<abstract xmlns="http://www.w3.org/1999/xhtml"><p>The most common types of beta-casein in cow’s milk are A1 and A2, which differ in one amino acid. During the gastrointestinal proteolysis of A1 beta-casein in humans this difference results in the release of beta-casomorphin-7, an opioid which may lead to severe effects on human health, causing various ailments (type-1 diabetes mellitus, ischemic heart disease, arteriosclerosis, sudden infant death syndrome, autism, schizophrenia, gastrointestinal digestive discomfort, as well as increased gastrointestinal transit time). By contrast, A2 beta-casein cannot exert these effects owing to its different composition and metabolism. Furthermore, studies have shown that it can influence milk productivity traits. Our research aimed to screen the frequency of A1 and A2 alleles of beta-casein gene in a population of Serbian Holstein-Friesian cows and to detect how the genotypes influence milk production, and milk protein and fat yields. Out of 106 animals, 13 (12.26%) were of A1A1 genotype, 58 (54.72%) of A1A2, and 35 (33.02%) of A2A2 genotype. Milk yield was significantly (P&lt;0.01) higher in A2A2 compared to both A1A1 and A1A2 genotypes. Milk protein concentrations were significantly (P&lt;0.01) higher in A2A2 compared to A1A2 genotype, while milk fat concentrations were significantly (P&lt;0.01) higher in A2A2 compared to both A1A1 and A1A2 genotypes.</p></abstract>

The most common types of beta-casein in cow’s milk are A1 and A2, which differ in one amino acid. During the gastrointestinal proteolysis of A1 beta-casein in humans this difference results in the release of beta-casomorphin-7, an opioid which may lead to severe effects on human health, causing various ailments (type-1 diabetes mellitus, ischemic heart disease, arteriosclerosis, sudden infant death syndrome, autism, schizophrenia, gastrointestinal digestive discomfort, as well as increased gastrointestinal transit time). By contrast, A2 beta-casein cannot exert these effects owing to its different composition and metabolism. Furthermore, studies have shown that it can influence milk productivity traits. Our research aimed to screen the frequency of A1 and A2 alleles of beta-casein gene in a population of Serbian Holstein-Friesian cows and to detect how the genotypes influence milk production, and milk protein and fat yields. Out of 106 animals, 13 (12.26%) were of A1A1 genotype, 58 (54.72%) of A1A2, and 35 (33.02%) of A2A2 genotype. Milk yield was significantly (P<0.01) higher in A2A2 compared to both A1A1 and A1A2 genotypes. Milk protein concentrations were significantly (P<0.01) higher in A2A2 compared to A1A2 genotype, while milk fat concentrations were significantly (P<0.01) higher in A2A2 compared to both A1A1 and A1A2 genotypes.

Beta-Casein Gene Polymorphism in Serbian Holstein-Friesian Cows and Its Relationship with Milk Production Traits

Department of Biology, Faculty of Veterinary Medicine

Department of Economics and statistics, Faculty of Veterinary Medicine

Department of Reproduction, Fertility and Artificial Insemination, Faculty of Veterinary Medicine

Department of Physiology and Biochemistry, Faculty of Veterinary Medicine

Department of Food Hygiene and Technology, Faculty of Veterinary Medicine

Acta Veterinaria

This work is licensed under the Creative Commons Attribution 4.0 International License.

The most common types of beta-casein in cow’s milk are A1 and A2, which differ in one amino acid. During the gastrointestinal proteolysis of A1 beta-casein in...

Beta-Casein Gene Polymorphism in Serbian Holstein-Friesian Cows and Its Relationship with Milk Production Traits

Publicado en línea: 31 dic 2020

Páginas: 497 - 510

Aceptado: 17 jul 2020

DOI: https://doi.org/10.2478/acve-2020-0037

Palabras clave
Holstein-Friesian, beta-casein, allele frequency, genotype frequency, RFLP-PCR, milk productivity traits

© 2020 Ristanic Marko et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Beta-Casein Gene Polymorphism in Serbian Holstein-Friesian Cows and Its Relationship with Milk Production Traits

Publicado en línea: 31 dic 2020

Páginas: 497 - 510

Aceptado: 17 jul 2020

DOI: https://doi.org/10.2478/acve-2020-0037

Palabras claveHolstein-Friesian, beta-casein, allele frequency, genotype frequency, RFLP-PCR, milk productivity traits

© 2020 Ristanic Marko et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Palabras clave
Holstein-Friesian, beta-casein, allele frequency, genotype frequency, RFLP-PCR, milk productivity traits