eNOS Promoter Activation by Red Wine Polyphenols: an Interaction Study

[1] Appeldoorn MM et al. Some phenolic compounds increase the nitric oxide level in endothelial cells in vitro. J Agric Food Chem. 2009;57:7693–7699. 10.1021/jf901381xSearch in Google Scholar

[2] Bao M, Lou Y. Flavonoids from seabuckthorn protect endothelial cells (EA.hy926) from oxidized low-density lipoprotein induced injuries via regulation of Lox-1 and eNOS expression. J Cardiovasc Pharmacol. 2006;48:834–841. 10.1097/01.fjc.0000232064.64837.67Search in Google Scholar

[3] Berenbaum, MC. What is synergy? Pharmacol Rev. 1989; 41:93–141. Search in Google Scholar

[4] Bradford, MM. A rapid and sensitive method for the quantitation of microgram quantities utilizing the principle of protein dye binding. Anal Biochem. 1976;72:248–254. 10.1016/0003-2697(76)90527-3Search in Google Scholar

[5] Chan MM, Mattiacci JA, Hwang HS, Shah A, Fong D. Synergy between ethanol and grape polyphenols, quercetin, and resveratrol, in the inhibition of the inducible nitric oxide synthase pathway. Biochem Pharmacol. 2000;60:1539– 1548. 10.1016/S0006-2952(00)00471-8Search in Google Scholar

[6] Chen CC, Ke WH, Ceng LH, Hsieh CW, Wung BS. Calcium- and phosphatidylinositol 3-kinase/Akt-dependent activation of endothelial nitric oxide synthase by apigenin. Life Sci. 2010;87:743–749. 10.1016/j.lfs.2010.10.01421034748Search in Google Scholar

[7] Chou TC. Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Pharmacol Rev. 2006; 58:621–681. 10.1124/pr.58.3.1016968952Search in Google Scholar

[8] Edgell CJ, McDonald CC, Graham JB. Permanent cell line expressing human factor VIII-related antigen established by hybridization. Proc Natl Acad Sci USA. 1983;80:3734–3737. 10.1073/pnas.80.12.37343941256407019Search in Google Scholar

[9] Han D, Yi OS, Shin HK. Solubilization of vitamin C in fish oil and synergistic effect with vitamin E in retarding oxidation. J Am Oil Chem Soc. 1991;68:740–743. 10.1007/BF02662163Search in Google Scholar

[10] Kurin E, Atanasov AG, Donath O, Heiss EH, Dirsch VM, Nagy M. Synergy study of the inhibitory potential of red wine polyphenols on vascular smooth muscle cell proliferation. Planta Med. 2012;78:772–778. 10.1055/s-0031-129844022499559Search in Google Scholar

[11] Leikert JF, Räthel TR, Wohlfart P, Cheynier V, Vollmar AM, Dirsch VM. Red wine polyphenols enhance endothelial nitric oxide synthase expression and subsequent nitric oxide release from endothelial cells. Circulation. 2002;106:1614–1617. 10.1161/01.CIR.0000034445.31543.4312270851Search in Google Scholar

[12] Li H et al. Activation of protein kinase C alpha and/or epsilon enhances transcription of the human endothelial nitric oxide synthase gene. Mol Pharmacol. 1998;53:630–637. 10.1124/mol.53.4.630Search in Google Scholar

[13] Ma XH et al. Synergistic therapeutic actions of herbal ingredients and their mechanisms from molecular interaction and network perspectives. Drug Discov Today. 2009;14:579–588. 10.1016/j.drudis.2009.03.012Search in Google Scholar

[14] Palozza P, Krinsky NI. Beta-carotene and alpha-tocopherol are synergistic antioxidants. Arch Biochem Biophys. 1992;297:184–187. 10.1016/0003-9861(92)90658-JSearch in Google Scholar

[15] Peyrat-Maillard MN, Bonnely S, Rondini L, Berset C. Effect of vitamin E and vitamin C on the antioxidant activity of malt rootlets extracts. Lebensm.-Wiss.Technol. 2001;34:176–182. Search in Google Scholar

[16] Räthel TR, Samtleben R, Vollmar AM, Dirsch VM. Activation of endothelial nitric oxide synthase by red wine polyphenols: impact of grape cultivars, growing area and the vinification process. J Hypertens. 2007;25:541–549. 10.1097/HJH.0b013e328013e805Search in Google Scholar

[17] Scarpa M, Rigo A, Maiorino M, Ursini F, Gregolin C. Formation of alpha-tocopherol radical and recycling of alpha-tocopherol by ascorbate during peroxidation of phosphatidylcholine liposomes: An electron paramagnetic resonance study. Biochim Biophys Acta. 1984;801:215–219. 10.1016/0304-4165(84)90070-9Search in Google Scholar

[18] Schmitt CA, Dirsch VM. Modulation of endothelial nitric oxide by plant-derived products. Nitric Oxide. 2009;21:77–91. 10.1016/j.niox.2009.05.006Search in Google Scholar

[19] St Leger AS, Cochrane AL, Moore F. Factors associated with cardiac mortality in developed countries with particular reference to the consumption of wine. Lancet 1979;313:1017– 1020. 10.1016/S0140-6736(79)92765-XSearch in Google Scholar

[20] Wallerath T et al. Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase. Circulation. 2002;106:1652– 1658. 10.1161/01.CIR.0000029925.18593.5CSearch in Google Scholar

[21] Wallerath T, Poleo D, Li H, Förstermann U. Red wine increases the expression of humanendothelial nitric oxide synthase a mechanism that maycontribute to its beneficial cardiovascular effects. J Am Coll Cardiol. 2003;41:471–478. 10.1016/S0735-1097(02)02826-7Search in Google Scholar

[22] Wallerath T, Li H, Gödtel-Ambrust U, Schwarz PM, Förstermann U. A blend of polyphenolic compounds explains the stimulatory effect. of red wine on human endothelial NO synthase. Nitric Oxide. 2005;12:97–104. 10.1016/j.niox.2004.12.00415740983Search in Google Scholar

[23] Wang H, Yang YJ, Qian HY, Zhang Q, Xu H, Li JJ. Resveratrol in cardiovascular disease: what is known from current research? Heart Fail Rev. 2012;17:437–448. 10.1007/s10741-011-9260-421688187Search in Google Scholar

[24] Xu JW, Ikeda K, Yamori Y. Cyanidin-3-glucoside regulates phosphorylation of endothelial nitric oxide synthase. FEBS Letters. 2004;574:176–180. 10.1016/j.febslet.2004.08.02715358561Search in Google Scholar

[25] Zhou B, Jia ZS, Chen ZH, Yang L, Wu LM., Liu ZL. Synergistic antioxidant effect of green tea polyphenols with alpha-tocopherol on free radical initiated peroxidation of linoleic acid in micelles. J Chem Soc Perkin Trans. 2000;2:785–791. 10.1039/a908084hSearch in Google Scholar

[26] Zhou B, Wu LM, Yang L, Liu ZL. Evidence for alfa-tocopherol regeneration reaction of green tea polyphenols in SDS micelles. Free Radic Biol Med. 2005;38:78–84. 10.1016/j.freeradbiomed.2004.09.02315589374Search in Google Scholar

[27] Zimmermann GR, Lehár J, Keith CT. Multi-target therapeutics: when the whole is greater than the sum of the parts. Drug Discov Today 2007;12:34–42.10.1016/j.drudis.2006.11.00817198971Search in Google Scholar