<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>In this study, the protective functions of bacteria-free conditioned media from <italic>Bifidobacterium</italic> and <italic>Lactobacillus</italic> species against ultraviolet radiation-induced skin ageing and associated cellular damage were investigated. The effects of ultraviolet radiation-induced reactive oxygen species production were suppressed by all conditioned media; particularly, the loss of cell viability and downregulation of collagen gene expression were significantly reversed by the conditioned media from <italic>B. longum</italic> and <italic>B. lactis</italic>. Further exa mination of potential anti-pigmentation effects revealed that the <italic>B. lactis</italic>-derived conditioned media significantly inhibited tyrosinase activity and alpha-melanocyte-stimulating hormone-induced melanin production in human epidermal melanocytes. Further, the conditioned media suppressed the phosphorylation of extracellular signal- related kinase, which functions as an upstream regulator of melanogenesis. Therefore, <italic>B. lactis</italic>-derived conditioned media can potentially protect against cellular damage involved in skin-ageing processes.</p>
</abstract>

In this study, the protective functions of bacteria-free conditioned media from Bifidobacterium and Lactobacillus species against ultraviolet radiation-induced skin ageing and associated cellular damage were investigated. The effects of ultraviolet radiation-induced reactive oxygen species production were suppressed by all conditioned media; particularly, the loss of cell viability and downregulation of collagen gene expression were significantly reversed by the conditioned media from B. longum and B. lactis. Further exa mination of potential anti-pigmentation effects revealed that the B. lactis-derived conditioned media significantly inhibited tyrosinase activity and alpha-melanocyte-stimulating hormone-induced melanin production in human epidermal melanocytes. Further, the conditioned media suppressed the phosphorylation of extracellular signal- related kinase, which functions as an upstream regulator of melanogenesis. Therefore, B. lactis-derived conditioned media can potentially protect against cellular damage involved in skin-ageing processes.

Potential anti-ageing effects of probiotic-derived conditioned media on human skin cells

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

In this study, the protective functions of bacteria-free conditioned media from Bifidobacterium and Lactobacillus species against ultraviolet radiation-induced...

Potential anti-ageing effects of probiotic-derived conditioned media on human skin cells

Publicado en línea: 13 abr 2022

Páginas: 359 - 374

Aceptado: 16 dic 2021

DOI: https://doi.org/10.2478/acph-2022-0027

Palabras clave
anti-ageing, skin cells, probiotics, conditioned media, protection, anti-pigmentation

© 2022 Yoo Kyung Hong et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Potential anti-ageing effects of probiotic-derived conditioned media on human skin cells

Publicado en línea: 13 abr 2022

Páginas: 359 - 374

Aceptado: 16 dic 2021

DOI: https://doi.org/10.2478/acph-2022-0027

Palabras claveanti-ageing, skin cells, probiotics, conditioned media, protection, anti-pigmentation

© 2022 Yoo Kyung Hong et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Palabras clave
anti-ageing, skin cells, probiotics, conditioned media, protection, anti-pigmentation