In Vitro Investigation of Potential Anti-Diabetic Activity of the Corm Extract of Hypoxis Argentea Harv. Ex Baker

1. World Health Organization, The Burden of Chronic Diseases in the African Region, Preventing Chronic Diseases, A Vital Investment, World Diabetes Foundation Summit, WHO global report, Geneva 2007.Search in Google Scholar

2. A. A. Motala, M. A. K. Omar and F. J. Pirie, Epidemiology of Diabetes in Africa, in The Epidemiology of Diabetes Mellitus (Eds. J. M. Ekoe, M. Rewers, R. Williams and P. Zimmet), 2nd ed., Wiley, Chichester 2008, pp. 133-146.10.1002/9780470779750.ch11Search in Google Scholar

3. N. S. Levitt, Diabetes in Africa: epidemiology, management and health-care challenges, Heart 4 (2008) 1376-1382; https://doi.org/10.1136/hrt.2008.14730610.1136/hrt.2008.147306Search in Google Scholar

4. C. N. He, C. L. Wang and S. X. Guo, Study on chemical constituents in herbs of Anoectochilus roxburghii II, China, J. Chin. Mat. Med. 30 (2005) 761-776.Search in Google Scholar

5. M. Jung, M. Park, H. C. Lee, Y. Kang, E. S. Kang and S. K. Kim, Antidiabetic agents from medicinal plants, Curr. Med. Chem. 13 (2006) 1203-1218; https://doi.org/10.2174/09298670677636086010.2174/092986706776360860Search in Google Scholar

6. S. O. Oyedemi, M. T. Yakubu and A. J. Afolayan, Antidiabetic activities of aqueous leaves extract of Leonotis leonurus in streptozotocin induced diabetic rats, J. Med. Plants Res. 5 (2011) 119-125.Search in Google Scholar

7. N. Meliani, M. El Amine Dib, H. Allali and B. Tabti, Hypoglycaemic effect of Berberis vulgaris L. in normal and streptozotocin-induced diabetic rats, Asian Pac. J. Trop. Biomed. 1 ( 2011) 4 68-471; https://doi.org/10.1016/S2221-1691(11)60102-010.1016/S2221-1691(11)60102-0Search in Google Scholar

8. S. O. Oyedemi, G. Bradley and A. J. Afolayan, Ethno-botanical survey of medicinal plants used for the management of diabetes mellitus in the Nkonkobe municipality of South Africa, J. Med. Plants Res. 3 (2009) 1040-1044.Search in Google Scholar

9. V. D. P. Nair and I. Kanfer, A capillary zone electrophoresis method for the quantitative determination of hypoxoside in commercial formulations of African potato (Hypoxis hemerocallidea), Phytochem. Anal. 18 (2007) 475-483; https://doi.org/10.1002/pca.100310.1002/pca.100317624891Search in Google Scholar

10. S. E. Drewes, E. Elliot, F. Khan, J. T. B. Dhlamini and M. S. S. Gcumisa, Hypoxis hemerocallidea -not merely a cure for benign prostate hyperplasia, J. Ethnopharmacol. 119 (2008) 593-598; https:// doi.org/10.1016/j.jep.2008.05.02710.1016/j.jep.2008.05.02718602776Search in Google Scholar

11. J. A. O. Ojewole, Anti-nociceptive, anti-inflammatory and anti-diabetic properties of Hypoxis hermerocallidea Fisch. & C.A. Mey (Hypoxidaceae) corm [‘African Potato’] aqueous extract in mice and rats, J. Ethnopharmacol. 103 (2006) 126-134; https://doi.org/10.1016/j.jep.2005.07.01210.1016/j.jep.2005.07.01216191469Search in Google Scholar

12. A. Vetere, A. Choudhary, S. M. Burns and B. K. Wagner, Targeting the pancreatic β-cell to treat diabetes, Nat. Rev. 13 (2014) 278-289; https://doi.org/10.1038/nrd423110.1038/nrd423124525781Search in Google Scholar

