Genotoxicity of Metal Nanoparticles: Focus on In Vivo Studies

Sosnovik DE, Nahrendorf M, Weissleder R. Magnetic nanoparticles for MR imaging: agents, techniques and cardiovascular applications. Basic Res Cardiol 2008;103:122-30.10.1007/s00395-008-0710-7Search in Google Scholar

Corchero J, Villaverde A. Biomedical applications of distally controlled magnetic nanoparticles. Trends Biotechnol 2009;27:468-76.10.1016/j.tibtech.2009.04.003Search in Google Scholar

Luther W. Industrial application of nanomaterials - chances and risks. Future Technologies 2004:54;1-112.Search in Google Scholar

European Agency for Safety and Health at Work (EU-OSHA). Workplace exposure to nanoparticles 2009 [displayed 29 Jan 2012]. Available at http://osha.europa.eu/en/publications/literature_reviews/workplace_exposure_to_nanoparticlesSearch in Google Scholar

Singh N, Manshian B, Jenkins G, Griffiths S, Williams P, Maffeis T, Wright C, Doak S. NanoGenotoxicology: the DNA damaging potential of engineered nanomaterials. Biomaterials 2009;30:3891-914.10.1016/j.biomaterials.2009.04.009Search in Google Scholar

Oberdörster G, Maynard A, Donaldson K, Castranova V, Fitzpatrick J, Ausman K, Carter J, Karn B, Kreyling W, Lai D, Olin S, Monteiro-Riviere N, Warheit D, Yang H; ILSI Research Foundation/Risk Science Institute Nanomaterial Toxicity Screening Working Group. Principles for characterizing the potential human health effects from exposure to nanomaterials: elements of a screening strategy. Part Fibre Toxicol 2005;2:8.10.1186/1743-8977-2-8Search in Google Scholar

Schatz G. Using theory and computation to model nanoscale properties. Proc Natl Acad Sci USA 2007;104:6885-92.10.1073/pnas.0702187104Search in Google Scholar

Brouwer D. Exposure to manufactured nanoparticles in different workplaces. Toxicology 2010;269:120-7.10.1016/j.tox.2009.11.017Search in Google Scholar

Food and drug administration (FDA). Sunscreen Drug Products for Over-the-Counter Human Use. Amendment to the Tentative Final Monograph; Enforcement Policy. Federal Register /Vol. 63, No. 204/1998 [displayed 29 Jan 2012]. Available at http://www.fda.gov/ohrms/dockets/98fr/102298b.pdfSearch in Google Scholar

Nakagawa Y, Wakuri S, Sakamoto K, Tanaka N. The photogenotoxicity of titanium dioxide particles. Mutat Res 1997;394:125-32.10.1016/S1383-5718(97)00126-5Search in Google Scholar

Wang JJ, Sanderson BJ, Wang H. Cyto- and genotoxicity of ultrafine TiO₂ particles in cultured human lymphoblastoid cells. Mutat Res 2007;628:99-106.10.1016/j.mrgentox.2006.12.00317223607Search in Google Scholar

Gurr JR, Wang AS, Chen CH, Jan KY. Ultrafine titanium dioxide particles in the absence of photoactivation can induce oxidative damage to human bronchial epithelial cells. Toxicology 2005;213:66-73.10.1016/j.tox.2005.05.00715970370Search in Google Scholar

Falck G, Lindberg H, Suhonen S, Vippola M, Vanhala E, Catalán J, Savolainen K, Norppa H. Genotoxic effects of nanosized and fine TiO2. Hum Exp Toxicol 2009;28:339-52.10.1177/096032710910516319755445Search in Google Scholar

Borm P, Robbins D, Haubold S, Kuhlbusch T, Fissan H, Donaldson K, Schins R, Stone V, Kreyling W, Lademann J, Krutmann J, Warheit D, Oberdorster E. The potential risks of nanomaterials: a review carried out for ECETOC. Part Fibre Toxicol 2006;3:11.10.1186/1743-8977-3-11Search in Google Scholar

Snyder M, Lee J, Davis T, Scriven L, Tsapatsis M. Silica nanoparticle crystals and ordered coatings using lys-sil and a novel coating device. Langmuir 2007;23:9924-8.10.1021/la701063vSearch in Google Scholar

Ostiguy C, Lapointe G, Ménard L, Cloutier Y, Trottier M, Boutin M, Antoun M, Normand C. Nanoparticles. Actual knowledge about occupational health and saftey risks and prevention measures. Studies and Research Projects. Report R-470. Montréal: IRSST; 2006.Search in Google Scholar

Hong SC, Lee JH, Lee J, Kim HY, Park JY, Cho J, Han DW. Subtle cytotoxicity and genotoxicity differences in superparamagnetic iron oxide nanoparticles coated with various functional groups. Int J Nanomedicine 2011;6:3219-31.Search in Google Scholar

Ahamed M, Karns M, Goodson M, Rowe J, Hussain SM, Schlager JJ, Hong Y. DNA damage response to different surface chemistry of silver nanoparticles in mammalian cells. Toxicol Appl Pharmacol 2008;233:404-10.10.1016/j.taap.2008.09.015Search in Google Scholar

