This work is licensed under the Creative Commons Attribution 4.0 International License.
Zaccardi F, Webb DR, Yates T, Davies MJ. Pathophysiology of type 1 and type 2 diabetes mellitus: a 90-year perspective. Postgrad Med J. 2016; 92(1084):63–9.ZaccardiFWebbDRYatesTDaviesMJPathophysiology of type 1 and type 2 diabetes mellitus: a 90-year perspective201692108463910.1136/postgradmedj-2015-13328126621825Search in Google Scholar
American Diabetes Association. 2. Classification and diagnosis of diabetes. Diabetes Care 2017; 40(Suppl 1):S11–24.American Diabetes Association2. Classification and diagnosis of diabetes201740Suppl 1S112410.2337/dc17-S00527979889Search in Google Scholar
Zimmet P, Alberti KG, Magliano DJ, Bennett PH. Diabetes mellitus statistics on prevalence and mortality: facts and fallacies. Nat Rev Endocrinol. 2016; 12:616–22.ZimmetPAlbertiKGMaglianoDJBennettPHDiabetes mellitus statistics on prevalence and mortality: facts and fallacies2016126162210.1038/nrendo.2016.10527388988Search in Google Scholar
Selvarajah D, Tesfaye S. Central nervous system involvement in diabetes mellitus. Curr Diab Rep. 2006; 6:431–8.SelvarajahDTesfayeSCentral nervous system involvement in diabetes mellitus20066431810.1007/s11892-006-0075-y17118225Search in Google Scholar
Tumminia A, Vinciguerra F, Parisi M, Frittitta L. Type 2 diabetes mellitus and Alzheimer's disease: role of insulin signalling and therapeutic implications. Int J Mol Sci. 2018; 19:3306. doi: 10.3390/ijms19113306TumminiaAVinciguerraFParisiMFrittittaLType 2 diabetes mellitus and Alzheimer's disease: role of insulin signalling and therapeutic implications201819330610.3390/ijms19113306627502530355995Open DOISearch in Google Scholar
Saedi E, Gheini MR, Faiz F, Arami MA. Diabetes mellitus and cognitive impairments. World J Diabetes. 2016; 7:412–22.SaediEGheiniMRFaizFAramiMADiabetes mellitus and cognitive impairments201674122210.4239/wjd.v7.i17.412502700527660698Search in Google Scholar
Pugazhenthi S, Qin L, Reddy PH. Common neurodegenerative pathways in obesity, diabetes, and Alzheimer's disease. Biochim Biophys Acta Mol Basis Dis. 2017; 1863:1037–45.PugazhenthiSQinLReddyPHCommon neurodegenerative pathways in obesity, diabetes, and Alzheimer's disease2017186310374510.1016/j.bbadis.2016.04.017534477127156888Search in Google Scholar
de la Monte SM. Brain insulin resistance and deficiency as therapeutic targets in Alzheimer's disease. Curr Alzheimer Res. 2012; 9:35–66.de la MonteSMBrain insulin resistance and deficiency as therapeutic targets in Alzheimer's disease20129356610.2174/156720512799015037334998522329651Search in Google Scholar
Chornenkyy Y, Wang W-X, Wei A, Nelson PT. Alzheimer's disease and type 2 diabetes mellitus are distinct diseases with potential overlapping metabolic dysfunction upstream of observed cognitive decline. Brain Pathol. 2019; 29:3–17.ChornenkyyYWangW-XWeiANelsonPTAlzheimer's disease and type 2 diabetes mellitus are distinct diseases with potential overlapping metabolic dysfunction upstream of observed cognitive decline20192931710.1111/bpa.12655642791930106209Search in Google Scholar
