<abstract xmlns="http://www.w3.org/1999/xhtml">The main objective of this study was to synthesize hydroxyapatite-ciprofloxacin composites using a chemical precipitation method and to evaluate the properties and <italic>in vitro</italic> release profile of the drug from the hydroxyapatite-ciprofloxacin composites. Composite characterization was achieved by FT-IR, XRD and DLS. Ciprofloxacin determination was accomplished by HPLC, resulting in good incorporation efficiency of the drug (18.13 %). The <italic>in vitro</italic> release study (Higuchi model <italic>C</italic> = <italic>K t</italic>1/2 and Ritger-Peppas model, <italic>C</italic> = <italic>K t</italic>0.6) showed a diffusion-controlled mechanism. The antibacterial activity showed that the bacterial growth inhibition zones were approximately equal for the synthesis composites and for the mechanical mixture on the <italic>Staphylococcus aureus</italic> germ.The use of hydroxyapatite, which is a biocompatible, bioactive and osteoconductive material, with ciprofloxacin, which has good antibacterial activity in this composite, makes it suitable for the development of bone grafts. Furthermore, the synthesis process allows a slow local release of the drug.</abstract>

The main objective of this study was to synthesize hydroxyapatite-ciprofloxacin composites using a chemical precipitation method and to evaluate the properties and in vitro release profile of the drug from the hydroxyapatite-ciprofloxacin composites. Composite characterization was achieved by FT-IR, XRD and DLS. Ciprofloxacin determination was accomplished by HPLC, resulting in good incorporation efficiency of the drug (18.13 %). The in vitro release study (Higuchi model C = K t1/2 and Ritger-Peppas model, C = K t0.6) showed a diffusion-controlled mechanism. The antibacterial activity showed that the bacterial growth inhibition zones were approximately equal for the synthesis composites and for the mechanical mixture on the Staphylococcus aureus germ.The use of hydroxyapatite, which is a biocompatible, bioactive and osteoconductive material, with ciprofloxacin, which has good antibacterial activity in this composite, makes it suitable for the development of bone grafts. Furthermore, the synthesis process allows a slow local release of the drug.

Hydroxyapatite-ciprofloxacin delivery system: Synthesis, characterisation and antibacterial activity

University of Medicine and Pharmacy of Craiova

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The main objective of this study was to synthesize hydroxyapatite-ciprofloxacin composites using a chemical precipitation method and to evaluate the properties...

Hydroxyapatite-ciprofloxacin delivery system: Synthesis, characterisation and antibacterial activity

Publicado en línea: 26 abr 2018

Páginas: 129 - 144

Aceptado: 09 dic 2017

DOI: https://doi.org/10.2478/acph-2018-0011

Palabras clave
hydroxiapatite-ciprofloxacin composites, wet precipitation synthesis, release profile, antibacterial activity

© 2018 Maria-Viorica Ciocilteu et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Hydroxyapatite-ciprofloxacin delivery system: Synthesis, characterisation and antibacterial activity

Publicado en línea: 26 abr 2018

Páginas: 129 - 144

Aceptado: 09 dic 2017

DOI: https://doi.org/10.2478/acph-2018-0011

Palabras clavehydroxiapatite-ciprofloxacin composites, wet precipitation synthesis, release profile, antibacterial activity

© 2018 Maria-Viorica Ciocilteu et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Palabras clave
hydroxiapatite-ciprofloxacin composites, wet precipitation synthesis, release profile, antibacterial activity