Synthesis and anti-tumor evaluation of novel hydrazide and hydrazide-hydrazone derivatives

1. S. K. Bharti, G. Nath, R. Tilak and S. K. Singh, Synthesis, anti-bacterial and anti-fungal activities of some novel Schiff bases containing 2,4-disubstituted thiazole ring, Eur. J. Med. Chem. 45 (2010) 651-660; DOI: 10.1016/j.ejmech.2009.11.008.10.1016/j.ejmech.2009.11.008Search in Google Scholar

2. C. Loncle, J. M. Brunel, N. Vidal, M. Dherbomez and Y. Letourneux, Synthesis and antifungal activity of cholesterol-hydrazone derivatives, Eur. J. Med. Chem. 39 (2004) 1067-1071; DOI: 10.1016/ j.ejmech.2004.07.005.10.1016/j.ejmech.2004.07.005Search in Google Scholar

3. S. P. Garoufalias, N. Pouli, P. Marakos and A. C. Ladas, Synthesis, antimicrobial and antifungal activity of some new 3-substituted derivatives of 4-(2,4-dichlorophenyl)-5-adamantyl-1H-1,2,4- -triazole, Farmaco 57 (2002) 973-977; DOI: 10.1016/S0014-827X(02)01273-9.10.1016/S0014-827X(02)01273-9Search in Google Scholar

4. P. Vicini, F. Zani, P. Cozzini and I. Doytchinova, Hydrazones of 1,2-benzisothiazole hydrazides: synthesis, antimicrobial activity and QSAR investigations, Eur. J. Med. Chem. 37 (2002) 553-567; DOI: 10.1016/S0223-5234(02)01378-8.10.1016/S0223-5234(02)01378-8Search in Google Scholar

5. F. D. Popp, Potential anticonvulsant. XII. Anticonvulsant activity of some aldehyde derivatives, Eur. J. Med. Chem. 24 (1989) 313-316; DOI: 10.1016/0223-5234(89)90016-0.10.1016/0223-5234(89)90016-0Search in Google Scholar

6. S. K. Sridhar, S. N. Pandeya, J. P. Stables and R. Atmakuru, Anticonvulsant activity of hydrazones, Schiff and Mannich bases of isatin derivatives, Eur. J. Pharm. Sci. 16 (2002) 129-132; DOI: 10.1016/S0928-0987(02)00077-5.10.1016/S0928-0987(02)00077-5Search in Google Scholar

7. S. G. Küçükgüzel, S. Rollas, I. Küçükgüzel and M. Kiraz, Synthesis and antimycobacterial activity of some coupling products from 4-aminobenzoic acid hydrazones, Eur. J. Med. Chem. 34 (1999) 1093-1100; DOI: 10.1016/S0223-5234(99)00129-4.10.1016/S0223-5234(99)00129-4Search in Google Scholar

8. B. K. Kaymakçýoǧlu and S. Rollas, Synthesis, characterization and evaluation of antituberculosis activity of some hydrazones, Farmaco 57 (2002) 595-599; DOI: 10.1016/S0014-827X(02)01255-7.10.1016/S0014-827X(02)01255-7Search in Google Scholar

9. S. G. Küçükgüzel, A. Mazi, F. Sahin, S. Öztürk and J. P. Stables, Synthesis and biological activities of diflunisal hydrazide-hydrazones, Eur. J. Med. Chem. 38 (2003) 1005-1013; DOI: 10.1016/ j.ejmech.2003.08.004.10.1016/j.ejmech.2003.08.004Search in Google Scholar

10. A. R. Todeschini, A. L. P. de Miranda, K. C. M. da Silva, S. C. Parrini and E. Barreiro, Synthesis and evaluation of analgesic, antiinflammatory and antiplatelet properties of new 2-pyridylarylhydrazone derivatives, Eur. J. Med. Chem. 33 (1998) 189-199; DOI: 10.1016/S0223-5234(98)80008-1.10.1016/S0223-5234(98)80008-1Search in Google Scholar