13. M. Feoktistova, P. Geserick and M. Leverkus, Crystal violet assay for determining the viability of cultured cells, Cold Spring Harb. Protoc. 2016; https://doi.org/ 1101/pdb.prot 08737910.1101/pdb.prot08737927037069Search in Google Scholar

14. M. S. Deutschlander, M. Van de Venter, S. Roux, J. Louw and N. Lall, Hypoglycemic activity of four plant extracts traditionally used in South Africa in diabetes, J. Ethnopharmacol. 124 (2009) 619-624; https://doi.org/ 10.1016/j.jep.2009.04.05210.1016/j.jep.2009.04.05219422900Search in Google Scholar

15. J. L. Ramirez-Zacarias, F. Castro-Mufiozledo and W. Kuri-Harcuch, Quantitation of adipose conversion and triglycerides by staining intracytoplasmic lipids with oil red O, Histochemistry 97 (1997) 493-497.10.1007/BF003160691385366Search in Google Scholar

16. L. G. Ranilla, Y. I. Kwon, E. Apostolidis and K. Shetty, Phenolic compounds, antioxidant activity and in vitro inhibitory potential against key enzymes relevant for hyperglycemia and hypertension of commonly used medicinal plants, herbs and spices in Latin America, Bioresour. Technol. 101 (2010) 4676-4689; https://doi.org/ 10.1016/j.biortech.2010.01.09310.1016/j.biortech.2010.01.09320185303Search in Google Scholar

17. M. Al-Masri, M. K. Mohammad and M. O. Tahaa, Inhibition of dipeptidyl peptidase IV (DPP IV) is one of the mechanisms explaining the hypoglycemic effect of berberine, J. Enzyme Inhib. Med. Chem. 24 (2009) 1061-1066; https://doi.org/10.1080/1475636080261076110.1080/1475636080261076119640223Search in Google Scholar

18. S. Schmidt, M. Jakab, S. Jav, D. Streif, A. Pitchmann, M. Zehl, S. Purevsuren, S. Glasl and M. Ritter, Extracts from Leonurus sibiricus L. increase insulin secretion and proliferation of rat INS-1E insulinoma cells, J. Ethnopharmacol. 150 (2013) 85-94; https://doi.org/10.1016/j.jep.2013.08.01310.1016/j.jep.2013.08.01323978659Search in Google Scholar

19. D. Liu, W. Zhen, Z. Yang, J. D. Carter, H. Si and K. A. Reynolds, Genistein acutely stimulates insulin secretion in pancreatic β cells through a cAMP-dependent protein kinase pathway, Diabetes 55 (2006) 1043-1050.10.2337/diabetes.55.04.06.db05-108916567527Search in Google Scholar

20. T. Lapidot, M. D. Walker and J. Kanner, Antioxidant and pro-oxidant effects of phenolics on pancreatic β-cells in vitro, J. Agric. Food Chem. 50 (2002) 7220-7225; https://doi.org/10.1021/jf020615a10.1021/jf020615a12452635Search in Google Scholar

21. M. Pinent, A. Castell, I. Baiges, G. Montagut, L. Arola and A. Ardevol, Bioactivity of flavonoids on insulin-secreting cells, Comp. Rev. Food Sci. Food Safety 7 (2008) 299-308; https://doi.org/10.1111/j. 1541-4337.2008.00048.x10.1111/j.1541-4337.2008.00048.xSearch in Google Scholar

22. E. M. Van Dam, R. Govers and D. E. James, Activation is required at a late stage of insulin-induced GLUT-4 translocation to the plasma membrane, Mol. Endocrinol. 19 (2005) 1067-1077; https://doi.org/10.1210/me.2004-041310.1210/me.2004-041315650020Search in Google Scholar

23. I. M. Mahomed and J. A. Ojewole, Hypoglycemic effect of Hypoxis hemerocallidea corm (African potato) aqueous extract in rats, Methods Find. Exp. Clin. Pharmacol. 25 (2003) 617-623; https://doi.org/10.1358/mf.2003.25.8.77808210.1358/mf.2003.25.8.77808214671679Search in Google Scholar