Baglietto-Vargas D, Shi J, Yaeger DM, Ager R, LaFerla FM. Diabetes and Alzheimer's disease crosstalk. Neurosci Biobehav Rev. 2016; 64:272–87.Baglietto-VargasDShiJYaegerDMAgerRLaFerlaFMDiabetes and Alzheimer's disease crosstalk2016642728710.1016/j.neubiorev.2016.03.00526969101Search in Google Scholar
Salas IH, De Strooper B. Diabetes and Alzheimer's disease: a link not as simple as it seems. Neurochem Res. 2019; 44:1271–8.SalasIHDe StrooperBDiabetes and Alzheimer's disease: a link not as simple as it seems2019441271810.1007/s11064-018-2690-930523576Search in Google Scholar
Ryan CM, van Duinkerken E, Rosano C. Neurocognitive consequences of diabetes. Am Psychol. 2016; 71:563–76.RyanCMvan DuinkerkenERosanoCNeurocognitive consequences of diabetes2016715637610.1037/a004045527690485Search in Google Scholar
Gabbouj S, Ryhänen S, Marttinen M, Wittrahm R, Takalo M, Kemppainen S, et al. Altered insulin signaling in Alzheimer's disease brain – special emphasis on PI3K-Akt Pathway. Front Neurosci. 2019; 13:629. doi: 10.3389/fnins.2019.00629GabboujSRyhänenSMarttinenMWittrahmRTakaloMKemppainenSAltered insulin signaling in Alzheimer's disease brain – special emphasis on PI3K-Akt Pathway20191362910.3389/fnins.2019.00629659147031275108Open DOISearch in Google Scholar
Stanley M, Macauley SL, Holtzman DM. Changes in insulin and insulin signaling in Alzheimer's disease: cause or consequence? J Exp Med. 2016; 213:1375–85.StanleyMMacauleySLHoltzmanDMChanges in insulin and insulin signaling in Alzheimer's disease: cause or consequence?201621313758510.1084/jem.20160493498653727432942Search in Google Scholar
Sun Y, Ma C, Sun H, Wang H, Peng W, Zhou Z, et al. Metabolism: a novel shared link between diabetes mellitus and Alzheimer's disease. J Diabetes Res. 2020; 2000:4981814. doi: 10.1155/2020/4981814SunYMaCSunHWangHPengWZhouZMetabolism: a novel shared link between diabetes mellitus and Alzheimer's disease20202000498181410.1155/2020/4981814701148132083135Open DOISearch in Google Scholar
Muriach M, Flores-Bellver M, Romero FJ, Barcia JM. Diabetes and the brain: oxidative stress, inflammation, and autophagy. Oxid Med Cell Longev. 2014; 2014:102158. doi: 10.1155/2014/102158MuriachMFlores-BellverMRomeroFJBarciaJMDiabetes and the brain: oxidative stress, inflammation, and autophagy2014201410215810.1155/2014/102158415855925215171Open DOISearch in Google Scholar
Lenzen S. The mechanisms of alloxan- and streptozotocin-induced diabetes. Diabetologia. 2008; 51:216–26.LenzenSThe mechanisms of alloxan- and streptozotocin-induced diabetes2008512162610.1007/s00125-007-0886-718087688Search in Google Scholar
Zhou F, Tan Y, Chen X-H, Wu F-L, Yang D-J, Zhang X-W, et al. Atorvastatin improves plaque stability in diabetic atherosclerosis through the RAGE pathway. Eur Rev Med Pharmacol Sci. 2018; 22:1142–9.ZhouFTanYChenX-HWuF-LYangD-JZhangX-WAtorvastatin improves plaque stability in diabetic atherosclerosis through the RAGE pathway20182211429Search in Google Scholar
Paseban M, Mohebbati R, Niazmand S, Sathyapalan T, Sahebkar A. Comparison of the neuroprotective effects of aspirin, atorvastatin, captopril and metformin in diabetes mellitus. Biomolecules. 2019; 9:118. doi: 10.3390/biom9040118PasebanMMohebbatiRNiazmandSSathyapalanTSahebkarAComparison of the neuroprotective effects of aspirin, atorvastatin, captopril and metformin in diabetes mellitus2019911810.3390/biom9040118652335930934759Open DOISearch in Google Scholar
