<abstract xmlns="http://www.w3.org/1999/xhtml">

The novel SARS-CoV-2 (severe acute respiratory syndrome coronavirus) has emerged as a significant threat to public health with startling drawbacks in all sectors globally. This study investigates the practicality of some medicinal plants for SARS-CoV-2 therapy using a systematic review and meta-analysis of their reported SARS-CoV-1 inhibitory potencies. Relevant data were systematically gathered from three databases, <italic>viz.</italic>, Web of Science, PubMed and Scopus. The information obtained included botanical information, extraction method and extracts concentrations, as well as the proposed mechanisms. Fourteen articles describing 30 different plants met our eligibility criteria. Random effects model and subgroup analysis were applied to investigate heterogeneity. According to subgroup analysis, the substantial heterogeneity of the estimated mean based on the <italic>IC</italic>50 values reporting the most potent anti-SARS-CoV 3C--like protease (3CLpro) inhibitors (10.07 %, <italic>p</italic> &lt; 0.0001), was significantly higher compared to the most active anti-SARS-CoV papain-like protease (PLpro) inhibitors (6.12 %, <italic>p</italic> &lt; 0.0001). More importantly, the literature analysis revealed that fruit extracts of <italic>Rheum palmatum</italic> L. and the compound cryptotanshinone isolated from the root of <italic>Salvia miltiorrhiza</italic> (<italic>IC</italic>50 = 0.8 ± 0.2 μmol L–1) were excellent candidates for anti--SARS-CoV targeting PLpro. Meanwhile, iguesterin (<italic>IC</italic>50 = 2.6 ± 0.6 μmol L–1) isolated from the bark of <italic>Tripterygium regelii</italic> emerged as the most excellent candidate for anti-SARS--CoV targeting 3CLpro. The present systematic review and meta-analysis provide valuable and comprehensive information about potential medicinal plants for SARS-CoV-2 inhibition. The chemotypes identified herein can be adopted as a starting point for developing new drugs to contain the novel virus.
</abstract>

The novel SARS-CoV-2 (severe acute respiratory syndrome coronavirus) has emerged as a significant threat to public health with startling drawbacks in all sectors globally. This study investigates the practicality of some medicinal plants for SARS-CoV-2 therapy using a systematic review and meta-analysis of their reported SARS-CoV-1 inhibitory potencies. Relevant data were systematically gathered from three databases, viz., Web of Science, PubMed and Scopus. The information obtained included botanical information, extraction method and extracts concentrations, as well as the proposed mechanisms. Fourteen articles describing 30 different plants met our eligibility criteria. Random effects model and subgroup analysis were applied to investigate heterogeneity. According to subgroup analysis, the substantial heterogeneity of the estimated mean based on the IC50 values reporting the most potent anti-SARS-CoV 3C--like protease (3CLpro) inhibitors (10.07 %, p < 0.0001), was significantly higher compared to the most active anti-SARS-CoV papain-like protease (PLpro) inhibitors (6.12 %, p < 0.0001). More importantly, the literature analysis revealed that fruit extracts of Rheum palmatum L. and the compound cryptotanshinone isolated from the root of Salvia miltiorrhiza (IC50 = 0.8 ± 0.2 μmol L–1) were excellent candidates for anti--SARS-CoV targeting PLpro. Meanwhile, iguesterin (IC50 = 2.6 ± 0.6 μmol L–1) isolated from the bark of Tripterygium regelii emerged as the most excellent candidate for anti-SARS--CoV targeting 3CLpro. The present systematic review and meta-analysis provide valuable and comprehensive information about potential medicinal plants for SARS-CoV-2 inhibition. The chemotypes identified herein can be adopted as a starting point for developing new drugs to contain the novel virus.

Medicinal plants with anti-SARS-CoV activity repurposing for treatment of COVID-19 infection: A systematic review and meta-analysis

Faculty of Natural Science, Department of Chemistry

Department of Agriculture and Animal Health

University of South Africa Florida Campus

School of Chemistry and Physics University of KwaZulu-Natal P/Bag X54001, Westville

Discipline of Public Health Medicine College of Health Sciences University of KwaZulu Natal

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

The novel SARS-CoV-2 (severe acute respiratory syndrome coronavirus) has emerged as a significant threat to public health with startling drawbacks in all...

Medicinal plants with anti-SARS-CoV activity repurposing for treatment of COVID-19 infection: A systematic review and meta-analysis

Article Category: Review

Publicado en línea: 30 dic 2021

Páginas: 199 - 224

Aceptado: 14 sept 2021

DOI: https://doi.org/10.2478/acph-2022-0021

Palabras clave
COVID-19 main protease, inhibition, medicinal plants, systematic review, meta-analysis

© 2022 Oluwakemi Ebenezer., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Medicinal plants with anti-SARS-CoV activity repurposing for treatment of COVID-19 infection: A systematic review and meta-analysis

Article Category: Review

Publicado en línea: 30 dic 2021

Páginas: 199 - 224

Aceptado: 14 sept 2021

DOI: https://doi.org/10.2478/acph-2022-0021

Palabras claveCOVID-19 main protease, inhibition, medicinal plants, systematic review, meta-analysis

© 2022 Oluwakemi Ebenezer., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Palabras clave
COVID-19 main protease, inhibition, medicinal plants, systematic review, meta-analysis