11. M. A. Gaston, L. R. S. Dias, A. C. C. Freitas, A. L. P. Miranda and E. J. Barreiro, Synthesis and analgesic properties of new 4-arylhydrazone 1H pyrazole[3,4-b]pyridine derivatives, Pharm. Acta Helv. 71 (1996) 213-219; DOI: 10.1016/0031-6865(96)00012-X.10.1016/0031-6865(96)00012-XSearch in Google Scholar

12. P. Melnyk, V. Leroux, C. Sergheraert and P. Grellier, Design, synthesis and in vitro antimalarial activity of an acylhydrazone library, Bioorg. Med. Chem. Lett. 16 (2006) 31-35; DOI: 10.1016/j.bmcl. 2005.09.058.Search in Google Scholar

13. N. Terzioglu and A. Gursoy, Synthesis and anticancer evaluation of some new hydrazone derivatives of 2,6-dimethylimidazo[2,1-b][1,3,4]thiadiazole-5-carbohydrazide, Eur. J. Med. Chem. 38 (2003) 781-786; DOI: 10.1002/chin.200401111.10.1002/chin.200401111Search in Google Scholar

14. S. M. Sondhi, M. Dinodia and A Kumar, Synthesis, anti-inflammatory and analgesic activity evaluation of some amidine and hydrazone derivatives, Bioorg. Med. Chem. 14 (2006) 4657-4663; DOI: 10.1016/j.bmc.2006.02.014.10.1016/j.bmc.2006.02.014Search in Google Scholar

15. C. Boga, L. Fiume, M. Baglioni, C. Bertucci, C. Farina, F. Kratz, M. Manerba, M. Naldi and G. Stefano, Characterisation of the conjugate of the (6-maleimidocaproyl)hydrazone derivative of doxorubicin with lactosaminated human albumin by 13C NMR spectroscopy, Eur. J. Pharm. Sci.38 (2009) 262-269; DOI: 10.1016/j.ejps.2009.08.001.10.1016/j.ejps.2009.08.001Search in Google Scholar

16. M. C. Garnett, Targeted drug conjugates: principles and progress, Adv. Drug Deliv. Rev. 53 (2001) 171-216; DOI: 10.1016/S0169-409X(01)00227-7.10.1016/S0169-409X(01)00227-7Search in Google Scholar

17. P. C. Rodrigues, K. Scheuermann, C. Stockmar, G. Maier, H. Fiebig, C. Unger, R. Mülhaupt and F. Kratz, Synthesis and in-vitro efficacy of acid-sensitive poly(ethylene glycol) paclitaxel conjugates, Bioorg. Med. Chem. Lett. 13 (2003) 355-360; DOI: 10.1016/S0960-894X(02)01002-8.10.1016/S0960-894X(02)01002-8Search in Google Scholar

18. O. I. El-Sabbagh and H. M. Rady, Synthesis of new acridines and hydrazones derived from cyclic â-diketone for cytotoxic and antiviral evaluation, Eur. J. Med. Chem. 44 (2009) 3680-3686; DOI: 10.1002/chin.200948062.10.1002/chin.200948062Search in Google Scholar

19. H. Krakovicova, T. Etrych and K. Ulbrich, HPMA-based polymer conjugates with drug combination, Eur. J. Pharm. Sci. 37 (2009) 405-412; DOI: 10.1016/j.ejps.2009.03.011.10.1016/j.ejps.2009.03.01119491032Search in Google Scholar

20. H. Z. Zhang, J. Drewe, B. Tseng, S. Kasibhatla and S. X. Cai, Discovery and SAR of indole-2- -carboxylic acid benzylidene-hydrazides as a new series of potent apoptosis inducers using a cell-based HTS assay, Bioorg. Med. Chem. 12 (2004) 3649-3655; DOI: 10.1016/j.bmc.2004.04.017.10.1016/j.bmc.2004.04.01715186849Search in Google Scholar

