<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Canine mammary tumors (CMTs) are one of the most common neoplasms in female dogs. Unfortunately, the current diagnosis often occurs in later stages, and there is a pressing need for more comprehensive data on treatment options to improve overall prognosis. Consequently, the early detection of these tumors is critical for improving treatment outcomes and survival rates. As such, biomarkers are essential for improving the diagnosis, treatment, and prognosis of CMT, the reason for which further research is required to enhance our understanding of the disease. The most studied biomarkers for CMT are evaluated from serum and tissue samples using different molecular approaches and relate to proliferation and cell cycle. Several biomarkers were also described regarding cell damage, autophagy and apoptotic-related pathways, hypoxia, angiogenesis, EMT, invasion, metastasis or cancer stem features. Overall, biomarkers have shown the potential to be used as a tool for the early detection of mammary tumors in dogs. However, more research is needed to validate these biomarkers and to develop sensitive and specific diagnostic tests. In this regard, we aimed to review known biomarkers and their role in CMT comprehensively. We also encouraged further investigations of reliable biomarkers that could improve treatment outcomes and survival rates for dogs with this disease.</p>
</abstract>

Canine mammary tumors (CMTs) are one of the most common neoplasms in female dogs. Unfortunately, the current diagnosis often occurs in later stages, and there is a pressing need for more comprehensive data on treatment options to improve overall prognosis. Consequently, the early detection of these tumors is critical for improving treatment outcomes and survival rates. As such, biomarkers are essential for improving the diagnosis, treatment, and prognosis of CMT, the reason for which further research is required to enhance our understanding of the disease. The most studied biomarkers for CMT are evaluated from serum and tissue samples using different molecular approaches and relate to proliferation and cell cycle. Several biomarkers were also described regarding cell damage, autophagy and apoptotic-related pathways, hypoxia, angiogenesis, EMT, invasion, metastasis or cancer stem features. Overall, biomarkers have shown the potential to be used as a tool for the early detection of mammary tumors in dogs. However, more research is needed to validate these biomarkers and to develop sensitive and specific diagnostic tests. In this regard, we aimed to review known biomarkers and their role in CMT comprehensively. We also encouraged further investigations of reliable biomarkers that could improve treatment outcomes and survival rates for dogs with this disease.

Molecular Markers in Canine Mammary Tumors

Animal Facility University of Medicine and Pharmacy Iuliu-Hatieganu

Acta Veterinaria

This work is licensed under the Creative Commons Attribution 4.0 International License.

{"article-title":"Molecular Markers in Canine Mammary Tumors"}

Canine mammary tumors (CMTs) are one of the most common neoplasms in female dogs. Unfortunately, the current diagnosis often occurs in later stages, and there...

Molecular Markers in Canine Mammary Tumors

Article Category: Review article

Publicado en línea: 24 jun 2024

Páginas: 159 - 182

Recibido: 19 mar 2024

Aceptado: 20 may 2024

DOI: https://doi.org/10.2478/acve-2024-0012

Palabras clave
canine mammary tumors, molecular markers, coding genome, non-coding genome

© 2024 Luciana-Mădălina Gherman et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Molecular Markers in Canine Mammary Tumors

Article Category: Review article

Publicado en línea: 24 jun 2024

Páginas: 159 - 182

Recibido: 19 mar 2024

Aceptado: 20 may 2024

DOI: https://doi.org/10.2478/acve-2024-0012

Palabras clavecanine mammary tumors, molecular markers, coding genome, non-coding genome

© 2024 Luciana-Mădălina Gherman et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Palabras clave
canine mammary tumors, molecular markers, coding genome, non-coding genome