<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Stem cells are cells that have the potential to replicate and/or differentiate, becoming any tissue. This process could be theoretically repeated indefinitely and can be used to create or fix damaged parts any organ. There are many <italic>in vivo</italic> factors that cause stem cells to replicate and differentiate. Many of these interactions and mechanisms are still unknown. <italic>In vitro</italic> models have been successful in inducing stem cells to differentiate into the desired lineage using controlled methods. Recently, epithelial tissue has been successfully created using scaffolds on which stem cells are grown <italic>in vitro</italic> and then transplanted into the host. This transition creates significant problems. This is because <italic>in vitro</italic> -grown stem cells or stem cell-derived tissues are created in an isolated environment where virtually every aspect can be monitored and controlled. <italic>In vivo</italic> monitoring and controlling is significantly more difficult for a plethora of reasons. Cells in the body are constantly exposed to many signals and molecules which affect them. Many of the mechanisms behind these interactions and reactions are known but many others are not. As the corpus of knowledge grows, stem cells become closer to being applied in a clinical setting. In this paper, we review the current evidence on stem cell therapy in regenerative medicine and some of the challenges this field faces.</p></abstract>

Stem cells are cells that have the potential to replicate and/or differentiate, becoming any tissue. This process could be theoretically repeated indefinitely and can be used to create or fix damaged parts any organ. There are many in vivo factors that cause stem cells to replicate and differentiate. Many of these interactions and mechanisms are still unknown. In vitro models have been successful in inducing stem cells to differentiate into the desired lineage using controlled methods. Recently, epithelial tissue has been successfully created using scaffolds on which stem cells are grown in vitro and then transplanted into the host. This transition creates significant problems. This is because in vitro -grown stem cells or stem cell-derived tissues are created in an isolated environment where virtually every aspect can be monitored and controlled. In vivo monitoring and controlling is significantly more difficult for a plethora of reasons. Cells in the body are constantly exposed to many signals and molecules which affect them. Many of the mechanisms behind these interactions and reactions are known but many others are not. As the corpus of knowledge grows, stem cells become closer to being applied in a clinical setting. In this paper, we review the current evidence on stem cell therapy in regenerative medicine and some of the challenges this field faces.

Stemness specificity of epithelial cells – application of cell and tissue technology in regenerative medicine

University Hospital and Masaryk University

Medical Journal of Cell Biology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Stem cells are cells that have the potential to replicate and/or differentiate, becoming any tissue. This process could be theoretically repeated indefinitely...

Stemness specificity of epithelial cells – application of cell and tissue technology in regenerative medicine

Publicado en línea: 24 dic 2018

Páginas: 114 - 119

Recibido: 23 sept 2018

Aceptado: 19 oct 2018

DOI: https://doi.org/10.2478/acb-2018-0018

Palabras clave
stem cells, epithelial cells, regenerative medicine

© 2018 Magdalena Rojewska et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Stemness specificity of epithelial cells – application of cell and tissue technology in regenerative medicine

Publicado en línea: 24 dic 2018

Páginas: 114 - 119

Recibido: 23 sept 2018

Aceptado: 19 oct 2018

DOI: https://doi.org/10.2478/acb-2018-0018

Palabras clavestem cells, epithelial cells, regenerative medicine

© 2018 Magdalena Rojewska et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Palabras clave
stem cells, epithelial cells, regenerative medicine