Percutaneous Toxicity and Decontamination of Soman, Vx, and Paraoxon in Rats Using Detergents

1. Greenfield RA, Brown BR, Hutchins JB, Iandolo JJ, Jackson R, Slater LN, Bronze MS. Microbiological, biological, and chemical weapons of warfare and terrorism. Am J Med Sci 2002;323:326-40.10.1097/00000441-200206000-00005Search in Google Scholar

2. Munro NB, Ambrose KR, Watson AP. Toxicity of the organophosphate chemical warfare agents GA, GB and VX: implications for public protection. Environ Health Perspect 1994;102:18-38.10.1289/ehp.9410218Search in Google Scholar

3. Gupta RC, editor. Handbook of Toxicology of Chemical Warfare Agents. 1st ed. London: Elsevier Inc; 2009.Search in Google Scholar

4. Yang YC, Baker JA, Ward JR. Decontamination of chemical warfare agents. Chem Rev 1992;92:1729-43. doi: 10.1021/cr00016a00310.1021/cr00016a003Search in Google Scholar

5. Tiwari S, Ghosh KK, Marek J, Kuca K. Functionalized surfactant mediated reactions of carboxylate, phosphate and sulphonate esters. J Phys Org Chem 2010;23:519-25. doi: 10.1002/poc.163510.1002/poc.1635Search in Google Scholar

6. Cabal J, Kassa J, Severa J. A comparison of the decontamination efficacy of foam-making blends based on cationic and nonionic tensides against organophosphorus compounds determined in vitro and in vivo. Hum Exp Toxicol 2003;22:507-14. doi: 10.1191/0960327103ht377oa10.1191/0960327103ht377oaSearch in Google Scholar

7. Amlot R, Larner J, Matar H, Jones DR, Carter H, Turner EA, Price SC, Chilcott RP. Comparative analysis of showering protocols for mass-casualty decontamination. Prehos Disaster Med 2010;25:435-39. doi: 10.1017/S1049023X0000852910.1017/S1049023X00008529Search in Google Scholar

8. Zilker T. Medical management of incidents with chemical warfare agents. Toxicology 2005;214:221-31. doi: 10.1016/ j.tox.2005.06.02810.1016/j.tox.2005.06.028Search in Google Scholar

9. Misik J, Pavlikova R, Cabal J, Vodakova E, Kuca K. A comparison of decontamination effects of commercially available detergents in rats preexposed to topical sulphur mustard. Cutan Ocul Toxicol 2013;32:135-9. doi: 10.3109/15569527.2012.73008710.3109/15569527.2012.730087Search in Google Scholar

10. Lipnick RL, Cotruvo JA, Hill RN, Bruce RD, Stitzel KA, Walker AP, Chus I, Goddards M, Segal L, Springer JA, Myers RC. Comparison of the up-and-down, conventional LD50, and fixed-dose acute toxicity procedures. Food Chem Toxicol 1995;33:223-31.10.1016/0278-6915(94)00136-CSearch in Google Scholar

11. Maxwell DM, Brecht KM, Koplovitz I, Sweeney RE. Acetylcholinesterase inhibition: does it explain the toxicity of organophosphorus compounds? Arch Toxicol 2006;80:756-60. doi: 10.1007/s00204-006-01Search in Google Scholar

12. Bajgar J. Organophosphates/nerve agent poisoning: mechanism of action, diagnosis, prophylaxis, and treatment. Adv Clin Chem 2004;38:151-216.10.1016/S0065-2423(04)38006-6Search in Google Scholar

13. Dalton CH, Hattersley IJ, Rutter SJ, Chilcott RP. Absorption of the nerve agent VX (O-ethyl-S-[2(diisopropylamino) ethyl] methyl phosphonothioate) through pig, human and guinea pig skin in vitro. Toxicol In Vitro 2006;20:1532-6. doi: 10.1016/j.tiv.2006.06.00910.1016/j.tiv.2006.06.009Search in Google Scholar

14. Moody RP, Maibach HI. Skin decontamination: Importance of the wash-in effect. Food Chem Toxicol 2006;44:1783-8. doi: 10.1016/j.fct.2006.05.02010.1016/j.fct.2006.05.020Search in Google Scholar

