Background: Klebsiella rhinoscleromatis is the etiologic bacterium of rhinoscleroma. While rare, it has been implicated as a cause of septicemia. Only five cases of septicemia due to K. rhinoscleromatis have been reported previously. Objective: Report a case of K. rhinoscleromatis septicemia in Thailand and literature review. Results: K. rhinoscleromatis septicemia was observed in a 71-years-old-female diabetic patient suffering with acute fever.