This work is licensed under the Creative Commons Attribution 4.0 International License.
Lee DYW, Li QY, Liu J, Efferth T. Traditional Chinese herbal medicine at the forefront battle against COVID-19: Clinical experience and scientific basis. Phytomedicine. 2021; 80:153337. doi: 10.1016/j.phymed.2020.153337LeeDYWLiQYLiuJEfferthTTraditional Chinese herbal medicine at the forefront battle against COVID-19: Clinical experience and scientific basis20218015333710.1016/j.phymed.2020.153337752188433221457Open DOISearch in Google Scholar
World Health Organization. Expert panel endorses protocol for COVID-19 herbal medicine clinical trials [internet]. Brazzaville, Republic of Congo: World Health Organization - Regional Office for Africa; 2020 [cited 2020 November 28]. Available from: https://www.afro.who.int/news/expert-panel-endorses-protocol-covid-19-herbal-medicine-clinical-trialsWorld Health OrganizationBrazzaville, Republic of CongoWorld Health Organization - Regional Office for Africa2020[cited 2020 November 28]. Available from: https://www.afro.who.int/news/expert-panel-endorses-protocol-covid-19-herbal-medicine-clinical-trialsSearch in Google Scholar
Russo M, Moccia S, Spagnuolo C, Tedesco I, Russo GL. Roles of flavonoids against coronavirus infection. Chem Biol Interact. 2020; 328:109211. doi: 10.1016/j.cbi.2020.109211RussoMMocciaSSpagnuoloCTedescoIRussoGLRoles of flavonoids against coronavirus infection202032810921110.1016/j.cbi.2020.109211738553832735799Open DOISearch in Google Scholar
Peterson L. COVID-19 and flavonoids: in silico molecular dynamics docking to the active catalytic site of SARS-CoV and SARS-CoV-2 main protease. SSRN Electronic J. 2020. doi: 10.2139/ssrn.3599426PetersonLCOVID-19 and flavonoids: in silico molecular dynamics docking to the active catalytic site of SARS-CoV and SARS-CoV-2 main protease202010.2139/ssrn.3599426Open DOISearch in Google Scholar
Jahan I, Onay A. Potentials of plant-based substance to inhabit and probable cure for the COVID-19. Turkish J Biol 2020; 44(Special Issue 1):228–41.JahanIOnayAPotentials of plant-based substance to inhabit and probable cure for the COVID-19202044Special Issue 12284110.3906/biy-2005-114731451432595359Search in Google Scholar
Orhan IE, Senol Deniz FS. Natural products as potential leads against coronaviruses: could they be encouraging structural models against SARS-CoV-2? Nat Products Bioprospect. 2020; 10:171–86.OrhanIESenol DenizFSNatural products as potential leads against coronaviruses: could they be encouraging structural models against SARS-CoV-2?2020101718610.1007/s13659-020-00250-4728922932529545Search in Google Scholar
Benarba B, Pandiella A. Medicinal plants as sources of active molecules against COVID-19. Front Pharmacol. 2020; 11:1–16.BenarbaBPandiellaAMedicinal plants as sources of active molecules against COVID-1920201111610.3389/fphar.2020.01189742746632848790Search in Google Scholar
Yu S, Yan H, Zhang L, Shan M, Chen P, Ding A, Li SF. A review on the phytochemistry, pharmacology, and pharmacokinetics of amentoflavone, a naturally-occurring biflavonoid. Molecules. 2017; 22:299. doi: 10.3390/molecules22020299YuSYanHZhangLShanMChenPDingALiSFA review on the phytochemistry, pharmacology, and pharmacokinetics of amentoflavone, a naturally-occurring biflavonoid20172229910.3390/molecules22020299615557428212342Open DOISearch in Google Scholar