Sharma V, Singh SK, Anderson D, Tobin DJ, Dhawan A. Zinc oxide nanoparticle induced genotoxicity in primary human epidermal keratinocytes. J Nanosci Nanotechnol 2011;11:3782-8.10.1166/jnn.2011.4250Search in Google Scholar

Papageorgiou I, Brown C, Schins R, Singh S, Newson R, Davis S, Fisher J, Ingham E, Case CP. The effect of nano- and micron-sized particles of cobalt-chromium alloy on human fibroblasts in vitro. Biomaterials 2007;28:2946-58.10.1016/j.biomaterials.2007.02.034Search in Google Scholar

Bhabra G, Sood A, Fisher B, Cartwright L, Saunders M, Evans WH, Surprenant A, Lopez-Castejon G, Mann S, Davis SA, Hails LA, Ingham E, Verkade P, Lane J, Heesom K, Newson R, Case CP. Nanoparticles can cause DNA damage across a cellular barrier. Nat Nanotechnol 2009;4:876-83.10.1038/nnano.2009.313Search in Google Scholar

Collins AR. The comet assay for DNA damage and repair: principles, applications, and limitations. Mol Biotechnol 2004;26:249-61.10.1385/MB:26:3:249Search in Google Scholar

Fenech M. The micronucleus assay determination of chromosomal level DNA damage. Methods Mol Biol 2008;410:185-216.10.1007/978-1-59745-548-0_1218642602Search in Google Scholar

Trouiller B, Reliene R, Westbrook A, Solaimani P, Schiestl RH. Titanium dioxide nanoparticles induce DNA damage and genetic instability in vivo in mice. Cancer Res 2009;69:8784-9.10.1158/0008-5472.CAN-09-2496387321919887611Search in Google Scholar

Sycheva LP, Zhurkov VS, Iurchenko VV, Daugel-Dauge NO, Kovalenko MA, Krivtsova EK, Durnev AD. Investigation of genotoxic and cytotoxic effects of micro- and nanosized titanium dioxide in six organs of mice in vivo. Mutat Res 2011;726:8-14.10.1016/j.mrgentox.2011.07.01021871579Search in Google Scholar

Saber AT, Jacobsen NR, Mortensen A, Szarek J, Jackson P, Madsen AM, Jensen KA, Koponen IK, Brunborg G, Gützkow KB, Vogel U, Wallin H. Nanotitanium dioxide toxicity in mouse lung is reduced in sanding dust from paint. Part Fibre Toxicol 2012;9:4.10.1186/1743-8977-9-4329847922300483Search in Google Scholar

Landsiedel R, Ma-Hock L, Van Ravenzwaay B, Schulz M, Wiench K, Champ S, Schulte S, Wohlleben W, Oesch F. Gene toxicity studies on titanium dioxide and zinc oxide nanomaterials used for UV-protection in cosmetic formulations. Nanotoxicology 2010;4:364-81.10.3109/17435390.2010.50669420925445Search in Google Scholar

Naya M, Kobayashi N, Ema M, Kasamoto S, Fukumuro M, Takami S, Nakajima M, Hayashi M, Nakanishi J. In vivo genotoxicity study of titanium dioxide nanoparticles using comet assay following intratracheal instillation in rats. Regul Toxicol Pharmacol 2011;62:1-6.10.1016/j.yrtph.2011.12.00222198002Search in Google Scholar

Sharma V, Singh P, Pandey AK, Dhawan A. Induction of oxidative stress, DNA damage and apoptosis in mouse liver after sub-acute oral exposure to zinc oxide nanoparticles. Mutat Res 2012;745:84-91.10.1016/j.mrgentox.2011.12.00922198329Search in Google Scholar

Jiang H, Liu F, Yang H, Li Y. Effects of cobalt nanoparticles on human T cells in vitro. Biol Trace Elem Res 2012;146:23-9.10.1007/s12011-011-9221-821968949Search in Google Scholar

Puntes VF, Krishnan KM, Alivisatos AP. Colloidal nanocrystal shape and size control: the case of cobalt. Science 2001;291:2115-7.10.1126/science.1058495Search in Google Scholar

Skumryev V, Stoyanov S, Zhang Y, Hadjipanayis G, Givord D, Nogués J. Beating the superparamagnetic limit with exchange bias. Nature 2003;423:850-3.10.1038/nature0168712815426Search in Google Scholar

Hwang dW, Lee DS, Kim S. Gene expression profiles for genotoxic effects of silica-free and silica-coated cobalt ferrite nanoparticles. J Nucl Med 2012;53:106-12.10.2967/jnumed.111.08844322147119Search in Google Scholar

Girgis E, Khalil WK, Emam AN, Mohamed MB, Rao KV. Nanotoxicity of gold and gold-cobalt nanoalloy. Chem Res Toxicol 2012;25:1086-98.10.1021/tx300053h22486372Search in Google Scholar

