ARNT | 1.5304 |
1.064 | 2.202 | 0.0219 | 1.498746 |
1.0238 | 2.194 | 0.0374 |
ATG4B | 0.5552 |
0.3172 | 0.972 | 0.0395 | 0.554451 |
0.3167 | 0.9708 | 0.0391 |
ATG4D | 0.5521 |
0.3891 | 0.7833 | 0.0008 | 0.568641 |
0.3919 | 0.825 | 0.00295 |
ATIC | 1.8684 |
1.236 | 2.824 | 0.00302 | 1.857592 |
1.2147 | 2.841 | 0.00427 |
BIRC5 | 1.30634 |
1.163 | 1.467 | 6.22e–06 | 1.343899 |
1.1901 | 1.518 | 1.87e–06 |
CAPN10 | 1.21016 |
1.008 | 1.453 | 0.041 | 1.26361 |
1.0470 | 1.525 | 0.0147 |
CASP3 | 1.4334 |
1.013 | 2.029 | 0.0422 | 1.505861 |
1.0472 | 2.165 | 0.0272 |
CDKN1A | 0.7103 |
0.5645 | 0.8938 | 0.00353 | 0.726627 |
0.5787 | 0.9124 | 0.00598 |
CDKN2A | 1.4842 |
1.056 | 2.085 | 0.0228 | 1.54526 |
1.0525 | 2.269 | 0.0263 |
CXCR4 | 0.73568 |
0.6289 | 0.8606 | 0.000125 | 0.765047 |
0.6486 | 0.9025 | 0.00148 |
DNAJB9 | 0.6088 |
0.389 | 0.9529 | 0.0299 | 0.593613 |
0.3766 | 0.9356 | 0.0246 |
EIF2S1 | 1.6981 |
1.156 | 2.494 | 0.00692 | 1.79448 |
1.1872 | 2.712 | 0.00553 |
EIF4EBP1 | 1.34577 |
1.128 | 1.605 | 0.000955 | 1.312952 |
1.1006 | 1.566 | 0.00249 |
EIF4G1 | 2.3264 |
1.493 | 3.626 | 0.000193 | 2.206738 |
1.3948 | 3.491 | 0.000721 |
FADD | 1.5694 |
1.063 | 2.317 | 0.0234 | 1.61684 |
1.0894 | 2.400 | 0.01708 |
FKBP1A | 1.8452 |
1.187 | 2.868 | 0.00647 | 1.88003 |
1.1997 | 2.946 | 0.00588 |
FKBP1B | 0.82577 |
0.7243 | 0.9414 | 0.0042 | 0.851602 |
0.7454 | 0.973 | 0.0181 |
FOXO1 | 0.6549 |
0.4739 | 0.9051 | 0.0103 | 0.645133 |
0.4668 | 0.8917 | 0.00794 |
FOXO3 | 0.7363 |
0.5657 | 0.9583 | 0.0228 | 0.72246 |
0.5501 | 0.9489 | 0.01942 |
GABARAP | 0.4739 |
0.2896 | 0.7753 | 0.00295 | 0.464234 |
0.2809 | 0.7672 | 0.00276 |
GNAI3 | 1.5955 |
1.082 | 2.353 | 0.0184 | 1.542438 |
1.0415 | 2.284 | 0.0305 |
HDAC6 | 1.7322 |
1.059 | 2.834 | 0.0288 | 1.645421 |
1.0051 | 2.694 | 0.0477 |
HGS | 1.8098 |
1.14 | 2.873 | 0.0119 | 1.696411 |
1.0619 | 2.710 | 0.027 |
HSP90AB1 | 1.6281 |
1.088 | 2.436 | 0.0178 | 1.594093 |
1.0567 | 2.405 | 0.0262 |
IL24 | 0.82369 |
0.6869 | 0.9877 | 0.0363 | 0.795624 |
0.6579 | 0.9622 | 0.0184 |
IRGM | 0.81103 |
0.6737 | 0.9763 | 0.0269 | 0.823283 |
0.6834 | 0.9919 | 0.0408 |
ITGA6 | 0.67844 |
0.5709 | 0.8063 | 1.06e–05 | 0.686741 |
0.5770 | 0.8174 | 2.35e–05 |
ATG13 | 0.4507 |
0.2866 | 0.7087 | 0.000558 | 0.425973 |
0.2721 | 0.6669 | 0.00019 |
