<abstract xmlns="http://www.w3.org/1999/xhtml">Available tablets or capsules for adults are often used to prepare extemporaneously formulated medicines appropriate for children. The most acceptable drug forms in pediatric population are oral liquids and pharmacists use commercial dispersing media to compound syrups from an active substance or from tablets available on the market. In many countries ready-to-use dispersing media are not available or refunded, but pharmacists can use other compounded media, providing their compatibility and stability are proven. The aim of this study was to formulate and evaluate the stability of syrups with candesartan cilexetil (1 mg mL-1) and valsartan (4 mg mL-1) extemporaneously prepared using commercial tablets (Diovan® and Atacand®). The following three different suspending media, which could be easily made in a pharmacy, were investigated: V1 - with xanthan gum (0.5 %), V2 - the USP/NF vehicle for oral solution and V3 - the medium based on a simple sucrose syrup. The stability of preparations was studied during 35 days of storage in a dark place at controlled temperature of 25 and 4 °C. During the study, microscopic observation was carried out and pH, viscosity, and concentration of candesartan cilexetil and valsartan were analyzed. Syrups with valsartan prepared with V2 and V3 media were stable for 3 or 4 weeks when stored at 25 °C, while syrups with candesartan were stable for as long as 35 days. For syrups prepared using V1 medium, the 14-day expiry date was not achieved because of microbial deterioration.</abstract>

Available tablets or capsules for adults are often used to prepare extemporaneously formulated medicines appropriate for children. The most acceptable drug forms in pediatric population are oral liquids and pharmacists use commercial dispersing media to compound syrups from an active substance or from tablets available on the market. In many countries ready-to-use dispersing media are not available or refunded, but pharmacists can use other compounded media, providing their compatibility and stability are proven. The aim of this study was to formulate and evaluate the stability of syrups with candesartan cilexetil (1 mg mL-1) and valsartan (4 mg mL-1) extemporaneously prepared using commercial tablets (Diovan® and Atacand®). The following three different suspending media, which could be easily made in a pharmacy, were investigated: V1 - with xanthan gum (0.5 %), V2 - the USP/NF vehicle for oral solution and V3 - the medium based on a simple sucrose syrup. The stability of preparations was studied during 35 days of storage in a dark place at controlled temperature of 25 and 4 °C. During the study, microscopic observation was carried out and pH, viscosity, and concentration of candesartan cilexetil and valsartan were analyzed. Syrups with valsartan prepared with V2 and V3 media were stable for 3 or 4 weeks when stored at 25 °C, while syrups with candesartan were stable for as long as 35 days. For syrups prepared using V1 medium, the 14-day expiry date was not achieved because of microbial deterioration.

Use of compounded dispersing media for extemporaneous pediatric syrups with candesartan cilexetil and valsartan

Department of Pharmaceutical Technology, Medical University of Bialystok, Faculty of Pharmacy Bialystok, Poland

Department of Clinical Pharmacy Medical University of Bialystok Faculty of Pharmacy, Bialystok, Poland

Department of Pharmaceutical Technology, Medical University of Gdansk, Faculty of Pharmacy Gdansk, Poland

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Available tablets or capsules for adults are often used to prepare extemporaneously formulated medicines appropriate for children. The most acceptable drug...

Use of compounded dispersing media for extemporaneous pediatric syrups with candesartan cilexetil and valsartan

Publicado en línea: 20 dic 2014

Páginas: 463 - 474

Aceptado: 08 jul 2014

DOI: https://doi.org/10.2478/acph-2014-0037

Palabras clave
extemporaneous formulation, pediatric syrups, candesartan cilexetil, valsartan, stability

© by Monika Musko

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Use of compounded dispersing media for extemporaneous pediatric syrups with candesartan cilexetil and valsartan

Publicado en línea: 20 dic 2014

Páginas: 463 - 474

Aceptado: 08 jul 2014

DOI: https://doi.org/10.2478/acph-2014-0037

Palabras claveextemporaneous formulation, pediatric syrups, candesartan cilexetil, valsartan, stability

© by Monika Musko

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Palabras clave
extemporaneous formulation, pediatric syrups, candesartan cilexetil, valsartan, stability