Chen T-R, Wei L-H, Guan X-Q, Huang C, Liu Z-Y, Wang F-J, et al. Biflavones from Ginkgo biloba as inhibitors of human thrombin. Bioorg Chem. 2019; 92:103199. doi: 10.1016/j.bioorg.2019.103199ChenT-RWeiL-HGuanX-QHuangCLiuZ-YWangF-JBiflavones from Ginkgo biloba as inhibitors of human thrombin20199210319910.1016/j.bioorg.2019.10319931446241Open DOISearch in Google Scholar
Ma S-C, But PP-H, Ooi VE-C, He Y-H, Lee SH-S, Lee S-F, Lin R-C. Antiviral amentoflavone from Selaginella sinensis. Biol Pharm Bull. 2001; 24:311–2.MaS-CButPP-HOoiVE-CHeY-HLeeSH-SLeeS-FLinR-CAntiviral amentoflavone from Selaginella sinensis200124311210.1248/bpb.24.31111256492Search in Google Scholar
Li F, Song X, Su G, Wang Y, Wang Z, Jia J, et al. Amentoflavone inhibits HSV-1 and ACV-resistant strain infection by suppressing viral early infection. Viruses 2019; 11:466. doi: 10.3390/v11050466.LiFSongXSuGWangYWangZJiaJAmentoflavone inhibits HSV-1 and ACV-resistant strain infection by suppressing viral early infection20191146610.3390/v11050466.Open DOISearch in Google Scholar
Lee WP, Lan KL, Liao SX, Huang YH, Hou MC, Lan KH. Inhibitory effects of amentoflavone and orobol on daclatasvir-induced resistance-associated variants of hepatitis C virus. Am J Chin Med. 2018; 46:835–52.LeeWPLanKLLiaoSXHuangYHHouMCLanKHInhibitory effects of amentoflavone and orobol on daclatasvir-induced resistance-associated variants of hepatitis C virus2018468355210.1142/S0192415X1850044129737209Search in Google Scholar
Wilsky S, Sobotta K, Wiesener N, Pilas J, Althof N, Munder T, et al. Inhibition of fatty acid synthase by amentoflavone reduces coxsackievirus B3 replication. Arch Virol. 2012; 157:259–69.WilskySSobottaKWiesenerNPilasJAlthofNMunderTInhibition of fatty acid synthase by amentoflavone reduces coxsackievirus B3 replication20121572596910.1007/s00705-011-1164-z22075919Search in Google Scholar
Coulerie P, Nour M, Maciuk A, Eydoux C, Guillemot J-C, Lebouvier N, et al. Structure-activity relationship study of biflavonoids on the Dengue virus polymerase DENV-NS5 RdRp. Planta Med. 2013; 79:1313–8.CouleriePNourMMaciukAEydouxCGuillemotJ-CLebouvierNStructure-activity relationship study of biflavonoids on the Dengue virus polymerase DENV-NS5 RdRp2013791313810.1055/s-0033-135067223929244Search in Google Scholar
Bhargava S, Patel T, Gaikwad R, Patil UK, Gayen S. Identification of structural requirements and prediction of inhibitory activity of natural flavonoids against Zika virus through molecular docking and Monte Carlo based QSAR Simulation. Nat Prod Res. 2019;33:851–7.BhargavaSPatelTGaikwadRPatilUKGayenSIdentification of structural requirements and prediction of inhibitory activity of natural flavonoids against Zika virus through molecular docking and Monte Carlo based QSAR Simulation201933851710.1080/14786419.2017.141357429241370Search in Google Scholar
Ullrich S, Nitsche C. The SARS-CoV-2 main protease as drug target. Bioorganic Med Chem Lett. 2020; 30:127377. doi: 10.1016/j.bmcl.2020.127377UllrichSNitscheCThe SARS-CoV-2 main protease as drug target20203012737710.1016/j.bmcl.2020.127377733156732738988Open DOISearch in Google Scholar
Ryu YB, Jeong HJ, Kim JH, Kim YM, Park JY, Kim D, et al. Biflavonoids from Torreya nucifera displaying SARS-CoV 3CLpro inhibition. Bioorganic Med Chem 2010; 18:7940–7.RyuYBJeongHJKimJHKimYMParkJYKimDBiflavonoids from Torreya nucifera displaying SARS-CoV 3CLpro inhibition2010187940710.1016/j.bmc.2010.09.035712630920934345Search in Google Scholar