LAMP2 | 0.7123 |
0.5495 | 0.9234 | 0.0104 | 0.73084 |
0.5619 | 0.9505 | 0.0193 |
MAPK1 | 1.496 |
1.027 | 2.18 | 0.0359 | 1.481801 |
1.0079 | 2.179 | 0.0455 |
MBTPS2 | 1.445 |
1.039 | 2.009 | 0.0287 | 1.435077 |
1.0182 | 2.023 | 0.0391 |
NCKAP1 | 0.8715 |
0.7823 | 0.9709 | 0.0126 | 0.8927 |
0.7987 | 0.9978 | 0.0456 |
PARP1 | 1.8204 |
1.286 | 2.577 | 0.000729 | 1.938906 |
0.8540 | 2.094 | 0.000271 |
PRKCD | 0.7481 |
0.5748 | 0.9735 | 0.0308 | 0.751456 |
0.5741 | 0.9837 | 0.03755 |
SIRT2 | 0.5835 |
0.4089 | 0.8327 | 0.00298 | 0.662074 |
0.4521 | 0.9696 | 0.0341 |
TNFSF10 | 0.88013 |
0.7841 | 0.988 | 0.0304 | 0.87052 |
0.7759 | 0.9767 | 0.01824 |
TP53 | 0.7408 |
0.6079 | 0.9029 | 0.00296 | 0.726943 |
0.5947 | 0.8887 | 0.00186 |
TSC2 | 1.5559 |
1.099 | 2.202 | 0.0126 | 1.4891644 |
1.0499 | 2.112 | 0.0255 |
VAMP3 | 0.571 |
0.4168 | 0.7823 | 0.000485 | 0.596231 |
0.4317 | 0.8235 | 0.0017 |
WDFY3 | 1.1406 |
1.017 | 1.28 | 0.025 | 1.132911 |
1.0127 | 1.267 | 0.0293 |
WDR45L | 0.5495 |
0.3283 | 0.9198 | 0.0227 | 0.57379 |
0.3396 | 0.9696 | 0.0379 |
Demographic properties of patients ( |
Validation of prognosis-related ARGs in MM patients with ABN (only for 1q21 amplification) ( |
Age (years); mean ± SD; 57.04 ± 9.37 | |
Gender | |
Male | 217 (39.59) |
Female | 331 (60.40) |
ABN | |
Yes | 349 (63.68) |
No | 199 (36.31) |
Treatment protocol | |
TT2 | 334 (60.94) |
TT3 | 214 (39.05) |
Race | |
Caucasian | 486 (88.68) |
Other | 62 (11.31) |
ARNT | 0.78874 |
0.6672 | 0.9324 | 0.00543 |
ATG4B | 2.1821 |
1.51 | 3.154 | 3.29e–05 |
ATG4D | 0.2839 |
0.1907 | 0.4226 | 5.56e–10 |
ATIC | 3.5622 |
2.485 | 5.107 | 4.72e–12 |
CAPN10 | 0.4837 |
0.3665 | 0.6383 | 2.87e–07 |
CASP3 | 0.84905 |
0.7409 | 0.973 | 0.0186 |
CDKN1A | 0.76380 |
0.6658 | 0.8762 | 0.00012 |
CDKN2A | 1.51399 |
1.356 | 1.69 | 1.55e–13 |
CXCR4 | 0.5576 |
0.4568 | 0.6807 | 9.5e–09 |
DNAJB9 | 1.7560 |
1.193 | 2.584 | 0.00427 |
EIF4EBP1 | 0.81096 |
0.726 | 0.9059 | 0.000207 |
EIF4G1 | 0.6512 |
0.4911 | 0.8633 | 0.00287 |
FADD | 1.6059 |
1.179 | 2.188 | 0.00268 |
FKBP1A | 0.3130 |
0.2093 | 0.4679 | 1.5e–08 |
FKBP1B | 0.6616 |
0.5228 | 0.8374 | 0.000589 |
FOXO1 | 0.3332 |
0.24 | 0.4626 | 5.25e–11 |
FOXO3 | 0.7879 |
0.6265 | 0.9908 | 0.0415 |
GNAI3 | 0.79854 |
0.6732 | 0.9472 | 0.00981 |
HGS | 0.70614 |
0.6254 | 0.7973 | 1.98e–08 |
