Recent findings on perinatal mesenchymal stem cells – their possible application in current advanced medicine
, , , , , y | 28 jun 2021
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Publicado en línea: 28 jun 2021
Páginas: 48 - 55
Recibido: 03 mar 2021
Aceptado: 20 abr 2021
DOI: https://doi.org/10.2478/acb-2021-0008
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© 2021 Rafał Sibiak, Katarzyna Stefańska, Kornel Ratajczak, Dorota Bukowska, Paweł Antosik, Paul Mozdziak, Michal Jeseta, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
Application of perinatal MSCs in human clinical trials
| STUDY TITLE [REFERENCE] | TYPE OF STUDY | NUMBER OF PARTICIPANTS | MEDICAL CONDITION | FIRST AUTHOR, (YEAR) |
|---|---|---|---|---|
| Immunomodulatory placental-expanded, mesenchymal stromal cells improve muscle function following hip arthroplasty. [ |
Randomized, double blind, and placebo-controlled, phase I/IIa study | 20 | Skeletal muscle injury – hip arthroplasty model | Winkler, (2018) |
| Safety and efficacy of allogenic placental mesenchymal stem cells for treating knee osteoarthritis: a pilot study. [ |
Randomized, controlled, double-blind clinical trial | 20 | Knee osteoarthritis | Soltani, (2018) |
| Determining the feasibility of managing erectile dysfunction in humans with placental-derived stem cells. [ |
Prospective, non-controlled, phase I clinical trial | 8 | Erectile dysfunction | Levy, (2016) |
| Placenta-derived mesenchymal-like cells (PDA-001) as therapy for chronic pulmonary sarcoidosis: a phase 1 study. [ |
Prospective, non-controlled, single-center, open-label phase I trial | 4 | Chronic pulmonary sarcoidosis | Baughman, (2015) |
| A phase 1b study of placenta-derived mesenchymal stromal cells in patients with idiopathic pulmonary fibrosis. [ |
Single center, non-randomized, dose escalation phase Ib trial | 8 | Idiopathic pulmonary fibrosis | Chambers, (2014) |
| Transplantation of placenta-derived mesenchymal stem cells in type 2 diabetes: a pilot study. [ |
Prospective, non-controlled, phase I clinical trial | 10 | Type 2 diabetes | Jiang, (2011) |
| Human placenta-derived cells (PDA-001) for the treatment of adults with multiple sclerosis: a randomized, placebo-controlled, multiple-dose study. [ |
Multicenter, randomized, double-blind, placebo-controlled, 2-dose ranging, phase Ib study | 16 | Multiple sclerosis | Lublin, (2014) |
| Safety and efficacy of the intravenous infusion of umbilical cord mesenchymal stem cells in patients with heart failure: a phase 1/2 randomized controlled trial (rimecard trial [randomized clinical trial of intravenous infusion umbilical cord mesenchymal stem cells on cardiopathy]). [ |
Randomized, controlled trial, Phase I/II | 30 | Chronic stable heart failure and reduced ejection fraction | Bartolucci, (2017) |
| Effect of intramyocardial grafting collagen scaffold with mesenchymal stromal cells in patients with chronic ischemic heart disease: a randomized clinical trial.[ |
Randomized, double-blind clinical trial | 50 | Chronic ischemic heart disease | He, (2020) |
| Umbilical cord-derived mesenchymal stromal cells (MSCs) for knee osteoarthritis: repeated MSC dosing is superior to a single MSC dose and to hyaluronic acid in a controlled randomized phase I/II trial. [ |
Randomized, controlled, phase I/II trial | 26 | Knee osteoarthritis | Matas, (2019) |
| Efficacy and safety of umbilical cord mesenchymal stem cell therapy for rheumatoid arthritis patients: a prospective phase I/II study. [ |
Prospective phase I/II study | 64 | Rheumatoid arthritis | Wang, (2019) |
| Umbilical cord mesenchymal stem cell treatment for Crohn’s disease: a randomized controlled clinical trial. [ |
Randomized controlled clinical trial | 82 | Crohn’s disease | Zhang, (2018) |
| Clinical feasibility of umbilical cord tissue-derived mesenchymal stem cells in the treatment of multiple sclerosis. [ |
Open-label, single-arm, single-center phase I/ II trial | 20 | Multiple sclerosis | Riordan, (2018) |
| Allogeneic mesenchymal stem cells as induction therapy are safe and feasible in renal allografts: pilot results of a multicenter randomized controlled trial. [ |
Multicenter randomized controlled trial | 42 | Renal transplantation | Sun, (2018) |
| A pilot study of mesenchymal stem cell therapy for acute liver allograft rejection. [ |
Randomized, controlled trial | 27 | Acute liver allograft rejection | Shi, (2017) |
| Allogeneic cell therapy using umbilical cord MSCs on collagen scaffolds for patients with recurrent uterine adhesion: a phase I clinical trial. [ |
Prospective, non-controlled, phase I clinical trial | 26 | Infertility caused by recurrent intrauterine adhesions | Cao, (2018) |
| Umbilical cord-derived mesenchymal stem (stromal) cells for treatment of severe sepsis: aphase 1 clinical trial. [ |
Single-center, open-label, dose-escalation phase I clinical trial | 15 | Severe sepsis | He, (2018) |
| Human umbilical cord-derived mesenchymal stem cell therapy in patients with COVID-19: a phase 1 clinical trial. [ |
Parallel assigned controlled, non-randomized, phase I clinical trial | 18 | COVID-19 | Meng, (2020) |
| Treatment of severe COVID-19 with human umbilical cord mesenchymal stem cells. [ |
Single-center open-label, individually randomized, standard treatment-controlled trial | 41 | COVID-19 | Shu, (2020) |