24. S. Oyedemi, T. Koekemoer, G. Bradley, M. Van de Venter and A. Afolayan, In vitro anti-hyperglycemia properties of the aqueous stem bark extract from Strychnos henningsii (Gilg), Int. J. Diabetes Dev. C. 33 (2013) 120-127; https://doi.org/10.1007/s13410-013-0120-810.1007/s13410-013-0120-8Search in Google Scholar

25. V. Rizzati, F. Boschi, M. Pedrotti, E. Zoico, A. Sharbati and M. Zamboni, Lipid droplets characterization in adipocyte differentiated 3T3-L1 cells: size and optical density distribution, Eur. J. Histochem. 57 (2013) 159-162; https://doi.org/10.4081/ejh.2013.e2410.4081/ejh.2013.e24379435524085273Search in Google Scholar

26. S.-J. Kim and S-Y. Choung, Inhibitory effects of Aster spathulifolius extract on adipogenesis and lipid accumulation in 3T3-L1 pre-adipocytes, J. Pharm. Pharmacol. 68 (2016) 107-118; https://doi.org/10.1111/jphp.1248510.1111/jphp.12485Search in Google Scholar

27. M. Lonn, K. Mehlig, C. Bengtsson and L. Lissner, Adipocyte size predicts incidence of type 2 diabetes in women, FASEB J. 24 (2010) 326-331; https://doi.org/10.1096/fj.09-13305810.1096/fj.09-133058Search in Google Scholar

28. A. J. Alonso-Castro and L. A. Salazar-Olivo, The anti-diabetic properties of Gazuma ulmifolia Lam. are mediated by the stimulation of glucose uptake in normal and diabetic adipocytes without inducing adipogenesis, J. Ethnopharmacol. 118 (2008) 252-256; https://doi.org/10.1016/j.jep.2008.04.00710.1016/j.jep.2008.04.007Search in Google Scholar

29. E. D. Abel, O. Peroni, J. A. Kim, Y. B. Kim, O. Boss, E. Hadro, T. Minnemann, G. I. Shulman and B. B. Kahn, Adipose-selective targeting of the GLUT 4 gene impairs insulin action in muscle and liver, Nature 409 (2001) 729-733; https://doi.org/10.1038/3505557510.1038/35055575Search in Google Scholar

30. N. Fabre, I. Rustan, E. de Hoffmann and J. Quetin-Leclercq, Determination of flavone, flavonol and flavanone aglycones by negative ion liquid chromatography electrospray ion trap mass spectrometry. J. Am. Soc. Mass Spectrom. 12 (2001) 707-715; https://doi.org/10.1016/S1044-0305(01)00226-410.1016/S1044-0305(01)00226-4Search in Google Scholar

31. L. A. Abdulkhaleg, M. A. Assi, M. H. M Noor, R. Abdullah, M. Z. Saad and Y. H. Taufig-Yap, Therapeutic uses of epicatechin in diabetes and cancer, Vet World 10 (2017) 869-872; https://doi.org/10.14202/vetworld.2017.869-87210.14202/vetworld.2017.869-872559147128919675Search in Google Scholar

32. A. Arya, M. M. Al-Obaidi, N. Shahid, M. I. Bin Noordin, C. Y. Looi, W. F. Wong, S. L. Khaing and M. R. Mustafa, Synergistic effect of quercetin and quinic acid by alleviating structural degeneration in the liver, kidney and pancreas tissues of STZ-induced diabetic rats: a mechanistic study, Food Chem. Toxicol. 71 (2014) 183-196; https://doi.org/10.1016/j.fct.2014.06.01010.1016/j.fct.2014.06.01024953551Search in Google Scholar

33. C. Bucolo, K. W. Ward, E. Mazzon, S. Cuzzocrea and F. Drago, Protective effects of a coumarin derivative in diabetic rats, Invest. Ophthalmol. Vis. Sci. 50 (2009) 3846-3852; https://doi.org/10.1167/iovs.08-332810.1167/iovs.08-332819279317Search in Google Scholar