Pistollato F, Iglesias RC, Ruiz R, Aparicio S, Crespo J, Lopez LD, et al. Nutritional patterns associated with the maintenance of neurocognitive functions and the risk of dementia and Alzheimer's disease: a focus on human studies. Pharmacol Res. 2018; 131:32–43.PistollatoFIglesiasRCRuizRAparicioSCrespoJLopezLDNutritional patterns associated with the maintenance of neurocognitive functions and the risk of dementia and Alzheimer's disease: a focus on human studies2018131324310.1016/j.phrs.2018.03.01229555333Search in Google Scholar
Chu C-S, Tseng P-T, Stubbs B, Chen T-Y, Tang C-H, Li D-J, et al. Use of statins and the risk of dementia and mild cognitive impairment: a systematic review and meta-analysis. Sci Rep. 2018; 8:5804. doi: 10.1038/s41598-018-24248-8ChuC-STsengP-TStubbsBChenT-YTangC-HLiD-JUse of statins and the risk of dementia and mild cognitive impairment: a systematic review and meta-analysis20188580410.1038/s41598-018-24248-8589561729643479Open DOISearch in Google Scholar
Kaviani E, Rahmani M, Kaeidi A, Shamsizadeh A, Allahtavakoli M, Mozafari N, Fatemi I. Protective effect of atorvastatin on D-galactose-induced aging model in mice. Behav Brain Res. 2017; 334:55–60.KavianiERahmaniMKaeidiAShamsizadehAAllahtavakoliMMozafariNFatemiIProtective effect of atorvastatin on D-galactose-induced aging model in mice2017334556010.1016/j.bbr.2017.07.02928750834Search in Google Scholar
Schultz BG, Patten DK, Berlau DJ. The role of statins in both cognitive impairment and protection against dementia: a tale of two mechanisms. Transl Neurodegener. 2018; 7:5. doi: 10.1186/s40035-018-0110-3SchultzBGPattenDKBerlauDJThe role of statins in both cognitive impairment and protection against dementia: a tale of two mechanisms20187510.1186/s40035-018-0110-3583005629507718Open DOISearch in Google Scholar
Samaras K, Makkar SR, Crawford JD, Kochan NA, Slavin MJ, Wen W, et al. Effects of statins on memory, cognition, and brain volume in the elderly. J Am Coll Cardiol. 2019; 74:2554–68.SamarasKMakkarSRCrawfordJDKochanNASlavinMJWenWEffects of statins on memory, cognition, and brain volume in the elderly20197425546810.1016/j.jacc.2019.09.04131753200Search in Google Scholar
Percie du Sert N, Hurst V, Ahluwalia A, Alam S, Avey MT, Baker M, et al. The ARRIVE guidelines 2.0: updated guidelines for reporting animal research. PLoS Biology 2020; 18:e3000410. doi: 10.1371/journal.pbio.3000410Percie du SertNHurstVAhluwaliaAAlamSAveyMTBakerMThe ARRIVE guidelines 2.0: updated guidelines for reporting animal research202018e300041010.1371/journal.pbio.3000410736002332663219Open DOISearch in Google Scholar
Kang H. Sample size determination and power analysis using the G*Power software. J Educ Eval Health Prof. 2021; 18:17. doi: 10.3352/jeehp.2021.18.17KangHSample size determination and power analysis using the G*Power software2021181710.3352/jeehp.2021.18.17844109634325496Open DOISearch in Google Scholar
Burkholder T, Foltz C, Karlsson E, Linton CG, Smith JM. Health Evaluation of Experimental Laboratory Mice. Curr Protoc Mouse Biol. 2012; 2:145–65.BurkholderTFoltzCKarlssonELintonCGSmithJMHealth Evaluation of Experimental Laboratory Mice201221456510.1002/9780470942390.mo110217339954522822473Search in Google Scholar