HSP90AB1 | 0.76746 |
0.6908 | 0.8526 | 8.12e–07 |
IL24 | 2.5083 |
1.675 | 3.756 | 7.98e–06 |
IRGM | 2.3205 |
1.664 | 3.236 | 7.07e–07 |
ITGA6 | 4.0435 |
2.847 | 5.744 | 6.11e–15 |
ATG13 | 0.3571 |
0.2254 | 0.5658 | 1.16e–05 |
LAMP2 | 2.4952 |
1.774 | 3.509 | 1.48e–07 |
MAPK1 | 2.0933 |
1.395 | 3.142 | 0.000363 |
TNFSF10 | 1.2571 |
1.021 | 1.548 | 0.0314 |
TP53 | 1.25520 |
1.038 | 1.518 | 0.019 |
TSC2 | 1.4152 |
1.04 | 1.925 | 0.027 |
Age | 1.0126 | 0.9989 | 1.027 | 0.0725 | 1.005 | 1.04 | ||
Sex | 0.9900 | 0.7652 | 1.281 | 0.9390 | 1.0018 | 0.7334 | 1.369 | 0.9910 |
Race | 1.4538 | 0.9372 | 2.255 | 0.0948 | 1.0279 | 0.6367 | 1.657 | 0.9120 |
Treatment protocol | 1.203 | 2.238 | 1.1982 | 0.8316 | 1.727 | 0.3320 | ||
ABN | 1.398 | 2.319 | 1.624 | 2.995 |
All patients (n = 548) | 48.23 ± 22.36 | 42.61 ± 22.15 |
Patients with ABN (n = 349) | 42.70 ± 24.79 | 37.63 ± 23.96 |
Patients without ABN (n = 199) | 50.56 ± 20.50 | 44.93 ± 20.50 |
0.80962 |
0.6862 | 0.9553 | 0.0124 | 0.828576 |
0.6996 | 0.9813 | 0.02935 | |
0.83103 |
0.7354 | 0.9391 | 0.003 | 0.845735 |
0.7462 | 0.9586 | 0.00873 | |
1.2505 |
1.013 | 1.543 | 0.0374 | 1.30139 |
1.0507 | 1.612 | 0.01583 | |
0.6562 |
0.5114 | 0.8419 | 0.000923 | 0.705951 |
0.5506 | 0.9051 | 0.00603 | |
0.6862 |
0.5156 | 0.9132 | 0.0098 | 0.703135 |
0.5146 | 0.9608 | 0.02703 | |
0.7468 |
0.5849 | 0.9536 | 0.0192 | 0.74999 |
0.5830 | 0.9648 | 0.02519 | |
0.7074 |
0.5316 | 0.9414 | 0.0176 | 0.72321 |
0.5419 | 0.9653 | 0.02781 | |
0.7561 |
0.5756 | 0.9932 | 0.0446 | 0.74669 |
0.5729 | 0.9733 | 0.030754 | |
0.82008 |
0.7218 | 0.9318 | 0.00233 | 0.830138 |
0.7293 | 0.9449 | 0.00483 | |
0.7109 |
0.5585 | 0.905 | 0.00559 | 0.70415 |
0.5516 | 0.899 | 0.00488 | |
0.6577 |
0.4565 | 0.9474 | 0.0244 | 0.649662 |
0.4491 | 0.9398 | 0.022037 | |
0.8088 |
0.7198 | 0.9089 | 0.000362 | 0.82788 |
0.7360 | 0.9312 | 0.00164 | |
0.7536 |
0.5958 | 0.953 | 0.0182 | 0.727826 |
0.5723 | 0.9256 | 0.009599 |
Age | 1.0113 | 0.9971 | 1.026 | 0.1202 | 1.0057 | 1.041 | ||
Sex | 0.9962 | 0.7689 | 1.291 | 0.9773 | 1.0308 | 0.7537 | 1.41 | 0.8489 |
Race | 1.4049 | 0.8969 | 2.201 | 0.1375 | 0.9012 | 0.5515 | 1.473 | 0.6781 |
Treatment protocol | 1.2168 | 2.272 | 1.2065 | 0.8357 | 1.742 | 0.3163 | ||
Chromosomal abnormality | 1.3676 | 2.272 | 1.6038 | 2.961 |