21. P. Vicini, M. I. Incerti, P. L. Colla and R. Loddo, Anti-HIV evaluation of benzo[d]isothiazole hydrazones, Eur. J. Med. Chem. 44 (2009) 1801-1807; DOI: 10.1016/j.ejmech.2008.05.030.10.1016/j.ejmech.2008.05.03018614259Search in Google Scholar

22. V. M. Rahman, S. Mukhtar, W. H. Ansari and G. Lemiere, Synthesis, stereochemistry and biological activity of some novel long alkyl chain substituted thiazolidin-4-ones and thiazan-4-one from 10- undecenoic acsid hydrazide, Eur. J. Med. Chem. 40 (2005) 173-184; DOI: 10.1016/j.ejmech.2004. 10.003.Search in Google Scholar

23. J. R. Dimmock, S. C. Vashishtha and J. P. Stables, Anticonvulsant properties of various acetylhydrazones, oxamoylhydrazones and semicarbazones derived from aromatic and unsaturated carbonyl compounds, Eur. J. Med. Chem. 35 (2000) 241-248; DOI: 10.1016/S0223-5234(00)00123-9.10.1016/S0223-5234(00)00123-9Search in Google Scholar

24. D. Kaushik, S. A. Khan, G. Chawla and S. Kumar, N'-[5-chloro-3-methyl-1-phenyl-1H-pyrazol- -4-yl)methylene]2/4-substituted hydrazide: Synthesis and anticonvulsant activity, Eur. J. Med. Chem. 45 (2010) 3943-3949; DOI: 10.1016/j.ejmech.2010.05.049.10.1016/j.ejmech.2010.05.04920573423Search in Google Scholar

25. S. G. Küçükgüzel, A. Mazi, F. Sahin, S. Öztürk and J. Stables, Synthesis and biological activities of diflunisal hydrazide-hydrazones, Eur. J. Med. Chem. 38 (2003) 1005-1013. DOI: 10.1016/ j.ejmech.2003.08.004.10.1016/j.ejmech.2003.08.00414642333Search in Google Scholar

26. Y. L. Xia, F. Chuan-Dong, B. X. Zhao, J. Zhao, D. S. Shin and J. Y. Miaom, Synthesis and structure- activity relationships of novel 1-arylmethyl-3-aryl-1H pyrazole-5-carbohydrazide hydrazone derivatives as potential agents against A549 lung cancer cells, Eur. J. Med. Chem. 43 (2008) 2347-2353; DOI: 10.1016/j.ejmech.2008.01.021.10.1016/j.ejmech.2008.01.02118313806Search in Google Scholar

27. C. Menendez, A. Chollet, F. Rodriguez, C. Inard, M. R. Pasca, C. Lherbet and M. Baltas, Chemical synthesis and biological evaluation of triazole derivatives as inhibitors of InhA and antituberculosis agents, Eur. J. Med. Chem. 52 (2012) 275-283; DOI: 10.1016/j.ejmech.2012.03.029.10.1016/j.ejmech.2012.03.02922483635Search in Google Scholar

28. N. Özbek, S. Alyar and N. Karacan, Experimental and theoretical studies on methanesulfonic acid 1-methylhydrazide: Antimicrobial activities of its sulfonyl hydrazone derivatives, J. Mol. Struct. 938 (2009) 48-53; DOI: 10.1016/j.molstruc.2009.09.002.10.1016/j.molstruc.2009.09.002Search in Google Scholar

29. R. M. Mohareb and J. Schatz, Anti-tumor and anti-leishmanial evaluations of 1,3,4-oxadiazine, pyran derivatives derived from cross-coupling reactions of b-bromo-6H-1,3,4-oxadiazine derivatives, Bioorg. Med. Chem. 19 (2011) 2707-2713; DOI: 10.1016/j.bmc.2011.02.051.10.1016/j.bmc.2011.02.05121435889Search in Google Scholar