Preparation and evaluation of an oral mucoadhesive gel containing nystatin-loaded alginate microparticles
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11 mar 2021
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Categoría del artículo: Original Paper
Publicado en línea: 11 mar 2021
Páginas: 15 - 21
Recibido: 27 may 2019
Aceptado: 14 ene 2020
DOI: https://doi.org/10.2478/afpuc-2020-0009
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© 2020 Mohammadi Samani S. et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
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Adhesion strength of cp934 gel with and without alginate microparticles (n=6)
| cp934 gel without alginate particles | 1.88 ± 0.04 |
| cp934 gel containing alginate particles | 1.94 ± 0.15 |
Effect of different parameters on size of microparticles
| Experiment | Alginate (w/v%) | Cacl2 (w/v%) | Alginate to cacl2 ratio | drug to polymer ratio | Particle size (μm) |
|---|---|---|---|---|---|
| 1 | 1 | 1:10 | 1:1 | <250 | |
| 0.5 | 1 | 1:10 | 1:1 | 710 | |
| 1 | 2 | 1:10 | 1:1 | 296 | |
| 1 | 1 | 1:5 | 1:1 | 450 | |
| 1 | 1 | 1:10 | 1:5 | 710 |
Run parameters for two – level four factorial experimental design
| 1 | 1 | 1:5 | 1:1 | |
| 1 | 1 | 1:10 | 1:1 | |
| 1 | 2 | 1:5 | 1:1 | |
| 1 | 2 | 1:10 | 1:1 | |
| 0.5 | 1 | 1:10 | 1:1 | |
| 0.5 | 1 | 1:5 | 1:1 | |
| 1 | 1 | 1:5 | 1:5 | |
| 1 | 1 | 1:5 | 1:5 | |
| 1 | 2 | 1:10 | 1:5 | |
| 1 | 2 | 1:5 | 1:5 | |
| 0.5 | 2 | 1:5 | 1:5 | |
| 0.5 | 1 | 1:5 | 1:5 | |
| 0.5 | 1 | 1:10 | 1:5 | |
| 0.5 | 2 | 1:10 | 1:1 | |
| 0.5 | 2 | 1:5 | 1:1 | |
| 0.5 | 2 | 1:10 | 1:5 | |