Jo S, Kim S, Shin DH, Kim M-S. Inhibition of SARS-CoV 3CL protease by flavonoids. J Enzyme Inhib Med Chem. 2020;35:145–51.JoSKimSShinDHKimM-SInhibition of SARS-CoV 3CL protease by flavonoids2020351455110.1080/14756366.2019.1690480688243431724441Search in Google Scholar
Mishra A, Pathak Y, Kumar A, Mishra SK, Tripathi V. Natural compounds as potential inhibitors of SARS-CoV-2 main protease: an in-silico study. Asian Pac J Trop Biomed. 2021; 11:155–63.MishraAPathakYKumarAMishraSKTripathiVNatural compounds as potential inhibitors of SARS-CoV-2 main protease: an in-silico study2021111556310.4103/2221-1691.310202Search in Google Scholar
Miroshnychenko KV. Shestopalova A. Combined use of the hepatitis C drugs and amentoflavone could interfere with binding of the spike glycoprotein of SARS-CoV-2 to ACE2: the results of a molecular simulation study. J Biomol Struct Dyn. 2021 Apr 26;1–15. [Online ahead of print]. doi: 10.1080/07391102.2021.1914168MiroshnychenkoKVShestopalovaACombined use of the hepatitis C drugs and amentoflavone could interfere with binding of the spike glycoprotein of SARS-CoV-2 to ACE2: the results of a molecular simulation study2021Apr26115[Online ahead of print]10.1080/07391102.2021.1914168807465333896392Open DOISearch in Google Scholar
National Institutes of Health. COVID-19 Treatment Guidelines Panel. Coronavirus Disease 2019 (COVID-19) Treatment Guidelines [Internet]. Bethesda, MD: National Institutes of Health; 2021 [cited 2021 July 13]. Available at: https://www.covid19treatmentguidelines.nih.gov/National Institutes of HealthBethesda, MDNational Institutes of Health2021[cited 2021 July 13]. Available at: https://www.covid19treatmentguidelines.nih.gov/Search in Google Scholar
Iannaccone G, Scacciavillani R, Del Buono MG, Camilli M, Ronco C, Lavie CJ, et al. Weathering the cytokine storm in COVID-19: therapeutic implications. Cardiorenal Med. 2020; 10:277–87.IannacconeGScacciavillaniRDel BuonoMGCamilliMRoncoCLavieCJWeathering the cytokine storm in COVID-19: therapeutic implications2020102778710.1159/000509483736050732599589Search in Google Scholar
Torres Acosta MA, Singer BD. Pathogenesis of COVID-19-induced ARDS: implications for an ageing population. Eur Respir J. 2020; 56:2002049. doi: 10.1183/13993003.02049-2020Torres AcostaMASingerBDPathogenesis of COVID-19-induced ARDS: implications for an ageing population202056200204910.1183/13993003.02049-2020739794532747391Open DOISearch in Google Scholar
Diniz LRL, Bezerra Filho CdSM, Fielding BC, de Sousa DP. Natural antioxidants: a review of studies on human and animal coronavirus. Oxid Med Cell Longev 2020; 2020:3173281. doi: 10.1155/2020/3173281DinizLRLBezerra FilhoCdSMFieldingBCde SousaDPNatural antioxidants: a review of studies on human and animal coronavirus20202020317328110.1155/2020/3173281744322932855764Open DOISearch in Google Scholar
Szklarczyk D, Franceschini A, Wyder S, Forslund K, Heller D, Huerta-Cepas J, et al. STRING v10: protein–protein interaction networks, integrated over the tree of life. Nucleic Acids Res. 2015; 43(D1):D447–52.SzklarczykDFranceschiniAWyderSForslundKHellerDHuerta-CepasJSTRING v10: protein–protein interaction networks, integrated over the tree of life201543D1D4475210.1093/nar/gku1003438387425352553Search in Google Scholar
Szklarczyk D, Santos A, von Mering C, Jensen LJ, Bork P, Kuhn M. STITCH 5: Augmenting protein–chemical interaction networks with tissue and affinity data. Nucleic Acids Res. 2016; 44(D1):D380–4.SzklarczykDSantosAvon MeringCJensenLJBorkPKuhnMSTITCH 5: Augmenting protein–chemical interaction networks with tissue and affinity data201644D1D380410.1093/nar/gkv1277470290426590256Search in Google Scholar
