Oral cavity-derived exosomes as promising tool in chronic wound healing

Wound healing is an important physiological process aimed at maintaining the integrity of the skin after injury, accidentally or intentionally. Physiological wound healing involves three consecutive but overlapping phases, including hemostasis, proliferation and remodeling. Wound healing abnormalities, such as excessive wound healing (e.g. keloid) or chronic wounds (e.g. ulcers) impair normal physiological function. Many experimental studies have provided insight into wound healing. There are numerous methods that support wound healing, including popular hydrogels, vegetable oils, ultrasound and even treatment with maggots. Stem cell therapies are also very popular, but they are not safe in all cases due to having specific antibodies. In the following article, in addition to a brief overview of current healing therapies we will examine exosomal therapy, which, although new, seems to be very promising if only because of the high safety of use.

Running title: Exosomes in wound healing