Li WR, Xie XB, Shi QS, Duan SS, Ouyang YS, Chen YB. Antibacterial effect of silver nanoparticles on Staphylococcus aureus. Biometals 2011;24:135-41.10.1007/s10534-010-9381-620938718Search in Google Scholar

Tiwari DK, Jin T, Behari J. Dose-dependent in vivo toxicity assessment of silver nanoparticle in Wistar rats. Toxicol Mech Methods 2011;21:13-24.10.3109/15376516.2010.52918421080782Search in Google Scholar

Choi JE, Kim S, Ahn JH, Youn P, Kang JS, Park K, Yi J, Ryu DY. Induction of oxidative stress and apoptosis by silver nanoparticles in the liver of adult zebrafish. Aquat Toxicol 2010;100:151-9.10.1016/j.aquatox.2009.12.01220060176Search in Google Scholar

Ahamed M, Posgai R, Gorey TJ, Nielsen M, Hussain SM, Rowe JJ. Silver nanoparticles induced heat shock protein 70, oxidative stress and apoptosis in Drosophila melanogaster. Toxicol Appl Pharmacol 2010;242:263-9.10.1016/j.taap.2009.10.01619874832Search in Google Scholar

Kim YS, Kim JS, Cho HS, Rha DS, Kim JM, Park JD, Choi BS, Lim R, Chang HK, Chung YH, Kwon IH, Jeong J, Han BS, Yu IJ. Twenty-eight-day oral toxicity, genotoxicity, and gender-related tissue distribution of silver nanoparticles in Sprague-Dawley rats. Inhal Toxicol 2008;20:575-83.10.1080/0895837070187466318444010Search in Google Scholar

Johnston HJ, Hutchison G, Christensen FM, Peters S, Hankin S, Stone V. A review of the in vivo and in vitro toxicity of silver and gold particulates: particle attributes and biological mechanisms responsible for the observed toxicity. Crit Rev Toxicol 2010;40:328-46.10.3109/1040844090345307420128631Search in Google Scholar

Schulz M, Ma-Hock L, Brill S, Strauss V, Treumann S, Gröters S, van Ravenzwaay B, Landsiedel R. Investigation on the genotoxicity of different sizes of gold nanoparticles administered to the lungs of rats. Mutat Res 2011;745:51-7.10.1016/j.mrgentox.2011.11.01622172426Search in Google Scholar

Balasubramanyam A, Sailaja N, Mahboob M, Rahman MF, Misra S, Hussain SM, Grover P. Evaluation of genotoxic effects of oral exposure to aluminum oxide nanomaterials in rat bone marrow. Mutat Res 2009;676:41-7.10.1016/j.mrgentox.2009.03.00419486863Search in Google Scholar

Balasubramanyam A, Sailaja N, Mahboob M, Rahman MF, Hussain SM, Grover P. In vivo genotoxicity assessment of aluminium oxide nanomaterials in rat peripheral blood cells using the comet assay and micronucleus test. Mutagenesis 2009;24:245-51.10.1093/mutage/gep00319237533Search in Google Scholar

Kang GS, Gillespie PA, Gunnison A, Moreira AL, Tchou-Wong KM, Chen LC. Long-term inhalation exposure to nickel nanoparticles exacerbated atherosclerosis in a susceptible mouse model. Environ Health Perspect 2011;119:176-81.10.1289/ehp.1002508304060320864429Search in Google Scholar

Saber AT, Jensen KA, Jacobsen NR, Birkedal R, Mikkelsen L, Møller P, Loft S, Wallin H, Vogel U. Inflammatory and genotoxic effects of nanoparticles designed for inclusion in paints and lacquers. Nanotoxicology 2011 [Epub ahead of print]10.3109/17435390.2011.58790021649461Search in Google Scholar

Organisation for Economics Co-operation and Development (OECD). Guidance Manual for the Testing of Manufactured Nanomaterials. 2010 [displayed 29 Jan 2012]. Available at http://www.oecd.org/officialdocuments/displaydocumentpdf/?cote=ENV/JM/MONO(2009)20/REV&doclanguage=enSearch in Google Scholar

National Institute for Occupational Safety and Health (NIOSH). Approaches to Safe Nanotechnology. Managing the Health and Safety Concerns Associated with Engineered Nanomaterials. 2009 [displayed 29 Jan 2012]. Available at http://www.cdc.gov/niosh/docs/2009-125/pdfs/2009-125.pdfSearch in Google Scholar

Institut de recherche Robert-Sauvé en santé et en sécurité du travail (IRSST). Chemical Substances and Biological Agents, Studies and Research Projects, Report R-599. Best Practices Guide to Synthetic Nanoparticle Risk Management. 2009 [displayed 30 Jan 2012]. Available at http://www.irsst.qc.ca/media/documents/pubirsst/r-599.pdfSearch in Google Scholar

Schulte PA, Mundt DJ, Nasterlack M, Mulloy KB, Mundt KA. Exposure registries: overview and utility for nanomaterial workers. J Occup Environ Med 2011;53(Suppl 6):S42-7.10.1097/JOM.0b013e31821aebed21654416Search in Google Scholar