Oh J, Rho HS, Yang Y, Yoon JY, Lee J, Hong YD, et al. Extracellular signal-regulated kinase is a direct target of the anti-inflammatory compound amentoflavone derived from Torreya nucifera. Mediators Inflamm. 2013; 2013:761506. doi: 10.1155/2013/761506.OhJRhoHSYangYYoonJYLeeJHongYDExtracellular signal-regulated kinase is a direct target of the anti-inflammatory compound amentoflavone derived from Torreya nucifera2013201376150610.1155/2013/761506.Open DOISearch in Google Scholar
Zong Y, Zhang H. Amentoflavone prevents sepsis-associated acute lung injury through Nrf2-GCLc-mediated upregulation of glutathione. Acta Biochim Pol. 2017; 64:93–8.ZongYZhangHAmentoflavone prevents sepsis-associated acute lung injury through Nrf2-GCLc-mediated upregulation of glutathione20176493810.18388/abp.2016_129627718499Search in Google Scholar
Cai J, Zhao C, Du Y, Huang Y, Zhao Q. Amentoflavone ameliorates cold stress-induced inflammation in lung by suppression of C3/BCR/NF-κB pathways. BMC Immunol. 2019; 20:49. doi: 10.1186/s12865-019-0331-yCaiJZhaoCDuYHuangYZhaoQAmentoflavone ameliorates cold stress-induced inflammation in lung by suppression of C3/BCR/NF-κB pathways2019204910.1186/s12865-019-0331-y693796131888465Open DOISearch in Google Scholar
Gan L, Ma J, You G, Mai J, Wang Z, Yang R, et al. Glucuronidation and its effect on the bioactivity of amentoflavone, a biflavonoid from Ginkgo biloba leaves. J Pharm Pharmacol. 2020; 72:1840–53.GanLMaJYouGMaiJWangZYangRGlucuronidation and its effect on the bioactivity of amentoflavone, a biflavonoid from Ginkgo biloba leaves20207218405310.1111/jphp.1324732144952Search in Google Scholar
Kimura Y, Ito H, Ohnishi R, Hatano T. Inhibitory effects of polyphenols on human cytochrome P450 3A4 and 2C9 activity. Food Chem Toxicol. 2010; 48:429–35.KimuraYItoHOhnishiRHatanoTInhibitory effects of polyphenols on human cytochrome P450 3A4 and 2C9 activity2010484293510.1016/j.fct.2009.10.04119883715Search in Google Scholar
Park S-Y, Nguyen P-H, Kim G, Jang S-N, Lee G-H, Phuc NM, et al. Strong and selective inhibitory effects of the biflavonoid selamariscina A against CYP2C8 and CYP2C9 enzyme activities in human liver microsomes. Pharmaceutics. 2020; 12:343. doi: 10.3390/pharmaceutics12040343ParkS-YNguyenP-HKimGJangS-NLeeG-HPhucNMStrong and selective inhibitory effects of the biflavonoid selamariscina A against CYP2C8 and CYP2C9 enzyme activities in human liver microsomes20201234310.3390/pharmaceutics12040343723812032290339Open DOISearch in Google Scholar
Pan X, Tan N, Zeng G, Zhang Y, Jia R. Amentoflavone and its derivatives as novel natural inhibitors of human Cathepsin B. Bioorganic Med Chem. 2005; 13:5819–25.PanXTanNZengGZhangYJiaRAmentoflavone and its derivatives as novel natural inhibitors of human Cathepsin B20051358192510.1016/j.bmc.2005.05.07116084098Search in Google Scholar
Lv X, Zhang J-B, Wang X-X, Hu W-Z, Shi Y-S, Liu S-W, et al. Amentoflavone is a potent broad-spectrum inhibitor of human UDP-glucuronosyltransferases. Chem Biol Interact. 2018;284:48–55.LvXZhangJ-BWangX-XHuW-ZShiY-SLiuS-WAmentoflavone is a potent broad-spectrum inhibitor of human UDP-glucuronosyltransferases2018284485510.1016/j.cbi.2018.02.00929470958Search in Google Scholar