Tuorkey MJ. Effects of Moringa oleifera aqueous leaf extract in alloxan induced diabetic mice. Interv Med Appl Sci. 2016; 8:109–17.TuorkeyMJEffects of Moringa oleifera aqueous leaf extract in alloxan induced diabetic mice2016810917Search in Google Scholar
Biswas RR, M C D, Rao A S R S, Kadali SRM. Effect of atorvastatin on memory in albino mice. J Clin Diagn Res. 2014; 8:HF01–4.BiswasRRDM CRaoA S R SKadaliSRMEffect of atorvastatin on memory in albino mice20148HF01410.7860/JCDR/2014/9730.5089429026325584244Search in Google Scholar
Georgieva-Kotetarova MT, Kostadinova, II. Effect of atorvastatin and rosuvastatin on learning and memory in rats with diazepam-induced amnesia. Folia Med (Plovdiv) 2013; 55:58–65.Georgieva-KotetarovaMTKostadinovaIIEffect of atorvastatin and rosuvastatin on learning and memory in rats with diazepam-induced amnesia201355586510.2478/folmed-2013-001824191400Search in Google Scholar
Vandresen-Filho S, França LM, Alcantara-Junior J, Nogueira LC, de Brito TM, Lopes L, et al. Statins enhance cognitive performance in object location test in albino Swiss mice: involvement of beta-adrenoceptors. Physiol Behav. 2015; 143:27–34.Vandresen-FilhoSFrançaLMAlcantara-JuniorJNogueiraLCde BritoTMLopesLStatins enhance cognitive performance in object location test in albino Swiss mice: involvement of beta-adrenoceptors2015143273410.1016/j.physbeh.2015.02.02425700896Search in Google Scholar
Bugáňová M, Pelantová H, Holubová M, Šedivá B, Maletínská L, Železná B, et al. The effects of liraglutide in mice with diet-induced obesity studied by metabolomics. J Endocrinol. 2017; 233:93–104.BugáňováMPelantováHHolubováMŠediváBMaletínskáLŽeleznáBThe effects of liraglutide in mice with diet-induced obesity studied by metabolomics20172339310410.1530/JOE-16-047828138003Search in Google Scholar
Knudsen LB. Liraglutide: the therapeutic promise from animal models. Int J Clin Pract Suppl. 2010; (167):4–11.KnudsenLBLiraglutide: the therapeutic promise from animal models201016741110.1111/j.1742-1241.2010.02499.x20887299Search in Google Scholar
Andrikopoulos S, Blair AR, Deluca N, Fam BC, Proietto J. Evaluating the glucose tolerance test in mice. Am J Physiol Endocrinol Metab. 2008; 295:E1323–32. doi: 10.1152/ajpendo.90617.2008AndrikopoulosSBlairARDelucaNFamBCProiettoJEvaluating the glucose tolerance test in mice2008295E13233210.1152/ajpendo.90617.200818812462Open DOISearch in Google Scholar
Du L, Liu C, Teng M, Meng Q, Lu J, Zhou Y, et al. Anti-diabetic activities of Paecilomyces tenuipes N45 extract in alloxan-induced diabetic mice. Mol Med Rep. 2016; 13:1701–8.DuLLiuCTengMMengQLuJZhouYAnti-diabetic activities of Paecilomyces tenuipes N45 extract in alloxan-induced diabetic mice2016131701810.3892/mmr.2015.473626718133Search in Google Scholar
Eagle AL, Wang H, Robison AJ. Sensitive assessment of hippocampal learning using temporally dissociated passive avoidance task. Bio Protoc. 2016; 6:e1821. doi: 10.21769/BioProtoc.1821EagleALWangHRobisonAJSensitive assessment of hippocampal learning using temporally dissociated passive avoidance task20166e182110.21769/BioProtoc.1821567262829119127Open DOISearch in Google Scholar
