<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec><h3>Background</h3>
<p>Adenosine monophosphate (AMP)-activated protein kinase (AMPK; EC 2.7.11.31) enzymes play a pivotal role in cell metabolism. They are involved in type 2 diabetes mellitus (T2DM) pathogenesis. Genetic variation of <italic>PRKAA2</italic> coding for the AMPK α2 catalytic subunit (AMPKα2) is reported to be associated with susceptibility for T2DM.</p>
</sec>
<sec><h3>Objectives</h3>
<p>To determine the association between <italic>PRKAA2</italic> genetic variations (rs2796498, rs9803799, and rs2746342) with clinical characteristics in patients newly diagnosed with T2DM.</p>
</sec>
<sec><h3>Methods</h3>
<p>We performed a cross-sectional study including 166 T2DM patients from 10 primary health care centers in Yogyakarta, Indonesia. We measured fasting plasma glucose, hemoglobin A1c, serum creatinine, glomerular filtration rate, blood pressure, and body mass index as clinical characteristics. <italic>PRKAA2</italic> genetic variations were determined by TaqMan SNP genotyping assay. Hardy–Weinberg equilibrium was calculated using χ<sup>2</sup> tests.</p>
</sec>
<sec><h3>Results</h3>
<p>There was no difference in clinical characteristics for genotypes rs2796498, rs9803799, or rs2746342 (<italic>P</italic> > 0.05). No significant association was found between <italic>PRKAA2</italic> genetic variations and any clinical feature observed. Further subgroup analysis adjusting for age, sex, and waist circumference did not detect any significant association of <italic>PRKAA2</italic> genetic variations with clinical characteristics (<italic>P</italic> > 0.05).</p>
</sec>
<sec><h3>Conclusion</h3>
<p><italic>PRKAA2</italic> genetic variation is not associated with the clinical characteristics of Indonesian patients with newly diagnosed T2DM.</p>
</sec>
</abstract>

Background
Adenosine monophosphate (AMP)-activated protein kinase (AMPK; EC 2.7.11.31) enzymes play a pivotal role in cell metabolism. They are involved in type 2 diabetes mellitus (T2DM) pathogenesis. Genetic variation of PRKAA2 coding for the AMPK α2 catalytic subunit (AMPKα2) is reported to be associated with susceptibility for T2DM.

Objectives
To determine the association between PRKAA2 genetic variations (rs2796498, rs9803799, and rs2746342) with clinical characteristics in patients newly diagnosed with T2DM.

Methods
We performed a cross-sectional study including 166 T2DM patients from 10 primary health care centers in Yogyakarta, Indonesia. We measured fasting plasma glucose, hemoglobin A1c, serum creatinine, glomerular filtration rate, blood pressure, and body mass index as clinical characteristics. PRKAA2 genetic variations were determined by TaqMan SNP genotyping assay. Hardy–Weinberg equilibrium was calculated using χ2 tests.

Results
There was no difference in clinical characteristics for genotypes rs2796498, rs9803799, or rs2746342 (P > 0.05). No significant association was found between PRKAA2 genetic variations and any clinical feature observed. Further subgroup analysis adjusting for age, sex, and waist circumference did not detect any significant association of PRKAA2 genetic variations with clinical characteristics (P > 0.05).

Conclusion
PRKAA2 genetic variation is not associated with the clinical characteristics of Indonesian patients with newly diagnosed T2DM.

<italic>PRKAA2</italic> variation and the clinical characteristics of patients newly diagnosed with type 2 diabetes mellitus in Yogyakarta, Indonesia

Department of Pharmacology and Therapy, Faculty of Medicine, Public Health and Nursing

Center of Genetic Study, Faculty of Medicine, Public Health and Nursing

Asian Biomedicine

This work is licensed under the Creative Commons Attribution 4.0 International License.

 variation and the clinical characteristics of patients newly diagnosed with type 2 diabetes mellitus in Yogyakarta, Indonesia

Background
Adenosine monophosphate (AMP)-activated protein kinase (AMPK; EC 2.7.11.31) enzymes play a pivotal role in cell metabolism. They are involved in...

PRKAA2 variation and the clinical characteristics of patients newly diagnosed with type 2 diabetes mellitus in Yogyakarta, Indonesia

Article Category: Original article

Publicado en línea: 20 ago 2021

Páginas: 161 - 170

DOI: https://doi.org/10.2478/abm-2021-0021

Palabras clave
genetic variation, Indonesia, type 2 diabetes mellitus

© 2021 Dita Maria Virginia et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

PRKAA2 variation and the clinical characteristics of patients newly diagnosed with type 2 diabetes mellitus in Yogyakarta, Indonesia

Article Category: Original article

Publicado en línea: 20 ago 2021

Páginas: 161 - 170

DOI: https://doi.org/10.2478/abm-2021-0021

Palabras clavegenetic variation, Indonesia, type 2 diabetes mellitus

© 2021 Dita Maria Virginia et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Palabras clave
genetic variation, Indonesia, type 2 diabetes mellitus