15. Hamilton MG, Hill I, Conley J, Sawyer TW, Caneva DC, Lundy PM. Clinical aspects of percutaneous poisoning by the chemical warfare agent VX. Effects of application site and decontamination. Mil Med 2004;169:856-62.10.7205/MILMED.169.11.856Search in Google Scholar

16. Joosen MJ, van den Boom JE, Kuijpers TM, Smit WC, Lucassen AB, van Helden HP. Long-term cognitive deficits accompanied by reduced neurogenesis after soman poisoning. Neurotoxicology 2009;30:72-80. doi: 10.1016/j. neuro.2008.11.010Search in Google Scholar

17. Bjarnason S, Mikler J, Hill I, Tenn C, Garrett M, Caddy N, Sawyer TW. Comparison of selected skin decontaminant products and regimens against VX in domestic swine. Hum Exp Toxicol 2008;27:253-61. doi: 10.1177/ 096032710809026910.1177/0960327108090269Search in Google Scholar

18. Braue EH Jr, Smith KH, Doxzon BF, Lumpkin HL, Clarkson ED. Efficacy studies of reactive skin decontamination lotion, M291 skin decontamination kit, 0.5% bleach, 1% soapy water, and skin exposure reduction paste against chemical warfare agents, Part 2: Guinea pigs challenged with soman. Cutan Ocul Toxicol 2011;30:29-37. doi: 10.3109/15569527 .2010.515281Search in Google Scholar

19. Loke WK, Lau SK, Lim JS, Tay GS, Koh CH. Wet decontamination-induced stratum corneum hydration: effects on the barrier function to diethylmalonate. J Appl Toxicol 1999; 19:285-90.doi: 10.1002/(SICI)1099-1263(199907/08)19:4<275::AID-JAT578>3.0.CO;2-B10.1002/(SICI)1099-1263(199907/08)19:4<275::AID-JAT578>3.0.CO;2-BSearch in Google Scholar

20. Misik J, Pavlikova R, Josse D, Cabal J, Kuca K. In vitro skin permeation and decontamination of the organophosphorus pesticide paraoxon under various physical conditions - evidence for a wash-in effect. Toxicol Mech Methods 2012;22:520-5. doi: 10.3109/15376516.2012.68653510.3109/15376516.2012.686535Search in Google Scholar

21. Chilcott RP, Dalton CH, Hill I, Davison CM, Blohm KL, Clarkson ED, Hamilton MG. Evaluation of a barrier cream against the chemical warfare agent VX using the domestic white pig. Basic Clin Pharmacol Toxicol 2005;97:35-8.10.1111/j.1742-7843.2005.pto_97106.xSearch in Google Scholar

22. Taysse L, Daulon S, Delamanche S, Bellier B, Breton P. Skin decontamination of mustards and oranophosphates: comparative efficiency of RSDL and Fuller’s earth in domestic swine. Hum Exp Toxicol 2007;26:135-41. doi: 10.1177/096032710707186610.1177/0960327107071866Search in Google Scholar

23. Kuca K, Jun D, Musilek K. Structural requirements of acetylcholinesterase reactivators. Mini Rev Med Chem 2006;6:269-77.10.2174/138955706776073510Search in Google Scholar

24. Kuca K, Jun D, Bajgar J. Currently used cholinesterase reactivators against nerve agent intoxication: comparison of their effectivity in vitro. Drug Chem Toxicol 2007;30:31-40.10.1080/01480540601017637Search in Google Scholar

25. Knezevic D, Tadic V, Katic S. Combined decontamination and parenteral therapy improve the chances of survival in rats percutaneously poisoned with organophosphorus insecticides. Acta Veterinaria (Beograd) 2001;51:187-95.Search in Google Scholar

26. Dorandeu F, Taysse L, Boudry I, Foquin A, Herodin F, Mathieu J, Daulon S, Cruz C, Lallement G. Cutaneous challenge with chemical warfare agents in the SKH-1 hairless mouse. (I) Development of a model for screening studies in skin decontamination and protection. Hum Exp Toxicol 2011;30:470-90. doi: 10.1177/096032711037361510.1177/096032711037361520547654Search in Google Scholar

27. Misik J, Pavlik M, Novotny L, Pavlikova R, Chilcott RP, Cabal J, Kuca K. In vivo decontamination of the nerve agent VX using the domestic swine model. Clin Toxicol 2012;50:807-11. doi: 10.3109/15563650.2012.72098610.3109/15563650.2012.72098622963275Search in Google Scholar