Damián JP, Acosta V, Da Cuña M, Ramírez I, Oddone N, Zambrana A, et al. Effect of resveratrol on behavioral performance of streptozotocin-induced diabetic mice in anxiety tests. Exp Anim. 2014; 63:277–87.DamiánJPAcostaVDa CuñaMRamírezIOddoneNZambranaAEffect of resveratrol on behavioral performance of streptozotocin-induced diabetic mice in anxiety tests2014632778710.1538/expanim.63.277420673125077757Search in Google Scholar
Bösel J, Gandor F, Harms C, Synowitz M, Harms U, Djoufack PC, et al. Neuroprotective effects of atorvastatin against glutamate-induced excitotoxicity in primary cortical neurones. J Neurochem. 2005; 92:1386–98.BöselJGandorFHarmsCSynowitzMHarmsUDjoufackPCNeuroprotective effects of atorvastatin against glutamate-induced excitotoxicity in primary cortical neurones20059213869810.1111/j.1471-4159.2004.02980.x15748157Search in Google Scholar
Lu D, Shen L, Mai H, Zang J, Liu Y, Tsang C-K, et al. HMG-CoA reductase inhibitors attenuate neuronal damage by suppressing oxygen glucose deprivation-induced activated microglial cells. Neural Plast. 2019; 2019:7675496. doi: 10.1155/2019/7675496LuDShenLMaiHZangJLiuYTsangC-KHMG-CoA reductase inhibitors attenuate neuronal damage by suppressing oxygen glucose deprivation-induced activated microglial cells20192019767549610.1155/2019/7675496639798230911291Open DOISearch in Google Scholar
Li HH, Lin CL, Huang CN. Neuroprotective effects of statins against amyloid b-induced neurotoxicity. Neural Regen Res. 2018; 13:198–206.LiHHLinCLHuangCNNeuroprotective effects of statins against amyloid b-induced neurotoxicity20181319820610.4103/1673-5374.226379587988229557360Search in Google Scholar
Barone E, Cenini G, Di Domenico F, Martin S, Sultana R, Mancuso C, et al. Long-term high-dose atorvastatin decreases brain oxidative and nitrosative stress in a preclinical model of Alzheimer disease: a novel mechanism of action. Pharmacol Res. 2011; 63:172–80.BaroneECeniniGDi DomenicoFMartinSSultanaRMancusoCLong-term high-dose atorvastatin decreases brain oxidative and nitrosative stress in a preclinical model of Alzheimer disease: a novel mechanism of action2011631728010.1016/j.phrs.2010.12.007303481021193043Search in Google Scholar
Wassmann S, Laufs U, Muller K, Konkol C, Ahlbory K, Bäumer AT, et al. Cellular antioxidant effects of atorvastatin in vitro and in vivo. Arterioscler Thromb Vasc Biol. 2002; 22:300–5.WassmannSLaufsUMullerKKonkolCAhlboryKBäumerATCellular antioxidant effects of atorvastatin in vitro and in vivo200222300510.1161/hq0202.10408111834532Search in Google Scholar
Farmer JA, Torre-Amione G. Comparative tolerability of the HMG-CoA reductase inhibitors. Drug Saf. 2000; 23:197–213.FarmerJATorre-AmioneGComparative tolerability of the HMG-CoA reductase inhibitors20002319721310.2165/00002018-200023030-00003Search in Google Scholar
Wong ST, Athos J, Figueroa XA, Pineda VV, Schaefer ML, Chavkin CC, et al. Calcium-stimulated adenylyl cyclase activity is critical for hippocampus-dependent long-term memory and late phase LTP. Neuron. 1999; 23:787–98.WongSTAthosJFigueroaXAPinedaVVSchaeferMLChavkinCCCalcium-stimulated adenylyl cyclase activity is critical for hippocampus-dependent long-term memory and late phase LTP1999237879810.1016/S0896-6273(01)80036-2Search in Google Scholar