.00 |
| CHM-2.50 | + | np | 4.52 ± 0.01 | 6.00 ± 0.00 |
| CHM-30.0 | + | np | 4.85 ± 0.01 | 6.00 ± 0.00 |
Dissolution parameters of the Korsmeyer–Peppas model and released amount of the drug after 60 min dissolution.
| C940-0.10 | 22.98 ± 4.95 | 0.31 ± 0.03 | 2.72 ± 0.21 | 16.54 ± 05.37 | 77.04 ± 5.94 |
| PCP-0.225 | 19.70 ± 2.86 | 0.24 ± 0.04 | 4.04 ± 0.27 | 61.01 ± 20.48 | 48.85 ± 5.74 |
| CHM-2.50 | 16.52 ± 3.42 | 0.39 ± 0.04 | 1.45 ± 0.61 | 19.29 ± 04.88 | 77.35 ± 4.98 |
Calculated adjusted coefficient of determination (R2adj) of different mathematical models, fitted to released data in whole dissolution time (0–60 min).
| C940-0.10 | 0.741 ± 0.046 | 0.975 ± 0.003 | 0.999 ± 0.001 |
| PCP-0.225 | 0.637 ± 0.077 | 0.993 ± 0.002 | 0.990 ± 0.003 |
| CHM-2.50 | 0.792 ± 0.032 | 0.956 ± 0.008 | 0.969 ± 0.004 |
Process parameters of preparation for individual polymers.
| Carbomer | 300 | 330 | 30 |
| Polycarbophil | 300 | 350 | 45 |
| Chitosan | 500 | 700 | 45 |