Ananchaisarp T, Rungruang S, Theerakulpisut S, Kamsakul P, Nilbupha N, Chansawangphop N, et al. Usage of herbal medicines among the elderly in a primary care unit in Hat Yai, Songkhla province, Thailand. Asian Biomed (Res Rev News) 2021; 15:35–42.AnanchaisarpTRungruangSTheerakulpisutSKamsakulPNilbuphaNChansawangphopNUsage of herbal medicines among the elderly in a primary care unit in Hat Yai, Songkhla province, Thailand202115354210.2478/abm-2020-0005Search in Google Scholar
Stolbach A, Paziana K, Heverling H, Pham P. A review of the toxicity of HIV medications II: interactions with drugs and complementary and alternative medicine products. J Med Toxicol. 2015; 11:326–41.StolbachAPazianaKHeverlingHPhamPA review of the toxicity of HIV medications II: interactions with drugs and complementary and alternative medicine products2015113264110.1007/s13181-015-0465-0454796626036354Search in Google Scholar
Borrelli F, Izzo AA. Herb–drug interactions with St John's Wort (Hypericum perforatum): an update on clinical observations. AAPS J. 2009; 11:710–27.BorrelliFIzzoAAHerb–drug interactions with St John's Wort (Hypericum perforatum): an update on clinical observations2009117102710.1208/s12248-009-9146-8278208019859815Search in Google Scholar
Lobstein-Guth A, Briançon-Scheid F, Victoire C, Haag-Berrurier M, Anton R. Isolation of amentoflavone from Ginkgo biloba. Planta Med. 1988; 54:555–6.Lobstein-GuthABriançon-ScheidFVictoireCHaag-BerrurierMAntonRIsolation of amentoflavone from Ginkgo biloba198854555610.1055/s-2006-9625493212094Search in Google Scholar
Nahrstedt A, Butterweck V. Biologically active and other chemical constituents of the herb of Hypericum perforatum L. Pharmacopsychiatry. 1997; 30:129–34.NahrstedtAButterweckVBiologically active and other chemical constituents of the herb of Hypericum perforatum L.1997301293410.1055/s-2007-9795339342774Search in Google Scholar
Chrubasik-Hausmann S, Vlachojannis J, McLachlan AJ. Understanding drug interactions with St John's wort (Hypericum perforatum L.): impact of hyperforin content. J Pharm Pharmacol. 2019; 71:129–38.Chrubasik-HausmannSVlachojannisJMcLachlanAJUnderstanding drug interactions with St John's wort (Hypericum perforatum L.): impact of hyperforin content2019711293810.1111/jphp.1285829411879Search in Google Scholar
Deng Y, Bi H-C, Zhao L-Z, He F, Liu Y-Q, Yu J-J, et al. Induction of cytochrome P450s by terpene trilactones and flavonoids of the Ginkgo biloba extract EGb 761 in rats. Xenobiotica 2008; 38:465–81.DengYBiH-CZhaoL-ZHeFLiuY-QYuJ-JInduction of cytochrome P450s by terpene trilactones and flavonoids of the Ginkgo biloba extract EGb 761 in rats2008384658110.1080/0049825070188323318421621Search in Google Scholar
Sanders JM, Monogue ML, Jodlowski TZ, Cutrell JB. Pharmacologic treatments for coronavirus disease 2019 (COVID-19): a review. JAMA. 2020; 323:1824–36.SandersJMMonogueMLJodlowskiTZCutrellJBPharmacologic treatments for coronavirus disease 2019 (COVID-19): a review202032318243610.1001/jama.2020.601932282022Search in Google Scholar
Huynh T, Wang H, Cornell W, Luan B. In silico exploration of repurposing and optimizing traditional Chinese medicine rutin for possibly inhibiting SARS-CoV-2's main protease. ChemRxiv. Preprint. 2020. doi: 10.26434/chemrxiv.12281078.v1HuynhTWangHCornellWLuanBIn silico exploration of repurposing and optimizing traditional Chinese medicine rutin for possibly inhibiting SARS-CoV-2's main protease202010.26434/chemrxiv.12281078.v1Open DOISearch in Google Scholar